Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03404:Lipo3'

421547

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lipo3

Ensembl Gene

ENSMUSG00000024766

Gene Name

lipase, member O3

Synonyms

Lipo1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL03404

Quality Score

Status

Chromosome

Chromosomal Location

33532560-33568069 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to C at 33560440 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000108127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025694] [ENSMUST00000112508]

AlphaFold

Q3UT41

Predicted Effect

probably benign
Transcript: ENSMUST00000025694

SMART Domains

Protein: ENSMUSP00000025694
Gene: ENSMUSG00000024766

Domain	Start	End	E-Value	Type
Pfam:Abhydro_lipase	33	95	4.2e-24	PFAM
Pfam:Abhydrolase_1	76	213	7.3e-16	PFAM
Pfam:Abhydrolase_5	76	370	4.8e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000112508

SMART Domains

Protein: ENSMUSP00000108127
Gene: ENSMUSG00000024766

Domain	Start	End	E-Value	Type
Pfam:Abhydro_lipase	33	95	8.8e-24	PFAM
Pfam:Abhydrolase_5	76	370	5.2e-12	PFAM
Pfam:Abhydrolase_6	77	384	8.5e-10	PFAM
Pfam:Abhydrolase_1	109	384	2e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133269

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap8	T	G	17: 32,531,250 (GRCm39)		probably benign	Het
Ap3d1	A	G	10: 80,565,871 (GRCm39)	S99P	probably damaging	Het
Arhgef1	T	A	7: 24,616,268 (GRCm39)	M304K	probably benign	Het
Arpc5l	T	C	2: 38,903,895 (GRCm39)	L128P	probably damaging	Het
Chl1	A	T	6: 103,670,052 (GRCm39)	I497F	probably damaging	Het
Dnah3	C	T	7: 119,538,200 (GRCm39)	G616E	probably damaging	Het
Filip1	T	C	9: 79,725,841 (GRCm39)	E926G	probably damaging	Het
Fras1	A	T	5: 96,876,440 (GRCm39)	H2391L	probably damaging	Het
Fry	A	T	5: 150,249,633 (GRCm39)	D148V	probably damaging	Het
Glg1	A	T	8: 111,886,534 (GRCm39)	M1086K	probably damaging	Het
Gm12185	T	A	11: 48,798,864 (GRCm39)	Y543F	probably damaging	Het
Gtf3a	T	C	5: 146,887,449 (GRCm39)		probably null	Het
Hydin	A	T	8: 111,296,409 (GRCm39)	Y3646F	probably benign	Het
Itpr3	A	G	17: 27,310,492 (GRCm39)	D425G	probably damaging	Het
Ltbp1	A	C	17: 75,532,301 (GRCm39)	K443T	probably damaging	Het
Mylk3	A	G	8: 86,069,310 (GRCm39)	I497T	probably damaging	Het
Nlrp5	A	G	7: 23,129,459 (GRCm39)	D842G	probably benign	Het
Or10j3	T	C	1: 173,031,766 (GRCm39)	V281A	probably benign	Het
Or52s6	A	T	7: 103,092,195 (GRCm39)	V45E	possibly damaging	Het
Or6n1	A	G	1: 173,917,464 (GRCm39)	N286S	probably damaging	Het
Or8k3b	A	G	2: 86,520,372 (GRCm39)		probably benign	Het
Pkd1	A	T	17: 24,783,380 (GRCm39)	I120L	probably damaging	Het
Ptprc	T	C	1: 138,020,739 (GRCm39)	N401S	probably damaging	Het
Rptn	A	G	3: 93,305,436 (GRCm39)	H923R	possibly damaging	Het
Rrp8	T	C	7: 105,384,145 (GRCm39)	K119R	probably benign	Het
Setd7	A	T	3: 51,440,407 (GRCm39)	Y211*	probably null	Het
Sfxn5	G	A	6: 85,276,518 (GRCm39)		probably benign	Het
Sun5	T	C	2: 153,712,924 (GRCm39)		probably benign	Het
Tnks	A	T	8: 35,407,858 (GRCm39)	V290D	probably damaging	Het
Trrap	C	T	5: 144,769,996 (GRCm39)	P2740L	probably benign	Het
Ttc23	G	T	7: 67,328,645 (GRCm39)	L195F	probably damaging	Het
Tubb1	G	T	2: 174,299,241 (GRCm39)	G308C	probably damaging	Het
Vmn1r217	A	T	13: 23,298,810 (GRCm39)	F31I	probably benign	Het
Zp1	A	T	19: 10,891,825 (GRCm39)		probably benign	Het

Other mutations in Lipo3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01521:Lipo3	APN	19	33,763,083 (GRCm39)	missense	probably damaging	1.00
IGL01697:Lipo3	APN	19	33,536,965 (GRCm39)	missense	probably damaging	1.00
IGL01916:Lipo3	APN	19	33,762,182 (GRCm39)	missense	probably damaging	1.00
IGL02027:Lipo3	APN	19	33,557,919 (GRCm39)	nonsense	probably null
IGL02047:Lipo3	APN	19	33,534,562 (GRCm39)	missense	probably benign	0.00
IGL02586:Lipo3	APN	19	33,559,539 (GRCm39)	missense	possibly damaging	0.95
IGL03005:Lipo3	APN	19	33,763,136 (GRCm39)	missense	possibly damaging	0.65
IGL03111:Lipo3	APN	19	33,559,637 (GRCm39)	missense	probably damaging	0.96
R0122:Lipo3	UTSW	19	33,600,086 (GRCm39)	intron	probably benign
R0128:Lipo3	UTSW	19	33,534,506 (GRCm39)	critical splice donor site	probably null
R0540:Lipo3	UTSW	19	33,536,967 (GRCm39)	missense	possibly damaging	0.62
R0551:Lipo3	UTSW	19	33,557,951 (GRCm39)	missense	probably damaging	1.00
R0568:Lipo3	UTSW	19	33,559,442 (GRCm39)	splice site	probably benign
R0646:Lipo3	UTSW	19	33,762,169 (GRCm39)	nonsense	probably null
R0669:Lipo3	UTSW	19	33,537,025 (GRCm39)	missense	probably benign	0.05
R1704:Lipo3	UTSW	19	33,757,743 (GRCm39)	missense	possibly damaging	0.87
R1772:Lipo3	UTSW	19	33,764,821 (GRCm39)	missense	probably benign	0.45
R1862:Lipo3	UTSW	19	33,762,092 (GRCm39)	missense	probably damaging	1.00
R1863:Lipo3	UTSW	19	33,762,092 (GRCm39)	missense	probably damaging	1.00
R2911:Lipo3	UTSW	19	33,556,767 (GRCm39)	missense	probably benign	0.00
R3801:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3802:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3803:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3973:Lipo3	UTSW	19	33,535,723 (GRCm39)	missense	probably damaging	1.00
R4020:Lipo3	UTSW	19	33,764,804 (GRCm39)	missense	probably benign	0.00
R4648:Lipo3	UTSW	19	33,760,860 (GRCm39)	missense	probably damaging	1.00
R4660:Lipo3	UTSW	19	33,598,360 (GRCm39)	intron	probably benign
R4775:Lipo3	UTSW	19	33,757,795 (GRCm39)	missense	probably damaging	1.00
R4787:Lipo3	UTSW	19	33,757,749 (GRCm39)	missense	probably benign	0.00
R4820:Lipo3	UTSW	19	33,560,497 (GRCm39)	missense	probably damaging	1.00
R4830:Lipo3	UTSW	19	33,753,987 (GRCm39)	missense	probably damaging	0.99
R4951:Lipo3	UTSW	19	33,759,621 (GRCm39)	missense	probably benign	0.01
R5117:Lipo3	UTSW	19	33,536,952 (GRCm39)	missense	probably benign
R5258:Lipo3	UTSW	19	33,591,243 (GRCm39)	intron	probably benign
R5799:Lipo3	UTSW	19	33,755,093 (GRCm39)	intron	probably benign
R5853:Lipo3	UTSW	19	33,759,630 (GRCm39)	missense	probably benign	0.37
R6235:Lipo3	UTSW	19	33,760,963 (GRCm39)	missense	probably damaging	0.96
R6296:Lipo3	UTSW	19	33,757,737 (GRCm39)	missense	probably benign	0.10
R6383:Lipo3	UTSW	19	33,533,831 (GRCm39)	missense	probably benign	0.02
R6659:Lipo3	UTSW	19	33,533,828 (GRCm39)	missense	possibly damaging	0.55
R6913:Lipo3	UTSW	19	33,757,705 (GRCm39)	missense	probably benign	0.00
R6915:Lipo3	UTSW	19	33,562,293 (GRCm39)	missense	probably damaging	1.00
R7092:Lipo3	UTSW	19	33,591,092 (GRCm39)	splice site	probably null
R7444:Lipo3	UTSW	19	33,535,663 (GRCm39)	critical splice donor site	probably null
R7532:Lipo3	UTSW	19	33,560,464 (GRCm39)	missense	possibly damaging	0.90
R7672:Lipo3	UTSW	19	33,757,785 (GRCm39)	missense	probably benign	0.23
R7796:Lipo3	UTSW	19	33,759,634 (GRCm39)	missense	possibly damaging	0.75
R7945:Lipo3	UTSW	19	33,533,831 (GRCm39)	missense	probably benign	0.02
R8683:Lipo3	UTSW	19	33,759,604 (GRCm39)	missense	probably benign	0.04
R8936:Lipo3	UTSW	19	33,557,880 (GRCm39)	missense	probably damaging	1.00
R9062:Lipo3	UTSW	19	33,757,714 (GRCm39)	missense	probably damaging	1.00
R9086:Lipo3	UTSW	19	33,534,529 (GRCm39)	missense	probably benign	0.44
R9432:Lipo3	UTSW	19	33,533,864 (GRCm39)	missense	probably damaging	1.00
R9615:Lipo3	UTSW	19	33,754,047 (GRCm39)	missense	probably benign	0.02
R9620:Lipo3	UTSW	19	33,559,629 (GRCm39)	nonsense	probably null
Z1176:Lipo3	UTSW	19	33,562,328 (GRCm39)	missense	probably null	0.97

Posted On

2016-08-02