Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03355:Tmprss11c'

419891

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmprss11c

Ensembl Gene

ENSMUSG00000061184

Gene Name

transmembrane protease, serine 11c

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03355

Quality Score

Status

Chromosome

Chromosomal Location

86379340-86437167 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 86379730 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 380 (I380F)

Ref Sequence

ENSEMBL: ENSMUSP00000142902 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059424] [ENSMUST00000196462]

AlphaFold

Q1JRP2

Predicted Effect

probably benign
Transcript: ENSMUST00000059424
AA Change: I393F

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000062915
Gene: ENSMUSG00000061184
AA Change: I393F

Domain	Start	End	E-Value	Type
transmembrane domain	34	56	N/A	INTRINSIC
SEA	58	183	5.19e-3	SMART
Tryp_SPc	199	425	8.42e-91	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180191

Predicted Effect

probably benign
Transcript: ENSMUST00000196462
AA Change: I380F

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000142902
Gene: ENSMUSG00000061184
AA Change: I380F

Domain	Start	End	E-Value	Type
transmembrane domain	34	56	N/A	INTRINSIC
SEA	58	176	3.6e-4	SMART
Tryp_SPc	186	412	4.1e-93	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actrt1	T	C	X: 45,418,624 (GRCm39)	V213A	probably benign	Het
Adam28	A	T	14: 68,872,252 (GRCm39)		probably benign	Het
Apeh	T	C	9: 107,963,644 (GRCm39)	H557R	probably benign	Het
Atmin	T	A	8: 117,684,164 (GRCm39)	L608*	probably null	Het
B3gnt5	A	T	16: 19,587,903 (GRCm39)	M41L	probably benign	Het
Best3	T	C	10: 116,829,010 (GRCm39)	F97L	possibly damaging	Het
Chmp1b2	C	A	X: 106,831,889 (GRCm39)	V180F	possibly damaging	Het
Col7a1	G	A	9: 108,807,228 (GRCm39)	V2486M	unknown	Het
Crym	T	C	7: 119,798,536 (GRCm39)		probably null	Het
Cubn	T	C	2: 13,482,868 (GRCm39)		probably null	Het
Dnah7b	A	G	1: 46,158,464 (GRCm39)	D349G	probably benign	Het
Eea1	T	C	10: 95,878,074 (GRCm39)		probably benign	Het
Emc1	C	T	4: 139,098,904 (GRCm39)		probably benign	Het
Eps8	T	C	6: 137,489,143 (GRCm39)		probably benign	Het
Ereg	A	G	5: 91,236,440 (GRCm39)		probably benign	Het
Faah	G	A	4: 115,859,725 (GRCm39)	P369S	probably benign	Het
Fam135a	A	T	1: 24,068,249 (GRCm39)	N703K	possibly damaging	Het
Frmpd1	T	C	4: 45,279,140 (GRCm39)	S622P	probably damaging	Het
Gm10030	A	G	9: 110,835,841 (GRCm39)		noncoding transcript	Het
Gpr179	A	T	11: 97,228,434 (GRCm39)	S1240R	possibly damaging	Het
Hax1	A	T	3: 89,904,754 (GRCm39)	H146Q	possibly damaging	Het
Ift46	A	G	9: 44,693,445 (GRCm39)	N31D	possibly damaging	Het
Kel	C	T	6: 41,675,821 (GRCm39)		probably null	Het
Khk	A	T	5: 31,086,904 (GRCm39)	I108L	probably benign	Het
Morc4	T	C	X: 138,750,431 (GRCm39)	N375S	probably null	Het
Mta3	A	T	17: 84,107,474 (GRCm39)		probably benign	Het
Nacc2	T	C	2: 25,952,249 (GRCm39)	K369R	probably damaging	Het
Nkap	T	C	X: 36,403,323 (GRCm39)		probably benign	Het
Obscn	A	T	11: 58,928,618 (GRCm39)	L6016Q	probably damaging	Het
Or52e2	T	C	7: 102,804,408 (GRCm39)	E182G	probably damaging	Het
Or8c9	A	T	9: 38,240,952 (GRCm39)	Q20L	probably benign	Het
Pde4c	T	A	8: 71,199,244 (GRCm39)	L182Q	probably damaging	Het
Pla2g10	G	T	16: 13,548,284 (GRCm39)		probably null	Het
Rap1gap2	T	A	11: 74,303,170 (GRCm39)	I426F	probably damaging	Het
Rbm33	C	A	5: 28,596,059 (GRCm39)		probably benign	Het
Rnf139	C	A	15: 58,771,881 (GRCm39)	D635E	probably benign	Het
Sar1a	T	C	10: 61,520,718 (GRCm39)	V15A	possibly damaging	Het
Scarb1	A	C	5: 125,366,766 (GRCm39)	S56A	probably benign	Het
Scn3a	T	C	2: 65,290,912 (GRCm39)	K1945E	possibly damaging	Het
Sec62	G	A	3: 30,864,071 (GRCm39)	G118R	unknown	Het
Sgce	T	A	6: 4,689,738 (GRCm39)	Q356L	probably damaging	Het
Slco4c1	A	T	1: 96,770,232 (GRCm39)	Y277*	probably null	Het
Smarca4	C	T	9: 21,547,132 (GRCm39)	T219I	probably benign	Het
Sphkap	A	T	1: 83,258,224 (GRCm39)	I173N	probably damaging	Het
Spred3	C	T	7: 28,860,997 (GRCm39)	C394Y	unknown	Het
Stra6l	A	G	4: 45,873,689 (GRCm39)	D283G	probably benign	Het
Tipin	A	T	9: 64,195,406 (GRCm39)	Q4L	probably benign	Het
Tymp	T	C	15: 89,259,219 (GRCm39)	D195G	possibly damaging	Het
Ugt2b34	T	A	5: 87,054,544 (GRCm39)	Y79F	probably benign	Het
Vmn2r16	T	A	5: 109,511,580 (GRCm39)	S596T	possibly damaging	Het
Wdhd1	A	G	14: 47,481,346 (GRCm39)	S1024P	possibly damaging	Het

Other mutations in Tmprss11c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Tmprss11c	APN	5	86,387,254 (GRCm39)	missense	probably benign	0.00
IGL01357:Tmprss11c	APN	5	86,379,666 (GRCm39)	missense	probably damaging	1.00
IGL01809:Tmprss11c	APN	5	86,385,521 (GRCm39)	missense	possibly damaging	0.89
IGL02972:Tmprss11c	APN	5	86,385,692 (GRCm39)	missense	possibly damaging	0.77
IGL03135:Tmprss11c	APN	5	86,385,509 (GRCm39)	missense	probably damaging	1.00
IGL03255:Tmprss11c	APN	5	86,419,341 (GRCm39)	missense	probably damaging	0.99
R0165:Tmprss11c	UTSW	5	86,379,786 (GRCm39)	splice site	probably benign
R0285:Tmprss11c	UTSW	5	86,419,289 (GRCm39)	missense	probably damaging	1.00
R0480:Tmprss11c	UTSW	5	86,385,468 (GRCm39)	splice site	probably benign
R0639:Tmprss11c	UTSW	5	86,383,328 (GRCm39)	missense	probably damaging	1.00
R1554:Tmprss11c	UTSW	5	86,437,119 (GRCm39)	start codon destroyed	possibly damaging	0.59
R1651:Tmprss11c	UTSW	5	86,387,283 (GRCm39)	missense	probably damaging	1.00
R2234:Tmprss11c	UTSW	5	86,429,945 (GRCm39)	missense	probably benign	0.12
R2235:Tmprss11c	UTSW	5	86,429,945 (GRCm39)	missense	probably benign	0.12
R2698:Tmprss11c	UTSW	5	86,419,322 (GRCm39)	missense	probably damaging	1.00
R4787:Tmprss11c	UTSW	5	86,404,312 (GRCm39)	missense	probably benign	0.00
R4962:Tmprss11c	UTSW	5	86,385,569 (GRCm39)	missense	probably damaging	1.00
R5063:Tmprss11c	UTSW	5	86,385,689 (GRCm39)	missense	probably benign	0.28
R5217:Tmprss11c	UTSW	5	86,404,249 (GRCm39)	missense	probably benign
R5366:Tmprss11c	UTSW	5	86,429,993 (GRCm39)	missense	possibly damaging	0.93
R6343:Tmprss11c	UTSW	5	86,404,204 (GRCm39)	missense	probably damaging	1.00
R6598:Tmprss11c	UTSW	5	86,437,092 (GRCm39)	missense	probably benign	0.01
R6681:Tmprss11c	UTSW	5	86,437,119 (GRCm39)	start codon destroyed	possibly damaging	0.59
R7170:Tmprss11c	UTSW	5	86,385,478 (GRCm39)	critical splice donor site	probably null
R7198:Tmprss11c	UTSW	5	86,379,691 (GRCm39)	missense	probably damaging	1.00
R7258:Tmprss11c	UTSW	5	86,419,272 (GRCm39)	missense	probably damaging	1.00
R7382:Tmprss11c	UTSW	5	86,379,723 (GRCm39)	missense	probably benign	0.19
R7391:Tmprss11c	UTSW	5	86,385,650 (GRCm39)	missense	probably damaging	1.00
R7590:Tmprss11c	UTSW	5	86,387,332 (GRCm39)	missense	probably benign	0.01
R7894:Tmprss11c	UTSW	5	86,379,655 (GRCm39)	missense	probably damaging	1.00
R8164:Tmprss11c	UTSW	5	86,379,712 (GRCm39)	missense	probably damaging	1.00
R8311:Tmprss11c	UTSW	5	86,383,412 (GRCm39)	missense	probably damaging	1.00
R8416:Tmprss11c	UTSW	5	86,387,276 (GRCm39)	missense	probably damaging	1.00
R8426:Tmprss11c	UTSW	5	86,379,677 (GRCm39)	missense	probably damaging	1.00
R8877:Tmprss11c	UTSW	5	86,385,540 (GRCm39)	nonsense	probably null
R9092:Tmprss11c	UTSW	5	86,385,495 (GRCm39)	missense	probably benign	0.04
R9400:Tmprss11c	UTSW	5	86,385,516 (GRCm39)	missense	probably benign	0.43
R9614:Tmprss11c	UTSW	5	86,383,379 (GRCm39)	missense	probably benign	0.12

Posted On

2016-08-02