Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03400:Tubgcp6'

421405

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tubgcp6

Ensembl Gene

ENSMUSG00000051786

Gene Name

tubulin, gamma complex component 6

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.963) question?

Stock #

IGL03400

Quality Score

Status

Chromosome

Chromosomal Location

88983300-89007411 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 88992302 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041656] [ENSMUST00000109353]

AlphaFold

G5E8P0

Predicted Effect

probably benign
Transcript: ENSMUST00000041656

SMART Domains

Protein: ENSMUSP00000040132
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
Pfam:Spc97_Spc98	355	1667	3.3e-119	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000109353

SMART Domains

Protein: ENSMUSP00000104977
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
Pfam:Spc97_Spc98	355	1675	2.8e-94	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000169069

SMART Domains

Protein: ENSMUSP00000132786
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
coiled coil region	77	107	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Bmp3	T	C	5: 99,019,957 (GRCm39)	S127P	probably damaging	Het
Cemip	A	G	7: 83,607,724 (GRCm39)	S761P	probably damaging	Het
Cenatac	A	G	9: 44,324,486 (GRCm39)	V185A	probably benign	Het
Ces3b	A	G	8: 105,819,568 (GRCm39)	T495A	probably damaging	Het
Cops3	A	T	11: 59,708,914 (GRCm39)	D413E	probably benign	Het
Cyp4f16	A	G	17: 32,769,327 (GRCm39)	I406V	probably benign	Het
Efcab6	A	T	15: 83,751,246 (GRCm39)		probably benign	Het
Emsy	A	G	7: 98,251,933 (GRCm39)	V703A	possibly damaging	Het
Fancb	T	C	X: 163,778,587 (GRCm39)	S587P	possibly damaging	Het
Farp1	A	G	14: 121,444,733 (GRCm39)	Y80C	probably damaging	Het
Fgf10	T	C	13: 118,918,151 (GRCm39)		probably null	Het
Fgf13	A	G	X: 58,171,248 (GRCm39)		probably benign	Het
Filip1	T	C	9: 79,727,755 (GRCm39)	K288R	probably benign	Het
L3mbtl3	T	C	10: 26,191,424 (GRCm39)	N458S	unknown	Het
Nek11	C	T	9: 105,082,065 (GRCm39)	A513T	probably benign	Het
Or10a3m	A	C	7: 108,312,733 (GRCm39)	I46L	probably benign	Het
Or11q2	T	A	X: 48,772,781 (GRCm39)	L134Q	probably damaging	Het
Or2ah1	T	C	2: 85,654,094 (GRCm39)	Y260H	probably damaging	Het
Palld	G	T	8: 61,966,489 (GRCm39)	A630E	probably damaging	Het
Pdk1	T	C	2: 71,726,091 (GRCm39)	M333T	probably benign	Het
Rab9	T	C	X: 165,240,744 (GRCm39)	N189S	probably benign	Het
Shtn1	C	T	19: 59,020,690 (GRCm39)		probably benign	Het
Sntg1	T	C	1: 8,533,638 (GRCm39)	I339V	probably damaging	Het
Spns3	A	G	11: 72,390,501 (GRCm39)	V418A	possibly damaging	Het
St14	T	A	9: 31,008,267 (GRCm39)		probably benign	Het
Tedc2	T	C	17: 24,438,777 (GRCm39)	D180G	probably benign	Het
Trim33	T	C	3: 103,236,459 (GRCm39)	I523T	probably damaging	Het
Ttn	T	A	2: 76,551,208 (GRCm39)	M23068L	probably benign	Het
Ttn	T	C	2: 76,579,266 (GRCm39)	M15549V	probably damaging	Het
Ube3c	A	G	5: 29,806,345 (GRCm39)	Y329C	probably benign	Het
Zmym4	G	T	4: 126,816,920 (GRCm39)	D259E	probably benign	Het

Other mutations in Tubgcp6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00417:Tubgcp6	APN	15	88,988,211 (GRCm39)	missense	probably benign	0.00
IGL00556:Tubgcp6	APN	15	88,985,165 (GRCm39)	missense	probably damaging	1.00
IGL00943:Tubgcp6	APN	15	89,006,600 (GRCm39)	nonsense	probably null
IGL01284:Tubgcp6	APN	15	88,994,258 (GRCm39)	missense	probably damaging	1.00
IGL01363:Tubgcp6	APN	15	88,991,728 (GRCm39)	missense	probably damaging	1.00
IGL01386:Tubgcp6	APN	15	88,992,199 (GRCm39)	nonsense	probably null
IGL01792:Tubgcp6	APN	15	88,985,484 (GRCm39)	missense	probably damaging	1.00
IGL01866:Tubgcp6	APN	15	88,987,691 (GRCm39)	missense	probably benign	0.01
IGL02596:Tubgcp6	APN	15	88,985,117 (GRCm39)	missense	probably damaging	1.00
IGL02858:Tubgcp6	APN	15	88,986,518 (GRCm39)	nonsense	probably null
IGL02873:Tubgcp6	APN	15	88,988,027 (GRCm39)	missense	probably benign	0.00
IGL02796:Tubgcp6	UTSW	15	89,006,593 (GRCm39)	missense	probably benign	0.03
R0010:Tubgcp6	UTSW	15	88,987,386 (GRCm39)	missense	probably benign	0.00
R0308:Tubgcp6	UTSW	15	89,006,639 (GRCm39)	missense	possibly damaging	0.85
R0440:Tubgcp6	UTSW	15	88,987,268 (GRCm39)	missense	probably benign	0.12
R0631:Tubgcp6	UTSW	15	88,985,190 (GRCm39)	missense	probably damaging	1.00
R1653:Tubgcp6	UTSW	15	88,991,645 (GRCm39)	missense	probably damaging	1.00
R1901:Tubgcp6	UTSW	15	89,000,444 (GRCm39)	missense	possibly damaging	0.68
R1902:Tubgcp6	UTSW	15	89,000,444 (GRCm39)	missense	possibly damaging	0.68
R1905:Tubgcp6	UTSW	15	88,984,811 (GRCm39)	missense	probably damaging	1.00
R2005:Tubgcp6	UTSW	15	88,988,369 (GRCm39)	missense	probably benign	0.01
R2067:Tubgcp6	UTSW	15	88,988,692 (GRCm39)	missense	probably benign	0.03
R2083:Tubgcp6	UTSW	15	89,006,579 (GRCm39)	missense	probably damaging	1.00
R2285:Tubgcp6	UTSW	15	89,006,677 (GRCm39)	missense	probably damaging	1.00
R2401:Tubgcp6	UTSW	15	88,987,187 (GRCm39)	missense	probably benign	0.22
R2436:Tubgcp6	UTSW	15	88,986,568 (GRCm39)	missense	probably benign	0.37
R3017:Tubgcp6	UTSW	15	88,987,285 (GRCm39)	nonsense	probably null
R3054:Tubgcp6	UTSW	15	89,006,806 (GRCm39)	missense	probably damaging	1.00
R3932:Tubgcp6	UTSW	15	88,988,617 (GRCm39)	unclassified	probably benign
R4350:Tubgcp6	UTSW	15	88,988,198 (GRCm39)	missense	probably benign	0.00
R4472:Tubgcp6	UTSW	15	88,987,857 (GRCm39)	missense	probably damaging	0.98
R4864:Tubgcp6	UTSW	15	88,988,021 (GRCm39)	missense	probably benign
R4937:Tubgcp6	UTSW	15	88,985,752 (GRCm39)	missense	probably damaging	0.98
R4983:Tubgcp6	UTSW	15	88,990,494 (GRCm39)	missense	probably damaging	1.00
R4996:Tubgcp6	UTSW	15	88,987,693 (GRCm39)	missense	possibly damaging	0.89
R5044:Tubgcp6	UTSW	15	88,983,748 (GRCm39)	unclassified	probably benign
R5122:Tubgcp6	UTSW	15	89,000,306 (GRCm39)	missense	probably damaging	1.00
R5607:Tubgcp6	UTSW	15	88,995,353 (GRCm39)	missense	probably benign	0.02
R5608:Tubgcp6	UTSW	15	88,995,353 (GRCm39)	missense	probably benign	0.02
R5653:Tubgcp6	UTSW	15	88,992,815 (GRCm39)	missense	possibly damaging	0.47
R5886:Tubgcp6	UTSW	15	88,987,450 (GRCm39)	missense	possibly damaging	0.82
R5945:Tubgcp6	UTSW	15	88,993,420 (GRCm39)	splice site	probably null
R6111:Tubgcp6	UTSW	15	88,985,123 (GRCm39)	missense	possibly damaging	0.83
R6195:Tubgcp6	UTSW	15	89,006,994 (GRCm39)	missense	probably benign	0.01
R6792:Tubgcp6	UTSW	15	89,007,080 (GRCm39)	start gained	probably benign
R7074:Tubgcp6	UTSW	15	89,004,839 (GRCm39)	missense	probably damaging	1.00
R7103:Tubgcp6	UTSW	15	88,985,232 (GRCm39)	missense	probably damaging	0.96
R7274:Tubgcp6	UTSW	15	88,987,173 (GRCm39)	nonsense	probably null
R7275:Tubgcp6	UTSW	15	88,987,146 (GRCm39)	nonsense	probably null
R7514:Tubgcp6	UTSW	15	89,004,728 (GRCm39)	missense	probably damaging	1.00
R7540:Tubgcp6	UTSW	15	88,986,526 (GRCm39)	missense	possibly damaging	0.48
R7571:Tubgcp6	UTSW	15	88,984,925 (GRCm39)	missense	probably damaging	1.00
R7706:Tubgcp6	UTSW	15	88,988,426 (GRCm39)	missense	probably benign
R7721:Tubgcp6	UTSW	15	88,985,604 (GRCm39)	missense	probably damaging	1.00
R7980:Tubgcp6	UTSW	15	88,986,232 (GRCm39)	missense	probably benign	0.03
R7996:Tubgcp6	UTSW	15	88,993,231 (GRCm39)	missense	possibly damaging	0.92
R8095:Tubgcp6	UTSW	15	89,006,977 (GRCm39)	missense	probably benign	0.07
R8191:Tubgcp6	UTSW	15	89,004,843 (GRCm39)	missense	probably damaging	1.00
R8510:Tubgcp6	UTSW	15	88,987,152 (GRCm39)	missense	possibly damaging	0.91
R8839:Tubgcp6	UTSW	15	88,987,681 (GRCm39)	missense	possibly damaging	0.91
R8862:Tubgcp6	UTSW	15	89,006,824 (GRCm39)	missense	probably benign	0.03
R9044:Tubgcp6	UTSW	15	88,987,397 (GRCm39)	missense	possibly damaging	0.89
R9321:Tubgcp6	UTSW	15	88,992,186 (GRCm39)	missense	probably damaging	1.00
R9402:Tubgcp6	UTSW	15	88,987,064 (GRCm39)	missense	probably benign	0.01
R9428:Tubgcp6	UTSW	15	88,985,100 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02