Incidental Mutation 'R5362:Or4l15'
ID 422894
Institutional Source Beutler Lab
Gene Symbol Or4l15
Ensembl Gene ENSMUSG00000096254
Gene Name olfactory receptor family 4 subfamily L member 15
Synonyms MOR247-2, Olfr724, GA_x6K02T2PMLR-5645801-5644872
MMRRC Submission 043264-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.220) question?
Stock # R5362 (G1)
Quality Score 152
Status Not validated
Chromosome 14
Chromosomal Location 50197548-50198553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50197986 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 181 (L181P)
Ref Sequence ENSEMBL: ENSMUSP00000149110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075030] [ENSMUST00000213390]
AlphaFold K7N5X7
Predicted Effect possibly damaging
Transcript: ENSMUST00000075030
AA Change: L181P

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000074546
Gene: ENSMUSG00000096254
AA Change: L181P

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 1.3e-42 PFAM
Pfam:7TM_GPCR_Srsx 34 302 3e-11 PFAM
Pfam:7tm_1 41 287 5.3e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213390
AA Change: L181P

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5530400C23Rik A T 6: 133,271,445 (GRCm39) D163V probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Ankrd17 G A 5: 90,413,404 (GRCm39) A1170V probably damaging Het
Ano1 A C 7: 144,202,337 (GRCm39) probably benign Het
Atl2 T C 17: 80,168,890 (GRCm39) N37D probably damaging Het
C2cd5 T C 6: 143,028,969 (GRCm39) Y90C probably damaging Het
Carm1 A G 9: 21,498,655 (GRCm39) N499S probably benign Het
Ccdc47 G A 11: 106,099,039 (GRCm39) probably null Het
Cd300lf G T 11: 115,007,940 (GRCm39) L251M probably damaging Het
Cfap74 A G 4: 155,522,623 (GRCm39) S670G probably damaging Het
Clec4a1 A G 6: 122,909,196 (GRCm39) D188G probably damaging Het
Col4a1 T C 8: 11,295,760 (GRCm39) probably benign Het
Csn2 T A 5: 87,842,508 (GRCm39) H165L probably benign Het
Cstdc1 G T 2: 148,625,298 (GRCm39) L77F probably damaging Het
Dlx3 T C 11: 95,011,326 (GRCm39) V60A possibly damaging Het
Elp1 A C 4: 56,778,969 (GRCm39) I616S probably damaging Het
Fam221a A G 6: 49,353,049 (GRCm39) H21R probably damaging Het
Foxj3 T A 4: 119,477,340 (GRCm39) H349Q unknown Het
Gm37240 G A 3: 84,423,000 (GRCm39) T123I probably damaging Het
Gpc1 A T 1: 92,782,615 (GRCm39) T121S probably benign Het
Insyn2b G A 11: 34,352,788 (GRCm39) E277K probably damaging Het
Itga2b A G 11: 102,351,961 (GRCm39) V512A probably damaging Het
Itgae A G 11: 73,002,675 (GRCm39) Y144C probably damaging Het
Izumo3 A T 4: 92,035,037 (GRCm39) I60K possibly damaging Het
Kif9 G A 9: 110,319,012 (GRCm39) V159M probably damaging Het
Lrp1b T C 2: 41,265,914 (GRCm39) D229G probably damaging Het
Nkpd1 G A 7: 19,257,193 (GRCm39) G324D probably damaging Het
Nrp2 T A 1: 62,808,221 (GRCm39) Y617N probably benign Het
Ocm T C 5: 143,960,674 (GRCm39) D91G probably damaging Het
Or52ad1 A G 7: 102,995,454 (GRCm39) V227A probably damaging Het
Or52n2b A G 7: 104,565,834 (GRCm39) I223T probably damaging Het
Or6c70 T C 10: 129,710,422 (GRCm39) E68G probably damaging Het
Pex5l G A 3: 33,047,065 (GRCm39) A295V probably damaging Het
Plekhg4 T A 8: 106,108,030 (GRCm39) V1029E possibly damaging Het
Pou2f2 G A 7: 24,792,320 (GRCm39) P512S probably benign Het
Prpf8 G A 11: 75,397,236 (GRCm39) R2023Q possibly damaging Het
Ptprd A T 4: 76,047,050 (GRCm39) S399R probably damaging Het
Qrich2 T C 11: 116,337,976 (GRCm39) Y1889C probably damaging Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Ranbp6 G T 19: 29,789,128 (GRCm39) T408K probably benign Het
Scn7a G A 2: 66,530,342 (GRCm39) R668C probably damaging Het
Sertad4 T C 1: 192,529,414 (GRCm39) N134S probably damaging Het
Spg11 G T 2: 121,891,481 (GRCm39) N1963K probably damaging Het
Svil C T 18: 5,057,345 (GRCm39) P598S probably damaging Het
Top2a T C 11: 98,909,738 (GRCm39) N120S probably damaging Het
Trappc9 C T 15: 72,930,066 (GRCm39) E97K possibly damaging Het
Vmn1r91 A T 7: 19,835,386 (GRCm39) T102S probably benign Het
Vmn2r99 G T 17: 19,599,601 (GRCm39) M428I probably benign Het
Zfp62 A T 11: 49,107,439 (GRCm39) H510L probably damaging Het
Other mutations in Or4l15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02811:Or4l15 APN 14 50,197,590 (GRCm39) utr 3 prime probably benign
R0829:Or4l15 UTSW 14 50,198,503 (GRCm39) missense probably benign 0.03
R1513:Or4l15 UTSW 14 50,198,558 (GRCm39) critical splice acceptor site probably null
R2016:Or4l15 UTSW 14 50,197,959 (GRCm39) missense probably benign 0.00
R2936:Or4l15 UTSW 14 50,197,611 (GRCm39) missense probably benign 0.03
R3082:Or4l15 UTSW 14 50,198,161 (GRCm39) missense probably damaging 1.00
R3738:Or4l15 UTSW 14 50,198,013 (GRCm39) missense possibly damaging 0.60
R4772:Or4l15 UTSW 14 50,198,452 (GRCm39) small deletion probably benign
R4830:Or4l15 UTSW 14 50,197,681 (GRCm39) missense probably damaging 1.00
R4839:Or4l15 UTSW 14 50,197,646 (GRCm39) missense probably benign 0.41
R5695:Or4l15 UTSW 14 50,198,080 (GRCm39) missense probably benign 0.00
R6187:Or4l15 UTSW 14 50,198,526 (GRCm39) start codon destroyed probably null 0.99
R7371:Or4l15 UTSW 14 50,198,563 (GRCm39) splice site probably null
R7611:Or4l15 UTSW 14 50,198,368 (GRCm39) missense probably benign 0.03
R9243:Or4l15 UTSW 14 50,197,881 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TCCCAAATGGCCAGGCATAG -3'
(R):5'- GTGGCCATATGCAAACCTTTG -3'

Sequencing Primer
(F):5'- CAGACAATGTGGACAGCGCC -3'
(R):5'- CCTTTGCACTACAGGATAATCATGAG -3'
Posted On 2016-08-04