Incidental Mutation 'IGL03374:Tas2r124'
| ID |
420407 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r124
|
| Ensembl Gene |
ENSMUSG00000060412 |
| Gene Name |
taste receptor, type 2, member 124 |
| Synonyms |
mt2r50, mGR24, Tas2r24, T2R24 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
IGL03374
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
132731693-132732622 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 132732081 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 130
(H130L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000075509
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076150]
|
| AlphaFold |
Q7M718 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076150
AA Change: H130L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000075509
Gene: ENSMUSG00000060412
AA Change: H130L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
2.3e-92 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aox3 |
G |
A |
1: 58,211,007 (GRCm39) |
R917Q |
probably damaging |
Het |
| Atl1 |
T |
C |
12: 70,002,141 (GRCm39) |
Y367H |
probably damaging |
Het |
| AW551984 |
T |
C |
9: 39,511,062 (GRCm39) |
E175G |
possibly damaging |
Het |
| Cacna2d1 |
T |
A |
5: 16,561,821 (GRCm39) |
D800E |
probably damaging |
Het |
| Cdon |
T |
A |
9: 35,389,299 (GRCm39) |
F801L |
possibly damaging |
Het |
| Dcaf13 |
C |
T |
15: 39,008,543 (GRCm39) |
Q382* |
probably null |
Het |
| Dpy19l3 |
T |
C |
7: 35,411,633 (GRCm39) |
N367S |
possibly damaging |
Het |
| F11 |
A |
G |
8: 45,714,111 (GRCm39) |
S3P |
possibly damaging |
Het |
| Fhip1b |
T |
C |
7: 105,033,158 (GRCm39) |
E57G |
probably damaging |
Het |
| Fryl |
A |
T |
5: 73,267,624 (GRCm39) |
|
probably benign |
Het |
| Gcnt3 |
A |
T |
9: 69,941,695 (GRCm39) |
M291K |
possibly damaging |
Het |
| Glg1 |
T |
C |
8: 111,889,412 (GRCm39) |
D927G |
probably damaging |
Het |
| Gm5862 |
C |
A |
5: 26,224,510 (GRCm39) |
R153L |
probably damaging |
Het |
| Gucy2c |
T |
C |
6: 136,742,628 (GRCm39) |
T237A |
probably benign |
Het |
| Helz |
A |
T |
11: 107,510,973 (GRCm39) |
I610F |
probably damaging |
Het |
| Hpd |
T |
C |
5: 123,310,108 (GRCm39) |
E372G |
probably damaging |
Het |
| Hsd17b13 |
A |
G |
5: 104,124,964 (GRCm39) |
|
probably benign |
Het |
| Klhl32 |
G |
A |
4: 24,649,533 (GRCm39) |
|
probably benign |
Het |
| Krt74 |
T |
A |
15: 101,668,937 (GRCm39) |
|
noncoding transcript |
Het |
| Nopchap1 |
G |
A |
10: 83,201,571 (GRCm39) |
V115M |
probably damaging |
Het |
| Or14a258 |
T |
A |
7: 86,035,574 (GRCm39) |
Q98L |
probably damaging |
Het |
| Or9g4b |
T |
C |
2: 85,616,053 (GRCm39) |
L66P |
probably damaging |
Het |
| Phyhipl |
A |
G |
10: 70,401,109 (GRCm39) |
V163A |
possibly damaging |
Het |
| Pknox2 |
T |
A |
9: 36,834,966 (GRCm39) |
T168S |
probably damaging |
Het |
| Pmfbp1 |
T |
C |
8: 110,269,046 (GRCm39) |
|
probably benign |
Het |
| Sgce |
G |
A |
6: 4,689,718 (GRCm39) |
R372* |
probably null |
Het |
| Stard5 |
T |
C |
7: 83,285,980 (GRCm39) |
S102P |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 76,121,360 (GRCm39) |
K5941R |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,546,027 (GRCm39) |
E32462G |
probably damaging |
Het |
| Tut4 |
T |
C |
4: 108,415,974 (GRCm39) |
S1647P |
probably damaging |
Het |
| Ube2d3 |
A |
G |
3: 135,165,844 (GRCm39) |
|
probably null |
Het |
| Vps13d |
G |
T |
4: 144,835,145 (GRCm39) |
H1561Q |
possibly damaging |
Het |
|
| Other mutations in Tas2r124 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00985:Tas2r124
|
APN |
6 |
132,732,492 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01343:Tas2r124
|
APN |
6 |
132,732,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01646:Tas2r124
|
APN |
6 |
132,732,332 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01743:Tas2r124
|
APN |
6 |
132,731,798 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02251:Tas2r124
|
APN |
6 |
132,732,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03081:Tas2r124
|
APN |
6 |
132,732,497 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL03309:Tas2r124
|
APN |
6 |
132,731,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0012:Tas2r124
|
UTSW |
6 |
132,732,503 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1450:Tas2r124
|
UTSW |
6 |
132,732,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Tas2r124
|
UTSW |
6 |
132,732,488 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2048:Tas2r124
|
UTSW |
6 |
132,731,858 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2846:Tas2r124
|
UTSW |
6 |
132,732,230 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3415:Tas2r124
|
UTSW |
6 |
132,732,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3416:Tas2r124
|
UTSW |
6 |
132,732,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3417:Tas2r124
|
UTSW |
6 |
132,732,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4306:Tas2r124
|
UTSW |
6 |
132,731,954 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4308:Tas2r124
|
UTSW |
6 |
132,731,954 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4823:Tas2r124
|
UTSW |
6 |
132,732,509 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4867:Tas2r124
|
UTSW |
6 |
132,732,156 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4949:Tas2r124
|
UTSW |
6 |
132,731,858 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5242:Tas2r124
|
UTSW |
6 |
132,732,503 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6001:Tas2r124
|
UTSW |
6 |
132,732,416 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6263:Tas2r124
|
UTSW |
6 |
132,731,867 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6313:Tas2r124
|
UTSW |
6 |
132,732,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6394:Tas2r124
|
UTSW |
6 |
132,732,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7685:Tas2r124
|
UTSW |
6 |
132,732,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8354:Tas2r124
|
UTSW |
6 |
132,732,410 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9045:Tas2r124
|
UTSW |
6 |
132,732,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9615:Tas2r124
|
UTSW |
6 |
132,732,492 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2016-08-02 |
Incidental Mutation