Incidental Mutation 'IGL03373:Or10ag57'
ID 420382
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ag57
Ensembl Gene ENSMUSG00000047594
Gene Name olfactory receptor family 10 subfamily AG member 57
Synonyms GA_x6K02T2Q125-48880078-48881058, Olfr1122, MOR264-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL03373
Quality Score
Status
Chromosome 2
Chromosomal Location 87218051-87219031 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87218577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 176 (F176S)
Ref Sequence ENSEMBL: ENSMUSP00000149403 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056435] [ENSMUST00000215371]
AlphaFold Q8VGT9
Predicted Effect probably damaging
Transcript: ENSMUST00000056435
AA Change: F176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052190
Gene: ENSMUSG00000047594
AA Change: F176S

DomainStartEndE-ValueType
Pfam:7tm_4 43 319 6.3e-51 PFAM
Pfam:7tm_1 53 302 5.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215371
AA Change: F176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6a A T 12: 113,509,172 (GRCm39) Y515F possibly damaging Het
Adgrv1 A G 13: 81,711,751 (GRCm39) V1075A probably damaging Het
Alox8 T C 11: 69,077,443 (GRCm39) T436A probably benign Het
Cdc7 T A 5: 107,120,785 (GRCm39) probably benign Het
Cdhr1 T A 14: 36,818,257 (GRCm39) D65V possibly damaging Het
Dnase1 A G 16: 3,857,707 (GRCm39) E278G probably damaging Het
Eif3g A T 9: 20,805,722 (GRCm39) probably benign Het
Flnb G A 14: 7,890,867 (GRCm38) probably null Het
Hars2 G T 18: 36,918,998 (GRCm39) R86L probably damaging Het
Lmod1 C T 1: 135,292,264 (GRCm39) A373V possibly damaging Het
Mdga2 A G 12: 66,763,496 (GRCm39) I200T probably damaging Het
Mup1 T G 4: 60,457,849 (GRCm39) probably benign Het
Nat8f5 A C 6: 85,794,529 (GRCm39) S144A probably benign Het
Ndnf A C 6: 65,681,272 (GRCm39) Y517S possibly damaging Het
Nedd4l G A 18: 65,314,391 (GRCm39) probably benign Het
Nlrp4g A T 9: 124,349,853 (GRCm38) noncoding transcript Het
Nob1 C T 8: 108,144,678 (GRCm39) probably benign Het
Nploc4 G A 11: 120,300,455 (GRCm39) R326* probably null Het
Obox3 A T 7: 15,359,715 (GRCm39) V318D probably benign Het
Or10a3m G A 7: 108,313,339 (GRCm39) V248I probably damaging Het
Pgm1 T C 4: 99,818,741 (GRCm39) I130T probably damaging Het
Ptprk A T 10: 28,442,533 (GRCm39) D845V probably damaging Het
Ptx4 T A 17: 25,339,873 (GRCm39) S17T probably benign Het
Rasgrf1 T C 9: 89,899,084 (GRCm39) probably benign Het
Rfx6 A G 10: 51,596,096 (GRCm39) T426A probably damaging Het
Sfpq C A 4: 126,920,578 (GRCm39) R564S possibly damaging Het
Spint2 A G 7: 28,957,634 (GRCm39) probably benign Het
Vmn1r27 A G 6: 58,192,689 (GRCm39) I105T probably damaging Het
Vmn1r78 T C 7: 11,887,270 (GRCm39) S294P possibly damaging Het
Vmn2r40 T C 7: 8,923,092 (GRCm39) D423G probably benign Het
Other mutations in Or10ag57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01783:Or10ag57 APN 2 87,218,182 (GRCm39) missense probably benign 0.39
IGL01783:Or10ag57 APN 2 87,218,187 (GRCm39) missense possibly damaging 0.91
IGL02396:Or10ag57 APN 2 87,218,049 (GRCm39) utr 5 prime probably benign
IGL03338:Or10ag57 APN 2 87,218,470 (GRCm39) missense probably benign 0.05
R0594:Or10ag57 UTSW 2 87,218,298 (GRCm39) missense probably damaging 1.00
R1245:Or10ag57 UTSW 2 87,218,553 (GRCm39) missense probably benign 0.00
R1376:Or10ag57 UTSW 2 87,218,162 (GRCm39) missense probably benign 0.00
R1376:Or10ag57 UTSW 2 87,218,162 (GRCm39) missense probably benign 0.00
R1471:Or10ag57 UTSW 2 87,218,862 (GRCm39) missense probably damaging 1.00
R1681:Or10ag57 UTSW 2 87,218,964 (GRCm39) missense possibly damaging 0.95
R1995:Or10ag57 UTSW 2 87,218,175 (GRCm39) missense probably damaging 0.97
R2246:Or10ag57 UTSW 2 87,218,195 (GRCm39) missense probably benign 0.00
R2341:Or10ag57 UTSW 2 87,218,084 (GRCm39) missense probably benign
R4008:Or10ag57 UTSW 2 87,218,924 (GRCm39) missense possibly damaging 0.67
R4009:Or10ag57 UTSW 2 87,218,924 (GRCm39) missense possibly damaging 0.67
R4011:Or10ag57 UTSW 2 87,218,924 (GRCm39) missense possibly damaging 0.67
R4119:Or10ag57 UTSW 2 87,218,187 (GRCm39) missense possibly damaging 0.91
R4547:Or10ag57 UTSW 2 87,218,504 (GRCm39) missense probably benign 0.07
R4665:Or10ag57 UTSW 2 87,218,220 (GRCm39) missense probably damaging 1.00
R4666:Or10ag57 UTSW 2 87,218,220 (GRCm39) missense probably damaging 1.00
R4801:Or10ag57 UTSW 2 87,218,553 (GRCm39) missense probably benign 0.00
R4802:Or10ag57 UTSW 2 87,218,553 (GRCm39) missense probably benign 0.00
R5049:Or10ag57 UTSW 2 87,219,002 (GRCm39) missense probably benign 0.00
R5070:Or10ag57 UTSW 2 87,218,507 (GRCm39) missense probably damaging 1.00
R7594:Or10ag57 UTSW 2 87,218,613 (GRCm39) missense probably damaging 1.00
R7684:Or10ag57 UTSW 2 87,218,372 (GRCm39) missense probably damaging 0.99
R8064:Or10ag57 UTSW 2 87,218,853 (GRCm39) missense probably benign 0.00
R8218:Or10ag57 UTSW 2 87,218,922 (GRCm39) missense probably damaging 0.99
R8282:Or10ag57 UTSW 2 87,218,852 (GRCm39) missense probably benign 0.01
R8335:Or10ag57 UTSW 2 87,218,204 (GRCm39) missense probably benign 0.02
R9800:Or10ag57 UTSW 2 87,218,508 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02