Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03392:Cd5'

421125

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cd5

Ensembl Gene

ENSMUSG00000024669

Gene Name

CD5 antigen

Synonyms

Ly-A, Ly-1, Ly-12, Lyt-1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03392

Quality Score

Status

Chromosome

Chromosomal Location

10695471-10716390 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 10703653 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025571 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025571]

AlphaFold

P13379

Predicted Effect

probably benign
Transcript: ENSMUST00000025571

SMART Domains

Protein: ENSMUSP00000025571
Gene: ENSMUSG00000024669

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
SR	34	133	7.43e-19	SMART
low complexity region	138	157	N/A	INTRINSIC
SR	276	367	7.27e-4	SMART
transmembrane domain	379	401	N/A	INTRINSIC
low complexity region	402	415	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutation of this gene does not result in a phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss2	T	A	2: 155,403,931 (GRCm39)	D692E	probably damaging	Het
Adgrb3	T	A	1: 25,543,529 (GRCm39)	R366S	probably damaging	Het
Afg3l2	C	A	18: 67,547,139 (GRCm39)		probably benign	Het
Cnbd1	A	G	4: 18,862,111 (GRCm39)	S360P	probably damaging	Het
Col13a1	A	T	10: 61,721,490 (GRCm39)	L305I	possibly damaging	Het
Commd7	A	T	2: 153,464,684 (GRCm39)		probably benign	Het
Cpsf6	A	T	10: 117,203,884 (GRCm39)	Y23N	probably damaging	Het
Cry1	A	G	10: 84,992,993 (GRCm39)	V75A	possibly damaging	Het
Cyp2c39	A	G	19: 39,501,767 (GRCm39)	N107D	probably benign	Het
Dcaf11	T	A	14: 55,798,878 (GRCm39)	V45E	probably damaging	Het
Dnm2	A	G	9: 21,385,907 (GRCm39)	E310G	probably damaging	Het
Fat3	T	A	9: 15,915,158 (GRCm39)	I1597L	probably benign	Het
Fcamr	A	G	1: 130,728,685 (GRCm39)		probably benign	Het
Fer	A	G	17: 64,298,637 (GRCm39)	I529V	probably damaging	Het
Fhdc1	T	C	3: 84,351,826 (GRCm39)	K1133R	possibly damaging	Het
Foxd3	A	G	4: 99,545,432 (GRCm39)	K191E	probably damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Gbp8	A	G	5: 105,164,410 (GRCm39)		probably null	Het
Glb1	T	G	9: 114,259,389 (GRCm39)	N106K	probably damaging	Het
Hpx	A	G	7: 105,241,609 (GRCm39)	I295T	probably damaging	Het
Ipo5	T	A	14: 121,180,099 (GRCm39)	D844E	probably damaging	Het
Krt17	T	C	11: 100,150,561 (GRCm39)	I159V	possibly damaging	Het
Lgi4	G	A	7: 30,762,605 (GRCm39)		probably null	Het
Lrrc49	T	C	9: 60,573,563 (GRCm39)		probably benign	Het
Ltn1	T	C	16: 87,222,499 (GRCm39)	K178R	probably damaging	Het
Myh8	T	A	11: 67,185,244 (GRCm39)	W832R	probably damaging	Het
Nbn	A	G	4: 15,962,362 (GRCm39)	N30S	probably damaging	Het
Or2j3	A	G	17: 38,615,786 (GRCm39)	S189P	probably benign	Het
Or4a72	A	T	2: 89,405,593 (GRCm39)	V159D	probably damaging	Het
Or4f59	T	A	2: 111,873,321 (GRCm39)	N19Y	probably benign	Het
Or51ai2	T	C	7: 103,587,232 (GRCm39)	V215A	probably benign	Het
Pcdh15	A	T	10: 74,460,104 (GRCm39)	I1314F	probably damaging	Het
Phf14	G	A	6: 11,962,658 (GRCm39)	S435N	probably damaging	Het
Prss45	T	A	9: 110,669,618 (GRCm39)	Y231*	probably null	Het
Pus7l	T	C	15: 94,434,449 (GRCm39)	D339G	probably damaging	Het
Sbk2	A	G	7: 4,960,408 (GRCm39)	F254S	probably damaging	Het
Serpina1b	T	G	12: 103,698,329 (GRCm39)	K173N	possibly damaging	Het
Slc13a5	G	A	11: 72,136,004 (GRCm39)	T469I	probably damaging	Het
Spon1	A	G	7: 113,633,522 (GRCm39)	E655G	probably damaging	Het
Sv2b	T	C	7: 74,806,508 (GRCm39)		probably null	Het
Treh	A	G	9: 44,597,228 (GRCm39)	D514G	probably damaging	Het
Umodl1	T	A	17: 31,215,329 (GRCm39)	L1051Q	probably damaging	Het
Usp5	A	G	6: 124,803,350 (GRCm39)	F4S	probably damaging	Het
Vmn1r16	A	G	6: 57,299,879 (GRCm39)	S248P	probably damaging	Het

Other mutations in Cd5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01705:Cd5	APN	19	10,703,659 (GRCm39)	critical splice donor site	probably null
PIT4305001:Cd5	UTSW	19	10,703,750 (GRCm39)	missense	possibly damaging	0.72
R0732:Cd5	UTSW	19	10,700,649 (GRCm39)	missense	probably damaging	1.00
R1831:Cd5	UTSW	19	10,696,933 (GRCm39)	missense	probably damaging	1.00
R2086:Cd5	UTSW	19	10,700,620 (GRCm39)	missense	probably benign	0.00
R4184:Cd5	UTSW	19	10,698,638 (GRCm39)	missense	probably damaging	1.00
R6162:Cd5	UTSW	19	10,703,244 (GRCm39)	missense	probably damaging	1.00
R6894:Cd5	UTSW	19	10,716,203 (GRCm39)	missense	possibly damaging	0.91
R7138:Cd5	UTSW	19	10,697,668 (GRCm39)	missense	probably damaging	1.00
R7653:Cd5	UTSW	19	10,703,910 (GRCm39)	missense	probably benign	0.00
R8297:Cd5	UTSW	19	10,697,609 (GRCm39)	missense	probably damaging	1.00
R8408:Cd5	UTSW	19	10,700,469 (GRCm39)	missense	possibly damaging	0.89
R8411:Cd5	UTSW	19	10,697,585 (GRCm39)	missense	probably damaging	1.00
R8699:Cd5	UTSW	19	10,702,556 (GRCm39)	missense	possibly damaging	0.67
R9663:Cd5	UTSW	19	10,703,858 (GRCm39)	missense	probably benign	0.10

Posted On

2016-08-02