Incidental Mutation 'R0482:Ticrr'
| ID |
42032 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ticrr
|
| Ensembl Gene |
ENSMUSG00000046591 |
| Gene Name |
TOPBP1-interacting checkpoint and replication regulator |
| Synonyms |
5730590G19Rik |
| MMRRC Submission |
038682-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.949)
|
| Stock # |
R0482 (G1)
|
| Quality Score |
210 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
79309944-79347896 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 79344236 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Glutamine
at position 1367
(P1367Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000041377
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035977]
[ENSMUST00000059836]
[ENSMUST00000178048]
[ENSMUST00000183846]
[ENSMUST00000184137]
[ENSMUST00000206591]
[ENSMUST00000206622]
|
| AlphaFold |
Q8BQ33 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000035977
AA Change: P1367Q
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000041377
Gene: ENSMUSG00000046591
AA Change: P1367Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
31 |
N/A |
INTRINSIC |
|
Pfam:Treslin_N
|
211 |
1005 |
N/A |
PFAM |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1339 |
1359 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1480 |
N/A |
INTRINSIC |
|
low complexity region
|
1496 |
1514 |
N/A |
INTRINSIC |
|
low complexity region
|
1630 |
1643 |
N/A |
INTRINSIC |
|
low complexity region
|
1694 |
1707 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059836
|
| SMART Domains |
Protein: ENSMUSP00000061806
Gene: ENSMUSG00000050382
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
13 |
357 |
2.88e-143 |
SMART |
|
low complexity region
|
391 |
410 |
N/A |
INTRINSIC |
|
Blast:KISc
|
413 |
481 |
1e-19 |
BLAST |
|
Blast:KISc
|
482 |
518 |
3e-11 |
BLAST |
|
low complexity region
|
523 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
543 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
636 |
N/A |
INTRINSIC |
|
low complexity region
|
669 |
685 |
N/A |
INTRINSIC |
|
Blast:KISc
|
780 |
879 |
2e-15 |
BLAST |
|
low complexity region
|
927 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
993 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1061 |
N/A |
INTRINSIC |
|
coiled coil region
|
1113 |
1139 |
N/A |
INTRINSIC |
|
coiled coil region
|
1186 |
1205 |
N/A |
INTRINSIC |
|
low complexity region
|
1293 |
1304 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178048
|
| SMART Domains |
Protein: ENSMUSP00000136993
Gene: ENSMUSG00000050382
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
13 |
357 |
2.88e-143 |
SMART |
|
low complexity region
|
391 |
410 |
N/A |
INTRINSIC |
|
Blast:KISc
|
413 |
481 |
1e-19 |
BLAST |
|
Blast:KISc
|
482 |
518 |
3e-11 |
BLAST |
|
low complexity region
|
523 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
543 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
636 |
N/A |
INTRINSIC |
|
low complexity region
|
669 |
685 |
N/A |
INTRINSIC |
|
Blast:KISc
|
780 |
879 |
2e-15 |
BLAST |
|
low complexity region
|
908 |
918 |
N/A |
INTRINSIC |
|
low complexity region
|
928 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
994 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1114 |
1140 |
N/A |
INTRINSIC |
|
coiled coil region
|
1187 |
1206 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1305 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183846
|
| SMART Domains |
Protein: ENSMUSP00000139359
Gene: ENSMUSG00000050382
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
13 |
357 |
2.88e-143 |
SMART |
|
low complexity region
|
391 |
410 |
N/A |
INTRINSIC |
|
Blast:KISc
|
413 |
481 |
1e-19 |
BLAST |
|
Blast:KISc
|
482 |
518 |
3e-11 |
BLAST |
|
low complexity region
|
523 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
543 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
636 |
N/A |
INTRINSIC |
|
low complexity region
|
669 |
685 |
N/A |
INTRINSIC |
|
Blast:KISc
|
780 |
879 |
2e-15 |
BLAST |
|
low complexity region
|
908 |
918 |
N/A |
INTRINSIC |
|
low complexity region
|
928 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
994 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1114 |
1140 |
N/A |
INTRINSIC |
|
coiled coil region
|
1187 |
1206 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1305 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184137
|
| SMART Domains |
Protein: ENSMUSP00000139224
Gene: ENSMUSG00000050382
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
13 |
357 |
2.88e-143 |
SMART |
|
low complexity region
|
391 |
410 |
N/A |
INTRINSIC |
|
Blast:KISc
|
413 |
481 |
1e-19 |
BLAST |
|
Blast:KISc
|
482 |
518 |
3e-11 |
BLAST |
|
low complexity region
|
523 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
543 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
636 |
N/A |
INTRINSIC |
|
low complexity region
|
669 |
685 |
N/A |
INTRINSIC |
|
Blast:KISc
|
780 |
879 |
2e-15 |
BLAST |
|
low complexity region
|
927 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
993 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1061 |
N/A |
INTRINSIC |
|
coiled coil region
|
1113 |
1139 |
N/A |
INTRINSIC |
|
coiled coil region
|
1186 |
1205 |
N/A |
INTRINSIC |
|
low complexity region
|
1293 |
1304 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206591
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206622
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.8%
- 20x: 93.4%
|
| Validation Efficiency |
95% (94/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
PHENOTYPE: Mice homozygous for an ENU-induced allele are mostly hairless, with only a light patch of hair around the face and tail. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
C |
17: 9,207,255 (GRCm39) |
|
probably null |
Het |
| Abca13 |
G |
A |
11: 9,278,207 (GRCm39) |
G3129D |
possibly damaging |
Het |
| Acnat2 |
T |
C |
4: 49,383,534 (GRCm39) |
I6M |
probably benign |
Het |
| Adcy4 |
T |
A |
14: 56,012,029 (GRCm39) |
|
probably null |
Het |
| Agrn |
A |
G |
4: 156,258,012 (GRCm39) |
S1117P |
probably damaging |
Het |
| Anks1b |
A |
G |
10: 90,195,057 (GRCm39) |
N545S |
probably benign |
Het |
| Antxr1 |
C |
T |
6: 87,246,220 (GRCm39) |
|
probably null |
Het |
| Arhgef17 |
T |
C |
7: 100,529,828 (GRCm39) |
K476E |
probably damaging |
Het |
| Bptf |
T |
C |
11: 106,972,088 (GRCm39) |
S927G |
probably benign |
Het |
| Cacna1s |
C |
T |
1: 136,041,132 (GRCm39) |
T1286I |
probably benign |
Het |
| Ccdc174 |
T |
A |
6: 91,872,247 (GRCm39) |
M292K |
probably benign |
Het |
| Cdk5rap2 |
G |
A |
4: 70,328,506 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
T |
A |
9: 108,706,272 (GRCm39) |
Y918* |
probably null |
Het |
| Cep250 |
T |
C |
2: 155,806,894 (GRCm39) |
|
probably benign |
Het |
| Ces2h |
A |
G |
8: 105,746,903 (GRCm39) |
D513G |
possibly damaging |
Het |
| Clec2l |
A |
G |
6: 38,640,327 (GRCm39) |
T53A |
probably benign |
Het |
| Cntnap2 |
C |
T |
6: 45,692,750 (GRCm39) |
S77L |
probably benign |
Het |
| Cped1 |
A |
T |
6: 22,016,957 (GRCm39) |
H102L |
probably benign |
Het |
| Crim1 |
T |
A |
17: 78,680,008 (GRCm39) |
D916E |
probably benign |
Het |
| Csmd1 |
T |
A |
8: 16,283,115 (GRCm39) |
I614F |
probably damaging |
Het |
| Csnk1g1 |
G |
A |
9: 65,917,751 (GRCm39) |
E37K |
probably damaging |
Het |
| Ctnnbl1 |
T |
A |
2: 157,713,110 (GRCm39) |
|
probably null |
Het |
| Cuzd1 |
A |
T |
7: 130,911,601 (GRCm39) |
|
probably benign |
Het |
| Cyp4f16 |
T |
A |
17: 32,769,525 (GRCm39) |
V433D |
probably damaging |
Het |
| Ddi1 |
A |
G |
9: 6,266,144 (GRCm39) |
L75P |
probably damaging |
Het |
| Ddias |
G |
A |
7: 92,508,736 (GRCm39) |
A393V |
probably benign |
Het |
| Dgka |
A |
T |
10: 128,569,990 (GRCm39) |
Y123* |
probably null |
Het |
| Dlgap1 |
T |
C |
17: 70,823,185 (GRCm39) |
C57R |
probably benign |
Het |
| Dysf |
T |
A |
6: 84,129,387 (GRCm39) |
V1458D |
probably benign |
Het |
| Eif2ak4 |
T |
A |
2: 118,292,828 (GRCm39) |
Y1230N |
probably damaging |
Het |
| Fbxl7 |
A |
T |
15: 26,543,632 (GRCm39) |
S338R |
probably benign |
Het |
| Fgf23 |
A |
T |
6: 127,050,122 (GRCm39) |
T44S |
probably damaging |
Het |
| Fhip1b |
G |
A |
7: 105,033,419 (GRCm39) |
P599L |
possibly damaging |
Het |
| Folh1 |
A |
T |
7: 86,395,309 (GRCm39) |
|
probably benign |
Het |
| Gpsm2 |
A |
T |
3: 108,609,710 (GRCm39) |
|
probably benign |
Het |
| H2bc13 |
A |
G |
13: 21,900,295 (GRCm39) |
|
probably benign |
Het |
| Hdac2 |
T |
A |
10: 36,865,130 (GRCm39) |
|
probably benign |
Het |
| Il31ra |
G |
T |
13: 112,664,015 (GRCm39) |
T446N |
possibly damaging |
Het |
| Irf5 |
T |
A |
6: 29,535,369 (GRCm39) |
L199H |
probably benign |
Het |
| Kif18a |
T |
A |
2: 109,118,188 (GRCm39) |
M1K |
probably null |
Het |
| Kif4-ps |
A |
C |
12: 101,114,921 (GRCm39) |
I1017L |
probably benign |
Het |
| Klhl2 |
C |
T |
8: 65,211,164 (GRCm39) |
V295M |
probably benign |
Het |
| Krt75 |
A |
T |
15: 101,478,746 (GRCm39) |
M296K |
probably benign |
Het |
| Krt81 |
C |
A |
15: 101,361,508 (GRCm39) |
R24L |
possibly damaging |
Het |
| Lgr4 |
T |
C |
2: 109,838,437 (GRCm39) |
S439P |
probably damaging |
Het |
| Lhfpl2 |
C |
A |
13: 94,311,118 (GRCm39) |
N129K |
probably damaging |
Het |
| Lnx2 |
A |
G |
5: 146,955,771 (GRCm39) |
V675A |
probably damaging |
Het |
| Med13 |
T |
C |
11: 86,175,977 (GRCm39) |
T1673A |
probably benign |
Het |
| Mif |
A |
G |
10: 75,695,974 (GRCm39) |
V10A |
possibly damaging |
Het |
| Mki67 |
A |
T |
7: 135,301,158 (GRCm39) |
I1292N |
possibly damaging |
Het |
| Mylip |
C |
A |
13: 45,558,059 (GRCm39) |
N89K |
probably benign |
Het |
| Myo19 |
G |
T |
11: 84,800,245 (GRCm39) |
D877Y |
probably benign |
Het |
| Nckap5 |
A |
G |
1: 125,954,102 (GRCm39) |
S753P |
possibly damaging |
Het |
| Nlrc3 |
T |
C |
16: 3,783,056 (GRCm39) |
T118A |
possibly damaging |
Het |
| Nptx2 |
T |
C |
5: 144,490,269 (GRCm39) |
Y233H |
probably damaging |
Het |
| Nsl1 |
T |
A |
1: 190,795,237 (GRCm39) |
M1K |
probably null |
Het |
| Ntsr1 |
T |
A |
2: 180,142,849 (GRCm39) |
S213R |
possibly damaging |
Het |
| Or4c120 |
A |
T |
2: 89,000,975 (GRCm39) |
F194I |
probably benign |
Het |
| Or4c58 |
A |
G |
2: 89,674,513 (GRCm39) |
V268A |
probably benign |
Het |
| Or52n5 |
T |
A |
7: 104,588,021 (GRCm39) |
F96Y |
possibly damaging |
Het |
| Pde4d |
G |
A |
13: 110,073,244 (GRCm39) |
V347I |
probably benign |
Het |
| Pik3r4 |
T |
A |
9: 105,546,244 (GRCm39) |
S865T |
probably benign |
Het |
| Ppp2r2d |
A |
G |
7: 138,472,160 (GRCm39) |
R136G |
probably benign |
Het |
| Proser2 |
A |
C |
2: 6,118,721 (GRCm39) |
S41A |
probably damaging |
Het |
| Proz |
A |
T |
8: 13,123,460 (GRCm39) |
K244* |
probably null |
Het |
| Prpf38b |
A |
T |
3: 108,812,586 (GRCm39) |
L209H |
probably damaging |
Het |
| R3hdm1 |
C |
A |
1: 128,112,254 (GRCm39) |
A390E |
probably benign |
Het |
| Rb1cc1 |
A |
C |
1: 6,310,547 (GRCm39) |
D315A |
probably damaging |
Het |
| Rnf141 |
G |
A |
7: 110,436,345 (GRCm39) |
R28* |
probably null |
Het |
| Rps6kc1 |
A |
T |
1: 190,531,627 (GRCm39) |
S792T |
probably benign |
Het |
| Rxrg |
A |
G |
1: 167,458,606 (GRCm39) |
D233G |
possibly damaging |
Het |
| Sh2d7 |
A |
G |
9: 54,448,321 (GRCm39) |
N114S |
probably benign |
Het |
| Slc25a38 |
T |
C |
9: 119,949,899 (GRCm39) |
V205A |
probably benign |
Het |
| Slc4a10 |
T |
C |
2: 62,127,361 (GRCm39) |
|
probably benign |
Het |
| Spred1 |
T |
A |
2: 116,983,459 (GRCm39) |
|
probably null |
Het |
| Stt3b |
A |
G |
9: 115,077,635 (GRCm39) |
S706P |
probably benign |
Het |
| Tcerg1 |
C |
A |
18: 42,697,305 (GRCm39) |
|
probably benign |
Het |
| Tent5a |
T |
C |
9: 85,207,108 (GRCm39) |
Y230C |
probably damaging |
Het |
| Thsd4 |
A |
T |
9: 59,910,261 (GRCm39) |
I109N |
probably damaging |
Het |
| Trpv1 |
A |
G |
11: 73,130,255 (GRCm39) |
D146G |
probably damaging |
Het |
| Tubd1 |
T |
G |
11: 86,448,602 (GRCm39) |
V305G |
possibly damaging |
Het |
| Tubgcp4 |
T |
C |
2: 121,005,855 (GRCm39) |
L81P |
probably benign |
Het |
| Ubxn2b |
T |
A |
4: 6,196,404 (GRCm39) |
|
probably null |
Het |
| Usp36 |
A |
T |
11: 118,156,020 (GRCm39) |
S586T |
probably benign |
Het |
| Vcan |
T |
A |
13: 89,826,264 (GRCm39) |
D2220V |
probably damaging |
Het |
| Vmn1r173 |
T |
A |
7: 23,402,216 (GRCm39) |
N150K |
probably damaging |
Het |
| Vmn1r70 |
G |
A |
7: 10,368,204 (GRCm39) |
A231T |
probably damaging |
Het |
| Vmn2r97 |
A |
G |
17: 19,167,930 (GRCm39) |
D728G |
probably damaging |
Het |
| Zbtb40 |
T |
C |
4: 136,710,539 (GRCm39) |
E1200G |
probably damaging |
Het |
| Zfp365 |
A |
T |
10: 67,733,436 (GRCm39) |
V252D |
probably damaging |
Het |
|
| Other mutations in Ticrr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Ticrr
|
APN |
7 |
79,327,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00596:Ticrr
|
APN |
7 |
79,327,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01327:Ticrr
|
APN |
7 |
79,344,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01525:Ticrr
|
APN |
7 |
79,332,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01565:Ticrr
|
APN |
7 |
79,344,296 (GRCm39) |
missense |
probably benign |
|
|
IGL01936:Ticrr
|
APN |
7 |
79,344,297 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02160:Ticrr
|
APN |
7 |
79,343,767 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02246:Ticrr
|
APN |
7 |
79,325,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02487:Ticrr
|
APN |
7 |
79,332,769 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02593:Ticrr
|
APN |
7 |
79,345,214 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02970:Ticrr
|
APN |
7 |
79,344,919 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4304:Ticrr
|
UTSW |
7 |
79,344,059 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Ticrr
|
UTSW |
7 |
79,328,771 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
PIT4791001:Ticrr
|
UTSW |
7 |
79,319,386 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0016:Ticrr
|
UTSW |
7 |
79,343,540 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0062:Ticrr
|
UTSW |
7 |
79,317,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0062:Ticrr
|
UTSW |
7 |
79,317,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0067:Ticrr
|
UTSW |
7 |
79,327,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Ticrr
|
UTSW |
7 |
79,327,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Ticrr
|
UTSW |
7 |
79,327,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Ticrr
|
UTSW |
7 |
79,345,311 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1118:Ticrr
|
UTSW |
7 |
79,343,701 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1119:Ticrr
|
UTSW |
7 |
79,343,701 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1572:Ticrr
|
UTSW |
7 |
79,331,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1658:Ticrr
|
UTSW |
7 |
79,345,297 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1757:Ticrr
|
UTSW |
7 |
79,328,794 (GRCm39) |
nonsense |
probably null |
|
|
R1757:Ticrr
|
UTSW |
7 |
79,325,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1862:Ticrr
|
UTSW |
7 |
79,344,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Ticrr
|
UTSW |
7 |
79,328,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1938:Ticrr
|
UTSW |
7 |
79,325,142 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1966:Ticrr
|
UTSW |
7 |
79,344,483 (GRCm39) |
nonsense |
probably null |
|
|
R2006:Ticrr
|
UTSW |
7 |
79,343,821 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2178:Ticrr
|
UTSW |
7 |
79,315,433 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3404:Ticrr
|
UTSW |
7 |
79,344,539 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3405:Ticrr
|
UTSW |
7 |
79,344,539 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3941:Ticrr
|
UTSW |
7 |
79,343,445 (GRCm39) |
intron |
probably benign |
|
|
R3950:Ticrr
|
UTSW |
7 |
79,331,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3951:Ticrr
|
UTSW |
7 |
79,331,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3952:Ticrr
|
UTSW |
7 |
79,331,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Ticrr
|
UTSW |
7 |
79,310,158 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4972:Ticrr
|
UTSW |
7 |
79,319,416 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5259:Ticrr
|
UTSW |
7 |
79,344,471 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5272:Ticrr
|
UTSW |
7 |
79,319,353 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5374:Ticrr
|
UTSW |
7 |
79,340,690 (GRCm39) |
nonsense |
probably null |
|
|
R5480:Ticrr
|
UTSW |
7 |
79,310,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5568:Ticrr
|
UTSW |
7 |
79,345,044 (GRCm39) |
nonsense |
probably null |
|
|
R5568:Ticrr
|
UTSW |
7 |
79,339,715 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5588:Ticrr
|
UTSW |
7 |
79,328,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5698:Ticrr
|
UTSW |
7 |
79,328,881 (GRCm39) |
missense |
probably benign |
|
|
R5879:Ticrr
|
UTSW |
7 |
79,346,438 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5980:Ticrr
|
UTSW |
7 |
79,310,703 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6128:Ticrr
|
UTSW |
7 |
79,343,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6277:Ticrr
|
UTSW |
7 |
79,344,444 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6335:Ticrr
|
UTSW |
7 |
79,344,031 (GRCm39) |
splice site |
probably null |
|
|
R6866:Ticrr
|
UTSW |
7 |
79,343,705 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6905:Ticrr
|
UTSW |
7 |
79,315,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6923:Ticrr
|
UTSW |
7 |
79,341,601 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6962:Ticrr
|
UTSW |
7 |
79,315,645 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7232:Ticrr
|
UTSW |
7 |
79,343,490 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7285:Ticrr
|
UTSW |
7 |
79,310,610 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7385:Ticrr
|
UTSW |
7 |
79,341,597 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7426:Ticrr
|
UTSW |
7 |
79,343,734 (GRCm39) |
missense |
probably benign |
|
|
R7583:Ticrr
|
UTSW |
7 |
79,346,487 (GRCm39) |
nonsense |
probably null |
|
|
R7749:Ticrr
|
UTSW |
7 |
79,328,844 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7863:Ticrr
|
UTSW |
7 |
79,331,760 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7899:Ticrr
|
UTSW |
7 |
79,319,233 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7935:Ticrr
|
UTSW |
7 |
79,331,584 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8005:Ticrr
|
UTSW |
7 |
79,343,796 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8080:Ticrr
|
UTSW |
7 |
79,334,012 (GRCm39) |
splice site |
probably null |
|
|
R8181:Ticrr
|
UTSW |
7 |
79,310,728 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8349:Ticrr
|
UTSW |
7 |
79,344,428 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8410:Ticrr
|
UTSW |
7 |
79,317,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8449:Ticrr
|
UTSW |
7 |
79,344,428 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9073:Ticrr
|
UTSW |
7 |
79,317,679 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9090:Ticrr
|
UTSW |
7 |
79,310,604 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9271:Ticrr
|
UTSW |
7 |
79,310,604 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9287:Ticrr
|
UTSW |
7 |
79,343,516 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9368:Ticrr
|
UTSW |
7 |
79,330,735 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9469:Ticrr
|
UTSW |
7 |
79,344,511 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9502:Ticrr
|
UTSW |
7 |
79,343,597 (GRCm39) |
missense |
probably benign |
|
|
R9614:Ticrr
|
UTSW |
7 |
79,345,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Ticrr
|
UTSW |
7 |
79,345,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Ticrr
|
UTSW |
7 |
79,328,802 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGTCCTTATTACCCAGCGTCCC -3'
(R):5'- ACAGTCACTTCTGAAACCAGTGCC -3'
Sequencing Primer
(F):5'- GAGTCAGTGTCTGACCCCTATAAG -3'
(R):5'- CTAGGTAACTCTGTCCTTCAGAAAAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation