Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03381:Gzmf'

420692

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gzmf

Ensembl Gene

ENSMUSG00000015441

Gene Name

granzyme F

Synonyms

MCSP-3, Ctla7, Ctla-7, granzyme G, CTL serine protease 3, CCP4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL03381

Quality Score

Status

Chromosome

Chromosomal Location

56442720-56448864 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 56444450 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 41 (V41E)

Ref Sequence

ENSEMBL: ENSMUSP00000022757 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022757]

AlphaFold

P08883

Predicted Effect

probably benign
Transcript: ENSMUST00000022757
AA Change: V41E

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000022757
Gene: ENSMUSG00000015441
AA Change: V41E

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Tryp_SPc	20	241	3.7e-78	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223614

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A330017A19Rik	T	C	17: 47,200,812 (GRCm39)		probably benign	Het
Abca16	T	C	7: 120,127,041 (GRCm39)	F1243S	probably benign	Het
Adgrv1	A	G	13: 81,666,086 (GRCm39)	V1990A	probably damaging	Het
Arhgdib	G	A	6: 136,909,314 (GRCm39)	T69I	probably benign	Het
Atf2	G	A	2: 73,659,012 (GRCm39)	A214V	probably benign	Het
Ccr2	G	A	9: 123,906,409 (GRCm39)	V230I	probably benign	Het
Cnksr1	T	C	4: 133,959,482 (GRCm39)	E384G	probably damaging	Het
Epha5	T	A	5: 84,479,191 (GRCm39)	D271V	probably damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Gpr15	A	G	16: 58,538,339 (GRCm39)	F250S	probably damaging	Het
H2-T10	C	T	17: 36,430,246 (GRCm39)	D232N	probably benign	Het
H2-T10	T	A	17: 36,430,249 (GRCm39)	K231*	probably null	Het
Hsd3b6	A	G	3: 98,715,128 (GRCm39)	V88A	possibly damaging	Het
Kit	C	T	5: 75,767,788 (GRCm39)	T57M	probably benign	Het
Klhl22	A	G	16: 17,610,591 (GRCm39)	D614G	possibly damaging	Het
Matr3	T	A	18: 35,712,078 (GRCm39)		probably benign	Het
Mff	A	G	1: 82,719,661 (GRCm39)	Y213C	probably damaging	Het
Mrnip	A	G	11: 50,090,417 (GRCm39)	T194A	probably benign	Het
Msh6	T	C	17: 88,292,537 (GRCm39)	F431L	probably damaging	Het
Mttp	G	A	3: 137,810,704 (GRCm39)	R637C	probably damaging	Het
Nlrc3	A	G	16: 3,782,179 (GRCm39)	V410A	probably benign	Het
Or4c120	A	G	2: 89,001,523 (GRCm39)	I11T	possibly damaging	Het
Or52a5b	T	C	7: 103,417,044 (GRCm39)	I187V	probably benign	Het
Or5b108	T	A	19: 13,168,769 (GRCm39)	V246D	probably damaging	Het
Pramel21	T	C	4: 143,343,625 (GRCm39)		probably benign	Het
Psip1	T	C	4: 83,404,022 (GRCm39)	T2A	probably benign	Het
Rbm33	T	C	5: 28,599,390 (GRCm39)	F921L	unknown	Het
Rhbdl2	T	C	4: 123,716,610 (GRCm39)	V189A	possibly damaging	Het
Rpap2	C	T	5: 107,768,067 (GRCm39)	P302S	probably benign	Het
Sec23ip	T	A	7: 128,352,029 (GRCm39)	V32D	probably damaging	Het
Sh3yl1	T	C	12: 30,976,836 (GRCm39)	I47T	possibly damaging	Het
Spmip4	T	C	6: 50,566,116 (GRCm39)	S120G	probably damaging	Het
Tenm2	A	C	11: 35,959,238 (GRCm39)	S1104A	probably benign	Het
Ufd1	A	G	16: 18,644,507 (GRCm39)	D190G	probably damaging	Het
Ugt1a7c	T	C	1: 88,023,512 (GRCm39)	F224L	probably benign	Het
Utp20	G	T	10: 88,657,867 (GRCm39)	F64L	probably damaging	Het
Vmn1r198	A	G	13: 22,539,006 (GRCm39)	Y164C	probably benign	Het
Wdcp	T	A	12: 4,901,926 (GRCm39)	V594D	probably damaging	Het
Xirp2	A	C	2: 67,344,570 (GRCm39)	E2270D	probably benign	Het

Other mutations in Gzmf

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1709:Gzmf	UTSW	14	56,444,397 (GRCm39)	missense	probably damaging	0.99
R6128:Gzmf	UTSW	14	56,443,443 (GRCm39)	nonsense	probably null
R6261:Gzmf	UTSW	14	56,443,949 (GRCm39)	missense	probably benign	0.05
R6786:Gzmf	UTSW	14	56,444,452 (GRCm39)	missense	probably benign	0.09
R7171:Gzmf	UTSW	14	56,443,391 (GRCm39)	missense	probably benign	0.01
R8770:Gzmf	UTSW	14	56,443,951 (GRCm39)	missense	probably damaging	1.00
R9401:Gzmf	UTSW	14	56,448,813 (GRCm39)	start codon destroyed	probably null
R9684:Gzmf	UTSW	14	56,444,444 (GRCm39)	missense	probably benign	0.02

Posted On

2016-08-02