Incidental Mutation 'R0485:Sez6'
| ID |
42223 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sez6
|
| Ensembl Gene |
ENSMUSG00000000632 |
| Gene Name |
seizure related gene 6 |
| Synonyms |
sez-6, D11Bhm177e |
| MMRRC Submission |
038684-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0485 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
77821626-77869874 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 77844639 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Histidine
at position 154
(L154H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091532
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000646]
[ENSMUST00000093995]
|
| AlphaFold |
Q7TSK2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000000646
AA Change: L154H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000000646
Gene: ENSMUSG00000000632
AA Change: L154H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
72 |
85 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
235 |
N/A |
INTRINSIC |
|
CUB
|
241 |
350 |
9.36e-2 |
SMART |
|
CCP
|
354 |
409 |
1.23e-10 |
SMART |
|
CUB
|
413 |
524 |
1.41e-28 |
SMART |
|
CCP
|
529 |
586 |
5.43e-12 |
SMART |
|
CUB
|
590 |
701 |
7.49e-24 |
SMART |
|
CCP
|
707 |
762 |
3.09e-16 |
SMART |
|
CCP
|
768 |
827 |
3.5e-15 |
SMART |
|
CCP
|
835 |
892 |
1.42e-15 |
SMART |
|
transmembrane domain
|
910 |
932 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093995
AA Change: L154H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000091532
Gene: ENSMUSG00000000632
AA Change: L154H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
72 |
85 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
235 |
N/A |
INTRINSIC |
|
CUB
|
241 |
350 |
9.36e-2 |
SMART |
|
CCP
|
354 |
409 |
1.23e-10 |
SMART |
|
CUB
|
413 |
524 |
1.41e-28 |
SMART |
|
CCP
|
529 |
586 |
5.43e-12 |
SMART |
|
CUB
|
590 |
701 |
7.49e-24 |
SMART |
|
CCP
|
707 |
762 |
3.09e-16 |
SMART |
|
CCP
|
768 |
827 |
3.5e-15 |
SMART |
|
CCP
|
835 |
892 |
1.42e-15 |
SMART |
|
transmembrane domain
|
923 |
945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138346
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138749
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142542
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151982
|
| SMART Domains |
Protein: ENSMUSP00000132041
Gene: ENSMUSG00000000632
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
|
CUB
|
75 |
184 |
9.36e-2 |
SMART |
|
CCP
|
188 |
243 |
1.23e-10 |
SMART |
|
CUB
|
247 |
358 |
8.08e-29 |
SMART |
|
low complexity region
|
379 |
394 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155087
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.4%
|
| Validation Efficiency |
100% (95/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a null allele exhibit increased short dendrites, decreased excitatory synaptic signaling, resistance to pharmacologically induces seizures, decreased activity and impaired learning and coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700037C18Rik |
A |
G |
16: 3,725,511 (GRCm39) |
V5A |
probably damaging |
Het |
| Abi3bp |
A |
G |
16: 56,424,375 (GRCm39) |
|
probably null |
Het |
| Acot11 |
G |
A |
4: 106,619,224 (GRCm39) |
R184C |
probably damaging |
Het |
| Adgre5 |
A |
T |
8: 84,458,627 (GRCm39) |
I133N |
probably damaging |
Het |
| Afap1 |
A |
T |
5: 36,108,347 (GRCm39) |
Q231L |
probably damaging |
Het |
| Alg12 |
T |
C |
15: 88,695,630 (GRCm39) |
T289A |
probably benign |
Het |
| Ank3 |
T |
A |
10: 69,718,374 (GRCm39) |
S542T |
possibly damaging |
Het |
| Ankmy2 |
G |
A |
12: 36,232,389 (GRCm39) |
R138Q |
possibly damaging |
Het |
| Ascc2 |
C |
T |
11: 4,622,302 (GRCm39) |
A456V |
probably benign |
Het |
| Atg4c |
G |
A |
4: 99,112,719 (GRCm39) |
V289I |
probably benign |
Het |
| Bbs7 |
A |
T |
3: 36,657,022 (GRCm39) |
Y269N |
probably damaging |
Het |
| Bcas3 |
T |
A |
11: 85,386,676 (GRCm39) |
D370E |
probably damaging |
Het |
| Bicc1 |
T |
G |
10: 70,761,145 (GRCm39) |
E955A |
probably damaging |
Het |
| Bok |
T |
C |
1: 93,616,999 (GRCm39) |
F115S |
probably damaging |
Het |
| Caap1 |
A |
T |
4: 94,438,758 (GRCm39) |
|
probably null |
Het |
| Cacna2d3 |
T |
A |
14: 29,256,476 (GRCm39) |
M95L |
possibly damaging |
Het |
| Calcrl |
T |
A |
2: 84,200,435 (GRCm39) |
D115V |
probably benign |
Het |
| Car7 |
A |
T |
8: 105,270,170 (GRCm39) |
M57L |
probably benign |
Het |
| Casq1 |
G |
T |
1: 172,037,957 (GRCm39) |
|
probably benign |
Het |
| Cep290 |
A |
T |
10: 100,385,206 (GRCm39) |
D1894V |
possibly damaging |
Het |
| Clec4a2 |
T |
A |
6: 123,100,588 (GRCm39) |
N14K |
probably damaging |
Het |
| Col16a1 |
G |
T |
4: 129,984,290 (GRCm39) |
|
probably benign |
Het |
| Col5a1 |
T |
C |
2: 27,880,109 (GRCm39) |
|
probably benign |
Het |
| Col5a2 |
A |
T |
1: 45,417,642 (GRCm39) |
I1311N |
probably damaging |
Het |
| Col5a3 |
T |
C |
9: 20,694,004 (GRCm39) |
T1050A |
probably damaging |
Het |
| Colgalt2 |
A |
T |
1: 152,360,622 (GRCm39) |
I220F |
probably damaging |
Het |
| Cpb1 |
A |
T |
3: 20,329,792 (GRCm39) |
V8E |
unknown |
Het |
| Dchs1 |
C |
T |
7: 105,421,934 (GRCm39) |
R162H |
probably benign |
Het |
| Dhx37 |
A |
G |
5: 125,499,295 (GRCm39) |
Y638H |
probably benign |
Het |
| Dhx40 |
T |
G |
11: 86,662,088 (GRCm39) |
|
probably benign |
Het |
| Ehd2 |
T |
A |
7: 15,686,001 (GRCm39) |
Q357L |
probably benign |
Het |
| Ewsr1 |
T |
C |
11: 5,020,737 (GRCm39) |
|
probably benign |
Het |
| Fcho1 |
C |
T |
8: 72,165,204 (GRCm39) |
A418T |
probably benign |
Het |
| Gid8 |
T |
A |
2: 180,355,004 (GRCm39) |
Y3* |
probably null |
Het |
| Gm10212 |
A |
C |
19: 11,548,174 (GRCm39) |
|
noncoding transcript |
Het |
| Grin3b |
T |
A |
10: 79,809,890 (GRCm39) |
N465K |
possibly damaging |
Het |
| H1f3 |
A |
T |
13: 23,739,924 (GRCm39) |
K221* |
probably null |
Het |
| Htr4 |
A |
T |
18: 62,561,225 (GRCm39) |
N162I |
probably damaging |
Het |
| Irag2 |
T |
C |
6: 145,110,938 (GRCm39) |
C248R |
probably damaging |
Het |
| Itga3 |
T |
C |
11: 94,952,796 (GRCm39) |
D325G |
probably benign |
Het |
| Itpr3 |
T |
G |
17: 27,330,903 (GRCm39) |
V1737G |
probably damaging |
Het |
| Kcnab2 |
C |
T |
4: 152,479,439 (GRCm39) |
V251I |
probably benign |
Het |
| Kcnn2 |
A |
T |
18: 45,693,215 (GRCm39) |
I264L |
probably benign |
Het |
| Klhl41 |
T |
C |
2: 69,501,600 (GRCm39) |
Y354H |
probably damaging |
Het |
| Klra6 |
T |
C |
6: 130,000,601 (GRCm39) |
I68V |
probably benign |
Het |
| Letm2 |
G |
T |
8: 26,082,574 (GRCm39) |
P178Q |
probably damaging |
Het |
| Lypd11 |
C |
A |
7: 24,422,170 (GRCm39) |
C193F |
possibly damaging |
Het |
| Mbtps1 |
A |
T |
8: 120,249,340 (GRCm39) |
|
probably benign |
Het |
| Mecom |
C |
T |
3: 30,035,121 (GRCm39) |
|
probably benign |
Het |
| Mrps5 |
T |
A |
2: 127,433,745 (GRCm39) |
S45T |
possibly damaging |
Het |
| Msra |
T |
A |
14: 64,678,210 (GRCm39) |
I29F |
possibly damaging |
Het |
| Mup5 |
T |
C |
4: 61,751,229 (GRCm39) |
|
probably null |
Het |
| Myo1a |
T |
C |
10: 127,555,111 (GRCm39) |
|
probably benign |
Het |
| Myrip |
C |
A |
9: 120,270,443 (GRCm39) |
N564K |
probably benign |
Het |
| Naa20 |
T |
A |
2: 145,757,592 (GRCm39) |
D148E |
probably damaging |
Het |
| Naga |
T |
G |
15: 82,220,956 (GRCm39) |
|
probably benign |
Het |
| Npc1 |
A |
G |
18: 12,346,503 (GRCm39) |
V231A |
probably benign |
Het |
| Nphs1 |
T |
C |
7: 30,166,940 (GRCm39) |
F716L |
probably benign |
Het |
| Or8s5 |
T |
C |
15: 98,238,810 (GRCm39) |
H20R |
probably benign |
Het |
| Parn |
G |
C |
16: 13,472,299 (GRCm39) |
|
probably benign |
Het |
| Polk |
A |
T |
13: 96,620,272 (GRCm39) |
C664S |
probably benign |
Het |
| Prkar2b |
A |
G |
12: 32,026,034 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
G |
16: 15,651,604 (GRCm39) |
E3747G |
probably damaging |
Het |
| Prmt5 |
A |
T |
14: 54,748,712 (GRCm39) |
M362K |
probably damaging |
Het |
| Prob1 |
T |
C |
18: 35,786,878 (GRCm39) |
T459A |
possibly damaging |
Het |
| Rttn |
C |
T |
18: 89,108,543 (GRCm39) |
|
probably benign |
Het |
| Scn1a |
T |
C |
2: 66,104,269 (GRCm39) |
M1664V |
probably damaging |
Het |
| Sh3tc1 |
A |
G |
5: 35,859,356 (GRCm39) |
|
probably benign |
Het |
| Shkbp1 |
C |
T |
7: 27,048,006 (GRCm39) |
G334D |
probably damaging |
Het |
| Slc8a1 |
A |
T |
17: 81,955,422 (GRCm39) |
F539I |
probably damaging |
Het |
| Spata31e5 |
G |
T |
1: 28,817,223 (GRCm39) |
Q270K |
probably damaging |
Het |
| Sptan1 |
T |
C |
2: 29,903,860 (GRCm39) |
|
probably benign |
Het |
| Ssc5d |
C |
T |
7: 4,940,470 (GRCm39) |
T861M |
probably damaging |
Het |
| Tbx5 |
A |
T |
5: 120,021,523 (GRCm39) |
M510L |
probably benign |
Het |
| Tdp1 |
A |
G |
12: 99,876,101 (GRCm39) |
T351A |
probably benign |
Het |
| Tmc8 |
T |
A |
11: 117,682,904 (GRCm39) |
|
probably benign |
Het |
| Tmco5 |
T |
A |
2: 116,720,588 (GRCm39) |
D205E |
probably benign |
Het |
| Tmprss2 |
T |
C |
16: 97,373,194 (GRCm39) |
|
probably benign |
Het |
| Top6bl |
A |
T |
19: 4,708,442 (GRCm39) |
I350N |
probably damaging |
Het |
| Tph1 |
T |
A |
7: 46,299,448 (GRCm39) |
K364N |
probably benign |
Het |
| Trim24 |
T |
C |
6: 37,934,001 (GRCm39) |
L648P |
probably damaging |
Het |
| Trmt6 |
C |
A |
2: 132,650,950 (GRCm39) |
|
probably benign |
Het |
| Ube2i |
A |
T |
17: 25,488,259 (GRCm39) |
|
probably benign |
Het |
| Vcan |
A |
C |
13: 89,852,779 (GRCm39) |
L727R |
possibly damaging |
Het |
| Vmn2r28 |
T |
C |
7: 5,491,689 (GRCm39) |
Y186C |
probably damaging |
Het |
| Wars1 |
C |
A |
12: 108,841,083 (GRCm39) |
D232Y |
probably damaging |
Het |
| Xrcc5 |
T |
C |
1: 72,378,104 (GRCm39) |
|
probably benign |
Het |
| Zbtb24 |
T |
A |
10: 41,340,532 (GRCm39) |
S543T |
probably damaging |
Het |
| Zfp91 |
A |
G |
19: 12,753,353 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Sez6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01125:Sez6
|
APN |
11 |
77,868,115 (GRCm39) |
splice site |
probably benign |
|
|
IGL01142:Sez6
|
APN |
11 |
77,864,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02252:Sez6
|
APN |
11 |
77,865,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02332:Sez6
|
APN |
11 |
77,845,568 (GRCm39) |
splice site |
probably benign |
|
|
IGL02366:Sez6
|
APN |
11 |
77,867,708 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02479:Sez6
|
APN |
11 |
77,868,852 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02963:Sez6
|
APN |
11 |
77,853,775 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
velum
|
UTSW |
11 |
77,865,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Sez6
|
UTSW |
11 |
77,844,699 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0054:Sez6
|
UTSW |
11 |
77,844,699 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0089:Sez6
|
UTSW |
11 |
77,865,170 (GRCm39) |
splice site |
probably benign |
|
|
R0598:Sez6
|
UTSW |
11 |
77,868,647 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0729:Sez6
|
UTSW |
11 |
77,867,411 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1117:Sez6
|
UTSW |
11 |
77,865,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1199:Sez6
|
UTSW |
11 |
77,844,711 (GRCm39) |
missense |
probably benign |
|
|
R1534:Sez6
|
UTSW |
11 |
77,853,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Sez6
|
UTSW |
11 |
77,844,329 (GRCm39) |
missense |
probably benign |
|
|
R1840:Sez6
|
UTSW |
11 |
77,844,543 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1929:Sez6
|
UTSW |
11 |
77,863,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Sez6
|
UTSW |
11 |
77,844,894 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3156:Sez6
|
UTSW |
11 |
77,844,605 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3930:Sez6
|
UTSW |
11 |
77,867,708 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3931:Sez6
|
UTSW |
11 |
77,867,708 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4894:Sez6
|
UTSW |
11 |
77,866,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Sez6
|
UTSW |
11 |
77,866,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5026:Sez6
|
UTSW |
11 |
77,859,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5040:Sez6
|
UTSW |
11 |
77,859,915 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5057:Sez6
|
UTSW |
11 |
77,863,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Sez6
|
UTSW |
11 |
77,867,388 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5640:Sez6
|
UTSW |
11 |
77,864,585 (GRCm39) |
intron |
probably benign |
|
|
R6013:Sez6
|
UTSW |
11 |
77,864,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6126:Sez6
|
UTSW |
11 |
77,864,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Sez6
|
UTSW |
11 |
77,868,648 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6279:Sez6
|
UTSW |
11 |
77,867,367 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6300:Sez6
|
UTSW |
11 |
77,867,367 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6475:Sez6
|
UTSW |
11 |
77,864,670 (GRCm39) |
|
|
|
|
R6722:Sez6
|
UTSW |
11 |
77,844,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Sez6
|
UTSW |
11 |
77,844,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6910:Sez6
|
UTSW |
11 |
77,844,695 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7012:Sez6
|
UTSW |
11 |
77,868,621 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7233:Sez6
|
UTSW |
11 |
77,863,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7265:Sez6
|
UTSW |
11 |
77,853,691 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7289:Sez6
|
UTSW |
11 |
77,865,149 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7405:Sez6
|
UTSW |
11 |
77,853,717 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7408:Sez6
|
UTSW |
11 |
77,844,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7485:Sez6
|
UTSW |
11 |
77,864,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7592:Sez6
|
UTSW |
11 |
77,868,876 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7778:Sez6
|
UTSW |
11 |
77,865,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7793:Sez6
|
UTSW |
11 |
77,868,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Sez6
|
UTSW |
11 |
77,867,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7824:Sez6
|
UTSW |
11 |
77,865,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Sez6
|
UTSW |
11 |
77,844,668 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8008:Sez6
|
UTSW |
11 |
77,864,082 (GRCm39) |
nonsense |
probably null |
|
|
R8840:Sez6
|
UTSW |
11 |
77,867,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8947:Sez6
|
UTSW |
11 |
77,844,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Sez6
|
UTSW |
11 |
77,865,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9040:Sez6
|
UTSW |
11 |
77,864,762 (GRCm39) |
missense |
probably benign |
|
|
R9081:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9082:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9092:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9094:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9095:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9097:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9169:Sez6
|
UTSW |
11 |
77,868,473 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9513:Sez6
|
UTSW |
11 |
77,865,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9630:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9632:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9646:Sez6
|
UTSW |
11 |
77,867,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9709:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
X0013:Sez6
|
UTSW |
11 |
77,845,606 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0067:Sez6
|
UTSW |
11 |
77,865,264 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1088:Sez6
|
UTSW |
11 |
77,864,023 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCACTGTGGCGTAGCAAGAGAGC -3'
(R):5'- CAAGCCCTGTGGTCTTAGACATGAC -3'
Sequencing Primer
(F):5'- TAGCAAGAGAGCCTCTGATCATTC -3'
(R):5'- GGTCTTAGACATGACCTCTGGAAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation