Incidental Mutation 'R5344:Or10j27'
ID 422468
Institutional Source Beutler Lab
Gene Symbol Or10j27
Ensembl Gene ENSMUSG00000062527
Gene Name olfactory receptor family 10 subfamily J member 27
Synonyms MOR267-4, GA_x6K02T2R7CC-715776-716708, Olfr1408
MMRRC Submission 042923-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R5344 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 172957767-172964901 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 172958673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 37 (L37P)
Ref Sequence ENSEMBL: ENSMUSP00000143864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073663] [ENSMUST00000200689]
AlphaFold Q8VG32
Predicted Effect probably benign
Transcript: ENSMUST00000073663
AA Change: L37P

PolyPhen 2 Score 0.159 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000073345
Gene: ENSMUSG00000062527
AA Change: L37P

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-55 PFAM
Pfam:7tm_1 41 289 9.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000200689
AA Change: L37P

PolyPhen 2 Score 0.159 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000143864
Gene: ENSMUSG00000062527
AA Change: L37P

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-55 PFAM
Pfam:7tm_1 41 289 9.4e-19 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T G 12: 71,289,801 (GRCm39) C1499G probably benign Het
Aldoart1 A G 4: 72,770,352 (GRCm39) V152A possibly damaging Het
Alms1 T C 6: 85,673,771 (GRCm39) L3591P probably benign Het
Ankrd12 A T 17: 66,356,843 (GRCm39) M58K probably damaging Het
Asb3 A C 11: 31,051,114 (GRCm39) I523L probably benign Het
Ascl2 T C 7: 142,522,436 (GRCm39) H4R possibly damaging Het
Asic2 T C 11: 80,862,413 (GRCm39) M246V probably damaging Het
Btc A T 5: 91,524,779 (GRCm39) C53S possibly damaging Het
Cdhr5 T C 7: 140,856,437 (GRCm39) I39M probably damaging Het
Cdkn3 T A 14: 47,004,807 (GRCm39) M123K possibly damaging Het
Cebpz A G 17: 79,233,542 (GRCm39) Y762H possibly damaging Het
Ces1g T A 8: 94,063,821 (GRCm39) probably benign Het
Cfap44 T C 16: 44,236,763 (GRCm39) probably null Het
Chd7 G T 4: 8,844,417 (GRCm39) G1537W probably damaging Het
Clca3a2 A T 3: 144,793,703 (GRCm39) D317E probably damaging Het
Clec3a C A 8: 115,149,712 (GRCm39) N56K probably damaging Het
Col11a1 T A 3: 114,002,011 (GRCm39) probably null Het
Cox20 G A 1: 178,149,598 (GRCm39) probably benign Het
Cyp2d22 A G 15: 82,255,839 (GRCm39) V471A possibly damaging Het
D630045J12Rik A G 6: 38,135,163 (GRCm39) V1339A probably damaging Het
Duox2 T C 2: 122,112,352 (GRCm39) D1278G probably benign Het
Epc1 G A 18: 6,450,614 (GRCm39) P284L probably benign Het
Evi5l G T 8: 4,235,990 (GRCm39) R61L possibly damaging Het
Fbln2 T C 6: 91,243,365 (GRCm39) Y914H probably damaging Het
Fbxo44 A G 4: 148,238,030 (GRCm39) S191P probably damaging Het
Fign A G 2: 63,809,569 (GRCm39) I567T probably benign Het
Fryl C T 5: 73,262,117 (GRCm39) R550K probably damaging Het
Gpcpd1 G A 2: 132,400,597 (GRCm39) probably benign Het
Hectd4 T C 5: 121,481,739 (GRCm39) I3096T probably benign Het
Hic2 T A 16: 17,075,712 (GRCm39) D180E probably benign Het
Ibtk A G 9: 85,617,057 (GRCm39) F172L possibly damaging Het
Itga1 A G 13: 115,138,845 (GRCm39) S369P possibly damaging Het
Itgb4 G A 11: 115,880,575 (GRCm39) R675Q probably null Het
Lrrc3b T C 14: 15,358,591 (GRCm38) D5G probably damaging Het
Maml3 T A 3: 52,011,146 (GRCm39) D140V probably damaging Het
Med21 A G 6: 146,550,683 (GRCm39) T65A probably benign Het
Mta1 T C 12: 113,095,186 (GRCm39) probably benign Het
Mybpc1 T C 10: 88,406,430 (GRCm39) D152G probably damaging Het
Oas1b C A 5: 120,960,269 (GRCm39) Q325K probably benign Het
Or2n1c C A 17: 38,519,995 (GRCm39) N286K probably damaging Het
Or5d44 A C 2: 88,141,334 (GRCm39) C269G probably benign Het
Pclo A G 5: 14,726,626 (GRCm39) probably benign Het
Phactr2 C T 10: 13,129,360 (GRCm39) V233I possibly damaging Het
Plekha2 A T 8: 25,533,063 (GRCm39) probably null Het
Reg3b A G 6: 78,349,843 (GRCm39) M128V probably benign Het
Rnaseh2a A G 8: 85,684,735 (GRCm39) probably benign Het
Scn5a T C 9: 119,363,073 (GRCm39) S516G probably benign Het
Serpina12 T A 12: 104,001,807 (GRCm39) probably null Het
Slc10a1 T C 12: 81,000,540 (GRCm39) T320A possibly damaging Het
Slc26a7 A T 4: 14,519,402 (GRCm39) D539E probably benign Het
Specc1l C A 10: 75,082,007 (GRCm39) R485S possibly damaging Het
Srp54b T G 12: 55,302,366 (GRCm39) I339S probably damaging Het
Tada1 G A 1: 166,207,081 (GRCm39) probably benign Het
Trim16 T C 11: 62,711,751 (GRCm39) C54R probably damaging Het
Trio C T 15: 27,735,618 (GRCm39) R2824Q probably benign Het
Ttpa A G 4: 20,021,245 (GRCm39) I138V probably damaging Het
Ubap2 A C 4: 41,251,578 (GRCm39) M18R possibly damaging Het
Usp38 A G 8: 81,712,392 (GRCm39) S548P possibly damaging Het
Vmn2r73 T C 7: 85,525,046 (GRCm39) D34G probably benign Het
Vps13d T A 4: 144,904,904 (GRCm39) H74L probably damaging Het
Zfp408 C T 2: 91,475,588 (GRCm39) C622Y probably benign Het
Zfp616 T C 11: 73,975,321 (GRCm39) I530T possibly damaging Het
Zfp9 C A 6: 118,442,140 (GRCm39) C174F probably damaging Het
Zfyve16 A G 13: 92,658,096 (GRCm39) I605T possibly damaging Het
Zmym5 T C 14: 57,031,519 (GRCm39) T530A probably damaging Het
Other mutations in Or10j27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Or10j27 APN 1 172,957,978 (GRCm39) nonsense probably null
IGL01371:Or10j27 APN 1 172,958,098 (GRCm39) missense possibly damaging 0.67
IGL01816:Or10j27 APN 1 172,957,840 (GRCm39) utr 3 prime probably benign
IGL02543:Or10j27 APN 1 172,957,901 (GRCm39) missense probably damaging 0.99
IGL03104:Or10j27 APN 1 172,958,526 (GRCm39) missense probably benign 0.00
IGL03183:Or10j27 APN 1 172,958,425 (GRCm39) missense probably damaging 0.97
R0940:Or10j27 UTSW 1 172,958,020 (GRCm39) missense probably benign 0.42
R1835:Or10j27 UTSW 1 172,958,382 (GRCm39) missense probably benign 0.00
R1993:Or10j27 UTSW 1 172,958,418 (GRCm39) missense possibly damaging 0.65
R1994:Or10j27 UTSW 1 172,958,418 (GRCm39) missense possibly damaging 0.65
R4438:Or10j27 UTSW 1 172,957,869 (GRCm39) missense probably benign 0.02
R4948:Or10j27 UTSW 1 172,958,526 (GRCm39) missense probably benign 0.00
R5088:Or10j27 UTSW 1 172,958,606 (GRCm39) missense probably damaging 1.00
R5117:Or10j27 UTSW 1 172,958,484 (GRCm39) missense possibly damaging 0.91
R5118:Or10j27 UTSW 1 172,958,484 (GRCm39) missense possibly damaging 0.91
R8176:Or10j27 UTSW 1 172,958,383 (GRCm39) missense probably benign 0.00
X0018:Or10j27 UTSW 1 172,958,266 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGGAGATGGTTTGGCTCAGAC -3'
(R):5'- GAACTAAGTCTCTGCTGTACTCAATG -3'

Sequencing Primer
(F):5'- TGGTTTGGCTCAGACCCACAAG -3'
(R):5'- CTACAGTGTACTCAGGGTCAGGATC -3'
Posted On 2016-08-04