Incidental Mutation 'R5345:Cdc25b'
ID 422544
Institutional Source Beutler Lab
Gene Symbol Cdc25b
Ensembl Gene ENSMUSG00000027330
Gene Name cell division cycle 25B
Synonyms
MMRRC Submission 042924-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5345 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 131028869-131040417 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 131034516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 222 (S222G)
Ref Sequence ENSEMBL: ENSMUSP00000078784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028804] [ENSMUST00000079857]
AlphaFold P30306
Predicted Effect probably benign
Transcript: ENSMUST00000028804
AA Change: S248G

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000028804
Gene: ENSMUSG00000027330
AA Change: S248G

DomainStartEndE-ValueType
low complexity region 86 105 N/A INTRINSIC
Pfam:M-inducer_phosp 111 379 3.3e-103 PFAM
RHOD 417 531 4.29e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079857
AA Change: S222G

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000078784
Gene: ENSMUSG00000027330
AA Change: S222G

DomainStartEndE-ValueType
low complexity region 86 105 N/A INTRINSIC
Pfam:M-inducer_phosp 111 354 2.4e-78 PFAM
RHOD 391 505 4.29e-26 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125423
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132727
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138669
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141732
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145556
Meta Mutation Damage Score 0.1659 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 96.0%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
PHENOTYPE: The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 T A 2: 31,687,059 (GRCm39) S519T probably damaging Het
Acap2 A G 16: 30,926,944 (GRCm39) S524P probably benign Het
Acot1 T A 12: 84,063,942 (GRCm39) I350N probably damaging Het
Adam8 A G 7: 139,567,552 (GRCm39) V397A probably benign Het
Ankar A G 1: 72,709,310 (GRCm39) M735T possibly damaging Het
Cacna1c A G 6: 118,633,497 (GRCm39) probably null Het
Celsr3 T C 9: 108,709,323 (GRCm39) S1390P probably damaging Het
Clca4a T G 3: 144,676,222 (GRCm39) D104A probably damaging Het
Clcn6 A T 4: 148,123,206 (GRCm39) probably benign Het
Coq8b A G 7: 26,949,773 (GRCm39) T320A probably benign Het
Cspg5 A T 9: 110,075,698 (GRCm39) M145L probably benign Het
Cyp2c67 T A 19: 39,614,676 (GRCm39) I284F probably benign Het
Eya4 T C 10: 22,985,947 (GRCm39) I565V probably benign Het
Fbxw11 A G 11: 32,688,471 (GRCm39) N410S probably damaging Het
Gabrb2 C T 11: 42,517,636 (GRCm39) A448V possibly damaging Het
Hectd4 A G 5: 121,402,037 (GRCm39) D375G possibly damaging Het
Itsn2 T C 12: 4,722,783 (GRCm39) V1073A probably damaging Het
Kif5c A G 2: 49,613,078 (GRCm39) T139A probably benign Het
L1td1 G A 4: 98,624,684 (GRCm39) G293D probably damaging Het
Lama1 A G 17: 68,124,558 (GRCm39) M2873V probably benign Het
Msantd5f6 A T 4: 73,319,514 (GRCm39) W77R probably damaging Het
Myo15a A G 11: 60,388,364 (GRCm39) R1960G probably damaging Het
Nbeal1 T C 1: 60,367,369 (GRCm39) probably null Het
Ndufb4 A G 16: 37,474,540 (GRCm39) probably null Het
Nup153 A T 13: 46,840,341 (GRCm39) L1089* probably null Het
Or10g3 G A 14: 52,609,725 (GRCm39) R262* probably null Het
Or2l13b T A 16: 19,349,527 (GRCm39) I48F probably damaging Het
Or5aq1b A G 2: 86,901,836 (GRCm39) V214A possibly damaging Het
P2rx1 A G 11: 72,900,056 (GRCm39) T158A probably damaging Het
Park7 A G 4: 150,992,880 (GRCm39) probably benign Het
Parl A T 16: 20,116,892 (GRCm39) F102I probably damaging Het
Plxnc1 T A 10: 94,685,831 (GRCm39) H720L probably benign Het
Ptpn4 A G 1: 119,693,207 (GRCm39) S140P probably benign Het
Rel A G 11: 23,692,462 (GRCm39) S524P probably benign Het
Ripply2 A G 9: 86,901,779 (GRCm39) probably null Het
Rmc1 C T 18: 12,312,234 (GRCm39) T158M probably benign Het
Rps4l-ps T C 7: 114,526,433 (GRCm39) noncoding transcript Het
Rtn4ip1 T C 10: 43,808,466 (GRCm39) L81P probably damaging Het
Sap130 T C 18: 31,781,251 (GRCm39) L138P probably benign Het
Scp2 A T 4: 107,912,776 (GRCm39) probably null Het
Sec24c T A 14: 20,743,288 (GRCm39) M970K probably benign Het
Setd5 C T 6: 113,092,968 (GRCm39) P340L probably damaging Het
Sgcg A T 14: 61,483,218 (GRCm39) M61K probably damaging Het
Slc22a27 C G 19: 7,843,303 (GRCm39) A359P probably damaging Het
Slc34a1 A G 13: 55,548,331 (GRCm39) R21G probably benign Het
Slc7a14 A C 3: 31,278,006 (GRCm39) L533W probably damaging Het
Srsf9 A G 5: 115,468,595 (GRCm39) D77G probably benign Het
Tab1 A T 15: 80,034,014 (GRCm39) E119V possibly damaging Het
Tcstv5 A T 13: 120,411,384 (GRCm39) V74E probably damaging Het
Tnrc6c C T 11: 117,614,113 (GRCm39) A757V possibly damaging Het
Tradd A T 8: 105,986,556 (GRCm39) I72N probably damaging Het
Trbv12-1 C T 6: 41,090,781 (GRCm39) T51M probably benign Het
Tsga10 T C 1: 37,802,392 (GRCm39) K605E probably damaging Het
Vwc2l A G 1: 70,768,077 (GRCm39) D47G probably damaging Het
Zfp647 T A 15: 76,795,695 (GRCm39) T322S possibly damaging Het
Zscan20 A C 4: 128,481,914 (GRCm39) S583A probably benign Het
Other mutations in Cdc25b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03230:Cdc25b APN 2 131,030,060 (GRCm39) missense probably benign 0.00
R0471:Cdc25b UTSW 2 131,039,204 (GRCm39) missense probably damaging 0.99
R0639:Cdc25b UTSW 2 131,039,182 (GRCm39) missense probably benign 0.00
R0645:Cdc25b UTSW 2 131,033,533 (GRCm39) missense probably benign 0.06
R0673:Cdc25b UTSW 2 131,039,182 (GRCm39) missense probably benign 0.00
R1574:Cdc25b UTSW 2 131,033,057 (GRCm39) splice site probably benign
R4094:Cdc25b UTSW 2 131,031,037 (GRCm39) missense probably benign
R4433:Cdc25b UTSW 2 131,033,618 (GRCm39) missense probably benign 0.02
R4722:Cdc25b UTSW 2 131,035,271 (GRCm39) missense probably damaging 1.00
R4817:Cdc25b UTSW 2 131,035,223 (GRCm39) missense probably damaging 1.00
R4957:Cdc25b UTSW 2 131,035,525 (GRCm39) missense possibly damaging 0.80
R5407:Cdc25b UTSW 2 131,035,567 (GRCm39) missense probably damaging 1.00
R5562:Cdc25b UTSW 2 131,036,678 (GRCm39) missense probably damaging 1.00
R5594:Cdc25b UTSW 2 131,033,538 (GRCm39) missense probably damaging 1.00
R5792:Cdc25b UTSW 2 131,033,679 (GRCm39) missense probably damaging 1.00
R5831:Cdc25b UTSW 2 131,029,301 (GRCm39) critical splice donor site probably null
R7204:Cdc25b UTSW 2 131,033,552 (GRCm39) missense probably damaging 1.00
R7292:Cdc25b UTSW 2 131,033,093 (GRCm39) missense probably damaging 1.00
R7399:Cdc25b UTSW 2 131,036,574 (GRCm39) missense probably damaging 1.00
R7501:Cdc25b UTSW 2 131,036,080 (GRCm39) missense probably damaging 1.00
R7772:Cdc25b UTSW 2 131,031,029 (GRCm39) missense probably damaging 1.00
R8186:Cdc25b UTSW 2 131,031,050 (GRCm39) missense probably benign 0.05
R8783:Cdc25b UTSW 2 131,033,772 (GRCm39) missense probably benign 0.05
R8985:Cdc25b UTSW 2 131,035,180 (GRCm39) missense probably damaging 1.00
R9141:Cdc25b UTSW 2 131,033,857 (GRCm39) critical splice donor site probably null
R9153:Cdc25b UTSW 2 131,034,564 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- AACTCTGGGGAGAGGTGGT -3'
(R):5'- TCAAATTCTTCTGGCATTGGGGTA -3'

Sequencing Primer
(F):5'- CACTTTGGAGTTCAAGGCCAG -3'
(R):5'- AAGGTTGTAGTCTTGCTGATTGTC -3'
Posted On 2016-08-04