Incidental Mutation 'R5344:Ces1g'
ID 422503
Institutional Source Beutler Lab
Gene Symbol Ces1g
Ensembl Gene ENSMUSG00000057074
Gene Name carboxylesterase 1G
Synonyms Ses-1, Ces-1, Ces1
MMRRC Submission 042923-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5344 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 94028997-94063837 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to A at 94063821 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000037555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044602]
AlphaFold Q8VCC2
Predicted Effect probably benign
Transcript: ENSMUST00000044602
SMART Domains Protein: ENSMUSP00000037555
Gene: ENSMUSG00000057074

DomainStartEndE-ValueType
Pfam:COesterase 1 545 3.6e-168 PFAM
Pfam:Abhydrolase_3 136 295 5.7e-11 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T G 12: 71,289,801 (GRCm39) C1499G probably benign Het
Aldoart1 A G 4: 72,770,352 (GRCm39) V152A possibly damaging Het
Alms1 T C 6: 85,673,771 (GRCm39) L3591P probably benign Het
Ankrd12 A T 17: 66,356,843 (GRCm39) M58K probably damaging Het
Asb3 A C 11: 31,051,114 (GRCm39) I523L probably benign Het
Ascl2 T C 7: 142,522,436 (GRCm39) H4R possibly damaging Het
Asic2 T C 11: 80,862,413 (GRCm39) M246V probably damaging Het
Btc A T 5: 91,524,779 (GRCm39) C53S possibly damaging Het
Cdhr5 T C 7: 140,856,437 (GRCm39) I39M probably damaging Het
Cdkn3 T A 14: 47,004,807 (GRCm39) M123K possibly damaging Het
Cebpz A G 17: 79,233,542 (GRCm39) Y762H possibly damaging Het
Cfap44 T C 16: 44,236,763 (GRCm39) probably null Het
Chd7 G T 4: 8,844,417 (GRCm39) G1537W probably damaging Het
Clca3a2 A T 3: 144,793,703 (GRCm39) D317E probably damaging Het
Clec3a C A 8: 115,149,712 (GRCm39) N56K probably damaging Het
Col11a1 T A 3: 114,002,011 (GRCm39) probably null Het
Cox20 G A 1: 178,149,598 (GRCm39) probably benign Het
Cyp2d22 A G 15: 82,255,839 (GRCm39) V471A possibly damaging Het
D630045J12Rik A G 6: 38,135,163 (GRCm39) V1339A probably damaging Het
Duox2 T C 2: 122,112,352 (GRCm39) D1278G probably benign Het
Epc1 G A 18: 6,450,614 (GRCm39) P284L probably benign Het
Evi5l G T 8: 4,235,990 (GRCm39) R61L possibly damaging Het
Fbln2 T C 6: 91,243,365 (GRCm39) Y914H probably damaging Het
Fbxo44 A G 4: 148,238,030 (GRCm39) S191P probably damaging Het
Fign A G 2: 63,809,569 (GRCm39) I567T probably benign Het
Fryl C T 5: 73,262,117 (GRCm39) R550K probably damaging Het
Gpcpd1 G A 2: 132,400,597 (GRCm39) probably benign Het
Hectd4 T C 5: 121,481,739 (GRCm39) I3096T probably benign Het
Hic2 T A 16: 17,075,712 (GRCm39) D180E probably benign Het
Ibtk A G 9: 85,617,057 (GRCm39) F172L possibly damaging Het
Itga1 A G 13: 115,138,845 (GRCm39) S369P possibly damaging Het
Itgb4 G A 11: 115,880,575 (GRCm39) R675Q probably null Het
Lrrc3b T C 14: 15,358,591 (GRCm38) D5G probably damaging Het
Maml3 T A 3: 52,011,146 (GRCm39) D140V probably damaging Het
Med21 A G 6: 146,550,683 (GRCm39) T65A probably benign Het
Mta1 T C 12: 113,095,186 (GRCm39) probably benign Het
Mybpc1 T C 10: 88,406,430 (GRCm39) D152G probably damaging Het
Oas1b C A 5: 120,960,269 (GRCm39) Q325K probably benign Het
Or10j27 A G 1: 172,958,673 (GRCm39) L37P probably benign Het
Or2n1c C A 17: 38,519,995 (GRCm39) N286K probably damaging Het
Or5d44 A C 2: 88,141,334 (GRCm39) C269G probably benign Het
Pclo A G 5: 14,726,626 (GRCm39) probably benign Het
Phactr2 C T 10: 13,129,360 (GRCm39) V233I possibly damaging Het
Plekha2 A T 8: 25,533,063 (GRCm39) probably null Het
Reg3b A G 6: 78,349,843 (GRCm39) M128V probably benign Het
Rnaseh2a A G 8: 85,684,735 (GRCm39) probably benign Het
Scn5a T C 9: 119,363,073 (GRCm39) S516G probably benign Het
Serpina12 T A 12: 104,001,807 (GRCm39) probably null Het
Slc10a1 T C 12: 81,000,540 (GRCm39) T320A possibly damaging Het
Slc26a7 A T 4: 14,519,402 (GRCm39) D539E probably benign Het
Specc1l C A 10: 75,082,007 (GRCm39) R485S possibly damaging Het
Srp54b T G 12: 55,302,366 (GRCm39) I339S probably damaging Het
Tada1 G A 1: 166,207,081 (GRCm39) probably benign Het
Trim16 T C 11: 62,711,751 (GRCm39) C54R probably damaging Het
Trio C T 15: 27,735,618 (GRCm39) R2824Q probably benign Het
Ttpa A G 4: 20,021,245 (GRCm39) I138V probably damaging Het
Ubap2 A C 4: 41,251,578 (GRCm39) M18R possibly damaging Het
Usp38 A G 8: 81,712,392 (GRCm39) S548P possibly damaging Het
Vmn2r73 T C 7: 85,525,046 (GRCm39) D34G probably benign Het
Vps13d T A 4: 144,904,904 (GRCm39) H74L probably damaging Het
Zfp408 C T 2: 91,475,588 (GRCm39) C622Y probably benign Het
Zfp616 T C 11: 73,975,321 (GRCm39) I530T possibly damaging Het
Zfp9 C A 6: 118,442,140 (GRCm39) C174F probably damaging Het
Zfyve16 A G 13: 92,658,096 (GRCm39) I605T possibly damaging Het
Zmym5 T C 14: 57,031,519 (GRCm39) T530A probably damaging Het
Other mutations in Ces1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Ces1g APN 8 94,029,615 (GRCm39) missense possibly damaging 0.61
IGL00971:Ces1g APN 8 94,029,660 (GRCm39) missense probably damaging 1.00
IGL01583:Ces1g APN 8 94,033,587 (GRCm39) missense probably damaging 1.00
IGL02993:Ces1g APN 8 94,043,707 (GRCm39) missense probably benign 0.00
IGL03386:Ces1g APN 8 94,052,440 (GRCm39) missense probably benign 0.00
R0359:Ces1g UTSW 8 94,055,163 (GRCm39) splice site probably benign
R0373:Ces1g UTSW 8 94,057,821 (GRCm39) missense probably benign 0.06
R0499:Ces1g UTSW 8 94,060,317 (GRCm39) missense probably benign 0.01
R0689:Ces1g UTSW 8 94,055,035 (GRCm39) missense probably damaging 1.00
R1756:Ces1g UTSW 8 94,033,582 (GRCm39) missense probably benign 0.03
R3052:Ces1g UTSW 8 94,061,676 (GRCm39) missense possibly damaging 0.50
R3150:Ces1g UTSW 8 94,052,444 (GRCm39) missense probably benign 0.45
R3899:Ces1g UTSW 8 94,029,678 (GRCm39) missense probably damaging 1.00
R3966:Ces1g UTSW 8 94,055,139 (GRCm39) missense possibly damaging 0.50
R4134:Ces1g UTSW 8 94,046,500 (GRCm39) missense probably benign 0.00
R4198:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.11
R4332:Ces1g UTSW 8 94,046,446 (GRCm39) missense probably benign 0.01
R4719:Ces1g UTSW 8 94,043,718 (GRCm39) missense possibly damaging 0.59
R4841:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4842:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4843:Ces1g UTSW 8 94,057,893 (GRCm39) missense probably damaging 1.00
R5405:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.29
R5425:Ces1g UTSW 8 94,052,428 (GRCm39) missense probably benign 0.20
R5884:Ces1g UTSW 8 94,033,558 (GRCm39) missense probably benign 0.24
R6022:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R6183:Ces1g UTSW 8 94,057,867 (GRCm39) missense possibly damaging 0.48
R6197:Ces1g UTSW 8 94,063,764 (GRCm39) missense probably benign 0.01
R6307:Ces1g UTSW 8 94,057,820 (GRCm39) missense possibly damaging 0.60
R6688:Ces1g UTSW 8 94,033,600 (GRCm39) missense possibly damaging 0.92
R6863:Ces1g UTSW 8 94,043,647 (GRCm39) missense possibly damaging 0.92
R7097:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7122:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7180:Ces1g UTSW 8 94,029,576 (GRCm39) missense probably benign 0.04
R7202:Ces1g UTSW 8 94,029,595 (GRCm39) missense probably benign 0.01
R7361:Ces1g UTSW 8 94,060,307 (GRCm39) missense not run
R7537:Ces1g UTSW 8 94,046,455 (GRCm39) missense probably benign 0.01
R7621:Ces1g UTSW 8 94,055,094 (GRCm39) missense probably damaging 1.00
R8200:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R8895:Ces1g UTSW 8 94,046,512 (GRCm39) missense possibly damaging 0.83
R9248:Ces1g UTSW 8 94,060,319 (GRCm39) missense possibly damaging 0.62
R9290:Ces1g UTSW 8 94,029,545 (GRCm39) missense probably benign 0.07
R9324:Ces1g UTSW 8 94,055,118 (GRCm39) missense probably damaging 1.00
R9361:Ces1g UTSW 8 94,061,646 (GRCm39) critical splice donor site probably null
R9565:Ces1g UTSW 8 94,061,792 (GRCm39) missense probably benign 0.06
R9615:Ces1g UTSW 8 94,061,807 (GRCm39) missense probably damaging 1.00
Z1176:Ces1g UTSW 8 94,052,439 (GRCm39) missense probably benign 0.02
Predicted Primers
Posted On 2016-08-04