Incidental Mutation 'IGL03355:Pla2g10'
ID 419927
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pla2g10
Ensembl Gene ENSMUSG00000022683
Gene Name phospholipase A2, group X
Synonyms mGXsPLA2, PLA2GX, GX sPLA2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03355
Quality Score
Status
Chromosome 16
Chromosomal Location 13532921-13548847 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 13548284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023364] [ENSMUST00000115807]
AlphaFold Q9QXX3
Predicted Effect probably benign
Transcript: ENSMUST00000023364
SMART Domains Protein: ENSMUSP00000023364
Gene: ENSMUSG00000022683

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PA2c 29 144 1.68e-35 SMART
Predicted Effect probably null
Transcript: ENSMUST00000115807
SMART Domains Protein: ENSMUSP00000111474
Gene: ENSMUSG00000022683

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PA2c 29 143 2.48e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127780
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141172
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156504
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt1 T C X: 45,418,624 (GRCm39) V213A probably benign Het
Adam28 A T 14: 68,872,252 (GRCm39) probably benign Het
Apeh T C 9: 107,963,644 (GRCm39) H557R probably benign Het
Atmin T A 8: 117,684,164 (GRCm39) L608* probably null Het
B3gnt5 A T 16: 19,587,903 (GRCm39) M41L probably benign Het
Best3 T C 10: 116,829,010 (GRCm39) F97L possibly damaging Het
Chmp1b2 C A X: 106,831,889 (GRCm39) V180F possibly damaging Het
Col7a1 G A 9: 108,807,228 (GRCm39) V2486M unknown Het
Crym T C 7: 119,798,536 (GRCm39) probably null Het
Cubn T C 2: 13,482,868 (GRCm39) probably null Het
Dnah7b A G 1: 46,158,464 (GRCm39) D349G probably benign Het
Eea1 T C 10: 95,878,074 (GRCm39) probably benign Het
Emc1 C T 4: 139,098,904 (GRCm39) probably benign Het
Eps8 T C 6: 137,489,143 (GRCm39) probably benign Het
Ereg A G 5: 91,236,440 (GRCm39) probably benign Het
Faah G A 4: 115,859,725 (GRCm39) P369S probably benign Het
Fam135a A T 1: 24,068,249 (GRCm39) N703K possibly damaging Het
Frmpd1 T C 4: 45,279,140 (GRCm39) S622P probably damaging Het
Gm10030 A G 9: 110,835,841 (GRCm39) noncoding transcript Het
Gpr179 A T 11: 97,228,434 (GRCm39) S1240R possibly damaging Het
Hax1 A T 3: 89,904,754 (GRCm39) H146Q possibly damaging Het
Ift46 A G 9: 44,693,445 (GRCm39) N31D possibly damaging Het
Kel C T 6: 41,675,821 (GRCm39) probably null Het
Khk A T 5: 31,086,904 (GRCm39) I108L probably benign Het
Morc4 T C X: 138,750,431 (GRCm39) N375S probably null Het
Mta3 A T 17: 84,107,474 (GRCm39) probably benign Het
Nacc2 T C 2: 25,952,249 (GRCm39) K369R probably damaging Het
Nkap T C X: 36,403,323 (GRCm39) probably benign Het
Obscn A T 11: 58,928,618 (GRCm39) L6016Q probably damaging Het
Or52e2 T C 7: 102,804,408 (GRCm39) E182G probably damaging Het
Or8c9 A T 9: 38,240,952 (GRCm39) Q20L probably benign Het
Pde4c T A 8: 71,199,244 (GRCm39) L182Q probably damaging Het
Rap1gap2 T A 11: 74,303,170 (GRCm39) I426F probably damaging Het
Rbm33 C A 5: 28,596,059 (GRCm39) probably benign Het
Rnf139 C A 15: 58,771,881 (GRCm39) D635E probably benign Het
Sar1a T C 10: 61,520,718 (GRCm39) V15A possibly damaging Het
Scarb1 A C 5: 125,366,766 (GRCm39) S56A probably benign Het
Scn3a T C 2: 65,290,912 (GRCm39) K1945E possibly damaging Het
Sec62 G A 3: 30,864,071 (GRCm39) G118R unknown Het
Sgce T A 6: 4,689,738 (GRCm39) Q356L probably damaging Het
Slco4c1 A T 1: 96,770,232 (GRCm39) Y277* probably null Het
Smarca4 C T 9: 21,547,132 (GRCm39) T219I probably benign Het
Sphkap A T 1: 83,258,224 (GRCm39) I173N probably damaging Het
Spred3 C T 7: 28,860,997 (GRCm39) C394Y unknown Het
Stra6l A G 4: 45,873,689 (GRCm39) D283G probably benign Het
Tipin A T 9: 64,195,406 (GRCm39) Q4L probably benign Het
Tmprss11c T A 5: 86,379,730 (GRCm39) I380F probably benign Het
Tymp T C 15: 89,259,219 (GRCm39) D195G possibly damaging Het
Ugt2b34 T A 5: 87,054,544 (GRCm39) Y79F probably benign Het
Vmn2r16 T A 5: 109,511,580 (GRCm39) S596T possibly damaging Het
Wdhd1 A G 14: 47,481,346 (GRCm39) S1024P possibly damaging Het
Other mutations in Pla2g10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Pla2g10 APN 16 13,545,950 (GRCm39) missense probably damaging 1.00
R0076:Pla2g10 UTSW 16 13,533,382 (GRCm39) missense possibly damaging 0.66
R8002:Pla2g10 UTSW 16 13,542,912 (GRCm39) missense unknown
R8155:Pla2g10 UTSW 16 13,543,048 (GRCm39) missense probably damaging 0.99
R8722:Pla2g10 UTSW 16 13,548,254 (GRCm39) missense unknown
R8850:Pla2g10 UTSW 16 13,545,914 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02