Incidental Mutation 'IGL03381:Mrnip'
| ID |
420707 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrnip
|
| Ensembl Gene |
ENSMUSG00000020381 |
| Gene Name |
MRN complex interacting protein |
| Synonyms |
3010026O09Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03381
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
11 |
| Chromosomal Location |
50065678-50090943 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 50090417 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 194
(T194A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020647
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015981]
[ENSMUST00000020647]
[ENSMUST00000102774]
[ENSMUST00000123164]
[ENSMUST00000136936]
[ENSMUST00000143379]
|
| AlphaFold |
Q9D1F5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000015981
|
| SMART Domains |
Protein: ENSMUSP00000015981
Gene: ENSMUSG00000015837
| Domain | Start | End | E-Value | Type |
|---|
|
PB1
|
3 |
102 |
1.96e-14 |
SMART |
|
ZnF_ZZ
|
122 |
165 |
8.62e-19 |
SMART |
|
low complexity region
|
269 |
281 |
N/A |
INTRINSIC |
|
UBA
|
358 |
397 |
9.33e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020647
AA Change: T194A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102774
|
| SMART Domains |
Protein: ENSMUSP00000099835
Gene: ENSMUSG00000015837
| Domain | Start | End | E-Value | Type |
|---|
|
PB1
|
3 |
102 |
1.96e-14 |
SMART |
|
ZnF_ZZ
|
122 |
165 |
8.62e-19 |
SMART |
|
low complexity region
|
269 |
281 |
N/A |
INTRINSIC |
|
UBA
|
396 |
435 |
9.33e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123164
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131214
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136936
|
| SMART Domains |
Protein: ENSMUSP00000120442
Gene: ENSMUSG00000015837
| Domain | Start | End | E-Value | Type |
|---|
|
UBA
|
63 |
102 |
9.33e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143379
|
| SMART Domains |
Protein: ENSMUSP00000118662
Gene: ENSMUSG00000015837
| Domain | Start | End | E-Value | Type |
|---|
|
PB1
|
3 |
102 |
1.96e-14 |
SMART |
|
ZnF_ZZ
|
122 |
165 |
8.62e-19 |
SMART |
|
low complexity region
|
269 |
281 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147846
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A330017A19Rik |
T |
C |
17: 47,200,812 (GRCm39) |
|
probably benign |
Het |
| Abca16 |
T |
C |
7: 120,127,041 (GRCm39) |
F1243S |
probably benign |
Het |
| Adgrv1 |
A |
G |
13: 81,666,086 (GRCm39) |
V1990A |
probably damaging |
Het |
| Arhgdib |
G |
A |
6: 136,909,314 (GRCm39) |
T69I |
probably benign |
Het |
| Atf2 |
G |
A |
2: 73,659,012 (GRCm39) |
A214V |
probably benign |
Het |
| Ccr2 |
G |
A |
9: 123,906,409 (GRCm39) |
V230I |
probably benign |
Het |
| Cnksr1 |
T |
C |
4: 133,959,482 (GRCm39) |
E384G |
probably damaging |
Het |
| Epha5 |
T |
A |
5: 84,479,191 (GRCm39) |
D271V |
probably damaging |
Het |
| Fut2 |
C |
T |
7: 45,300,193 (GRCm39) |
G193E |
possibly damaging |
Het |
| Gpr15 |
A |
G |
16: 58,538,339 (GRCm39) |
F250S |
probably damaging |
Het |
| Gzmf |
A |
T |
14: 56,444,450 (GRCm39) |
V41E |
probably benign |
Het |
| H2-T10 |
C |
T |
17: 36,430,246 (GRCm39) |
D232N |
probably benign |
Het |
| H2-T10 |
T |
A |
17: 36,430,249 (GRCm39) |
K231* |
probably null |
Het |
| Hsd3b6 |
A |
G |
3: 98,715,128 (GRCm39) |
V88A |
possibly damaging |
Het |
| Kit |
C |
T |
5: 75,767,788 (GRCm39) |
T57M |
probably benign |
Het |
| Klhl22 |
A |
G |
16: 17,610,591 (GRCm39) |
D614G |
possibly damaging |
Het |
| Matr3 |
T |
A |
18: 35,712,078 (GRCm39) |
|
probably benign |
Het |
| Mff |
A |
G |
1: 82,719,661 (GRCm39) |
Y213C |
probably damaging |
Het |
| Msh6 |
T |
C |
17: 88,292,537 (GRCm39) |
F431L |
probably damaging |
Het |
| Mttp |
G |
A |
3: 137,810,704 (GRCm39) |
R637C |
probably damaging |
Het |
| Nlrc3 |
A |
G |
16: 3,782,179 (GRCm39) |
V410A |
probably benign |
Het |
| Or4c120 |
A |
G |
2: 89,001,523 (GRCm39) |
I11T |
possibly damaging |
Het |
| Or52a5b |
T |
C |
7: 103,417,044 (GRCm39) |
I187V |
probably benign |
Het |
| Or5b108 |
T |
A |
19: 13,168,769 (GRCm39) |
V246D |
probably damaging |
Het |
| Pramel21 |
T |
C |
4: 143,343,625 (GRCm39) |
|
probably benign |
Het |
| Psip1 |
T |
C |
4: 83,404,022 (GRCm39) |
T2A |
probably benign |
Het |
| Rbm33 |
T |
C |
5: 28,599,390 (GRCm39) |
F921L |
unknown |
Het |
| Rhbdl2 |
T |
C |
4: 123,716,610 (GRCm39) |
V189A |
possibly damaging |
Het |
| Rpap2 |
C |
T |
5: 107,768,067 (GRCm39) |
P302S |
probably benign |
Het |
| Sec23ip |
T |
A |
7: 128,352,029 (GRCm39) |
V32D |
probably damaging |
Het |
| Sh3yl1 |
T |
C |
12: 30,976,836 (GRCm39) |
I47T |
possibly damaging |
Het |
| Spmip4 |
T |
C |
6: 50,566,116 (GRCm39) |
S120G |
probably damaging |
Het |
| Tenm2 |
A |
C |
11: 35,959,238 (GRCm39) |
S1104A |
probably benign |
Het |
| Ufd1 |
A |
G |
16: 18,644,507 (GRCm39) |
D190G |
probably damaging |
Het |
| Ugt1a7c |
T |
C |
1: 88,023,512 (GRCm39) |
F224L |
probably benign |
Het |
| Utp20 |
G |
T |
10: 88,657,867 (GRCm39) |
F64L |
probably damaging |
Het |
| Vmn1r198 |
A |
G |
13: 22,539,006 (GRCm39) |
Y164C |
probably benign |
Het |
| Wdcp |
T |
A |
12: 4,901,926 (GRCm39) |
V594D |
probably damaging |
Het |
| Xirp2 |
A |
C |
2: 67,344,570 (GRCm39) |
E2270D |
probably benign |
Het |
|
| Other mutations in Mrnip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01518:Mrnip
|
APN |
11 |
50,088,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01836:Mrnip
|
APN |
11 |
50,090,675 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02080:Mrnip
|
APN |
11 |
50,088,502 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03059:Mrnip
|
APN |
11 |
50,090,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0391:Mrnip
|
UTSW |
11 |
50,090,747 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1388:Mrnip
|
UTSW |
11 |
50,087,772 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1561:Mrnip
|
UTSW |
11 |
50,067,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1736:Mrnip
|
UTSW |
11 |
50,067,718 (GRCm39) |
splice site |
probably null |
|
|
R1768:Mrnip
|
UTSW |
11 |
50,067,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5660:Mrnip
|
UTSW |
11 |
50,087,918 (GRCm39) |
missense |
probably null |
1.00 |
|
R6505:Mrnip
|
UTSW |
11 |
50,090,679 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6803:Mrnip
|
UTSW |
11 |
50,090,730 (GRCm39) |
missense |
probably benign |
|
|
R7290:Mrnip
|
UTSW |
11 |
50,087,808 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7735:Mrnip
|
UTSW |
11 |
50,087,800 (GRCm39) |
nonsense |
probably null |
|
|
R8197:Mrnip
|
UTSW |
11 |
50,090,607 (GRCm39) |
missense |
probably benign |
|
|
R8462:Mrnip
|
UTSW |
11 |
50,090,654 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8826:Mrnip
|
UTSW |
11 |
50,067,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9009:Mrnip
|
UTSW |
11 |
50,073,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9106:Mrnip
|
UTSW |
11 |
50,065,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation