Incidental Mutation 'IGL03372:Vmn1r75'
ID 420320
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r75
Ensembl Gene ENSMUSG00000043308
Gene Name vomeronasal 1 receptor 75
Synonyms V1rg6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL03372
Quality Score
Status
Chromosome 7
Chromosomal Location 11614270-11615187 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11614496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 76 (D76G)
Ref Sequence ENSEMBL: ENSMUSP00000154577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]
AlphaFold Q8R289
Predicted Effect probably benign
Transcript: ENSMUST00000057229
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: D76G

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.9e-10 PFAM
Pfam:V1R 35 293 1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226622
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000226855
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000227611
AA Change: D34G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228268
AA Change: D34G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228463
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000228646
AA Change: D34G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 C T 4: 129,911,362 (GRCm39) A1161V probably benign Het
Alpi A G 1: 87,028,350 (GRCm39) probably benign Het
Asxl1 A T 2: 153,242,333 (GRCm39) N961I probably damaging Het
Bcl2l10 A G 9: 75,255,329 (GRCm39) I49V probably benign Het
Bod1l T C 5: 41,962,578 (GRCm39) probably benign Het
Ccl20 A G 1: 83,095,597 (GRCm39) M54V probably benign Het
Cep72 A C 13: 74,191,637 (GRCm39) L200V possibly damaging Het
Clic4 T C 4: 134,945,925 (GRCm39) D164G probably damaging Het
Col5a3 G A 9: 20,686,624 (GRCm39) P1334S unknown Het
Dab2 T C 15: 6,459,030 (GRCm39) L293P probably damaging Het
Ddx50 A T 10: 62,479,109 (GRCm39) S140T probably benign Het
Dnah6 A T 6: 73,052,833 (GRCm39) M2897K probably benign Het
Dnmt3a A G 12: 3,952,666 (GRCm39) E721G probably damaging Het
Esyt3 A T 9: 99,218,109 (GRCm39) probably benign Het
Fat4 G T 3: 38,943,283 (GRCm39) K725N possibly damaging Het
Fezf1 T C 6: 23,246,909 (GRCm39) I308V probably damaging Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
Gapdhs T C 7: 30,432,674 (GRCm39) probably benign Het
Gm10109 A T 7: 43,871,126 (GRCm39) probably benign Het
Gpd2 G A 2: 57,245,519 (GRCm39) V405I probably damaging Het
Gtf2e1 T C 16: 37,356,077 (GRCm39) probably benign Het
Iqca1 A G 1: 90,072,691 (GRCm39) I63T possibly damaging Het
Kcmf1 A C 6: 72,826,546 (GRCm39) L161R probably damaging Het
Kif19a G T 11: 114,670,044 (GRCm39) V80L probably damaging Het
Kif21a A T 15: 90,840,579 (GRCm39) M1179K probably benign Het
Krtap19-2 A G 16: 88,670,774 (GRCm39) probably benign Het
Ksr2 T A 5: 117,840,783 (GRCm39) I575N possibly damaging Het
L3mbtl1 A T 2: 162,813,077 (GRCm39) probably benign Het
Larp1b A T 3: 40,978,962 (GRCm39) H6L possibly damaging Het
Map4k2 T A 19: 6,392,279 (GRCm39) probably benign Het
Mdh1b T C 1: 63,759,154 (GRCm39) H146R possibly damaging Het
Morc2a T C 11: 3,631,813 (GRCm39) probably benign Het
Mvd A G 8: 123,170,113 (GRCm39) probably benign Het
Myo7b C T 18: 32,131,654 (GRCm39) S514N probably damaging Het
Nav1 A T 1: 135,378,641 (GRCm39) I1610K probably damaging Het
Nbas T C 12: 13,584,473 (GRCm39) L2095P probably damaging Het
Nrros T C 16: 31,963,588 (GRCm39) N115S probably damaging Het
Or5p52 T C 7: 107,502,577 (GRCm39) Y218H probably damaging Het
Otud6b A C 4: 14,812,519 (GRCm39) I276R possibly damaging Het
P2rx6 G A 16: 17,385,356 (GRCm39) E150K probably damaging Het
Pan2 T A 10: 128,150,996 (GRCm39) L771Q probably benign Het
Pbrm1 T A 14: 30,806,976 (GRCm39) N1087K probably benign Het
Pcdhb5 G T 18: 37,453,713 (GRCm39) R31L probably benign Het
Proser3 A C 7: 30,242,993 (GRCm39) S195A probably damaging Het
Rad50 T C 11: 53,586,121 (GRCm39) K292E probably benign Het
Rbm27 G A 18: 42,438,781 (GRCm39) R394H probably damaging Het
Samd9l A G 6: 3,375,314 (GRCm39) I649T probably damaging Het
Skint3 G A 4: 112,113,103 (GRCm39) probably benign Het
Slc4a4 T A 5: 89,304,285 (GRCm39) L576Q probably damaging Het
Snx2 A G 18: 53,349,463 (GRCm39) D408G probably damaging Het
Taar2 T C 10: 23,817,069 (GRCm39) V203A probably benign Het
Tdrd6 C T 17: 43,936,459 (GRCm39) V1530M probably damaging Het
Tsc2 A C 17: 24,838,444 (GRCm39) L515R probably damaging Het
Unc13a A T 8: 72,108,353 (GRCm39) M500K probably damaging Het
Whrn T C 4: 63,336,855 (GRCm39) D127G probably damaging Het
Other mutations in Vmn1r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01901:Vmn1r75 APN 7 11,614,739 (GRCm39) missense probably damaging 1.00
IGL02175:Vmn1r75 APN 7 11,614,774 (GRCm39) missense probably damaging 1.00
IGL02399:Vmn1r75 APN 7 11,615,093 (GRCm39) missense possibly damaging 0.82
IGL02648:Vmn1r75 APN 7 11,615,091 (GRCm39) missense probably benign 0.04
R0538:Vmn1r75 UTSW 7 11,614,797 (GRCm39) missense probably damaging 0.97
R0599:Vmn1r75 UTSW 7 11,615,189 (GRCm39) splice site probably null
R3910:Vmn1r75 UTSW 7 11,614,757 (GRCm39) missense possibly damaging 0.92
R4491:Vmn1r75 UTSW 7 11,614,909 (GRCm39) missense probably damaging 0.97
R5566:Vmn1r75 UTSW 7 11,614,407 (GRCm39) missense probably damaging 1.00
R6051:Vmn1r75 UTSW 7 11,614,978 (GRCm39) missense probably damaging 1.00
R6230:Vmn1r75 UTSW 7 11,614,966 (GRCm39) missense probably damaging 0.98
R6490:Vmn1r75 UTSW 7 11,615,003 (GRCm39) missense probably damaging 1.00
R6570:Vmn1r75 UTSW 7 11,614,883 (GRCm39) missense probably damaging 0.98
R7184:Vmn1r75 UTSW 7 11,614,915 (GRCm39) nonsense probably null
R7189:Vmn1r75 UTSW 7 11,614,475 (GRCm39) missense possibly damaging 0.93
R7501:Vmn1r75 UTSW 7 11,614,997 (GRCm39) missense possibly damaging 0.67
R7973:Vmn1r75 UTSW 7 11,614,961 (GRCm39) missense probably benign 0.04
R7997:Vmn1r75 UTSW 7 11,614,600 (GRCm39) missense probably damaging 1.00
R8372:Vmn1r75 UTSW 7 11,614,657 (GRCm39) missense probably benign 0.10
R8812:Vmn1r75 UTSW 7 11,614,630 (GRCm39) missense possibly damaging 0.54
R8932:Vmn1r75 UTSW 7 11,614,838 (GRCm39) missense probably damaging 1.00
R9089:Vmn1r75 UTSW 7 11,614,453 (GRCm39) missense probably damaging 1.00
R9129:Vmn1r75 UTSW 7 11,614,513 (GRCm39) missense probably benign 0.15
Posted On 2016-08-02