Incidental Mutation 'IGL03366:Magee2'
ID420088
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Magee2
Ensembl Gene ENSMUSG00000031224
Gene Namemelanoma antigen, family E, 2
Synonyms9630059J11Rik, Mage-e2
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL03366
Quality Score
Status
ChromosomeX
Chromosomal Location104854952-104857267 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 104855528 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 506 (E506*)
Ref Sequence ENSEMBL: ENSMUSP00000033575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033575]
Predicted Effect probably null
Transcript: ENSMUST00000033575
AA Change: E506*
SMART Domains Protein: ENSMUSP00000033575
Gene: ENSMUSG00000031224
AA Change: E506*

DomainStartEndE-ValueType
MAGE 95 266 1.86e-57 SMART
MAGE 318 480 3.42e-47 SMART
low complexity region 500 516 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap2a2 T A 7: 141,629,273 S793T probably benign Het
Btnl6 T C 17: 34,508,179 D459G probably damaging Het
Cacna1g C A 11: 94,457,151 D704Y probably damaging Het
Cry2 A G 2: 92,413,715 I371T probably damaging Het
Dock3 A T 9: 107,005,433 F384I probably benign Het
Dpp4 T C 2: 62,356,957 probably null Het
Hecw1 G T 13: 14,377,797 D72E probably damaging Het
Htt T A 5: 34,907,580 W3046R probably damaging Het
Hydin A T 8: 110,267,363 N10Y unknown Het
Ighv8-8 T A 12: 115,294,140 T94S probably benign Het
Igkv4-58 A G 6: 69,500,554 S20P probably damaging Het
Il4i1 T C 7: 44,837,495 probably benign Het
Kif13a A T 13: 46,764,623 S403T probably benign Het
Klhl40 T C 9: 121,783,380 L616P probably damaging Het
Krt7 T C 15: 101,427,610 L440P possibly damaging Het
Lpin1 A G 12: 16,544,677 L755P probably damaging Het
Mast3 G A 8: 70,781,563 R143* probably null Het
Med12 T A X: 101,278,089 H459Q probably benign Het
Mmp3 T C 9: 7,450,149 S294P probably benign Het
Muc6 T C 7: 141,648,082 Y714C probably damaging Het
Myh2 T C 11: 67,183,523 L662S probably damaging Het
Notch4 G T 17: 34,572,568 C567F probably damaging Het
Nprl3 A G 11: 32,250,256 I20T probably damaging Het
Olfr1123 A T 2: 87,418,243 D65V possibly damaging Het
Pcdhb19 A G 18: 37,498,612 T487A possibly damaging Het
Phlpp2 A G 8: 109,940,835 E1332G probably benign Het
Pick1 T C 15: 79,241,281 S113P probably damaging Het
Ptpru T C 4: 131,779,867 E1023G probably damaging Het
Rspry1 A C 8: 94,650,334 I382L probably benign Het
Sf3b3 A C 8: 110,839,954 V248G probably damaging Het
Smg5 T A 3: 88,346,452 Y126* probably null Het
Spert A G 14: 75,583,389 S299P probably benign Het
Spin1 T C 13: 51,127,937 V22A probably benign Het
Stab1 C T 14: 31,150,263 R1189Q possibly damaging Het
Sytl5 A G X: 9,963,700 D538G probably damaging Het
Taar7e T A 10: 24,037,915 M101K probably damaging Het
Taf4 A G 2: 179,935,054 V578A probably damaging Het
Tmem266 G T 9: 55,437,233 C383F probably benign Het
Trim34a T C 7: 104,260,933 probably null Het
Vmn2r104 T C 17: 20,029,604 T802A probably damaging Het
Vmn2r32 A C 7: 7,464,030 I833S probably damaging Het
Vmn2r85 T C 10: 130,426,459 D137G probably benign Het
Vps13c C T 9: 67,946,026 S2467L probably benign Het
Other mutations in Magee2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00908:Magee2 APN X 104856841 missense probably benign 0.05
IGL01700:Magee2 APN X 104855968 missense possibly damaging 0.49
IGL02377:Magee2 APN X 104856793 missense possibly damaging 0.86
IGL03231:Magee2 APN X 104856338 missense probably damaging 1.00
R0741:Magee2 UTSW X 104855866 missense probably damaging 1.00
X0009:Magee2 UTSW X 104856842 missense probably benign
Posted On2016-08-02