Incidental Mutation 'R5348:Olfml2b'
ID 422717
Institutional Source Beutler Lab
Gene Symbol Olfml2b
Ensembl Gene ENSMUSG00000038463
Gene Name olfactomedin-like 2B
Synonyms 4832415H08Rik, 1110018N05Rik, photomedin-2
MMRRC Submission 042927-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5348 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 170472101-170510356 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 170489995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 205 (E205G)
Ref Sequence ENSEMBL: ENSMUSP00000047291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046792]
AlphaFold Q3V1G4
Predicted Effect probably benign
Transcript: ENSMUST00000046792
AA Change: E205G

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000047291
Gene: ENSMUSG00000038463
AA Change: E205G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
coiled coil region 41 68 N/A INTRINSIC
coiled coil region 179 213 N/A INTRINSIC
low complexity region 233 238 N/A INTRINSIC
Blast:OLF 254 306 1e-6 BLAST
low complexity region 308 319 N/A INTRINSIC
low complexity region 343 382 N/A INTRINSIC
OLF 492 746 4.76e-61 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 A T 17: 84,978,634 (GRCm39) C275S possibly damaging Het
Bltp1 A G 3: 37,102,295 (GRCm39) E1331G probably damaging Het
Cdk12 T A 11: 98,095,118 (GRCm39) S309T probably benign Het
Cep295nl T C 11: 118,224,425 (GRCm39) R140G probably damaging Het
Chd8 A G 14: 52,470,155 (GRCm39) V485A probably damaging Het
Chn2 A G 6: 54,277,203 (GRCm39) I279V probably damaging Het
Cux2 A G 5: 122,004,041 (GRCm39) S1032P probably damaging Het
Ddx55 T A 5: 124,692,628 (GRCm39) M44K probably damaging Het
Dpyd T A 3: 118,575,592 (GRCm39) H143Q probably benign Het
Fbxo10 A G 4: 45,058,934 (GRCm39) W268R probably damaging Het
Gmfg A G 7: 28,145,819 (GRCm39) D86G probably benign Het
Gpd1 T C 15: 99,620,021 (GRCm39) V273A possibly damaging Het
Grhpr T C 4: 44,985,393 (GRCm39) I158T probably damaging Het
Itpr2 A G 6: 146,378,191 (GRCm39) F53L possibly damaging Het
Kctd21 A G 7: 96,997,177 (GRCm39) I217V probably benign Het
Lrfn2 A G 17: 49,403,718 (GRCm39) T614A probably benign Het
Lrrc7 T A 3: 157,880,963 (GRCm39) D491V probably benign Het
Myo7b T C 18: 32,116,972 (GRCm39) E916G probably damaging Het
Nf1 C T 11: 79,455,725 (GRCm39) T550I probably damaging Het
Nsd1 A G 13: 55,460,147 (GRCm39) T2125A probably benign Het
Or8k37 A T 2: 86,469,150 (GRCm39) L301I probably benign Het
Papolb T C 5: 142,514,972 (GRCm39) T224A possibly damaging Het
Pcnx2 T C 8: 126,545,495 (GRCm39) E1172G probably damaging Het
Ppip5k2 A G 1: 97,675,317 (GRCm39) L362S possibly damaging Het
Ppp1r9b T A 11: 94,887,438 (GRCm39) Y59* probably null Het
Pramel12 T C 4: 143,143,351 (GRCm39) L39P probably damaging Het
Rapgef5 T A 12: 117,652,346 (GRCm39) S76R probably benign Het
Rnh1 A T 7: 140,743,321 (GRCm39) V218D probably damaging Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Slc4a7 G T 14: 14,786,310 (GRCm38) V999L probably benign Het
Slco4c1 A T 1: 96,770,254 (GRCm39) I270N probably damaging Het
Tdp1 A G 12: 99,881,765 (GRCm39) Y498C probably damaging Het
Tfip11 A G 5: 112,483,534 (GRCm39) S650G probably benign Het
Ttn T C 2: 76,608,638 (GRCm39) T17793A possibly damaging Het
Ulk2 T C 11: 61,674,439 (GRCm39) T856A probably benign Het
Vps13d C T 4: 144,792,459 (GRCm39) G3726E probably damaging Het
Other mutations in Olfml2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Olfml2b APN 1 170,496,635 (GRCm39) missense probably damaging 0.96
IGL01871:Olfml2b APN 1 170,489,924 (GRCm39) splice site probably benign
IGL02475:Olfml2b APN 1 170,509,743 (GRCm39) missense probably damaging 1.00
IGL02657:Olfml2b APN 1 170,508,645 (GRCm39) missense probably benign 0.00
IGL03375:Olfml2b APN 1 170,477,401 (GRCm39) missense probably benign 0.35
PIT4280001:Olfml2b UTSW 1 170,475,305 (GRCm39) missense probably damaging 1.00
R0040:Olfml2b UTSW 1 170,496,320 (GRCm39) missense probably benign 0.00
R0194:Olfml2b UTSW 1 170,508,684 (GRCm39) missense possibly damaging 0.89
R0834:Olfml2b UTSW 1 170,475,413 (GRCm39) missense probably benign 0.00
R1218:Olfml2b UTSW 1 170,477,351 (GRCm39) missense probably damaging 1.00
R1386:Olfml2b UTSW 1 170,508,731 (GRCm39) missense probably damaging 0.97
R1420:Olfml2b UTSW 1 170,496,596 (GRCm39) missense probably benign 0.01
R1699:Olfml2b UTSW 1 170,472,642 (GRCm39) missense possibly damaging 0.89
R1730:Olfml2b UTSW 1 170,509,358 (GRCm39) missense probably damaging 1.00
R1755:Olfml2b UTSW 1 170,509,346 (GRCm39) missense probably damaging 1.00
R1869:Olfml2b UTSW 1 170,496,812 (GRCm39) missense probably damaging 0.96
R2295:Olfml2b UTSW 1 170,490,107 (GRCm39) splice site probably benign
R2394:Olfml2b UTSW 1 170,477,319 (GRCm39) missense possibly damaging 0.82
R3784:Olfml2b UTSW 1 170,509,551 (GRCm39) missense probably damaging 0.96
R4523:Olfml2b UTSW 1 170,496,791 (GRCm39) missense probably benign
R4611:Olfml2b UTSW 1 170,472,516 (GRCm39) missense probably damaging 0.99
R4900:Olfml2b UTSW 1 170,489,947 (GRCm39) missense probably damaging 1.00
R5201:Olfml2b UTSW 1 170,496,433 (GRCm39) missense probably benign
R5245:Olfml2b UTSW 1 170,496,443 (GRCm39) missense probably benign
R5268:Olfml2b UTSW 1 170,477,330 (GRCm39) missense probably damaging 1.00
R5283:Olfml2b UTSW 1 170,508,758 (GRCm39) nonsense probably null
R5408:Olfml2b UTSW 1 170,472,545 (GRCm39) missense probably damaging 1.00
R5673:Olfml2b UTSW 1 170,509,698 (GRCm39) missense probably damaging 1.00
R5758:Olfml2b UTSW 1 170,496,833 (GRCm39) critical splice donor site probably null
R5893:Olfml2b UTSW 1 170,490,042 (GRCm39) missense probably benign
R6290:Olfml2b UTSW 1 170,477,359 (GRCm39) nonsense probably null
R6380:Olfml2b UTSW 1 170,496,800 (GRCm39) missense probably benign 0.00
R6778:Olfml2b UTSW 1 170,472,639 (GRCm39) missense probably damaging 1.00
R7155:Olfml2b UTSW 1 170,494,354 (GRCm39) missense probably benign 0.01
R7538:Olfml2b UTSW 1 170,477,402 (GRCm39) missense possibly damaging 0.79
R8354:Olfml2b UTSW 1 170,509,793 (GRCm39) missense possibly damaging 0.96
R8377:Olfml2b UTSW 1 170,496,353 (GRCm39) missense probably damaging 0.99
R8792:Olfml2b UTSW 1 170,508,669 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- GCAAATCTCCATGCTCCAAG -3'
(R):5'- GACACAGAACTGAGACCCTG -3'

Sequencing Primer
(F):5'- TGCTCCAAGCCACCCTG -3'
(R):5'- AGAACTGAGACCCTGGCCTTG -3'
Posted On 2016-08-04