Incidental Mutation 'IGL03375:H4c14'
ID 420442
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol H4c14
Ensembl Gene ENSMUSG00000091405
Gene Name H4 clustered histone 14
Synonyms Hist2h4, X04652, H4
Accession Numbers
Essential gene? Not available question?
Stock # IGL03375
Quality Score
Status
Chromosome 3
Chromosomal Location 96170250-96170633 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96170458 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 55 (T55A)
Ref Sequence ENSEMBL: ENSMUSP00000129930 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171473]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000171473
AA Change: T55A

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000129930
Gene: ENSMUSG00000091405
AA Change: T55A

DomainStartEndE-ValueType
H4 16 90 2.59e-29 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177363
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193036
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap31 A G 16: 38,423,190 (GRCm39) S959P probably damaging Het
Arrb2 G A 11: 70,327,005 (GRCm39) G24D probably damaging Het
Catsper4 A G 4: 133,945,519 (GRCm39) I180T probably damaging Het
Chst15 G A 7: 131,872,186 (GRCm39) Q32* probably null Het
Cntnap5c A T 17: 58,469,200 (GRCm39) Y594F possibly damaging Het
Cse1l T A 2: 166,784,977 (GRCm39) probably benign Het
Dab1 A T 4: 104,538,798 (GRCm39) I201F possibly damaging Het
Eif2ak4 T C 2: 118,252,799 (GRCm39) V457A probably benign Het
Fkbp1b T C 12: 4,888,220 (GRCm39) probably benign Het
Fryl C A 5: 73,245,792 (GRCm39) V1122F possibly damaging Het
Gas2l2 A G 11: 83,317,036 (GRCm39) probably benign Het
Gstt2 A T 10: 75,668,655 (GRCm39) probably null Het
Hcst T G 7: 30,118,036 (GRCm39) probably benign Het
Hectd4 A G 5: 121,466,445 (GRCm39) E2420G possibly damaging Het
Ifi206 A T 1: 173,308,344 (GRCm39) S551T probably benign Het
Itgb3bp A G 4: 99,657,724 (GRCm39) probably benign Het
Krtap6-2 A G 16: 89,216,644 (GRCm39) Y108H unknown Het
Krtap6-5 T G 16: 88,844,740 (GRCm39) probably benign Het
Muc5b A G 7: 141,415,699 (GRCm39) T2882A possibly damaging Het
Nup214 C T 2: 31,900,233 (GRCm39) T854M probably damaging Het
Olfml2b A G 1: 170,477,401 (GRCm39) K179E probably benign Het
Or10d1b A G 9: 39,613,871 (GRCm39) S65P probably damaging Het
Or4k37 A T 2: 111,159,229 (GRCm39) H155L probably damaging Het
Per2 A T 1: 91,351,950 (GRCm39) I852K possibly damaging Het
Pkhd1 A T 1: 20,187,247 (GRCm39) I3687N probably damaging Het
Slc7a2 A T 8: 41,369,410 (GRCm39) S622C probably damaging Het
Smarcc2 G A 10: 128,318,781 (GRCm39) V719I probably damaging Het
Syne2 T C 12: 75,972,209 (GRCm39) I1033T possibly damaging Het
Tmod1 T C 4: 46,096,999 (GRCm39) I264T probably damaging Het
Tmtc3 G A 10: 100,283,581 (GRCm39) A658V possibly damaging Het
Top6bl T C 19: 4,748,206 (GRCm39) E164G probably benign Het
Tpm3 A G 3: 89,981,079 (GRCm39) E56G possibly damaging Het
Tra2b T C 16: 22,065,993 (GRCm39) probably benign Het
Trmu T A 15: 85,779,138 (GRCm39) Y262N possibly damaging Het
Uox C T 3: 146,331,590 (GRCm39) T213I probably damaging Het
Vps13d A G 4: 144,818,517 (GRCm39) W2R probably damaging Het
Other mutations in H4c14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02814:H4c14 APN 3 96,170,603 (GRCm39) missense probably benign 0.13
Posted On 2016-08-02