Incidental Mutation 'R0486:Glipr1'
ID 42294
Institutional Source Beutler Lab
Gene Symbol Glipr1
Ensembl Gene ENSMUSG00000056888
Gene Name GLI pathogenesis related 1
Synonyms mRTVP-1, RTVP-1, RTVP1, 2410114O14Rik
MMRRC Submission 038685-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R0486 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 111821353-111838536 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 111832754 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000123990 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074805] [ENSMUST00000161870] [ENSMUST00000162508]
AlphaFold Q9CWG1
Predicted Effect probably benign
Transcript: ENSMUST00000074805
SMART Domains Protein: ENSMUSP00000074359
Gene: ENSMUSG00000056888

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
SCP 32 172 4.04e-55 SMART
transmembrane domain 222 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159550
Predicted Effect probably benign
Transcript: ENSMUST00000161870
SMART Domains Protein: ENSMUSP00000134094
Gene: ENSMUSG00000056888

DomainStartEndE-ValueType
Pfam:CAP 1 42 9.2e-10 PFAM
low complexity region 82 93 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162508
SMART Domains Protein: ENSMUSP00000123990
Gene: ENSMUSG00000056888

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
SCP 32 172 4.04e-55 SMART
transmembrane domain 222 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174201
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted inactivation of this gene renders mice more vulnerable to spontaneous tumorigenesis, leading to the formation of a wide spectrum of tumors and significantly shorter tumor-free survival times. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco1 T C 4: 40,177,783 (GRCm39) L268P probably damaging Het
Adam22 A T 5: 8,380,048 (GRCm39) H83Q probably damaging Het
Anln T C 9: 22,264,122 (GRCm39) D886G probably benign Het
Arhgef11 T A 3: 87,596,159 (GRCm39) probably null Het
Ark2c T A 18: 77,571,950 (GRCm39) Q91L probably damaging Het
Arl8b A T 6: 108,792,287 (GRCm39) D116V possibly damaging Het
BC051665 C T 13: 60,931,859 (GRCm39) G180D probably damaging Het
Bloc1s2 A G 19: 44,131,589 (GRCm39) probably benign Het
Ccdc185 T G 1: 182,575,424 (GRCm39) S422R possibly damaging Het
Cd101 T C 3: 100,915,408 (GRCm39) K720E possibly damaging Het
Cdh23 C A 10: 60,222,725 (GRCm39) A1236S probably damaging Het
Chd1 G A 17: 15,954,604 (GRCm39) A491T probably damaging Het
Chdh T C 14: 29,754,815 (GRCm39) V275A possibly damaging Het
Cmtm2b A T 8: 105,057,047 (GRCm39) I136F probably damaging Het
Cps1 T C 1: 67,204,551 (GRCm39) V457A probably damaging Het
Cwf19l1 A G 19: 44,103,129 (GRCm39) V362A probably benign Het
Cyp4f17 T C 17: 32,743,797 (GRCm39) probably benign Het
Cyp4f18 C A 8: 72,749,861 (GRCm39) V263L probably benign Het
Dclre1a A G 19: 56,529,922 (GRCm39) probably benign Het
Dpp6 T C 5: 27,866,640 (GRCm39) I446T probably benign Het
F11r T C 1: 171,288,156 (GRCm39) W61R probably damaging Het
Fam120b C T 17: 15,646,550 (GRCm39) probably benign Het
Fastkd2 T C 1: 63,791,499 (GRCm39) V669A possibly damaging Het
Foxg1 T C 12: 49,431,314 (GRCm39) probably benign Het
Foxo3 A G 10: 42,073,477 (GRCm39) Y347H probably damaging Het
G3bp1 T C 11: 55,389,452 (GRCm39) F383L probably damaging Het
Gbp7 C A 3: 142,252,078 (GRCm39) probably benign Het
Gm11555 A G 11: 99,540,986 (GRCm39) S8P unknown Het
H6pd G A 4: 150,067,393 (GRCm39) probably benign Het
Haus8 C A 8: 71,709,181 (GRCm39) G76W probably damaging Het
Haus8 C T 8: 71,709,182 (GRCm39) M75I probably benign Het
Kcnj13 C A 1: 87,314,752 (GRCm39) V157L probably damaging Het
Kcnt2 T A 1: 140,437,218 (GRCm39) C550* probably null Het
Kdm5d A G Y: 927,107 (GRCm39) N615S probably damaging Het
Naip2 A C 13: 100,298,290 (GRCm39) I582S probably benign Het
Ncapd2 G A 6: 125,160,990 (GRCm39) R292* probably null Het
Ngef T A 1: 87,406,848 (GRCm39) N640I probably damaging Het
Nhlrc3 T C 3: 53,359,858 (GRCm39) Y335C probably damaging Het
Nipbl A T 15: 8,368,354 (GRCm39) probably benign Het
Nop2 A G 6: 125,117,636 (GRCm39) K434R probably null Het
Nr4a3 T C 4: 48,056,525 (GRCm39) probably benign Het
Or8b35 A G 9: 37,903,998 (GRCm39) N70S possibly damaging Het
Piezo2 A C 18: 63,162,132 (GRCm39) I2233R probably damaging Het
Prag1 A T 8: 36,613,787 (GRCm39) E1113V probably damaging Het
Prpsap2 A G 11: 61,631,826 (GRCm39) I177T possibly damaging Het
Psmd1 T A 1: 86,022,012 (GRCm39) N611K probably damaging Het
Ptpn7 C T 1: 135,065,096 (GRCm39) T168I probably damaging Het
Pus1 A T 5: 110,927,596 (GRCm39) V53E probably damaging Het
Rgs22 A G 15: 36,093,028 (GRCm39) M415T probably damaging Het
Rnf17 C T 14: 56,751,632 (GRCm39) T1490M probably benign Het
Rnf20 C A 4: 49,645,907 (GRCm39) L332I possibly damaging Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Spam1 A T 6: 24,796,394 (GRCm39) Q115L probably damaging Het
Syce1l A T 8: 114,381,395 (GRCm39) probably null Het
Synj1 T C 16: 90,735,151 (GRCm39) probably benign Het
Tas2r126 A T 6: 42,412,225 (GRCm39) I253F probably benign Het
Tecpr2 G A 12: 110,862,803 (GRCm39) V72I probably benign Het
Tfap2a G T 13: 40,882,170 (GRCm39) P45Q probably damaging Het
Trip12 C A 1: 84,738,805 (GRCm39) G714* probably null Het
Wdr31 A G 4: 62,372,130 (GRCm39) S330P probably damaging Het
Wdr64 T C 1: 175,622,769 (GRCm39) probably benign Het
Yes1 T A 5: 32,812,926 (GRCm39) Y343* probably null Het
Other mutations in Glipr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Glipr1 APN 10 111,821,555 (GRCm39) missense probably benign
IGL00553:Glipr1 APN 10 111,822,574 (GRCm39) missense possibly damaging 0.79
IGL02391:Glipr1 APN 10 111,824,799 (GRCm39) unclassified probably benign
R0115:Glipr1 UTSW 10 111,829,446 (GRCm39) missense probably benign 0.00
R1349:Glipr1 UTSW 10 111,829,437 (GRCm39) missense probably benign 0.02
R1822:Glipr1 UTSW 10 111,832,765 (GRCm39) missense possibly damaging 0.84
R4364:Glipr1 UTSW 10 111,821,542 (GRCm39) missense possibly damaging 0.84
R4905:Glipr1 UTSW 10 111,821,545 (GRCm39) missense probably damaging 1.00
R4974:Glipr1 UTSW 10 111,829,411 (GRCm39) nonsense probably null
R5734:Glipr1 UTSW 10 111,821,698 (GRCm39) nonsense probably null
R7603:Glipr1 UTSW 10 111,824,737 (GRCm39) missense probably benign 0.07
R8238:Glipr1 UTSW 10 111,829,345 (GRCm39) critical splice donor site probably null
R9489:Glipr1 UTSW 10 111,832,801 (GRCm39) missense probably damaging 1.00
R9605:Glipr1 UTSW 10 111,832,801 (GRCm39) missense probably damaging 1.00
Z1176:Glipr1 UTSW 10 111,824,742 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- TATTGCTCAAGACAGTCGGGGAAGG -3'
(R):5'- GATTCTAGGTCCAGCAGCAACCAG -3'

Sequencing Primer
(F):5'- TCGGGGAAGGTAACGGTC -3'
(R):5'- GAGAGACCATGCAGGTCATCC -3'
Posted On 2013-05-23