Incidental Mutation 'IGL03389:Ttc27'
ID 420987
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ttc27
Ensembl Gene ENSMUSG00000024078
Gene Name tetratricopeptide repeat domain 27
Synonyms 2610511O17Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # IGL03389
Quality Score
Status
Chromosome 17
Chromosomal Location 75024730-75170565 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 75165028 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 745 (Y745H)
Ref Sequence ENSEMBL: ENSMUSP00000024882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024882]
AlphaFold Q8CD92
Predicted Effect probably benign
Transcript: ENSMUST00000024882
AA Change: Y745H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000024882
Gene: ENSMUSG00000024078
AA Change: Y745H

DomainStartEndE-ValueType
TPR 531 564 7.34e-3 SMART
TPR 565 598 5.56e-3 SMART
TPR 599 632 3.81e-1 SMART
Blast:TPR 633 666 7e-15 BLAST
coiled coil region 817 847 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 A T 1: 38,249,430 (GRCm39) V559E possibly damaging Het
Alpk2 G T 18: 65,437,937 (GRCm39) P1619Q possibly damaging Het
Amz1 C A 5: 140,737,782 (GRCm39) F347L probably benign Het
Ank1 T C 8: 23,578,076 (GRCm39) probably null Het
Ank2 C A 3: 126,749,519 (GRCm39) E503D probably damaging Het
Cdc16 A G 8: 13,809,179 (GRCm39) Y48C probably damaging Het
Cfap91 C T 16: 38,144,498 (GRCm39) probably null Het
Cul2 A G 18: 3,431,029 (GRCm39) D538G probably benign Het
Cyp2j13 T A 4: 95,956,558 (GRCm39) I184F probably damaging Het
Cyp4a12b A T 4: 115,291,005 (GRCm39) R344S possibly damaging Het
Dis3 A G 14: 99,332,783 (GRCm39) probably benign Het
Dnah17 T C 11: 117,985,805 (GRCm39) H1424R probably damaging Het
Eef2 A G 10: 81,015,540 (GRCm39) I354V probably benign Het
Elmo1 A G 13: 20,526,596 (GRCm39) D382G probably damaging Het
Epas1 T A 17: 87,131,131 (GRCm39) S304T probably benign Het
Fry A T 5: 150,317,696 (GRCm39) D892V probably damaging Het
Gprc5a G T 6: 135,060,823 (GRCm39) D355Y possibly damaging Het
Hsd17b7 G A 1: 169,787,320 (GRCm39) T228I probably damaging Het
Ift74 T C 4: 94,510,149 (GRCm39) V60A possibly damaging Het
Insrr A T 3: 87,716,038 (GRCm39) I578F probably damaging Het
Izumo1 T C 7: 45,273,613 (GRCm39) F122S probably damaging Het
Lss G A 10: 76,372,173 (GRCm39) R176H probably damaging Het
Ltb T C 17: 35,414,044 (GRCm39) S61P probably benign Het
Mybphl T C 3: 108,283,034 (GRCm39) V274A probably benign Het
Myo9a T G 9: 59,776,890 (GRCm39) L1096W probably damaging Het
Nlrc5 T A 8: 95,248,102 (GRCm39) L1690H probably damaging Het
Nrap A T 19: 56,340,148 (GRCm39) S790T probably benign Het
Nrcam A G 12: 44,596,689 (GRCm39) D308G probably benign Het
Or10a3 G A 7: 108,479,982 (GRCm39) T277M probably damaging Het
Or1j17 A G 2: 36,578,274 (GRCm39) T87A probably benign Het
Pias2 A G 18: 77,185,354 (GRCm39) D138G probably damaging Het
Prpf4b T C 13: 35,084,439 (GRCm39) probably benign Het
Rapgef3 A G 15: 97,647,397 (GRCm39) S788P probably damaging Het
Slc5a6 T C 5: 31,194,821 (GRCm39) Y525C probably damaging Het
Snx32 T C 19: 5,546,082 (GRCm39) probably benign Het
Tnfaip3 T C 10: 18,880,735 (GRCm39) E444G probably benign Het
Other mutations in Ttc27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Ttc27 APN 17 75,087,811 (GRCm39) missense probably damaging 1.00
IGL01508:Ttc27 APN 17 75,142,352 (GRCm39) missense probably damaging 0.98
IGL02010:Ttc27 APN 17 75,087,906 (GRCm39) splice site probably benign
IGL02189:Ttc27 APN 17 75,036,894 (GRCm39) missense probably damaging 0.99
IGL02487:Ttc27 APN 17 75,163,549 (GRCm39) missense probably damaging 1.00
IGL02745:Ttc27 APN 17 75,046,728 (GRCm39) missense probably benign 0.37
IGL02816:Ttc27 APN 17 75,054,769 (GRCm39) splice site probably benign
R0024:Ttc27 UTSW 17 75,077,259 (GRCm39) missense possibly damaging 0.79
R0511:Ttc27 UTSW 17 75,025,710 (GRCm39) missense probably benign 0.22
R0518:Ttc27 UTSW 17 75,163,544 (GRCm39) missense possibly damaging 0.80
R0521:Ttc27 UTSW 17 75,163,544 (GRCm39) missense possibly damaging 0.80
R0633:Ttc27 UTSW 17 75,036,972 (GRCm39) missense probably benign 0.02
R1415:Ttc27 UTSW 17 75,046,667 (GRCm39) missense probably benign
R1597:Ttc27 UTSW 17 75,170,402 (GRCm39) missense possibly damaging 0.95
R1961:Ttc27 UTSW 17 75,087,851 (GRCm39) missense probably damaging 0.99
R2038:Ttc27 UTSW 17 75,163,497 (GRCm39) missense probably benign 0.00
R3012:Ttc27 UTSW 17 75,147,454 (GRCm39) missense probably benign 0.17
R3619:Ttc27 UTSW 17 75,058,123 (GRCm39) splice site probably null
R4155:Ttc27 UTSW 17 75,147,455 (GRCm39) missense probably benign 0.09
R4272:Ttc27 UTSW 17 75,147,355 (GRCm39) missense probably damaging 1.00
R4291:Ttc27 UTSW 17 75,163,474 (GRCm39) missense probably damaging 1.00
R4557:Ttc27 UTSW 17 75,136,544 (GRCm39) missense probably benign 0.00
R5068:Ttc27 UTSW 17 75,106,337 (GRCm39) missense probably damaging 1.00
R5069:Ttc27 UTSW 17 75,106,337 (GRCm39) missense probably damaging 1.00
R5070:Ttc27 UTSW 17 75,106,337 (GRCm39) missense probably damaging 1.00
R5074:Ttc27 UTSW 17 75,054,750 (GRCm39) missense probably damaging 1.00
R5169:Ttc27 UTSW 17 75,054,690 (GRCm39) nonsense probably null
R5203:Ttc27 UTSW 17 75,084,649 (GRCm39) missense probably damaging 1.00
R5272:Ttc27 UTSW 17 75,049,972 (GRCm39) missense probably damaging 1.00
R6260:Ttc27 UTSW 17 75,165,086 (GRCm39) missense probably damaging 0.99
R6797:Ttc27 UTSW 17 75,036,883 (GRCm39) missense probably benign 0.28
R6830:Ttc27 UTSW 17 75,163,550 (GRCm39) nonsense probably null
R6987:Ttc27 UTSW 17 75,084,736 (GRCm39) critical splice donor site probably null
R7121:Ttc27 UTSW 17 75,054,710 (GRCm39) missense probably benign 0.04
R7393:Ttc27 UTSW 17 75,077,259 (GRCm39) missense possibly damaging 0.79
R7543:Ttc27 UTSW 17 75,024,745 (GRCm39) start gained probably benign
R7635:Ttc27 UTSW 17 75,025,710 (GRCm39) missense probably benign 0.22
R8231:Ttc27 UTSW 17 75,024,959 (GRCm39) missense probably benign 0.19
R8365:Ttc27 UTSW 17 75,054,669 (GRCm39) missense probably damaging 1.00
R8464:Ttc27 UTSW 17 75,024,925 (GRCm39) missense probably benign
R8493:Ttc27 UTSW 17 75,050,047 (GRCm39) critical splice donor site probably null
R8687:Ttc27 UTSW 17 75,046,679 (GRCm39) missense probably benign 0.00
X0026:Ttc27 UTSW 17 75,163,432 (GRCm39) missense probably benign 0.19
Posted On 2016-08-02