Incidental Mutation 'IGL03370:Lyn'
ID 420253
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lyn
Ensembl Gene ENSMUSG00000042228
Gene Name LYN proto-oncogene, Src family tyrosine kinase
Synonyms Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03370
Quality Score
Status
Chromosome 4
Chromosomal Location 3676865-3791612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3780931 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 357 (Y357H)
Ref Sequence ENSEMBL: ENSMUSP00000038838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041377] [ENSMUST00000103010]
AlphaFold P25911
PDB Structure Lyn Tyrosine Kinase Domain, apo form [X-RAY DIFFRACTION]
Lyn Tyrosine Kinase Domain-AMP-PNP complex [X-RAY DIFFRACTION]
Lyn Tyrosine Kinase Domain-PP2 complex [X-RAY DIFFRACTION]
Lyn Tyrosine Kinase Domain-Dasatinib complex [X-RAY DIFFRACTION]
Structure of unliganded Lyn SH2 domain [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000041377
AA Change: Y357H

PolyPhen 2 Score 0.815 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000038838
Gene: ENSMUSG00000042228
AA Change: Y357H

DomainStartEndE-ValueType
SH3 66 122 9.24e-21 SMART
SH2 127 217 5.38e-33 SMART
TyrKc 247 497 3.25e-137 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103010
AA Change: Y336H

PolyPhen 2 Score 0.260 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000100075
Gene: ENSMUSG00000042228
AA Change: Y336H

DomainStartEndE-ValueType
SH3 45 101 5.8e-23 SMART
SH2 106 196 3.3e-35 SMART
TyrKc 226 476 1.6e-139 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137943
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
PHENOTYPE: Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7b A G 4: 56,741,173 (GRCm39) Y62H probably damaging Het
Cfap52 A G 11: 67,829,881 (GRCm39) I296T probably damaging Het
Col14a1 A G 15: 55,351,937 (GRCm39) probably null Het
Daam2 G T 17: 49,793,529 (GRCm39) D329E probably benign Het
Defb26 A G 2: 152,349,902 (GRCm39) V126A probably benign Het
Fasn A T 11: 120,703,621 (GRCm39) I1535N possibly damaging Het
Fbxw15 A T 9: 109,384,219 (GRCm39) Y431N probably benign Het
Fbxw26 T G 9: 109,575,087 (GRCm39) I13L probably damaging Het
Fggy A T 4: 95,710,301 (GRCm39) H300L probably damaging Het
Fndc3c1 G A X: 105,464,307 (GRCm39) T1277I probably benign Het
Gigyf1 G T 5: 137,523,952 (GRCm39) V1041L possibly damaging Het
Kif26b G A 1: 178,742,946 (GRCm39) R567H probably benign Het
Kpna6 G A 4: 129,549,314 (GRCm39) T156M probably damaging Het
Lrrc37a C T 11: 103,388,499 (GRCm39) E2309K unknown Het
Mki67 A G 7: 135,297,219 (GRCm39) V2605A probably benign Het
Mtmr3 T C 11: 4,437,385 (GRCm39) D1023G probably damaging Het
Muc5b G T 7: 141,418,514 (GRCm39) R3820L probably benign Het
Mus81 A G 19: 5,534,991 (GRCm39) probably benign Het
Nup188 A G 2: 30,230,653 (GRCm39) Y1397C possibly damaging Het
Pgd A T 4: 149,249,685 (GRCm39) V29D probably damaging Het
Plch2 T C 4: 155,071,371 (GRCm39) S244G probably benign Het
Rapgef5 C A 12: 117,694,294 (GRCm39) T372K probably damaging Het
Rb1 A G 14: 73,520,306 (GRCm39) probably null Het
Ryr3 A T 2: 112,586,944 (GRCm39) V2680E possibly damaging Het
Sgsm3 A C 15: 80,895,855 (GRCm39) probably null Het
Slc38a1 C T 15: 96,477,228 (GRCm39) V362I possibly damaging Het
Sun1 T A 5: 139,216,886 (GRCm39) D308E probably damaging Het
Tns1 C T 1: 74,025,053 (GRCm39) V387M probably damaging Het
Ttn C A 2: 76,582,083 (GRCm39) G22937C probably damaging Het
Ubr1 C A 2: 120,725,641 (GRCm39) A1258S probably benign Het
Vmn2r74 A G 7: 85,607,265 (GRCm39) F153L probably benign Het
Other mutations in Lyn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01752:Lyn APN 4 3,743,286 (GRCm39) missense probably benign
IGL02744:Lyn APN 4 3,738,808 (GRCm39) missense probably benign 0.00
IGL02860:Lyn APN 4 3,745,594 (GRCm39) missense possibly damaging 0.77
IGL03328:Lyn APN 4 3,745,327 (GRCm39) missense probably benign 0.01
bibb UTSW 4 3,783,055 (GRCm39) missense probably damaging 1.00
butterhead UTSW 4 3,748,765 (GRCm39) missense probably benign 0.11
Cress UTSW 4 3,789,908 (GRCm39) nonsense probably null
Friede UTSW 4 3,789,834 (GRCm39) nonsense probably null
Kohlrabi UTSW 4 3,783,089 (GRCm39) missense possibly damaging 0.74
lechuga UTSW 4 3,783,050 (GRCm39) missense probably damaging 1.00
Lemon UTSW 4 3,746,768 (GRCm39) missense probably damaging 1.00
Pacific UTSW 4 3,745,330 (GRCm39) missense probably damaging 1.00
water UTSW 4 3,748,787 (GRCm39) missense possibly damaging 0.93
R0079:Lyn UTSW 4 3,746,768 (GRCm39) missense probably damaging 1.00
R0089:Lyn UTSW 4 3,748,768 (GRCm39) missense probably benign 0.23
R0582:Lyn UTSW 4 3,743,296 (GRCm39) missense probably damaging 1.00
R0747:Lyn UTSW 4 3,745,638 (GRCm39) splice site probably benign
R1460:Lyn UTSW 4 3,789,908 (GRCm39) nonsense probably null
R1615:Lyn UTSW 4 3,748,765 (GRCm39) missense probably benign 0.11
R1654:Lyn UTSW 4 3,789,912 (GRCm39) missense probably damaging 0.99
R1703:Lyn UTSW 4 3,738,867 (GRCm39) splice site probably null
R2301:Lyn UTSW 4 3,780,959 (GRCm39) missense probably damaging 1.00
R2421:Lyn UTSW 4 3,748,787 (GRCm39) missense possibly damaging 0.93
R2512:Lyn UTSW 4 3,745,542 (GRCm39) missense probably benign 0.01
R3418:Lyn UTSW 4 3,746,833 (GRCm39) missense probably damaging 0.97
R3419:Lyn UTSW 4 3,746,833 (GRCm39) missense probably damaging 0.97
R3701:Lyn UTSW 4 3,742,455 (GRCm39) missense probably benign
R3702:Lyn UTSW 4 3,742,455 (GRCm39) missense probably benign
R3736:Lyn UTSW 4 3,745,330 (GRCm39) missense probably damaging 1.00
R4350:Lyn UTSW 4 3,789,796 (GRCm39) missense probably damaging 0.99
R4351:Lyn UTSW 4 3,789,796 (GRCm39) missense probably damaging 0.99
R4352:Lyn UTSW 4 3,789,796 (GRCm39) missense probably damaging 0.99
R4649:Lyn UTSW 4 3,738,850 (GRCm39) missense probably benign
R5738:Lyn UTSW 4 3,782,987 (GRCm39) missense probably damaging 1.00
R5875:Lyn UTSW 4 3,745,631 (GRCm39) splice site probably null
R6375:Lyn UTSW 4 3,745,527 (GRCm39) missense probably damaging 1.00
R7029:Lyn UTSW 4 3,782,996 (GRCm39) missense probably damaging 0.98
R7621:Lyn UTSW 4 3,789,834 (GRCm39) nonsense probably null
R7726:Lyn UTSW 4 3,756,428 (GRCm39) nonsense probably null
R7940:Lyn UTSW 4 3,783,089 (GRCm39) missense possibly damaging 0.74
R8169:Lyn UTSW 4 3,783,050 (GRCm39) missense probably damaging 1.00
R8341:Lyn UTSW 4 3,743,304 (GRCm39) critical splice donor site probably null
R8782:Lyn UTSW 4 3,783,055 (GRCm39) missense probably damaging 1.00
R9056:Lyn UTSW 4 3,780,925 (GRCm39) missense possibly damaging 0.89
R9353:Lyn UTSW 4 3,746,804 (GRCm39) missense possibly damaging 0.71
R9567:Lyn UTSW 4 3,746,757 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02