Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03396:Vmn2r23'

421246

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL03396

Quality Score

Status

Chromosome

Chromosomal Location

123679780-123719198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123706585 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 472 (S472P)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably damaging
Transcript: ENSMUST00000172391
AA Change: S472P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: S472P

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadvl	G	A	11: 69,902,239 (GRCm39)	R457*	probably null	Het
Arl5b	C	A	2: 15,079,915 (GRCm39)	T153K	probably damaging	Het
Arsb	A	T	13: 94,075,825 (GRCm39)	Y436F	probably benign	Het
Azgp1	C	T	5: 137,983,445 (GRCm39)	P40L	possibly damaging	Het
B020004C17Rik	A	G	14: 57,253,993 (GRCm39)	T39A	possibly damaging	Het
Cacna2d3	G	A	14: 29,442,834 (GRCm39)	Q67*	probably null	Het
Cdcp2	C	A	4: 106,964,369 (GRCm39)	Y406*	probably null	Het
Cep89	T	A	7: 35,128,603 (GRCm39)	D585E	probably benign	Het
Cfap65	A	G	1: 74,943,801 (GRCm39)	F1570S	probably damaging	Het
Cnfn	A	G	7: 25,067,783 (GRCm39)		probably benign	Het
Fgd6	G	A	10: 93,880,318 (GRCm39)	V391I	probably benign	Het
Fra10ac1	C	T	19: 38,189,994 (GRCm39)		probably null	Het
Gjd3	T	C	11: 102,691,353 (GRCm39)	K217E	probably benign	Het
Il20rb	T	C	9: 100,341,251 (GRCm39)	E285G	probably damaging	Het
Ints2	T	C	11: 86,103,888 (GRCm39)	T1086A	probably damaging	Het
Itih4	A	T	14: 30,609,906 (GRCm39)	I79F	probably damaging	Het
Jmjd6	A	T	11: 116,732,077 (GRCm39)	L208H	probably damaging	Het
Lilrb4b	A	G	10: 51,357,253 (GRCm39)	I30V	possibly damaging	Het
Limch1	A	G	5: 67,111,016 (GRCm39)	N81S	probably damaging	Het
Mettl21e	A	T	1: 44,245,759 (GRCm39)	N162K	possibly damaging	Het
Ninl	A	G	2: 150,808,132 (GRCm39)	S299P	possibly damaging	Het
Obscn	A	G	11: 58,964,404 (GRCm39)	L3046P	probably benign	Het
Or1j14	C	A	2: 36,417,692 (GRCm39)	S89R	probably benign	Het
Or5b98	T	A	19: 12,931,184 (GRCm39)	V77E	probably damaging	Het
Or6c68	A	G	10: 129,157,916 (GRCm39)	I141M	probably benign	Het
Pnpla8	G	A	12: 44,330,309 (GRCm39)	R287H	probably benign	Het
Pot1a	A	C	6: 25,745,913 (GRCm39)	I596R	possibly damaging	Het
Prkaa1	A	G	15: 5,206,131 (GRCm39)	D329G	probably damaging	Het
Ptprr	T	G	10: 116,024,235 (GRCm39)	V182G	probably damaging	Het
Rrp1b	T	A	17: 32,276,237 (GRCm39)		probably benign	Het
Sec24a	A	G	11: 51,599,794 (GRCm39)	V837A	probably benign	Het
Slc17a6	A	G	7: 51,318,840 (GRCm39)	Y494C	probably damaging	Het
Slc38a10	A	T	11: 120,019,301 (GRCm39)	I360N	probably damaging	Het
Snrpb2	T	C	2: 142,913,377 (GRCm39)	F194L	possibly damaging	Het
Tcam1	A	G	11: 106,176,212 (GRCm39)	I313V	probably benign	Het
Trpv1	A	G	11: 73,143,882 (GRCm39)	N238S	probably benign	Het
Usp20	T	C	2: 30,901,729 (GRCm39)	V498A	probably benign	Het
Vmn2r98	A	T	17: 19,290,107 (GRCm39)	T548S	possibly damaging	Het
Zfp429	A	T	13: 67,544,159 (GRCm39)		probably benign	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,706,684 (GRCm39)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,706,555 (GRCm39)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,689,759 (GRCm39)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,681,383 (GRCm39)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,681,366 (GRCm39)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,718,845 (GRCm39)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,718,819 (GRCm39)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,718,703 (GRCm39)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,718,795 (GRCm39)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,681,437 (GRCm39)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,681,344 (GRCm39)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,681,355 (GRCm39)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,718,578 (GRCm39)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,718,741 (GRCm39)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,681,333 (GRCm39)	missense	probably benign	0.01
PIT4472001:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,706,680 (GRCm39)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,719,094 (GRCm39)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,718,963 (GRCm39)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,690,229 (GRCm39)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,690,386 (GRCm39)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,706,649 (GRCm39)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,679,874 (GRCm39)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,689,969 (GRCm39)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,718,458 (GRCm39)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,681,384 (GRCm39)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,719,147 (GRCm39)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,690,129 (GRCm39)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,718,348 (GRCm39)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,706,697 (GRCm39)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,679,884 (GRCm39)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,718,689 (GRCm39)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,718,785 (GRCm39)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,710,308 (GRCm39)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,689,961 (GRCm39)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,689,718 (GRCm39)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,689,901 (GRCm39)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,718,854 (GRCm39)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,681,359 (GRCm39)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,689,861 (GRCm39)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,690,384 (GRCm39)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,681,512 (GRCm39)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,689,981 (GRCm39)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,718,540 (GRCm39)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,681,538 (GRCm39)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,681,500 (GRCm39)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,718,312 (GRCm39)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,681,599 (GRCm39)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,718,615 (GRCm39)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,690,431 (GRCm39)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,679,991 (GRCm39)	missense
R8966:Vmn2r23	UTSW	6	123,719,079 (GRCm39)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,719,038 (GRCm39)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,718,782 (GRCm39)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,690,075 (GRCm39)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,690,120 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,719,067 (GRCm39)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,706,684 (GRCm39)	frame shift	probably null

Posted On

2016-08-02