Incidental Mutation 'R0482:Anks1b'
| ID |
42057 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Anks1b
|
| Ensembl Gene |
ENSMUSG00000058589 |
| Gene Name |
ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms |
C030032C09Rik, Gm10937, AIDA-1b, LOC380650, E530015N03Rik |
| MMRRC Submission |
038682-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0482 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
89709371-90809162 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 90195057 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 545
(N545S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138209
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099368]
[ENSMUST00000182907]
[ENSMUST00000182936]
[ENSMUST00000183156]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099368
AA Change: N579S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000096968
Gene: ENSMUSG00000058589
AA Change: N579S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
931 |
4.44e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182907
|
| SMART Domains |
Protein: ENSMUSP00000138614
Gene: ENSMUSG00000058589
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
45 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182936
AA Change: N545S
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000138209
Gene: ENSMUSG00000058589
AA Change: N545S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
5.03e2 |
SMART |
|
low complexity region
|
464 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
543 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183156
AA Change: N579S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000138539
Gene: ENSMUSG00000058589
AA Change: N579S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
948 |
5.66e-17 |
SMART |
|
low complexity region
|
968 |
983 |
N/A |
INTRINSIC |
|
PTB
|
1056 |
1194 |
2.94e-38 |
SMART |
|
| Meta Mutation Damage Score |
0.0819 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.8%
- 20x: 93.4%
|
| Validation Efficiency |
95% (94/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
C |
17: 9,207,255 (GRCm39) |
|
probably null |
Het |
| Abca13 |
G |
A |
11: 9,278,207 (GRCm39) |
G3129D |
possibly damaging |
Het |
| Acnat2 |
T |
C |
4: 49,383,534 (GRCm39) |
I6M |
probably benign |
Het |
| Adcy4 |
T |
A |
14: 56,012,029 (GRCm39) |
|
probably null |
Het |
| Agrn |
A |
G |
4: 156,258,012 (GRCm39) |
S1117P |
probably damaging |
Het |
| Antxr1 |
C |
T |
6: 87,246,220 (GRCm39) |
|
probably null |
Het |
| Arhgef17 |
T |
C |
7: 100,529,828 (GRCm39) |
K476E |
probably damaging |
Het |
| Bptf |
T |
C |
11: 106,972,088 (GRCm39) |
S927G |
probably benign |
Het |
| Cacna1s |
C |
T |
1: 136,041,132 (GRCm39) |
T1286I |
probably benign |
Het |
| Ccdc174 |
T |
A |
6: 91,872,247 (GRCm39) |
M292K |
probably benign |
Het |
| Cdk5rap2 |
G |
A |
4: 70,328,506 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
T |
A |
9: 108,706,272 (GRCm39) |
Y918* |
probably null |
Het |
| Cep250 |
T |
C |
2: 155,806,894 (GRCm39) |
|
probably benign |
Het |
| Ces2h |
A |
G |
8: 105,746,903 (GRCm39) |
D513G |
possibly damaging |
Het |
| Clec2l |
A |
G |
6: 38,640,327 (GRCm39) |
T53A |
probably benign |
Het |
| Cntnap2 |
C |
T |
6: 45,692,750 (GRCm39) |
S77L |
probably benign |
Het |
| Cped1 |
A |
T |
6: 22,016,957 (GRCm39) |
H102L |
probably benign |
Het |
| Crim1 |
T |
A |
17: 78,680,008 (GRCm39) |
D916E |
probably benign |
Het |
| Csmd1 |
T |
A |
8: 16,283,115 (GRCm39) |
I614F |
probably damaging |
Het |
| Csnk1g1 |
G |
A |
9: 65,917,751 (GRCm39) |
E37K |
probably damaging |
Het |
| Ctnnbl1 |
T |
A |
2: 157,713,110 (GRCm39) |
|
probably null |
Het |
| Cuzd1 |
A |
T |
7: 130,911,601 (GRCm39) |
|
probably benign |
Het |
| Cyp4f16 |
T |
A |
17: 32,769,525 (GRCm39) |
V433D |
probably damaging |
Het |
| Ddi1 |
A |
G |
9: 6,266,144 (GRCm39) |
L75P |
probably damaging |
Het |
| Ddias |
G |
A |
7: 92,508,736 (GRCm39) |
A393V |
probably benign |
Het |
| Dgka |
A |
T |
10: 128,569,990 (GRCm39) |
Y123* |
probably null |
Het |
| Dlgap1 |
T |
C |
17: 70,823,185 (GRCm39) |
C57R |
probably benign |
Het |
| Dysf |
T |
A |
6: 84,129,387 (GRCm39) |
V1458D |
probably benign |
Het |
| Eif2ak4 |
T |
A |
2: 118,292,828 (GRCm39) |
Y1230N |
probably damaging |
Het |
| Fbxl7 |
A |
T |
15: 26,543,632 (GRCm39) |
S338R |
probably benign |
Het |
| Fgf23 |
A |
T |
6: 127,050,122 (GRCm39) |
T44S |
probably damaging |
Het |
| Fhip1b |
G |
A |
7: 105,033,419 (GRCm39) |
P599L |
possibly damaging |
Het |
| Folh1 |
A |
T |
7: 86,395,309 (GRCm39) |
|
probably benign |
Het |
| Gpsm2 |
A |
T |
3: 108,609,710 (GRCm39) |
|
probably benign |
Het |
| H2bc13 |
A |
G |
13: 21,900,295 (GRCm39) |
|
probably benign |
Het |
| Hdac2 |
T |
A |
10: 36,865,130 (GRCm39) |
|
probably benign |
Het |
| Il31ra |
G |
T |
13: 112,664,015 (GRCm39) |
T446N |
possibly damaging |
Het |
| Irf5 |
T |
A |
6: 29,535,369 (GRCm39) |
L199H |
probably benign |
Het |
| Kif18a |
T |
A |
2: 109,118,188 (GRCm39) |
M1K |
probably null |
Het |
| Kif4-ps |
A |
C |
12: 101,114,921 (GRCm39) |
I1017L |
probably benign |
Het |
| Klhl2 |
C |
T |
8: 65,211,164 (GRCm39) |
V295M |
probably benign |
Het |
| Krt75 |
A |
T |
15: 101,478,746 (GRCm39) |
M296K |
probably benign |
Het |
| Krt81 |
C |
A |
15: 101,361,508 (GRCm39) |
R24L |
possibly damaging |
Het |
| Lgr4 |
T |
C |
2: 109,838,437 (GRCm39) |
S439P |
probably damaging |
Het |
| Lhfpl2 |
C |
A |
13: 94,311,118 (GRCm39) |
N129K |
probably damaging |
Het |
| Lnx2 |
A |
G |
5: 146,955,771 (GRCm39) |
V675A |
probably damaging |
Het |
| Med13 |
T |
C |
11: 86,175,977 (GRCm39) |
T1673A |
probably benign |
Het |
| Mif |
A |
G |
10: 75,695,974 (GRCm39) |
V10A |
possibly damaging |
Het |
| Mki67 |
A |
T |
7: 135,301,158 (GRCm39) |
I1292N |
possibly damaging |
Het |
| Mylip |
C |
A |
13: 45,558,059 (GRCm39) |
N89K |
probably benign |
Het |
| Myo19 |
G |
T |
11: 84,800,245 (GRCm39) |
D877Y |
probably benign |
Het |
| Nckap5 |
A |
G |
1: 125,954,102 (GRCm39) |
S753P |
possibly damaging |
Het |
| Nlrc3 |
T |
C |
16: 3,783,056 (GRCm39) |
T118A |
possibly damaging |
Het |
| Nptx2 |
T |
C |
5: 144,490,269 (GRCm39) |
Y233H |
probably damaging |
Het |
| Nsl1 |
T |
A |
1: 190,795,237 (GRCm39) |
M1K |
probably null |
Het |
| Ntsr1 |
T |
A |
2: 180,142,849 (GRCm39) |
S213R |
possibly damaging |
Het |
| Or4c120 |
A |
T |
2: 89,000,975 (GRCm39) |
F194I |
probably benign |
Het |
| Or4c58 |
A |
G |
2: 89,674,513 (GRCm39) |
V268A |
probably benign |
Het |
| Or52n5 |
T |
A |
7: 104,588,021 (GRCm39) |
F96Y |
possibly damaging |
Het |
| Pde4d |
G |
A |
13: 110,073,244 (GRCm39) |
V347I |
probably benign |
Het |
| Pik3r4 |
T |
A |
9: 105,546,244 (GRCm39) |
S865T |
probably benign |
Het |
| Ppp2r2d |
A |
G |
7: 138,472,160 (GRCm39) |
R136G |
probably benign |
Het |
| Proser2 |
A |
C |
2: 6,118,721 (GRCm39) |
S41A |
probably damaging |
Het |
| Proz |
A |
T |
8: 13,123,460 (GRCm39) |
K244* |
probably null |
Het |
| Prpf38b |
A |
T |
3: 108,812,586 (GRCm39) |
L209H |
probably damaging |
Het |
| R3hdm1 |
C |
A |
1: 128,112,254 (GRCm39) |
A390E |
probably benign |
Het |
| Rb1cc1 |
A |
C |
1: 6,310,547 (GRCm39) |
D315A |
probably damaging |
Het |
| Rnf141 |
G |
A |
7: 110,436,345 (GRCm39) |
R28* |
probably null |
Het |
| Rps6kc1 |
A |
T |
1: 190,531,627 (GRCm39) |
S792T |
probably benign |
Het |
| Rxrg |
A |
G |
1: 167,458,606 (GRCm39) |
D233G |
possibly damaging |
Het |
| Sh2d7 |
A |
G |
9: 54,448,321 (GRCm39) |
N114S |
probably benign |
Het |
| Slc25a38 |
T |
C |
9: 119,949,899 (GRCm39) |
V205A |
probably benign |
Het |
| Slc4a10 |
T |
C |
2: 62,127,361 (GRCm39) |
|
probably benign |
Het |
| Spred1 |
T |
A |
2: 116,983,459 (GRCm39) |
|
probably null |
Het |
| Stt3b |
A |
G |
9: 115,077,635 (GRCm39) |
S706P |
probably benign |
Het |
| Tcerg1 |
C |
A |
18: 42,697,305 (GRCm39) |
|
probably benign |
Het |
| Tent5a |
T |
C |
9: 85,207,108 (GRCm39) |
Y230C |
probably damaging |
Het |
| Thsd4 |
A |
T |
9: 59,910,261 (GRCm39) |
I109N |
probably damaging |
Het |
| Ticrr |
C |
A |
7: 79,344,236 (GRCm39) |
P1367Q |
probably damaging |
Het |
| Trpv1 |
A |
G |
11: 73,130,255 (GRCm39) |
D146G |
probably damaging |
Het |
| Tubd1 |
T |
G |
11: 86,448,602 (GRCm39) |
V305G |
possibly damaging |
Het |
| Tubgcp4 |
T |
C |
2: 121,005,855 (GRCm39) |
L81P |
probably benign |
Het |
| Ubxn2b |
T |
A |
4: 6,196,404 (GRCm39) |
|
probably null |
Het |
| Usp36 |
A |
T |
11: 118,156,020 (GRCm39) |
S586T |
probably benign |
Het |
| Vcan |
T |
A |
13: 89,826,264 (GRCm39) |
D2220V |
probably damaging |
Het |
| Vmn1r173 |
T |
A |
7: 23,402,216 (GRCm39) |
N150K |
probably damaging |
Het |
| Vmn1r70 |
G |
A |
7: 10,368,204 (GRCm39) |
A231T |
probably damaging |
Het |
| Vmn2r97 |
A |
G |
17: 19,167,930 (GRCm39) |
D728G |
probably damaging |
Het |
| Zbtb40 |
T |
C |
4: 136,710,539 (GRCm39) |
E1200G |
probably damaging |
Het |
| Zfp365 |
A |
T |
10: 67,733,436 (GRCm39) |
V252D |
probably damaging |
Het |
|
| Other mutations in Anks1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01669:Anks1b
|
APN |
10 |
90,733,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01890:Anks1b
|
APN |
10 |
90,480,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01966:Anks1b
|
APN |
10 |
90,730,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02176:Anks1b
|
APN |
10 |
89,878,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02205:Anks1b
|
APN |
10 |
89,906,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02465:Anks1b
|
APN |
10 |
89,999,127 (GRCm39) |
nonsense |
probably null |
|
|
IGL02534:Anks1b
|
APN |
10 |
90,730,979 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02554:Anks1b
|
APN |
10 |
90,757,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Anks1b
|
APN |
10 |
89,912,921 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03164:Anks1b
|
APN |
10 |
89,878,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0542:Anks1b
|
UTSW |
10 |
89,909,829 (GRCm39) |
splice site |
probably benign |
|
|
R0848:Anks1b
|
UTSW |
10 |
89,906,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1056:Anks1b
|
UTSW |
10 |
90,757,291 (GRCm39) |
splice site |
probably null |
|
|
R1398:Anks1b
|
UTSW |
10 |
89,885,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Anks1b
|
UTSW |
10 |
90,346,935 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1548:Anks1b
|
UTSW |
10 |
89,885,847 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1551:Anks1b
|
UTSW |
10 |
89,912,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1607:Anks1b
|
UTSW |
10 |
89,878,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Anks1b
|
UTSW |
10 |
90,347,046 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1701:Anks1b
|
UTSW |
10 |
89,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Anks1b
|
UTSW |
10 |
90,348,751 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1899:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Anks1b
|
UTSW |
10 |
89,885,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Anks1b
|
UTSW |
10 |
90,805,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2279:Anks1b
|
UTSW |
10 |
89,885,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Anks1b
|
UTSW |
10 |
90,802,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2937:Anks1b
|
UTSW |
10 |
89,912,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3739:Anks1b
|
UTSW |
10 |
89,869,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Anks1b
|
UTSW |
10 |
90,143,484 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4459:Anks1b
|
UTSW |
10 |
90,346,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4479:Anks1b
|
UTSW |
10 |
89,885,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4511:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4780:Anks1b
|
UTSW |
10 |
89,709,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Anks1b
|
UTSW |
10 |
90,750,612 (GRCm39) |
missense |
probably null |
0.88 |
|
R4790:Anks1b
|
UTSW |
10 |
89,999,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5012:Anks1b
|
UTSW |
10 |
90,194,999 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5400:Anks1b
|
UTSW |
10 |
90,348,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Anks1b
|
UTSW |
10 |
89,912,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5687:Anks1b
|
UTSW |
10 |
90,750,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5899:Anks1b
|
UTSW |
10 |
90,759,379 (GRCm39) |
splice site |
probably null |
|
|
R5917:Anks1b
|
UTSW |
10 |
90,412,803 (GRCm39) |
intron |
probably benign |
|
|
R5999:Anks1b
|
UTSW |
10 |
90,194,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6080:Anks1b
|
UTSW |
10 |
90,802,211 (GRCm39) |
nonsense |
probably null |
|
|
R6216:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Anks1b
|
UTSW |
10 |
90,777,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6298:Anks1b
|
UTSW |
10 |
90,516,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6337:Anks1b
|
UTSW |
10 |
90,757,158 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6522:Anks1b
|
UTSW |
10 |
90,733,189 (GRCm39) |
intron |
probably benign |
|
|
R6843:Anks1b
|
UTSW |
10 |
90,784,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Anks1b
|
UTSW |
10 |
90,096,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Anks1b
|
UTSW |
10 |
89,905,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7211:Anks1b
|
UTSW |
10 |
90,346,932 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7241:Anks1b
|
UTSW |
10 |
90,348,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Anks1b
|
UTSW |
10 |
90,348,732 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7325:Anks1b
|
UTSW |
10 |
90,777,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Anks1b
|
UTSW |
10 |
90,516,648 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7578:Anks1b
|
UTSW |
10 |
89,885,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Anks1b
|
UTSW |
10 |
90,096,708 (GRCm39) |
splice site |
probably null |
|
|
R7633:Anks1b
|
UTSW |
10 |
90,784,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7881:Anks1b
|
UTSW |
10 |
90,802,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7910:Anks1b
|
UTSW |
10 |
90,516,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Anks1b
|
UTSW |
10 |
90,413,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8045:Anks1b
|
UTSW |
10 |
90,516,722 (GRCm39) |
missense |
probably benign |
|
|
R8146:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Anks1b
|
UTSW |
10 |
89,905,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8535:Anks1b
|
UTSW |
10 |
90,784,493 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Anks1b
|
UTSW |
10 |
89,885,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9300:Anks1b
|
UTSW |
10 |
90,412,966 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Anks1b
|
UTSW |
10 |
90,733,205 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9541:Anks1b
|
UTSW |
10 |
90,412,947 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9550:Anks1b
|
UTSW |
10 |
90,412,360 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9653:Anks1b
|
UTSW |
10 |
90,346,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF004:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF017:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Anks1b
|
UTSW |
10 |
90,348,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCAAAACAACGGACATCTATTGTGT -3'
(R):5'- GTGACAGCATCCAACTCAGCCTT -3'
Sequencing Primer
(F):5'- AACGGACATCTATTGTGTCTTCTC -3'
(R):5'- GAGAGAGCATTTCCAGATCTCTGTC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation