Incidental Mutation 'IGL03390:Or1o11'
ID 421012
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1o11
Ensembl Gene ENSMUSG00000059687
Gene Name olfactory receptor family 1 subfamily O member 11
Synonyms MOR156-5, GA_x6K02T2PSCP-1893605-1894534, Olfr108
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL03390
Quality Score
Status
Chromosome 17
Chromosomal Location 37756371-37757408 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37757255 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 281 (V281A)
Ref Sequence ENSEMBL: ENSMUSP00000151360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078207] [ENSMUST00000207414] [ENSMUST00000218675]
AlphaFold Q8VFA1
Predicted Effect probably benign
Transcript: ENSMUST00000078207
AA Change: V270A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000077337
Gene: ENSMUSG00000059687
AA Change: V270A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 33 315 8.8e-9 PFAM
Pfam:7tm_4 39 316 9.5e-54 PFAM
Pfam:7tm_1 49 298 1.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207414
AA Change: V281A
Predicted Effect probably benign
Transcript: ENSMUST00000218675
AA Change: V281A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810004N23Rik A G 8: 125,566,564 (GRCm39) probably benign Het
Ccdc18 A G 5: 108,359,997 (GRCm39) Y1127C probably damaging Het
Cdnf T A 2: 3,524,863 (GRCm39) L134* probably null Het
Col11a1 A G 3: 113,883,902 (GRCm39) D257G unknown Het
Cthrc1 T A 15: 38,940,529 (GRCm39) I44N probably benign Het
Dlec1 T C 9: 118,952,288 (GRCm39) Y545H probably benign Het
Drosha T G 15: 12,885,069 (GRCm39) probably null Het
Ebf2 A G 14: 67,661,558 (GRCm39) N562S probably benign Het
Fem1b G A 9: 62,704,246 (GRCm39) A338V probably benign Het
Gga3 A T 11: 115,477,820 (GRCm39) probably null Het
Gm7247 A T 14: 51,760,914 (GRCm39) H161L probably benign Het
Gm7367 A G 7: 59,805,517 (GRCm39) noncoding transcript Het
Inpp5a T G 7: 139,105,664 (GRCm39) V213G probably benign Het
Kcns3 T C 12: 11,141,233 (GRCm39) T489A probably benign Het
Kifc3 G A 8: 95,835,241 (GRCm39) A211V probably damaging Het
Krt71 T C 15: 101,642,987 (GRCm39) D507G possibly damaging Het
Lama5 T C 2: 179,849,011 (GRCm39) Y224C probably damaging Het
Lrrc37a A G 11: 103,386,857 (GRCm39) L2421P unknown Het
Mtch2 C T 2: 90,689,894 (GRCm39) T205I probably benign Het
Prkdc T A 16: 15,488,490 (GRCm39) C537* probably null Het
Prl2a1 T C 13: 27,985,699 (GRCm39) V5A probably benign Het
Prob1 T C 18: 35,787,192 (GRCm39) Y354C probably benign Het
Rimklb C T 6: 122,433,280 (GRCm39) S347N possibly damaging Het
Rnase2a T C 14: 51,492,945 (GRCm39) D140G probably damaging Het
Ryr2 G A 13: 11,787,302 (GRCm39) P1017S probably benign Het
Slc3a1 A G 17: 85,340,205 (GRCm39) D209G probably damaging Het
Sntn T A 14: 13,682,205 (GRCm38) probably benign Het
Tal2 G T 4: 53,785,994 (GRCm39) L58F probably damaging Het
Trim39 T C 17: 36,571,463 (GRCm39) K432E probably damaging Het
Trmt5 A T 12: 73,329,501 (GRCm39) M219K probably benign Het
Vmn2r3 T A 3: 64,182,767 (GRCm39) I311L possibly damaging Het
Wfdc17 A T 11: 83,595,611 (GRCm39) probably benign Het
Zbtb6 T G 2: 37,319,584 (GRCm39) I115L probably damaging Het
Zfp750 A T 11: 121,402,770 (GRCm39) C659* probably null Het
Other mutations in Or1o11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Or1o11 APN 17 37,756,605 (GRCm39) missense probably benign 0.44
IGL01469:Or1o11 APN 17 37,756,426 (GRCm39) missense probably benign 0.00
IGL02291:Or1o11 APN 17 37,757,176 (GRCm39) missense possibly damaging 0.62
IGL02892:Or1o11 APN 17 37,756,925 (GRCm39) missense probably damaging 1.00
R0115:Or1o11 UTSW 17 37,756,670 (GRCm39) missense probably benign 0.00
R0395:Or1o11 UTSW 17 37,756,757 (GRCm39) missense probably damaging 1.00
R0427:Or1o11 UTSW 17 37,756,593 (GRCm39) missense probably damaging 0.99
R0557:Or1o11 UTSW 17 37,756,712 (GRCm39) missense probably damaging 1.00
R1709:Or1o11 UTSW 17 37,757,091 (GRCm39) nonsense probably null
R3076:Or1o11 UTSW 17 37,756,375 (GRCm39) start gained probably benign
R5467:Or1o11 UTSW 17 37,756,973 (GRCm39) missense probably damaging 1.00
R5642:Or1o11 UTSW 17 37,756,663 (GRCm39) missense probably damaging 1.00
R5916:Or1o11 UTSW 17 37,756,570 (GRCm39) missense probably benign 0.16
R7451:Or1o11 UTSW 17 37,757,196 (GRCm39) missense probably damaging 1.00
R8205:Or1o11 UTSW 17 37,757,180 (GRCm39) missense probably damaging 1.00
R8280:Or1o11 UTSW 17 37,756,744 (GRCm39) missense probably benign 0.11
R9748:Or1o11 UTSW 17 37,756,595 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02