Incidental Mutation 'IGL03372:Taar2'
| ID |
420327 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Taar2
|
| Ensembl Gene |
ENSMUSG00000059763 |
| Gene Name |
trace amine-associated receptor 2 |
| Synonyms |
Gpr58 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03372
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
23814470-23817481 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23817069 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 203
(V203A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078137
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079134]
|
| AlphaFold |
Q5QD17 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079134
AA Change: V203A
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000078137
Gene: ENSMUSG00000059763
AA Change: V203A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srsx
|
42 |
318 |
2.4e-10 |
PFAM |
|
Pfam:7tm_1
|
48 |
303 |
2.9e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb2 |
C |
T |
4: 129,911,362 (GRCm39) |
A1161V |
probably benign |
Het |
| Alpi |
A |
G |
1: 87,028,350 (GRCm39) |
|
probably benign |
Het |
| Asxl1 |
A |
T |
2: 153,242,333 (GRCm39) |
N961I |
probably damaging |
Het |
| Bcl2l10 |
A |
G |
9: 75,255,329 (GRCm39) |
I49V |
probably benign |
Het |
| Bod1l |
T |
C |
5: 41,962,578 (GRCm39) |
|
probably benign |
Het |
| Ccl20 |
A |
G |
1: 83,095,597 (GRCm39) |
M54V |
probably benign |
Het |
| Cep72 |
A |
C |
13: 74,191,637 (GRCm39) |
L200V |
possibly damaging |
Het |
| Clic4 |
T |
C |
4: 134,945,925 (GRCm39) |
D164G |
probably damaging |
Het |
| Col5a3 |
G |
A |
9: 20,686,624 (GRCm39) |
P1334S |
unknown |
Het |
| Dab2 |
T |
C |
15: 6,459,030 (GRCm39) |
L293P |
probably damaging |
Het |
| Ddx50 |
A |
T |
10: 62,479,109 (GRCm39) |
S140T |
probably benign |
Het |
| Dnah6 |
A |
T |
6: 73,052,833 (GRCm39) |
M2897K |
probably benign |
Het |
| Dnmt3a |
A |
G |
12: 3,952,666 (GRCm39) |
E721G |
probably damaging |
Het |
| Esyt3 |
A |
T |
9: 99,218,109 (GRCm39) |
|
probably benign |
Het |
| Fat4 |
G |
T |
3: 38,943,283 (GRCm39) |
K725N |
possibly damaging |
Het |
| Fezf1 |
T |
C |
6: 23,246,909 (GRCm39) |
I308V |
probably damaging |
Het |
| Fut2 |
C |
T |
7: 45,300,193 (GRCm39) |
G193E |
possibly damaging |
Het |
| Gapdhs |
T |
C |
7: 30,432,674 (GRCm39) |
|
probably benign |
Het |
| Gm10109 |
A |
T |
7: 43,871,126 (GRCm39) |
|
probably benign |
Het |
| Gpd2 |
G |
A |
2: 57,245,519 (GRCm39) |
V405I |
probably damaging |
Het |
| Gtf2e1 |
T |
C |
16: 37,356,077 (GRCm39) |
|
probably benign |
Het |
| Iqca1 |
A |
G |
1: 90,072,691 (GRCm39) |
I63T |
possibly damaging |
Het |
| Kcmf1 |
A |
C |
6: 72,826,546 (GRCm39) |
L161R |
probably damaging |
Het |
| Kif19a |
G |
T |
11: 114,670,044 (GRCm39) |
V80L |
probably damaging |
Het |
| Kif21a |
A |
T |
15: 90,840,579 (GRCm39) |
M1179K |
probably benign |
Het |
| Krtap19-2 |
A |
G |
16: 88,670,774 (GRCm39) |
|
probably benign |
Het |
| Ksr2 |
T |
A |
5: 117,840,783 (GRCm39) |
I575N |
possibly damaging |
Het |
| L3mbtl1 |
A |
T |
2: 162,813,077 (GRCm39) |
|
probably benign |
Het |
| Larp1b |
A |
T |
3: 40,978,962 (GRCm39) |
H6L |
possibly damaging |
Het |
| Map4k2 |
T |
A |
19: 6,392,279 (GRCm39) |
|
probably benign |
Het |
| Mdh1b |
T |
C |
1: 63,759,154 (GRCm39) |
H146R |
possibly damaging |
Het |
| Morc2a |
T |
C |
11: 3,631,813 (GRCm39) |
|
probably benign |
Het |
| Mvd |
A |
G |
8: 123,170,113 (GRCm39) |
|
probably benign |
Het |
| Myo7b |
C |
T |
18: 32,131,654 (GRCm39) |
S514N |
probably damaging |
Het |
| Nav1 |
A |
T |
1: 135,378,641 (GRCm39) |
I1610K |
probably damaging |
Het |
| Nbas |
T |
C |
12: 13,584,473 (GRCm39) |
L2095P |
probably damaging |
Het |
| Nrros |
T |
C |
16: 31,963,588 (GRCm39) |
N115S |
probably damaging |
Het |
| Or5p52 |
T |
C |
7: 107,502,577 (GRCm39) |
Y218H |
probably damaging |
Het |
| Otud6b |
A |
C |
4: 14,812,519 (GRCm39) |
I276R |
possibly damaging |
Het |
| P2rx6 |
G |
A |
16: 17,385,356 (GRCm39) |
E150K |
probably damaging |
Het |
| Pan2 |
T |
A |
10: 128,150,996 (GRCm39) |
L771Q |
probably benign |
Het |
| Pbrm1 |
T |
A |
14: 30,806,976 (GRCm39) |
N1087K |
probably benign |
Het |
| Pcdhb5 |
G |
T |
18: 37,453,713 (GRCm39) |
R31L |
probably benign |
Het |
| Proser3 |
A |
C |
7: 30,242,993 (GRCm39) |
S195A |
probably damaging |
Het |
| Rad50 |
T |
C |
11: 53,586,121 (GRCm39) |
K292E |
probably benign |
Het |
| Rbm27 |
G |
A |
18: 42,438,781 (GRCm39) |
R394H |
probably damaging |
Het |
| Samd9l |
A |
G |
6: 3,375,314 (GRCm39) |
I649T |
probably damaging |
Het |
| Skint3 |
G |
A |
4: 112,113,103 (GRCm39) |
|
probably benign |
Het |
| Slc4a4 |
T |
A |
5: 89,304,285 (GRCm39) |
L576Q |
probably damaging |
Het |
| Snx2 |
A |
G |
18: 53,349,463 (GRCm39) |
D408G |
probably damaging |
Het |
| Tdrd6 |
C |
T |
17: 43,936,459 (GRCm39) |
V1530M |
probably damaging |
Het |
| Tsc2 |
A |
C |
17: 24,838,444 (GRCm39) |
L515R |
probably damaging |
Het |
| Unc13a |
A |
T |
8: 72,108,353 (GRCm39) |
M500K |
probably damaging |
Het |
| Vmn1r75 |
A |
G |
7: 11,614,496 (GRCm39) |
D76G |
probably benign |
Het |
| Whrn |
T |
C |
4: 63,336,855 (GRCm39) |
D127G |
probably damaging |
Het |
|
| Other mutations in Taar2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00229:Taar2
|
APN |
10 |
23,817,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL00807:Taar2
|
APN |
10 |
23,816,573 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01346:Taar2
|
APN |
10 |
23,816,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01433:Taar2
|
APN |
10 |
23,816,657 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01782:Taar2
|
APN |
10 |
23,817,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03106:Taar2
|
APN |
10 |
23,817,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0090:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0103:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0157:Taar2
|
UTSW |
10 |
23,817,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0189:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0190:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0226:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0226:Taar2
|
UTSW |
10 |
23,816,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0267:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0349:Taar2
|
UTSW |
10 |
23,817,407 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0349:Taar2
|
UTSW |
10 |
23,817,327 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0426:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0556:Taar2
|
UTSW |
10 |
23,816,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0698:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1191:Taar2
|
UTSW |
10 |
23,816,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Taar2
|
UTSW |
10 |
23,817,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4615:Taar2
|
UTSW |
10 |
23,817,263 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4658:Taar2
|
UTSW |
10 |
23,817,401 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4766:Taar2
|
UTSW |
10 |
23,816,669 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4872:Taar2
|
UTSW |
10 |
23,816,591 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5205:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5271:Taar2
|
UTSW |
10 |
23,816,930 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5517:Taar2
|
UTSW |
10 |
23,816,627 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
|
R6325:Taar2
|
UTSW |
10 |
23,816,615 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6398:Taar2
|
UTSW |
10 |
23,817,177 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6762:Taar2
|
UTSW |
10 |
23,817,300 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7121:Taar2
|
UTSW |
10 |
23,816,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Taar2
|
UTSW |
10 |
23,816,597 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7709:Taar2
|
UTSW |
10 |
23,816,621 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8045:Taar2
|
UTSW |
10 |
23,817,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8223:Taar2
|
UTSW |
10 |
23,817,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8743:Taar2
|
UTSW |
10 |
23,817,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9307:Taar2
|
UTSW |
10 |
23,817,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9350:Taar2
|
UTSW |
10 |
23,817,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9351:Taar2
|
UTSW |
10 |
23,816,900 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9755:Taar2
|
UTSW |
10 |
23,817,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Taar2
|
UTSW |
10 |
23,817,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Posted On |
2016-08-02 |
Incidental Mutation