Incidental Mutation 'R5328:Adora3'
ID 422118
Institutional Source Beutler Lab
Gene Symbol Adora3
Ensembl Gene ENSMUSG00000000562
Gene Name adenosine A3 receptor
Synonyms A3R, 1700001D09Rik, 4930578J19Rik, AA3R, ARA3, A3AR, Gpcr 2
MMRRC Submission 042843-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R5328 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 105811737-105816244 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 105814619 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 123 (T123I)
Ref Sequence ENSEMBL: ENSMUSP00000000574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000574] [ENSMUST00000010279] [ENSMUST00000164730] [ENSMUST00000196748] [ENSMUST00000200482]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000000574
AA Change: T123I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000000574
Gene: ENSMUSG00000000562
AA Change: T123I

DomainStartEndE-ValueType
Pfam:7tm_4 21 301 3.5e-12 PFAM
Pfam:7TM_GPCR_Srsx 24 298 5e-12 PFAM
Pfam:7tm_1 30 283 2.8e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000010279
SMART Domains Protein: ENSMUSP00000010279
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IG 20 115 3.94e0 SMART
transmembrane domain 151 173 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164730
SMART Domains Protein: ENSMUSP00000126710
Gene: ENSMUSG00000000562

DomainStartEndE-ValueType
Pfam:7tm_1 1 137 6.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196748
SMART Domains Protein: ENSMUSP00000143674
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
Pfam:7tm_4 21 131 7.3e-9 PFAM
Pfam:7TM_GPCR_Srsx 24 123 1.3e-7 PFAM
Pfam:7tm_1 30 129 2.9e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197613
Predicted Effect probably benign
Transcript: ENSMUST00000200482
SMART Domains Protein: ENSMUSP00000142695
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IG 20 115 1.6e-2 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene are phenotypically indistinguishable from wild-type mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T A 5: 8,887,694 (GRCm39) V860E possibly damaging Het
Abcc6 T C 7: 45,641,735 (GRCm39) D881G probably benign Het
Abcc9 A G 6: 142,627,785 (GRCm39) V415A probably benign Het
Adgrb3 A C 1: 25,133,356 (GRCm39) N1003K possibly damaging Het
Amotl2 A C 9: 102,600,967 (GRCm39) T345P probably benign Het
Arap3 C T 18: 38,124,740 (GRCm39) E247K possibly damaging Het
Atp8b1 A T 18: 64,664,462 (GRCm39) D1235E probably benign Het
Axl A T 7: 25,472,836 (GRCm39) V400E probably damaging Het
Brd8 T A 18: 34,741,034 (GRCm39) N431Y probably benign Het
Cadps A T 14: 12,457,790 (GRCm38) N1025K probably benign Het
Cblc A T 7: 19,526,505 (GRCm39) S195T possibly damaging Het
Chd2 C T 7: 73,113,429 (GRCm39) A1184T possibly damaging Het
Chst10 G A 1: 38,935,043 (GRCm39) probably benign Het
Col12a1 T C 9: 79,527,342 (GRCm39) K2663E probably damaging Het
Cspg4 A T 9: 56,793,140 (GRCm39) I292L probably benign Het
Cul1 T C 6: 47,485,251 (GRCm39) V294A probably damaging Het
Cyp2d11 G A 15: 82,275,972 (GRCm39) P203L probably benign Het
Dnaaf10 C A 11: 17,172,220 (GRCm39) P103Q probably damaging Het
Dscam T C 16: 96,474,878 (GRCm39) H1228R probably benign Het
Eif3l A T 15: 78,977,561 (GRCm39) K534* probably null Het
Enpep T C 3: 129,074,159 (GRCm39) E796G probably benign Het
Ext1 C A 15: 52,939,213 (GRCm39) W612L probably damaging Het
Faap100 T A 11: 120,268,458 (GRCm39) E105V possibly damaging Het
Fam117a T A 11: 95,254,996 (GRCm39) probably null Het
Fan1 A T 7: 64,004,217 (GRCm39) Y750N probably damaging Het
Fat4 T A 3: 39,011,017 (GRCm39) I2039N probably damaging Het
Gabrr2 G T 4: 33,082,565 (GRCm39) D106Y probably damaging Het
Gak A C 5: 108,764,867 (GRCm39) C145G possibly damaging Het
Galnt14 A T 17: 73,812,454 (GRCm39) N406K possibly damaging Het
Gm10439 T G X: 148,419,159 (GRCm39) *434E probably null Het
Gm10837 G T 14: 122,728,190 (GRCm39) R22L unknown Het
Gm19965 T A 1: 116,749,148 (GRCm39) H276Q possibly damaging Het
Gm43517 T C 12: 49,437,939 (GRCm39) probably benign Het
Greb1l A T 18: 10,553,720 (GRCm39) I1574F probably damaging Het
Gzme G A 14: 56,355,224 (GRCm39) H236Y probably benign Het
Heatr5b G A 17: 79,133,791 (GRCm39) T266I possibly damaging Het
Hk3 T C 13: 55,161,306 (GRCm39) I185V probably benign Het
Hnrnpr A G 4: 136,066,527 (GRCm39) E302G probably benign Het
Itgal T C 7: 126,910,847 (GRCm39) probably null Het
Itk A G 11: 46,222,703 (GRCm39) S583P probably benign Het
Loxhd1 A T 18: 77,498,268 (GRCm39) I1448F probably damaging Het
Macf1 GCCCCC GCCCCCC 4: 123,244,784 (GRCm39) probably null Het
Man2a2 A T 7: 80,018,504 (GRCm39) F118L probably benign Het
Mfsd5 T A 15: 102,189,447 (GRCm39) V273E probably damaging Het
Nfe2l2 A G 2: 75,507,200 (GRCm39) L300P probably damaging Het
Nt5c1a T G 4: 123,102,786 (GRCm39) L122R possibly damaging Het
Nt5c3b A G 11: 100,331,067 (GRCm39) F42S probably damaging Het
Or2av9 C A 11: 58,381,255 (GRCm39) A109S possibly damaging Het
Or51g2 T A 7: 102,623,175 (GRCm39) N8I possibly damaging Het
Pabpc1 A T 15: 36,603,121 (GRCm39) D204E probably benign Het
Panx2 A G 15: 88,952,298 (GRCm39) N255S probably damaging Het
Pcnt A G 10: 76,247,553 (GRCm39) L993P probably damaging Het
Pfas A T 11: 68,879,418 (GRCm39) C1160S probably damaging Het
Plekhh3 T A 11: 101,058,484 (GRCm39) probably benign Het
Plod3 T A 5: 137,018,537 (GRCm39) N258K probably damaging Het
Prr14l T C 5: 32,987,365 (GRCm39) Q710R probably benign Het
Rnf216 G T 5: 143,078,754 (GRCm39) T65K possibly damaging Het
Samd9l T C 6: 3,376,739 (GRCm39) E174G probably damaging Het
Septin12 T A 16: 4,811,857 (GRCm39) M63L possibly damaging Het
Sh3bgrl2 T A 9: 83,459,509 (GRCm39) D22E probably benign Het
Sirpd T C 3: 15,397,234 (GRCm39) M17V unknown Het
Skil A G 3: 31,171,718 (GRCm39) K488R probably benign Het
Slamf6 T A 1: 171,765,662 (GRCm39) I262K probably benign Het
Slc27a3 T C 3: 90,294,139 (GRCm39) D470G probably damaging Het
Sorbs3 A T 14: 70,418,623 (GRCm39) V680E probably damaging Het
Sox9 C T 11: 112,673,484 (GRCm39) T25I probably benign Het
Srsf1 G T 11: 87,940,819 (GRCm39) probably benign Het
Stard9 A C 2: 120,529,711 (GRCm39) E1989D probably damaging Het
Thumpd2 T A 17: 81,351,591 (GRCm39) I277F possibly damaging Het
Tinag C A 9: 76,912,913 (GRCm39) G299* probably null Het
Tk2 A T 8: 104,955,931 (GRCm39) probably null Het
Tmem44 A G 16: 30,359,709 (GRCm39) S210P possibly damaging Het
Traf3ip1 C A 1: 91,447,791 (GRCm39) P423T probably damaging Het
Trmt12 A G 15: 58,744,704 (GRCm39) D34G probably damaging Het
Ttc39b A G 4: 83,180,178 (GRCm39) Y72H probably damaging Het
Ttn G A 2: 76,708,755 (GRCm39) probably benign Het
Ttyh2 T A 11: 114,600,894 (GRCm39) I381N possibly damaging Het
Uaca A T 9: 60,777,814 (GRCm39) N734Y probably benign Het
Usp34 T C 11: 23,414,616 (GRCm39) I2853T probably benign Het
Usp34 G A 11: 23,438,659 (GRCm39) G3407D probably benign Het
Vmn2r78 A G 7: 86,570,238 (GRCm39) Y252C probably damaging Het
Wdr19 G A 5: 65,401,522 (GRCm39) C979Y probably damaging Het
Yeats2 A T 16: 19,989,955 (GRCm39) H277L probably damaging Het
Zbtb2 T C 10: 4,319,267 (GRCm39) Y253C possibly damaging Het
Zfat C A 15: 68,051,677 (GRCm39) G706C probably damaging Het
Zfp106 A T 2: 120,350,898 (GRCm39) N1584K possibly damaging Het
Other mutations in Adora3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02565:Adora3 APN 3 105,815,128 (GRCm39) missense probably benign 0.02
IGL03210:Adora3 APN 3 105,815,176 (GRCm39) missense probably benign 0.01
R1885:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R1886:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R1887:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R3434:Adora3 UTSW 3 105,812,231 (GRCm39) missense probably benign 0.11
R4864:Adora3 UTSW 3 105,815,131 (GRCm39) missense probably damaging 1.00
R5746:Adora3 UTSW 3 105,815,126 (GRCm39) missense possibly damaging 0.49
R6322:Adora3 UTSW 3 105,814,760 (GRCm39) missense probably benign 0.10
R6432:Adora3 UTSW 3 105,814,991 (GRCm39) nonsense probably null
R7264:Adora3 UTSW 3 105,812,141 (GRCm39) missense probably benign 0.02
R7772:Adora3 UTSW 3 105,815,039 (GRCm39) missense probably benign
R9020:Adora3 UTSW 3 105,815,141 (GRCm39) missense probably damaging 1.00
R9350:Adora3 UTSW 3 105,814,613 (GRCm39) missense possibly damaging 0.80
Z1177:Adora3 UTSW 3 105,815,101 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGAGGAGTTTCTGGATTTTCCTC -3'
(R):5'- CGAAGCTGAAGAAGACCATGTAATC -3'

Sequencing Primer
(F):5'- GGATTTTCCTCTGATAATGCTAGTC -3'
(R):5'- TGAAGAAGACCATGTAATCCAAACTG -3'
Posted On 2016-08-04