Incidental Mutation 'IGL03365:Morf4l2'
ID420056
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morf4l2
Ensembl Gene ENSMUSG00000031422
Gene Namemortality factor 4 like 2
SynonymsSid393p, 2410017O14Rik
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL03365
Quality Score
Status
ChromosomeX
Chromosomal Location136732942-136743690 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 136733715 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 255 (Y255H)
Ref Sequence ENSEMBL: ENSMUSP00000132643 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033797] [ENSMUST00000080411] [ENSMUST00000113095] [ENSMUST00000113097] [ENSMUST00000131923] [ENSMUST00000135731] [ENSMUST00000136650] [ENSMUST00000137605] [ENSMUST00000152150] [ENSMUST00000155207] [ENSMUST00000164609] [ENSMUST00000166478] [ENSMUST00000166930] [ENSMUST00000169418]
Predicted Effect probably benign
Transcript: ENSMUST00000033797
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000033797
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080411
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000108722
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113095
SMART Domains Protein: ENSMUSP00000108718
Gene: ENSMUSG00000031422

DomainStartEndE-ValueType
Pfam:MRG 94 174 2.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113097
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000108720
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131923
Predicted Effect probably benign
Transcript: ENSMUST00000135731
Predicted Effect probably benign
Transcript: ENSMUST00000136650
Predicted Effect probably benign
Transcript: ENSMUST00000137605
SMART Domains Protein: ENSMUSP00000115303
Gene: ENSMUSG00000031422

DomainStartEndE-ValueType
Pfam:MRG 94 205 4.7e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137979
Predicted Effect probably benign
Transcript: ENSMUST00000152150
Predicted Effect probably benign
Transcript: ENSMUST00000155207
SMART Domains Protein: ENSMUSP00000121632
Gene: ENSMUSG00000031422

DomainStartEndE-ValueType
Pfam:MRG 94 214 4.1e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164609
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000129774
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166478
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000131909
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166930
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000126363
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169418
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000132643
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null females and hemizygous null males are healthy and fertile with no obvious abnormalities and null MEFs have normal growth rates. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500035N22Rik T G 5: 24,997,811 probably benign Het
5830411N06Rik T A 7: 140,296,769 V691E probably damaging Het
Adam6a T A 12: 113,544,145 I46N possibly damaging Het
Adipor1 A G 1: 134,431,642 D371G possibly damaging Het
Akr1c21 C T 13: 4,583,852 P307S probably benign Het
Asxl1 T A 2: 153,401,754 I1408N probably damaging Het
Avil T C 10: 127,010,983 V472A probably damaging Het
Bpifa6 C A 2: 153,989,284 Q257K possibly damaging Het
Cacna2d4 G T 6: 119,271,264 V380L probably benign Het
Clip1 A C 5: 123,583,586 S1111A probably damaging Het
Dennd4c A G 4: 86,807,426 probably null Het
Dock8 C T 19: 25,099,684 P506L possibly damaging Het
Ecsit A C 9: 22,076,526 H72Q probably damaging Het
Eif1b T A 9: 120,494,120 D15E probably benign Het
Enpp1 A G 10: 24,669,025 Y319H probably damaging Het
Fam126a A T 5: 23,983,160 Y245N probably benign Het
Fat3 T C 9: 15,996,469 N2746D probably damaging Het
Fgf20 G T 8: 40,279,891 L115I possibly damaging Het
Hip1r C T 5: 124,000,167 R775W probably damaging Het
Lrp12 A T 15: 39,872,521 S672T probably benign Het
Mri1 A G 8: 84,251,633 V343A possibly damaging Het
Mybphl T A 3: 108,364,998 M1K probably null Het
Nelfcd G A 2: 174,426,832 A559T possibly damaging Het
Ofd1 C A X: 166,392,516 V951F probably damaging Het
Olfr1301 G T 2: 111,754,427 M59I possibly damaging Het
Olfr550 G T 7: 102,578,629 V45F probably benign Het
Olfr784 T A 10: 129,388,239 V202D possibly damaging Het
Parp12 G A 6: 39,102,647 R310W probably damaging Het
Pcdh11x T A X: 120,516,238 D1019E probably benign Het
Ppp1r9a T A 6: 5,110,993 probably benign Het
Ptprz1 T A 6: 23,030,582 probably benign Het
Qser1 T A 2: 104,786,999 N1156I probably damaging Het
Rgs3 T A 4: 62,689,675 D59E probably benign Het
Rims2 T C 15: 39,476,541 F917S probably damaging Het
Sap30bp G A 11: 115,964,252 V263M possibly damaging Het
Scfd2 G T 5: 74,530,935 H229N possibly damaging Het
Sspo T C 6: 48,459,415 V1233A possibly damaging Het
Stam T A 2: 14,146,390 Y519* probably null Het
Svs1 A G 6: 48,988,597 D513G probably damaging Het
Synj2 A G 17: 6,019,404 T602A probably damaging Het
Tas2r126 C T 6: 42,435,457 A308V probably benign Het
Tm4sf20 T C 1: 82,768,227 probably benign Het
Ttc23 G A 7: 67,662,337 probably benign Het
Vmn1r90 T C 7: 14,561,304 I290V probably damaging Het
Xirp1 A C 9: 120,018,539 L426W probably damaging Het
Zgrf1 T G 3: 127,598,774 F430L possibly damaging Het
Other mutations in Morf4l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
FR4976:Morf4l2 UTSW X 136733622 missense probably benign 0.29
Posted On2016-08-02