Incidental Mutation 'IGL03381:Vmn1r198'
ID420678
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r198
Ensembl Gene ENSMUSG00000095125
Gene Namevomeronasal 1 receptor 198
SynonymsV1ri3
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.278) question?
Stock #IGL03381
Quality Score
Status
Chromosome13
Chromosomal Location22350364-22360301 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22354836 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 164 (Y164C)
Ref Sequence ENSEMBL: ENSMUSP00000089327 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091733] [ENSMUST00000226786] [ENSMUST00000226909] [ENSMUST00000227167]
Predicted Effect probably benign
Transcript: ENSMUST00000091733
AA Change: Y164C

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000089327
Gene: ENSMUSG00000095125
AA Change: Y164C

DomainStartEndE-ValueType
Pfam:TAS2R 1 299 9.3e-7 PFAM
Pfam:V1R 35 299 5.5e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226786
AA Change: Y164C

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000226909
AA Change: Y164C

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000227167
AA Change: Y75C

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921507P07Rik T C 6: 50,589,136 S120G probably damaging Het
A330017A19Rik T C 17: 46,889,886 E107G probably benign Het
Abca16 T C 7: 120,527,818 F1243S probably benign Het
Adgrv1 A G 13: 81,517,967 V1990A probably damaging Het
Arhgdib G A 6: 136,932,316 T69I probably benign Het
Atf2 G A 2: 73,828,668 A214V probably benign Het
Ccr2 G A 9: 124,106,372 V230I probably benign Het
Cnksr1 T C 4: 134,232,171 E384G probably damaging Het
Epha5 T A 5: 84,331,332 D271V probably damaging Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Gm13083 T C 4: 143,617,055 probably benign Het
Gpr15 A G 16: 58,717,976 F250S probably damaging Het
Gzmf A T 14: 56,206,993 V41E probably benign Het
H2-T10 C T 17: 36,119,354 D232N probably benign Het
H2-T10 T A 17: 36,119,357 K231* probably null Het
Hsd3b6 A G 3: 98,807,812 V88A possibly damaging Het
Kit C T 5: 75,607,128 T57M probably benign Het
Klhl22 A G 16: 17,792,727 D614G possibly damaging Het
Matr3 T A 18: 35,579,025 probably benign Het
Mff A G 1: 82,741,940 Y213C probably damaging Het
Mrnip A G 11: 50,199,590 T194A probably benign Het
Msh6 T C 17: 87,985,109 F431L probably damaging Het
Mttp G A 3: 138,104,943 R637C probably damaging Het
Nlrc3 A G 16: 3,964,315 V410A probably benign Het
Olfr1225 A G 2: 89,171,179 I11T possibly damaging Het
Olfr1462 T A 19: 13,191,405 V246D probably damaging Het
Olfr69 T C 7: 103,767,837 I187V probably benign Het
Psip1 T C 4: 83,485,785 T2A probably benign Het
Rbm33 T C 5: 28,394,392 F961L unknown Het
Rhbdl2 T C 4: 123,822,817 V189A possibly damaging Het
Rpap2 C T 5: 107,620,201 P302S probably benign Het
Sec23ip T A 7: 128,750,305 V32D probably damaging Het
Sh3yl1 T C 12: 30,926,837 I47T possibly damaging Het
Tenm2 A C 11: 36,068,411 S1104A probably benign Het
Ufd1 A G 16: 18,825,757 D190G probably damaging Het
Ugt1a7c T C 1: 88,095,790 F224L probably benign Het
Utp20 G T 10: 88,822,005 F64L probably damaging Het
Wdcp T A 12: 4,851,926 V594D probably damaging Het
Xirp2 A C 2: 67,514,226 E2270D probably benign Het
Other mutations in Vmn1r198
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01964:Vmn1r198 APN 13 22354406 missense probably benign
R0498:Vmn1r198 UTSW 13 22354974 missense probably damaging 1.00
R0755:Vmn1r198 UTSW 13 22355232 missense probably benign 0.00
R2092:Vmn1r198 UTSW 13 22354715 missense possibly damaging 0.95
R2093:Vmn1r198 UTSW 13 22354685 missense probably benign 0.25
R5571:Vmn1r198 UTSW 13 22354998 missense probably damaging 0.99
R5943:Vmn1r198 UTSW 13 22355197 nonsense probably null
R6083:Vmn1r198 UTSW 13 22354758 missense possibly damaging 0.80
R6531:Vmn1r198 UTSW 13 22354407 missense probably benign 0.01
X0024:Vmn1r198 UTSW 13 22354510 missense probably benign
Posted OnAug 02, 2016