Incidental Mutation 'IGL03393:Vmn2r76'
ID421134
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r76
Ensembl Gene ENSMUSG00000091239
Gene Namevomeronasal 2, receptor 76
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.277) question?
Stock #IGL03393
Quality Score
Status
Chromosome7
Chromosomal Location86225206-86246201 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 86229826 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Threonine at position 422 (N422T)
Ref Sequence ENSEMBL: ENSMUSP00000127309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165771]
Predicted Effect probably benign
Transcript: ENSMUST00000165771
AA Change: N422T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000127309
Gene: ENSMUSG00000091239
AA Change: N422T

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 78 470 1.2e-29 PFAM
low complexity region 476 489 N/A INTRINSIC
Pfam:NCD3G 513 565 3.7e-22 PFAM
Pfam:7tm_3 598 833 1.4e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A G 10: 87,074,038 probably benign Het
Adamts5 G T 16: 85,868,195 S627Y probably damaging Het
Allc G A 12: 28,560,011 R196C probably damaging Het
Ccdc65 A C 15: 98,720,687 E241A probably benign Het
Dclk3 T C 9: 111,488,673 probably benign Het
Fzd4 T C 7: 89,407,297 V184A probably benign Het
Gfap T A 11: 102,893,257 probably null Het
Gpr149 A G 3: 62,603,945 V211A probably benign Het
Gprc6a A G 10: 51,615,259 I623T probably damaging Het
Gucy2c T C 6: 136,719,667 T687A probably benign Het
Kcnc4 T G 3: 107,447,927 M402L possibly damaging Het
Ktn1 T C 14: 47,690,934 L584S probably damaging Het
Mrgprb2 C T 7: 48,552,902 S25N probably benign Het
Muc5b T A 7: 141,864,138 V3607E probably benign Het
Olfr48 C A 2: 89,844,569 V135L probably benign Het
Olfr803 T C 10: 129,691,278 I254M probably damaging Het
Otx2 A G 14: 48,661,324 I75T probably damaging Het
Pabpc4l T C 3: 46,446,537 D224G probably damaging Het
Peg3 A T 7: 6,707,649 C1525S probably damaging Het
Polq A T 16: 37,044,794 L669F probably damaging Het
Prss40 A C 1: 34,558,101 V122G probably damaging Het
Rims2 A G 15: 39,462,613 probably null Het
Rrp12 A T 19: 41,871,793 M997K possibly damaging Het
Sbno2 G A 10: 80,066,901 R414W probably damaging Het
Scn1a T C 2: 66,318,018 D41G probably benign Het
Serpinb1c A T 13: 32,882,061 D300E probably damaging Het
Timeless G A 10: 128,252,055 D1165N probably damaging Het
Tnpo1 T G 13: 98,888,473 K66N probably damaging Het
Trappc11 A T 8: 47,510,877 N629K possibly damaging Het
Ubr4 T A 4: 139,452,678 L255M probably damaging Het
Vmn1r10 T A 6: 57,114,057 Y211* probably null Het
Xylt1 C A 7: 117,593,713 N415K probably damaging Het
Zfp786 A T 6: 47,821,524 V160E possibly damaging Het
Other mutations in Vmn2r76
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Vmn2r76 APN 7 86228717 missense probably benign
IGL01374:Vmn2r76 APN 7 86225649 missense probably benign 0.02
IGL01419:Vmn2r76 APN 7 86225702 missense probably benign 0.32
IGL01627:Vmn2r76 APN 7 86225663 missense probably damaging 1.00
IGL01730:Vmn2r76 APN 7 86230198 missense probably benign 0.02
IGL01957:Vmn2r76 APN 7 86228717 missense probably benign
IGL02214:Vmn2r76 APN 7 86229930 missense probably benign 0.07
IGL02489:Vmn2r76 APN 7 86228863 missense probably benign 0.41
IGL02543:Vmn2r76 APN 7 86230148 missense probably benign 0.06
IGL02579:Vmn2r76 APN 7 86228753 nonsense probably null
IGL02598:Vmn2r76 APN 7 86228671 missense probably benign 0.05
IGL02720:Vmn2r76 APN 7 86225706 missense probably benign 0.35
IGL02745:Vmn2r76 APN 7 86230287 missense probably benign 0.06
R0483:Vmn2r76 UTSW 7 86225751 missense probably damaging 1.00
R0513:Vmn2r76 UTSW 7 86228779 missense probably benign 0.01
R0528:Vmn2r76 UTSW 7 86230298 missense possibly damaging 0.80
R0601:Vmn2r76 UTSW 7 86226115 critical splice acceptor site probably null
R0662:Vmn2r76 UTSW 7 86230370 missense probably benign 0.39
R0883:Vmn2r76 UTSW 7 86228696 missense probably benign 0.00
R1532:Vmn2r76 UTSW 7 86230246 missense probably benign 0.02
R1694:Vmn2r76 UTSW 7 86230148 missense probably benign 0.06
R1696:Vmn2r76 UTSW 7 86231256 missense possibly damaging 0.56
R2135:Vmn2r76 UTSW 7 86231011 missense probably benign 0.02
R2151:Vmn2r76 UTSW 7 86230484 missense probably benign
R2181:Vmn2r76 UTSW 7 86225535 missense probably benign 0.00
R2268:Vmn2r76 UTSW 7 86230499 missense probably benign 0.03
R2877:Vmn2r76 UTSW 7 86225993 missense probably benign 0.00
R3155:Vmn2r76 UTSW 7 86225751 missense probably damaging 1.00
R3746:Vmn2r76 UTSW 7 86225555 missense probably benign 0.11
R3799:Vmn2r76 UTSW 7 86226036 missense probably benign 0.00
R3825:Vmn2r76 UTSW 7 86231207 missense probably benign 0.10
R4058:Vmn2r76 UTSW 7 86230300 missense probably benign 0.00
R4237:Vmn2r76 UTSW 7 86230532 missense probably benign 0.00
R4404:Vmn2r76 UTSW 7 86228303 missense probably benign 0.16
R4796:Vmn2r76 UTSW 7 86230444 missense possibly damaging 0.95
R4838:Vmn2r76 UTSW 7 86225525 missense probably damaging 1.00
R5175:Vmn2r76 UTSW 7 86228707 missense probably benign 0.00
R5268:Vmn2r76 UTSW 7 86226059 missense probably damaging 1.00
R5381:Vmn2r76 UTSW 7 86225288 missense probably damaging 1.00
R5531:Vmn2r76 UTSW 7 86225449 missense probably damaging 1.00
R5566:Vmn2r76 UTSW 7 86226078 missense probably damaging 1.00
R5646:Vmn2r76 UTSW 7 86226053 missense probably damaging 0.98
R5664:Vmn2r76 UTSW 7 86245994 critical splice donor site probably null
R5818:Vmn2r76 UTSW 7 86229934 missense probably benign 0.00
R6093:Vmn2r76 UTSW 7 86228261 nonsense probably null
R6651:Vmn2r76 UTSW 7 86228851 missense possibly damaging 0.64
R6741:Vmn2r76 UTSW 7 86230352 missense probably benign
R6750:Vmn2r76 UTSW 7 86225906 missense probably damaging 1.00
Posted On2016-08-02