Incidental Mutation 'IGL03365:Vmn1r90'
ID420040
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r90
Ensembl Gene ENSMUSG00000100586
Gene Namevomeronasal 1 receptor 90
SynonymsB430211C08Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL03365
Quality Score
Status
Chromosome7
Chromosomal Location14555474-14563506 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 14561304 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 290 (I290V)
Ref Sequence ENSEMBL: ENSMUSP00000153726 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000185220] [ENSMUST00000226264] [ENSMUST00000226510] [ENSMUST00000226802] [ENSMUST00000227566] [ENSMUST00000227692] [ENSMUST00000227788] [ENSMUST00000227855]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000044683
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173220
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173766
Predicted Effect probably damaging
Transcript: ENSMUST00000185220
AA Change: I290V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000140455
Gene: ENSMUSG00000100586
AA Change: I290V

DomainStartEndE-ValueType
Pfam:TAS2R 8 296 3.9e-9 PFAM
Pfam:V1R 41 295 2.7e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226264
AA Change: I290V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000226510
AA Change: I208V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000226802
AA Change: I290V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226981
Predicted Effect probably damaging
Transcript: ENSMUST00000227566
AA Change: I283V

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227692
AA Change: I290V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000227788
AA Change: I290V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000227855
AA Change: I290V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500035N22Rik T G 5: 24,997,811 probably benign Het
5830411N06Rik T A 7: 140,296,769 V691E probably damaging Het
Adam6a T A 12: 113,544,145 I46N possibly damaging Het
Adipor1 A G 1: 134,431,642 D371G possibly damaging Het
Akr1c21 C T 13: 4,583,852 P307S probably benign Het
Asxl1 T A 2: 153,401,754 I1408N probably damaging Het
Avil T C 10: 127,010,983 V472A probably damaging Het
Bpifa6 C A 2: 153,989,284 Q257K possibly damaging Het
Cacna2d4 G T 6: 119,271,264 V380L probably benign Het
Clip1 A C 5: 123,583,586 S1111A probably damaging Het
Dennd4c A G 4: 86,807,426 probably null Het
Dock8 C T 19: 25,099,684 P506L possibly damaging Het
Ecsit A C 9: 22,076,526 H72Q probably damaging Het
Eif1b T A 9: 120,494,120 D15E probably benign Het
Enpp1 A G 10: 24,669,025 Y319H probably damaging Het
Fam126a A T 5: 23,983,160 Y245N probably benign Het
Fat3 T C 9: 15,996,469 N2746D probably damaging Het
Fgf20 G T 8: 40,279,891 L115I possibly damaging Het
Hip1r C T 5: 124,000,167 R775W probably damaging Het
Lrp12 A T 15: 39,872,521 S672T probably benign Het
Morf4l2 A G X: 136,733,715 Y255H probably benign Het
Mri1 A G 8: 84,251,633 V343A possibly damaging Het
Mybphl T A 3: 108,364,998 M1K probably null Het
Nelfcd G A 2: 174,426,832 A559T possibly damaging Het
Ofd1 C A X: 166,392,516 V951F probably damaging Het
Olfr1301 G T 2: 111,754,427 M59I possibly damaging Het
Olfr550 G T 7: 102,578,629 V45F probably benign Het
Olfr784 T A 10: 129,388,239 V202D possibly damaging Het
Parp12 G A 6: 39,102,647 R310W probably damaging Het
Pcdh11x T A X: 120,516,238 D1019E probably benign Het
Ppp1r9a T A 6: 5,110,993 probably benign Het
Ptprz1 T A 6: 23,030,582 probably benign Het
Qser1 T A 2: 104,786,999 N1156I probably damaging Het
Rgs3 T A 4: 62,689,675 D59E probably benign Het
Rims2 T C 15: 39,476,541 F917S probably damaging Het
Sap30bp G A 11: 115,964,252 V263M possibly damaging Het
Scfd2 G T 5: 74,530,935 H229N possibly damaging Het
Sspo T C 6: 48,459,415 V1233A possibly damaging Het
Stam T A 2: 14,146,390 Y519* probably null Het
Svs1 A G 6: 48,988,597 D513G probably damaging Het
Synj2 A G 17: 6,019,404 T602A probably damaging Het
Tas2r126 C T 6: 42,435,457 A308V probably benign Het
Tm4sf20 T C 1: 82,768,227 probably benign Het
Ttc23 G A 7: 67,662,337 probably benign Het
Xirp1 A C 9: 120,018,539 L426W probably damaging Het
Zgrf1 T G 3: 127,598,774 F430L possibly damaging Het
Other mutations in Vmn1r90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02395:Vmn1r90 APN 7 14561897 missense probably damaging 1.00
IGL03282:Vmn1r90 APN 7 14561501 missense probably benign 0.36
IGL03282:Vmn1r90 APN 7 14562168 missense possibly damaging 0.92
R2519:Vmn1r90 UTSW 7 14561718 missense probably damaging 1.00
R2996:Vmn1r90 UTSW 7 14561534 missense probably damaging 1.00
R4086:Vmn1r90 UTSW 7 14563294 splice site probably benign
R4303:Vmn1r90 UTSW 7 14561570 nonsense probably null
R4508:Vmn1r90 UTSW 7 14562159 missense probably benign 0.01
R4551:Vmn1r90 UTSW 7 14561969 missense possibly damaging 0.88
R4672:Vmn1r90 UTSW 7 14561568 missense probably benign 0.25
R4915:Vmn1r90 UTSW 7 14562025 missense possibly damaging 0.82
R5227:Vmn1r90 UTSW 7 14561676 missense possibly damaging 0.50
R5629:Vmn1r90 UTSW 7 14562086 missense possibly damaging 0.48
R5888:Vmn1r90 UTSW 7 14561855 missense probably damaging 1.00
Posted On2016-08-02