Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00577:Ang6'

4211

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ang6

Ensembl Gene

ENSMUSG00000072598

Gene Name

angiogenin, ribonuclease A family, member 6

Synonyms

EG630952

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00577

Quality Score

Status

Chromosome

Chromosomal Location

44239121-44243875 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 44239458 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 90 (Y90F)

Ref Sequence

ENSEMBL: ENSMUSP00000094632 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096869] [ENSMUST00000160223]

AlphaFold

Q5GAN0

Predicted Effect

probably benign
Transcript: ENSMUST00000096869
AA Change: Y90F

PolyPhen 2 Score 0.357 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000094632
Gene: ENSMUSG00000072598
AA Change: Y90F

Domain	Start	End	E-Value	Type
low complexity region	7	20	N/A	INTRINSIC
RNAse_Pc	26	144	3.87e-49	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160223

SMART Domains

Protein: ENSMUSP00000125045
Gene: ENSMUSG00000072598

Domain	Start	End	E-Value	Type
low complexity region	7	20	N/A	INTRINSIC
RNAse_Pc	26	144	3.87e-49	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgef6	T	A	X: 56,290,992 (GRCm39)		probably null	Het
Ccdc88a	A	G	11: 29,374,772 (GRCm39)	E115G	probably damaging	Het
Ceacam12	T	A	7: 17,801,186 (GRCm39)	V55E	probably damaging	Het
Depdc1a	A	T	3: 159,228,375 (GRCm39)	R376*	probably null	Het
Dop1a	A	T	9: 86,402,999 (GRCm39)	I1398F	probably damaging	Het
Eif2s1	T	G	12: 78,913,420 (GRCm39)	N40K	possibly damaging	Het
Epb41	T	A	4: 131,702,042 (GRCm39)	H531L	probably benign	Het
Frrs1	T	A	3: 116,696,049 (GRCm39)	W523R	probably damaging	Het
Gpatch8	T	C	11: 102,369,704 (GRCm39)	D1278G	probably damaging	Het
Mybpc1	C	T	10: 88,372,246 (GRCm39)	A795T	probably damaging	Het
Nrdc	T	C	4: 108,903,884 (GRCm39)		probably benign	Het
Os9	C	T	10: 126,933,845 (GRCm39)	R524K	probably benign	Het
Pisd	T	C	5: 32,895,756 (GRCm39)	I441V	probably benign	Het
Plekha5	T	A	6: 140,515,822 (GRCm39)		probably benign	Het
Prnp	A	G	2: 131,779,031 (GRCm39)	R228G	probably benign	Het
Prrc2c	G	A	1: 162,525,685 (GRCm39)	P307L	unknown	Het
Prss1	T	C	6: 41,439,645 (GRCm39)	V126A	possibly damaging	Het
Ptpn21	G	A	12: 98,699,860 (GRCm39)	S18F	probably damaging	Het
Setdb1	T	C	3: 95,245,888 (GRCm39)	D678G	probably damaging	Het
Sltm	G	T	9: 70,486,624 (GRCm39)	V430L	probably damaging	Het
Sphkap	A	G	1: 83,256,565 (GRCm39)	S395P	probably damaging	Het
Tas2r119	T	C	15: 32,177,599 (GRCm39)	I55T	probably damaging	Het
Tmc3	A	C	7: 83,252,682 (GRCm39)	E361A	probably null	Het
Uggt2	A	T	14: 119,272,312 (GRCm39)	S922T	possibly damaging	Het
Znhit1	A	T	5: 137,011,437 (GRCm39)	Y125*	probably null	Het

Other mutations in Ang6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02259:Ang6	APN	14	44,239,363 (GRCm39)	missense	probably benign	0.25
IGL02589:Ang6	APN	14	44,239,419 (GRCm39)	missense	possibly damaging	0.92
R1844:Ang6	UTSW	14	44,239,330 (GRCm39)	missense	possibly damaging	0.87
R1926:Ang6	UTSW	14	44,239,695 (GRCm39)	missense	possibly damaging	0.91
R7545:Ang6	UTSW	14	44,239,636 (GRCm39)	missense	probably benign	0.00
R8483:Ang6	UTSW	14	44,239,285 (GRCm39)	makesense	probably null
R9210:Ang6	UTSW	14	44,239,407 (GRCm39)	missense	probably benign	0.10

Posted On

2012-04-20