Incidental Mutation 'IGL03381:Gpr15'
ID |
420706 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Gpr15
|
Ensembl Gene |
ENSMUSG00000047293 |
Gene Name |
G protein-coupled receptor 15 |
Synonyms |
4933439K08Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL03381
|
Quality Score |
|
Status
|
|
Chromosome |
16 |
Chromosomal Location |
58537796-58539433 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 58538339 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Serine
at position 250
(F250S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000086731
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000089318]
|
AlphaFold |
Q0VDU3 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000089318
AA Change: F250S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000086731 Gene: ENSMUSG00000047293 AA Change: F250S
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
50 |
302 |
1.3e-46 |
PFAM |
Pfam:7TM_GPCR_Srv
|
66 |
317 |
7.1e-9 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231342
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232532
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012] PHENOTYPE: Mice homozygous for a a knock-out allele exhibit impaired regulatory T cell homing in the large intestine mucosa. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A330017A19Rik |
T |
C |
17: 47,200,812 (GRCm39) |
|
probably benign |
Het |
Abca16 |
T |
C |
7: 120,127,041 (GRCm39) |
F1243S |
probably benign |
Het |
Adgrv1 |
A |
G |
13: 81,666,086 (GRCm39) |
V1990A |
probably damaging |
Het |
Arhgdib |
G |
A |
6: 136,909,314 (GRCm39) |
T69I |
probably benign |
Het |
Atf2 |
G |
A |
2: 73,659,012 (GRCm39) |
A214V |
probably benign |
Het |
Ccr2 |
G |
A |
9: 123,906,409 (GRCm39) |
V230I |
probably benign |
Het |
Cnksr1 |
T |
C |
4: 133,959,482 (GRCm39) |
E384G |
probably damaging |
Het |
Epha5 |
T |
A |
5: 84,479,191 (GRCm39) |
D271V |
probably damaging |
Het |
Fut2 |
C |
T |
7: 45,300,193 (GRCm39) |
G193E |
possibly damaging |
Het |
Gzmf |
A |
T |
14: 56,444,450 (GRCm39) |
V41E |
probably benign |
Het |
H2-T10 |
C |
T |
17: 36,430,246 (GRCm39) |
D232N |
probably benign |
Het |
H2-T10 |
T |
A |
17: 36,430,249 (GRCm39) |
K231* |
probably null |
Het |
Hsd3b6 |
A |
G |
3: 98,715,128 (GRCm39) |
V88A |
possibly damaging |
Het |
Kit |
C |
T |
5: 75,767,788 (GRCm39) |
T57M |
probably benign |
Het |
Klhl22 |
A |
G |
16: 17,610,591 (GRCm39) |
D614G |
possibly damaging |
Het |
Matr3 |
T |
A |
18: 35,712,078 (GRCm39) |
|
probably benign |
Het |
Mff |
A |
G |
1: 82,719,661 (GRCm39) |
Y213C |
probably damaging |
Het |
Mrnip |
A |
G |
11: 50,090,417 (GRCm39) |
T194A |
probably benign |
Het |
Msh6 |
T |
C |
17: 88,292,537 (GRCm39) |
F431L |
probably damaging |
Het |
Mttp |
G |
A |
3: 137,810,704 (GRCm39) |
R637C |
probably damaging |
Het |
Nlrc3 |
A |
G |
16: 3,782,179 (GRCm39) |
V410A |
probably benign |
Het |
Or4c120 |
A |
G |
2: 89,001,523 (GRCm39) |
I11T |
possibly damaging |
Het |
Or52a5b |
T |
C |
7: 103,417,044 (GRCm39) |
I187V |
probably benign |
Het |
Or5b108 |
T |
A |
19: 13,168,769 (GRCm39) |
V246D |
probably damaging |
Het |
Pramel21 |
T |
C |
4: 143,343,625 (GRCm39) |
|
probably benign |
Het |
Psip1 |
T |
C |
4: 83,404,022 (GRCm39) |
T2A |
probably benign |
Het |
Rbm33 |
T |
C |
5: 28,599,390 (GRCm39) |
F921L |
unknown |
Het |
Rhbdl2 |
T |
C |
4: 123,716,610 (GRCm39) |
V189A |
possibly damaging |
Het |
Rpap2 |
C |
T |
5: 107,768,067 (GRCm39) |
P302S |
probably benign |
Het |
Sec23ip |
T |
A |
7: 128,352,029 (GRCm39) |
V32D |
probably damaging |
Het |
Sh3yl1 |
T |
C |
12: 30,976,836 (GRCm39) |
I47T |
possibly damaging |
Het |
Spmip4 |
T |
C |
6: 50,566,116 (GRCm39) |
S120G |
probably damaging |
Het |
Tenm2 |
A |
C |
11: 35,959,238 (GRCm39) |
S1104A |
probably benign |
Het |
Ufd1 |
A |
G |
16: 18,644,507 (GRCm39) |
D190G |
probably damaging |
Het |
Ugt1a7c |
T |
C |
1: 88,023,512 (GRCm39) |
F224L |
probably benign |
Het |
Utp20 |
G |
T |
10: 88,657,867 (GRCm39) |
F64L |
probably damaging |
Het |
Vmn1r198 |
A |
G |
13: 22,539,006 (GRCm39) |
Y164C |
probably benign |
Het |
Wdcp |
T |
A |
12: 4,901,926 (GRCm39) |
V594D |
probably damaging |
Het |
Xirp2 |
A |
C |
2: 67,344,570 (GRCm39) |
E2270D |
probably benign |
Het |
|
Other mutations in Gpr15 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00473:Gpr15
|
APN |
16 |
58,538,441 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02616:Gpr15
|
APN |
16 |
58,538,567 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4418001:Gpr15
|
UTSW |
16 |
58,538,313 (GRCm39) |
missense |
probably benign |
0.13 |
R1484:Gpr15
|
UTSW |
16 |
58,538,937 (GRCm39) |
missense |
probably damaging |
1.00 |
R1775:Gpr15
|
UTSW |
16 |
58,538,921 (GRCm39) |
missense |
probably benign |
0.05 |
R1959:Gpr15
|
UTSW |
16 |
58,538,370 (GRCm39) |
missense |
probably benign |
0.03 |
R1961:Gpr15
|
UTSW |
16 |
58,538,370 (GRCm39) |
missense |
probably benign |
0.03 |
R2127:Gpr15
|
UTSW |
16 |
58,538,618 (GRCm39) |
missense |
possibly damaging |
0.67 |
R3825:Gpr15
|
UTSW |
16 |
58,538,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R4957:Gpr15
|
UTSW |
16 |
58,538,537 (GRCm39) |
missense |
probably damaging |
0.99 |
R5098:Gpr15
|
UTSW |
16 |
58,538,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R5180:Gpr15
|
UTSW |
16 |
58,538,248 (GRCm39) |
missense |
probably benign |
0.07 |
R5668:Gpr15
|
UTSW |
16 |
58,538,013 (GRCm39) |
missense |
probably damaging |
1.00 |
R6104:Gpr15
|
UTSW |
16 |
58,538,339 (GRCm39) |
missense |
probably damaging |
1.00 |
R6281:Gpr15
|
UTSW |
16 |
58,538,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R6921:Gpr15
|
UTSW |
16 |
58,538,144 (GRCm39) |
missense |
probably benign |
0.00 |
R6980:Gpr15
|
UTSW |
16 |
58,539,105 (GRCm39) |
start gained |
probably benign |
|
R6981:Gpr15
|
UTSW |
16 |
58,538,548 (GRCm39) |
missense |
probably benign |
0.44 |
R7252:Gpr15
|
UTSW |
16 |
58,538,760 (GRCm39) |
missense |
probably damaging |
1.00 |
R7643:Gpr15
|
UTSW |
16 |
58,538,179 (GRCm39) |
nonsense |
probably null |
|
R7680:Gpr15
|
UTSW |
16 |
58,538,328 (GRCm39) |
missense |
probably damaging |
1.00 |
R7844:Gpr15
|
UTSW |
16 |
58,538,873 (GRCm39) |
missense |
probably damaging |
1.00 |
R7954:Gpr15
|
UTSW |
16 |
58,539,047 (GRCm39) |
missense |
probably benign |
0.00 |
R8100:Gpr15
|
UTSW |
16 |
58,538,076 (GRCm39) |
missense |
probably benign |
0.00 |
R8372:Gpr15
|
UTSW |
16 |
58,538,850 (GRCm39) |
missense |
probably benign |
0.09 |
R9414:Gpr15
|
UTSW |
16 |
58,538,516 (GRCm39) |
missense |
probably benign |
0.03 |
R9729:Gpr15
|
UTSW |
16 |
58,538,249 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Posted On |
2016-08-02 |