Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03398:Fcamr'

421333

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fcamr

Ensembl Gene

ENSMUSG00000026415

Gene Name

Fc receptor, IgA, IgM, high affinity

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL03398

Quality Score

Status

Chromosome

Chromosomal Location

130728639-130742477 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 130730985 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 79 (I79M)

Ref Sequence

ENSEMBL: ENSMUSP00000108096 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027670] [ENSMUST00000112477]

AlphaFold

Q2TB54

Predicted Effect

possibly damaging
Transcript: ENSMUST00000027670
AA Change: I23M

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415
AA Change: I23M

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
IG	87	191	1.19e-5	SMART
low complexity region	208	220	N/A	INTRINSIC
low complexity region	241	253	N/A	INTRINSIC
transmembrane domain	456	475	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000112477
AA Change: I79M

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415
AA Change: I79M

Domain	Start	End	E-Value	Type
low complexity region	80	87	N/A	INTRINSIC
IG	143	247	1.19e-5	SMART
low complexity region	264	276	N/A	INTRINSIC
low complexity region	297	309	N/A	INTRINSIC
transmembrane domain	512	531	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	A	5: 77,039,566 (GRCm39)	I248L	probably benign	Het
Ackr2	C	T	9: 121,737,654 (GRCm39)	L10F	probably damaging	Het
Ankhd1	A	G	18: 36,789,890 (GRCm39)		probably benign	Het
Arhgap5	A	G	12: 52,564,094 (GRCm39)	E355G	probably damaging	Het
Arhgef12	A	G	9: 42,889,522 (GRCm39)	V1031A	probably damaging	Het
Ash1l	T	A	3: 88,914,527 (GRCm39)	V1719E	probably benign	Het
Chd5	A	G	4: 152,461,539 (GRCm39)	N1284D	probably damaging	Het
Dennd4a	A	G	9: 64,779,164 (GRCm39)	D549G	probably benign	Het
Dhx32	A	G	7: 133,361,254 (GRCm39)	Y60H	probably damaging	Het
Elapor1	A	T	3: 108,368,537 (GRCm39)	V818D	possibly damaging	Het
Filip1	A	G	9: 79,726,225 (GRCm39)	V798A	probably benign	Het
Ifi208	A	C	1: 173,510,817 (GRCm39)	N324T	probably damaging	Het
Nelfcd	G	A	2: 174,268,625 (GRCm39)	A559T	possibly damaging	Het
Nsl1	T	C	1: 190,814,361 (GRCm39)		probably benign	Het
Parp6	T	C	9: 59,548,336 (GRCm39)	I483T	probably damaging	Het
Ppp2r5e	A	C	12: 75,509,179 (GRCm39)	W367G	possibly damaging	Het
Pramel31	A	G	4: 144,090,061 (GRCm39)	D367G	probably damaging	Het
Serpini2	G	A	3: 75,166,852 (GRCm39)	T135I	probably benign	Het
Sgsm1	T	A	5: 113,403,182 (GRCm39)	N955I	possibly damaging	Het
Tenm2	A	G	11: 35,915,370 (GRCm39)	Y2055H	probably damaging	Het
Tex2	T	C	11: 106,459,098 (GRCm39)	N111D	probably damaging	Het
Ttc5	T	C	14: 51,018,964 (GRCm39)	E51G	possibly damaging	Het
Usp47	A	T	7: 111,673,710 (GRCm39)	E334V	probably damaging	Het
Wdfy4	T	C	14: 32,769,247 (GRCm39)	K2227E	probably benign	Het
Xkr4	T	C	1: 3,286,798 (GRCm39)	E464G	probably damaging	Het

Other mutations in Fcamr

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00840:Fcamr	APN	1	130,740,951 (GRCm39)	missense	probably benign	0.01
IGL02880:Fcamr	APN	1	130,741,071 (GRCm39)	missense	probably benign	0.00
IGL03199:Fcamr	APN	1	130,740,655 (GRCm39)	missense	probably damaging	1.00
IGL03392:Fcamr	APN	1	130,728,685 (GRCm39)	utr 5 prime	probably benign
R1101:Fcamr	UTSW	1	130,742,223 (GRCm39)	splice site	probably null
R1312:Fcamr	UTSW	1	130,739,224 (GRCm39)	missense	probably damaging	1.00
R1351:Fcamr	UTSW	1	130,740,757 (GRCm39)	missense	possibly damaging	0.83
R1387:Fcamr	UTSW	1	130,732,379 (GRCm39)	missense	possibly damaging	0.85
R1475:Fcamr	UTSW	1	130,742,221 (GRCm39)	splice site	probably null
R1728:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1728:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,732,306 (GRCm39)	missense	probably benign	0.06
R1728:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1728:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1729:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1730:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1730:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1730:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1730:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1730:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1739:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1739:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1739:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1762:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1762:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1762:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1783:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1783:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1783:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1783:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1784:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1784:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1784:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1785:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1785:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,732,306 (GRCm39)	missense	probably benign	0.06
R1785:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1793:Fcamr	UTSW	1	130,739,284 (GRCm39)	missense	probably benign	0.03
R2085:Fcamr	UTSW	1	130,739,335 (GRCm39)	missense	probably damaging	1.00
R3937:Fcamr	UTSW	1	130,732,313 (GRCm39)	missense	probably damaging	0.97
R4529:Fcamr	UTSW	1	130,732,313 (GRCm39)	missense	probably damaging	0.99
R4624:Fcamr	UTSW	1	130,730,999 (GRCm39)	missense	probably damaging	0.99
R4822:Fcamr	UTSW	1	130,740,423 (GRCm39)	missense	possibly damaging	0.82
R5055:Fcamr	UTSW	1	130,739,174 (GRCm39)	missense	probably damaging	1.00
R5514:Fcamr	UTSW	1	130,741,793 (GRCm39)	missense	probably damaging	1.00
R5807:Fcamr	UTSW	1	130,739,263 (GRCm39)	missense	probably damaging	1.00
R6077:Fcamr	UTSW	1	130,740,663 (GRCm39)	missense	probably damaging	1.00
R6200:Fcamr	UTSW	1	130,730,927 (GRCm39)	missense	probably benign	0.16
R6653:Fcamr	UTSW	1	130,740,939 (GRCm39)	missense	possibly damaging	0.89
R7081:Fcamr	UTSW	1	130,740,949 (GRCm39)	missense	probably damaging	1.00
R7362:Fcamr	UTSW	1	130,741,760 (GRCm39)	missense	possibly damaging	0.52
R7828:Fcamr	UTSW	1	130,739,443 (GRCm39)	missense	probably damaging	1.00
R7861:Fcamr	UTSW	1	130,742,375 (GRCm39)	missense	probably benign
R8188:Fcamr	UTSW	1	130,730,665 (GRCm39)	splice site	probably null
R8869:Fcamr	UTSW	1	130,739,335 (GRCm39)	missense	probably damaging	1.00
R8907:Fcamr	UTSW	1	130,740,328 (GRCm39)	missense	probably damaging	1.00
R9568:Fcamr	UTSW	1	130,732,356 (GRCm39)	missense	probably damaging	0.99
X0012:Fcamr	UTSW	1	130,740,471 (GRCm39)	missense	probably benign	0.09

Posted On

2016-08-02