Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03401:Scgb2b7'

421412

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scgb2b7

Ensembl Gene

ENSMUSG00000094053

Gene Name

secretoglobin, family 2B, member 7

Synonyms

Gm4684, Abpbg7

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL03401

Quality Score

Status

Chromosome

Chromosomal Location

31403204-31405179 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 31404506 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 65 (C65S)

Ref Sequence

ENSEMBL: ENSMUSP00000136731 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178258]

AlphaFold

D3YYY1

Predicted Effect

probably damaging
Transcript: ENSMUST00000178258
AA Change: C65S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000136731
Gene: ENSMUSG00000094053
AA Change: C65S

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	7.8e-33	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188968

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	A	14: 32,384,223 (GRCm39)	R581*	probably null	Het
Actn1	A	T	12: 80,215,741 (GRCm39)	L799*	probably null	Het
Adam12	A	T	7: 133,518,192 (GRCm39)	N327K	probably damaging	Het
Adamts9	A	G	6: 92,763,849 (GRCm39)	V1314A	probably damaging	Het
Agbl4	G	T	4: 110,976,216 (GRCm39)	R191L	probably damaging	Het
Ano6	T	C	15: 95,847,786 (GRCm39)	I611T	probably damaging	Het
Arhgef26	T	A	3: 62,330,953 (GRCm39)	S556T	possibly damaging	Het
AW209491	A	G	13: 14,812,041 (GRCm39)	D298G	probably benign	Het
Cc2d1a	A	G	8: 84,861,258 (GRCm39)	M763T	probably benign	Het
Cep290	A	G	10: 100,336,127 (GRCm39)	D388G	probably benign	Het
Cept1	T	C	3: 106,440,706 (GRCm39)	E151G	probably damaging	Het
Chat	T	C	14: 32,174,526 (GRCm39)	K139E	probably damaging	Het
Edc4	T	A	8: 106,614,146 (GRCm39)	Y7*	probably null	Het
Enpep	T	A	3: 129,106,269 (GRCm39)	Q319L	probably benign	Het
F13a1	A	G	13: 37,082,054 (GRCm39)	I550T	probably benign	Het
Fbxw19	A	G	9: 109,324,038 (GRCm39)		probably null	Het
Frem3	T	G	8: 81,341,170 (GRCm39)	D1154E	probably damaging	Het
Frmpd1	G	T	4: 45,284,383 (GRCm39)	C1068F	probably benign	Het
Fsip2	C	A	2: 82,820,814 (GRCm39)	P5516T	probably benign	Het
Hyou1	G	A	9: 44,296,206 (GRCm39)	A429T	probably damaging	Het
Lrp1b	C	T	2: 41,000,790 (GRCm39)	E2145K	probably benign	Het
Map1b	A	T	13: 99,563,776 (GRCm39)	V2397D	unknown	Het
Mcm3ap	T	C	10: 76,320,483 (GRCm39)		probably benign	Het
Mgst2	T	G	3: 51,571,933 (GRCm39)	S20R	possibly damaging	Het
Nr4a3	T	A	4: 48,070,987 (GRCm39)		probably null	Het
Nup93	T	A	8: 95,036,339 (GRCm39)		probably null	Het
Or1e1f	T	C	11: 73,856,388 (GRCm39)		probably benign	Het
Papola	A	T	12: 105,795,381 (GRCm39)	T611S	probably benign	Het
Pik3ca	C	A	3: 32,491,963 (GRCm39)		probably null	Het
Pklr	T	C	3: 89,050,036 (GRCm39)	V337A	probably benign	Het
Prl7b1	A	G	13: 27,785,964 (GRCm39)	Y235H	probably benign	Het
Proc	T	C	18: 32,256,326 (GRCm39)	Y447C	possibly damaging	Het
Pum1	T	C	4: 130,470,992 (GRCm39)		probably benign	Het
Rimklb	A	T	6: 122,441,077 (GRCm39)	I32N	probably damaging	Het
Rrm1	T	A	7: 102,114,951 (GRCm39)	D644E	possibly damaging	Het
Shbg	A	G	11: 69,505,925 (GRCm39)	S361P	probably damaging	Het
Trmt9b	A	C	8: 36,972,823 (GRCm39)	D91A	probably damaging	Het
Zfp647	T	A	15: 76,795,568 (GRCm39)	H364L	probably damaging	Het
Zfp715	A	T	7: 42,949,160 (GRCm39)	S267T	probably benign	Het

Other mutations in Scgb2b7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01994:Scgb2b7	APN	7	31,403,409 (GRCm39)	missense	probably benign	0.26
IGL03242:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03252:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03261:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03271:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03277:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03280:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03302:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03308:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03388:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03402:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03411:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
R0457:Scgb2b7	UTSW	7	31,403,437 (GRCm39)	missense	possibly damaging	0.85
R7741:Scgb2b7	UTSW	7	31,404,454 (GRCm39)	critical splice donor site	probably null
R8925:Scgb2b7	UTSW	7	31,404,602 (GRCm39)	missense	probably benign	0.00
R8927:Scgb2b7	UTSW	7	31,404,602 (GRCm39)	missense	probably benign	0.00
R9801:Scgb2b7	UTSW	7	31,404,580 (GRCm39)	missense	probably damaging	1.00
Z1186:Scgb2b7	UTSW	7	31,404,547 (GRCm39)	missense	probably benign	0.13
Z1186:Scgb2b7	UTSW	7	31,404,489 (GRCm39)	missense	probably benign

Posted On

2016-08-02