Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03366:Taar7e'

420077

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar7e

Ensembl Gene

ENSMUSG00000100689

Gene Name

trace amine-associated receptor 7E

Synonyms

LOC276742

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

IGL03366

Quality Score

Status

Chromosome

Chromosomal Location

23913512-23914588 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23913813 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 101 (M101K)

Ref Sequence

ENSEMBL: ENSMUSP00000090326 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092656]

AlphaFold

Q5QD09

Predicted Effect

probably damaging
Transcript: ENSMUST00000092656
AA Change: M101K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000090326
Gene: ENSMUSG00000100689
AA Change: M101K

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	56	261	5.4e-8	PFAM
Pfam:7TM_GPCR_Srsx	58	341	4.3e-10	PFAM
Pfam:7tm_1	64	326	9.4e-59	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap2a2	T	A	7: 141,209,186 (GRCm39)	S793T	probably benign	Het
Btnl6	T	C	17: 34,727,153 (GRCm39)	D459G	probably damaging	Het
Cacna1g	C	A	11: 94,347,977 (GRCm39)	D704Y	probably damaging	Het
Cby2	A	G	14: 75,820,829 (GRCm39)	S299P	probably benign	Het
Cry2	A	G	2: 92,244,060 (GRCm39)	I371T	probably damaging	Het
Dock3	A	T	9: 106,882,632 (GRCm39)	F384I	probably benign	Het
Dpp4	T	C	2: 62,187,301 (GRCm39)		probably null	Het
Hecw1	G	T	13: 14,552,382 (GRCm39)	D72E	probably damaging	Het
Htt	T	A	5: 35,064,924 (GRCm39)	W3046R	probably damaging	Het
Hydin	A	T	8: 110,993,995 (GRCm39)	N10Y	unknown	Het
Ighv8-8	T	A	12: 115,257,760 (GRCm39)	T94S	probably benign	Het
Igkv4-58	A	G	6: 69,477,538 (GRCm39)	S20P	probably damaging	Het
Il4i1	T	C	7: 44,486,919 (GRCm39)		probably benign	Het
Kif13a	A	T	13: 46,918,099 (GRCm39)	S403T	probably benign	Het
Klhl40	T	C	9: 121,612,446 (GRCm39)	L616P	probably damaging	Het
Krt7	T	C	15: 101,325,491 (GRCm39)	L440P	possibly damaging	Het
Lpin1	A	G	12: 16,594,678 (GRCm39)	L755P	probably damaging	Het
Magee2	C	A	X: 103,899,134 (GRCm39)	E506*	probably null	Het
Mast3	G	A	8: 71,234,207 (GRCm39)	R143*	probably null	Het
Med12	T	A	X: 100,321,695 (GRCm39)	H459Q	probably benign	Het
Mmp3	T	C	9: 7,450,149 (GRCm39)	S294P	probably benign	Het
Muc6	T	C	7: 141,234,349 (GRCm39)	Y714C	probably damaging	Het
Myh2	T	C	11: 67,074,349 (GRCm39)	L662S	probably damaging	Het
Notch4	G	T	17: 34,791,542 (GRCm39)	C567F	probably damaging	Het
Nprl3	A	G	11: 32,200,256 (GRCm39)	I20T	probably damaging	Het
Or10ag2	A	T	2: 87,248,587 (GRCm39)	D65V	possibly damaging	Het
Pcdhb19	A	G	18: 37,631,665 (GRCm39)	T487A	possibly damaging	Het
Phlpp2	A	G	8: 110,667,467 (GRCm39)	E1332G	probably benign	Het
Pick1	T	C	15: 79,125,481 (GRCm39)	S113P	probably damaging	Het
Ptpru	T	C	4: 131,507,178 (GRCm39)	E1023G	probably damaging	Het
Rspry1	A	C	8: 95,376,962 (GRCm39)	I382L	probably benign	Het
Sf3b3	A	C	8: 111,566,586 (GRCm39)	V248G	probably damaging	Het
Smg5	T	A	3: 88,253,759 (GRCm39)	Y126*	probably null	Het
Spin1	T	C	13: 51,281,973 (GRCm39)	V22A	probably benign	Het
Stab1	C	T	14: 30,872,220 (GRCm39)	R1189Q	possibly damaging	Het
Sytl5	A	G	X: 9,829,939 (GRCm39)	D538G	probably damaging	Het
Taf4	A	G	2: 179,576,847 (GRCm39)	V578A	probably damaging	Het
Tmem266	G	T	9: 55,344,517 (GRCm39)	C383F	probably benign	Het
Trim34a	T	C	7: 103,910,140 (GRCm39)		probably null	Het
Vmn2r104	T	C	17: 20,249,866 (GRCm39)	T802A	probably damaging	Het
Vmn2r32	A	C	7: 7,467,029 (GRCm39)	I833S	probably damaging	Het
Vmn2r85	T	C	10: 130,262,328 (GRCm39)	D137G	probably benign	Het
Vps13c	C	T	9: 67,853,308 (GRCm39)	S2467L	probably benign	Het

Other mutations in Taar7e

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00494:Taar7e	APN	10	23,914,038 (GRCm39)	missense	probably benign
IGL03150:Taar7e	APN	10	23,913,528 (GRCm39)	missense	probably benign	0.01
R2013:Taar7e	UTSW	10	23,913,732 (GRCm39)	missense	possibly damaging	0.63
R2095:Taar7e	UTSW	10	23,913,949 (GRCm39)	nonsense	probably null
R4210:Taar7e	UTSW	10	23,913,932 (GRCm39)	missense	probably damaging	1.00
R4211:Taar7e	UTSW	10	23,913,932 (GRCm39)	missense	probably damaging	1.00
R4766:Taar7e	UTSW	10	23,914,464 (GRCm39)	missense	probably damaging	0.99
R6085:Taar7e	UTSW	10	23,913,761 (GRCm39)	missense	probably benign	0.03
R6117:Taar7e	UTSW	10	23,914,427 (GRCm39)	missense	probably damaging	0.98
R6918:Taar7e	UTSW	10	23,913,513 (GRCm39)	start codon destroyed	probably null	0.15
R7410:Taar7e	UTSW	10	23,914,424 (GRCm39)	missense	probably benign
R7913:Taar7e	UTSW	10	23,913,902 (GRCm39)	missense	possibly damaging	0.79
R9008:Taar7e	UTSW	10	23,913,810 (GRCm39)	missense	probably damaging	1.00
R9081:Taar7e	UTSW	10	23,913,893 (GRCm39)	missense	probably benign	0.00
R9205:Taar7e	UTSW	10	23,913,972 (GRCm39)	missense	probably benign
R9360:Taar7e	UTSW	10	23,913,949 (GRCm39)	nonsense	probably null
R9465:Taar7e	UTSW	10	23,914,310 (GRCm39)	missense	possibly damaging	0.81
R9790:Taar7e	UTSW	10	23,913,554 (GRCm39)	missense	probably benign	0.00
R9791:Taar7e	UTSW	10	23,913,554 (GRCm39)	missense	probably benign	0.00

Posted On

2016-08-02