Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03410:Or5m11b'

421764

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5m11b

Ensembl Gene

ENSMUSG00000059873

Gene Name

olfactory receptor family 5 subfamily M member 11B

Synonyms

GA_x6K02T2Q125-47454152-47455126, Olfr1029, MOR198-1P

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL03410

Quality Score

Status

Chromosome

Chromosomal Location

85805557-85806617 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85805764 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 59 (M59K)

Ref Sequence

ENSEMBL: ENSMUSP00000150637 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056849] [ENSMUST00000082191] [ENSMUST00000217244]

AlphaFold

A2ATE0

Predicted Effect

probably benign
Transcript: ENSMUST00000056849

SMART Domains

Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	2.4e-58	PFAM
Pfam:7tm_1	47	296	3.2e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000082191
AA Change: M59K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000080828
Gene: ENSMUSG00000059873
AA Change: M59K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4.2e-56	PFAM
Pfam:7tm_1	41	290	2.1e-25	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000217244
AA Change: M59K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	A	17: 9,220,728 (GRCm39)	V409E	probably damaging	Het
1700086D15Rik	A	G	11: 65,043,393 (GRCm39)		probably benign	Het
Apba1	A	G	19: 23,914,945 (GRCm39)	N715S	possibly damaging	Het
Arfgef3	G	T	10: 18,476,238 (GRCm39)	A1527D	probably damaging	Het
Cmtm2a	G	T	8: 105,010,501 (GRCm39)	P133T	probably damaging	Het
Cyp2d9	T	C	15: 82,340,900 (GRCm39)	V483A	probably benign	Het
Dclre1b	T	A	3: 103,715,456 (GRCm39)	D14V	probably damaging	Het
Dock5	T	C	14: 68,083,535 (GRCm39)	I125V	probably benign	Het
Dok3	G	T	13: 55,672,044 (GRCm39)	Y211*	probably null	Het
Fat4	T	C	3: 38,945,325 (GRCm39)	V1406A	probably damaging	Het
Fbn2	A	G	18: 58,183,315 (GRCm39)	F1790S	possibly damaging	Het
Gm4787	A	T	12: 81,425,948 (GRCm39)	M70K	probably damaging	Het
Gulp1	A	T	1: 44,747,777 (GRCm39)	D10V	probably damaging	Het
Hagh	T	C	17: 25,079,916 (GRCm39)		probably benign	Het
Htt	A	G	5: 34,956,789 (GRCm39)	E206G	probably damaging	Het
Hyou1	A	G	9: 44,299,355 (GRCm39)	E682G	probably benign	Het
Ift56	T	C	6: 38,362,435 (GRCm39)	L70P	probably damaging	Het
Igkv4-59	G	T	6: 69,415,450 (GRCm39)	A35E	probably damaging	Het
Krt78	A	G	15: 101,862,421 (GRCm39)	V80A	probably damaging	Het
Lars2	G	A	9: 123,247,841 (GRCm39)	A333T	possibly damaging	Het
Lrrc4	G	A	6: 28,830,515 (GRCm39)	R367W	probably damaging	Het
Med1	A	T	11: 98,080,009 (GRCm39)	M44K	possibly damaging	Het
Mep1a	T	A	17: 43,788,986 (GRCm39)		probably null	Het
Mmrn1	A	G	6: 60,952,819 (GRCm39)	I367V	probably benign	Het
Myo18a	T	C	11: 77,738,830 (GRCm39)	L1677P	probably damaging	Het
Neb	T	C	2: 52,209,717 (GRCm39)	T246A	probably benign	Het
Nkiras1	A	G	14: 18,280,073 (GRCm38)	R155G	probably benign	Het
Nrip1	T	C	16: 76,089,379 (GRCm39)	N726S	probably benign	Het
Nyap2	A	G	1: 81,219,156 (GRCm39)	T393A	possibly damaging	Het
Oprm1	A	T	10: 6,780,051 (GRCm39)	I238F	probably damaging	Het
Or4b1b	A	G	2: 90,112,557 (GRCm39)	Y121H	probably damaging	Het
Or4b1d	G	A	2: 89,969,489 (GRCm39)		probably benign	Het
Pcnx2	T	A	8: 126,613,779 (GRCm39)	E557D	probably damaging	Het
Pole	A	G	5: 110,472,425 (GRCm39)	I1563V	probably benign	Het
Pramel21	C	A	4: 143,341,851 (GRCm39)	H93Q	probably benign	Het
Prdx3	T	G	19: 60,859,848 (GRCm39)		probably benign	Het
Rgsl1	C	T	1: 153,669,501 (GRCm39)	R295K	probably null	Het
Rhbdl2	T	A	4: 123,723,463 (GRCm39)	L289*	probably null	Het
Rnps1	A	G	17: 24,640,835 (GRCm39)		probably benign	Het
Rpgrip1	A	G	14: 52,395,823 (GRCm39)		probably benign	Het
Ryr2	A	T	13: 11,603,033 (GRCm39)	Y4518N	probably damaging	Het
Scyl3	A	G	1: 163,772,436 (GRCm39)	N296S	probably damaging	Het
Sipa1l3	G	A	7: 29,047,964 (GRCm39)	T1308M	probably damaging	Het
Slc39a9	A	G	12: 80,691,662 (GRCm39)	D3G	probably damaging	Het
Slc4a9	A	G	18: 36,662,740 (GRCm39)	E165G	probably benign	Het
Slc6a3	A	T	13: 73,686,776 (GRCm39)	I48F	probably benign	Het
Stxbp3	C	T	3: 108,709,476 (GRCm39)	C354Y	probably damaging	Het
Terb1	C	A	8: 105,199,674 (GRCm39)		probably benign	Het
Tfrc	G	A	16: 32,443,649 (GRCm39)		probably null	Het
Toporsl	A	C	4: 52,611,134 (GRCm39)	R342S	probably benign	Het
Ube2d3	T	A	3: 135,170,978 (GRCm39)	W141R	probably damaging	Het
Vps13b	G	T	15: 35,910,486 (GRCm39)	V3417L	probably benign	Het

Other mutations in Or5m11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02020:Or5m11b	APN	2	85,805,579 (GRCm39)	utr 5 prime	probably benign
IGL02126:Or5m11b	APN	2	85,806,517 (GRCm39)	missense	probably benign	0.00
IGL02584:Or5m11b	APN	2	85,806,219 (GRCm39)	missense	probably damaging	0.96
R1466:Or5m11b	UTSW	2	85,806,339 (GRCm39)	missense	probably damaging	1.00
R1466:Or5m11b	UTSW	2	85,806,339 (GRCm39)	missense	probably damaging	1.00
R1499:Or5m11b	UTSW	2	85,806,372 (GRCm39)	missense	possibly damaging	0.62
R1584:Or5m11b	UTSW	2	85,806,339 (GRCm39)	missense	probably damaging	1.00
R2925:Or5m11b	UTSW	2	85,806,125 (GRCm39)	nonsense	probably null
R2970:Or5m11b	UTSW	2	85,806,454 (GRCm39)	missense	possibly damaging	0.75
R4571:Or5m11b	UTSW	2	85,806,175 (GRCm39)	missense	probably damaging	0.97
R5533:Or5m11b	UTSW	2	85,805,797 (GRCm39)	missense	possibly damaging	0.78
R5654:Or5m11b	UTSW	2	85,806,500 (GRCm39)	missense	probably benign	0.00
R5827:Or5m11b	UTSW	2	85,805,650 (GRCm39)	missense	probably benign	0.00
R5967:Or5m11b	UTSW	2	85,806,535 (GRCm39)	missense	probably benign	0.01
R6291:Or5m11b	UTSW	2	85,805,926 (GRCm39)	missense	probably damaging	1.00
R6735:Or5m11b	UTSW	2	85,805,778 (GRCm39)	missense	possibly damaging	0.81
R6897:Or5m11b	UTSW	2	85,805,700 (GRCm39)	missense	possibly damaging	0.45
R7053:Or5m11b	UTSW	2	85,806,358 (GRCm39)	missense	possibly damaging	0.64
R7163:Or5m11b	UTSW	2	85,805,932 (GRCm39)	missense	probably damaging	1.00
R7358:Or5m11b	UTSW	2	85,805,780 (GRCm39)	missense	possibly damaging	0.81
R8047:Or5m11b	UTSW	2	85,806,271 (GRCm39)	missense	possibly damaging	0.52
R8271:Or5m11b	UTSW	2	85,806,085 (GRCm39)	missense	probably benign	0.40
R8271:Or5m11b	UTSW	2	85,805,766 (GRCm39)	missense	probably damaging	1.00
R8364:Or5m11b	UTSW	2	85,806,358 (GRCm39)	missense	possibly damaging	0.64
R9100:Or5m11b	UTSW	2	85,806,096 (GRCm39)	missense	probably benign	0.00
R9190:Or5m11b	UTSW	2	85,805,884 (GRCm39)	missense	possibly damaging	0.66
R9646:Or5m11b	UTSW	2	85,806,446 (GRCm39)	missense	probably benign	0.18

Posted On

2016-08-02