Incidental Mutation 'R5341:Ms4a20'
ID 422361
Institutional Source Beutler Lab
Gene Symbol Ms4a20
Ensembl Gene ENSMUSG00000024729
Gene Name membrane-spanning 4-domains, subfamily A, member 20
Synonyms 1700017D01Rik
MMRRC Submission 042920-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R5341 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 11074180-11108240 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 11087745 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025635]
AlphaFold G5E851
Predicted Effect probably benign
Transcript: ENSMUST00000025635
SMART Domains Protein: ENSMUSP00000025635
Gene: ENSMUSG00000024729

DomainStartEndE-ValueType
Pfam:CD20 18 118 2.4e-8 PFAM
transmembrane domain 130 152 N/A INTRINSIC
low complexity region 169 185 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188756
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 96.2%
Validation Efficiency 97% (64/66)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb3 A G 10: 85,223,236 (GRCm39) D15G unknown Het
Actr5 C A 2: 158,467,144 (GRCm39) S28* probably null Het
Adcy1 A C 11: 7,080,375 (GRCm39) M373L probably damaging Het
Adcyap1r1 C G 6: 55,455,054 (GRCm39) F111L probably benign Het
Arid5b A T 10: 68,113,957 (GRCm39) F27I possibly damaging Het
Art5 C A 7: 101,747,306 (GRCm39) V158L probably benign Het
Bora T A 14: 99,305,530 (GRCm39) Y300N probably damaging Het
Cd300a A G 11: 114,784,288 (GRCm39) T99A probably damaging Het
Cdon A G 9: 35,381,431 (GRCm39) Y607C probably damaging Het
Cenatac A G 9: 44,328,406 (GRCm39) probably null Het
Cpxm2 T A 7: 131,756,342 (GRCm39) probably benign Het
Cstdc7 A G 18: 42,306,496 (GRCm39) D21G possibly damaging Het
Dhx8 AGACCGGGACCGGGACCGGGACCGGGAC AGACCGGGACCGGGACCGGGAC 11: 101,629,016 (GRCm39) probably benign Het
Dync2i1 T C 12: 116,219,534 (GRCm39) E136G possibly damaging Het
Enox1 A C 14: 77,815,096 (GRCm39) T85P possibly damaging Het
Fanci T C 7: 79,055,926 (GRCm39) L158P probably damaging Het
Gbgt1 C A 2: 28,395,019 (GRCm39) T219N probably damaging Het
Gulo T C 14: 66,225,707 (GRCm39) D373G probably benign Het
Hivep2 C A 10: 14,008,336 (GRCm39) Q1645K possibly damaging Het
Iqce A C 5: 140,675,814 (GRCm39) M114R possibly damaging Het
Lmbrd1 A T 1: 24,785,892 (GRCm39) K396* probably null Het
Lrrk2 A T 15: 91,657,061 (GRCm39) D1785V probably damaging Het
Matcap1 A T 8: 106,011,687 (GRCm39) M226K probably damaging Het
Mcmdc2 ATAAAAAAAAAGGAAAAATTACCTT AT 1: 10,011,142 (GRCm39) probably null Het
Mepce A G 5: 137,781,522 (GRCm39) V564A probably damaging Het
Mmp17 A T 5: 129,679,193 (GRCm39) D364V possibly damaging Het
Mrgpre T C 7: 143,335,246 (GRCm39) N86D probably benign Het
Or2r11 A T 6: 42,437,098 (GRCm39) L285Q probably damaging Het
Or4f53 T A 2: 111,087,982 (GRCm39) I174K probably damaging Het
Pate11 A T 9: 36,388,357 (GRCm39) K61* probably null Het
Pax5 T C 4: 44,697,630 (GRCm39) D35G probably damaging Het
Pip5k1b T A 19: 24,281,440 (GRCm39) T473S probably benign Het
Pkd2l2 A G 18: 34,542,987 (GRCm39) probably null Het
Pygo2 C A 3: 89,340,067 (GRCm39) P155Q probably damaging Het
Rb1cc1 G T 1: 6,285,266 (GRCm39) probably benign Het
Rbpj A G 5: 53,799,425 (GRCm39) E80G possibly damaging Het
Sbno1 A C 5: 124,546,538 (GRCm39) probably null Het
Slc1a1 T A 19: 28,874,968 (GRCm39) V182E probably benign Het
Slc34a3 A T 2: 25,120,671 (GRCm39) F419I probably benign Het
Snx8 A G 5: 140,343,886 (GRCm39) V62A probably damaging Het
Sp9 T C 2: 73,104,858 (GRCm39) S471P possibly damaging Het
Sspo A T 6: 48,436,549 (GRCm39) S1270C probably damaging Het
Stk11 A T 10: 79,962,094 (GRCm39) T83S probably benign Het
Syt13 A G 2: 92,783,897 (GRCm39) E389G probably benign Het
Taf10 T C 7: 105,390,139 (GRCm39) probably benign Het
Tgm1 A T 14: 55,937,705 (GRCm39) S801R possibly damaging Het
Thoc2l A T 5: 104,665,942 (GRCm39) T155S probably damaging Het
Timeless T C 10: 128,083,047 (GRCm39) F628L possibly damaging Het
Tmem171 G T 13: 98,824,956 (GRCm39) P225T probably damaging Het
Tspan12 A T 6: 21,835,458 (GRCm39) C72S possibly damaging Het
Txk T C 5: 72,853,964 (GRCm39) T458A probably benign Het
Txndc9 A G 1: 38,026,704 (GRCm39) probably benign Het
Uap1 C A 1: 169,971,000 (GRCm39) C464F probably damaging Het
Ugt2b36 A T 5: 87,240,087 (GRCm39) Y99* probably null Het
Usp35 T C 7: 96,975,134 (GRCm39) Y13C probably damaging Het
Vmn1r6 T G 6: 56,979,789 (GRCm39) N128K probably damaging Het
Vmn2r106 T A 17: 20,497,788 (GRCm39) I484L probably benign Het
Zdbf2 T A 1: 63,347,092 (GRCm39) S1824T probably benign Het
Zdhhc4 A G 5: 143,311,915 (GRCm39) V19A probably benign Het
Zfp955b C T 17: 33,524,095 (GRCm39) probably benign Het
Zfp97 T A 17: 17,365,472 (GRCm39) C324S probably damaging Het
Zswim8 G A 14: 20,766,122 (GRCm39) D803N probably damaging Het
Other mutations in Ms4a20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02142:Ms4a20 APN 19 11,087,695 (GRCm39) nonsense probably null
IGL02182:Ms4a20 APN 19 11,074,436 (GRCm39) splice site probably benign
IGL03156:Ms4a20 APN 19 11,083,114 (GRCm39) missense possibly damaging 0.80
R0189:Ms4a20 UTSW 19 11,074,311 (GRCm39) missense possibly damaging 0.46
R0218:Ms4a20 UTSW 19 11,093,801 (GRCm39) nonsense probably null
R0464:Ms4a20 UTSW 19 11,089,801 (GRCm39) missense probably damaging 1.00
R0617:Ms4a20 UTSW 19 11,089,764 (GRCm39) missense probably damaging 1.00
R1171:Ms4a20 UTSW 19 11,089,741 (GRCm39) missense probably damaging 0.97
R2341:Ms4a20 UTSW 19 11,083,157 (GRCm39) missense probably benign
R5099:Ms4a20 UTSW 19 11,089,825 (GRCm39) critical splice acceptor site probably null
R5330:Ms4a20 UTSW 19 11,069,222 (GRCm39) unclassified probably benign
R5331:Ms4a20 UTSW 19 11,069,222 (GRCm39) unclassified probably benign
R6109:Ms4a20 UTSW 19 11,079,276 (GRCm39) missense possibly damaging 0.66
R6177:Ms4a20 UTSW 19 11,083,114 (GRCm39) missense possibly damaging 0.53
R6970:Ms4a20 UTSW 19 11,089,678 (GRCm39) critical splice donor site probably null
R7038:Ms4a20 UTSW 19 11,087,675 (GRCm39) missense probably benign
R7584:Ms4a20 UTSW 19 11,087,725 (GRCm39) missense possibly damaging 0.94
R7752:Ms4a20 UTSW 19 11,079,224 (GRCm39) missense probably benign 0.02
R7854:Ms4a20 UTSW 19 11,089,741 (GRCm39) missense probably benign 0.01
R8261:Ms4a20 UTSW 19 11,087,707 (GRCm39) missense probably damaging 0.97
R8723:Ms4a20 UTSW 19 11,083,055 (GRCm39) missense probably damaging 0.99
R9027:Ms4a20 UTSW 19 11,083,055 (GRCm39) missense probably damaging 0.99
R9264:Ms4a20 UTSW 19 11,093,830 (GRCm39) start codon destroyed probably benign 0.14
X0019:Ms4a20 UTSW 19 11,083,156 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGAAGCTTTCTCACTCCCC -3'
(R):5'- GTTGATCGCATGAATGACCATC -3'

Sequencing Primer
(F):5'- CCCTTCCAAGTCTCAGAATCATC -3'
(R):5'- CTCAGGGATAGTCTAGACATC -3'
Posted On 2016-08-04