Incidental Mutation 'R5364:Cdc42bpa'
| ID |
422967 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cdc42bpa
|
| Ensembl Gene |
ENSMUSG00000026490 |
| Gene Name |
CDC42 binding protein kinase alpha |
| Synonyms |
DMPK-like, A930014J19Rik |
| MMRRC Submission |
042942-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.834)
|
| Stock # |
R5364 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
179788037-179993168 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 179894747 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 309
(D309G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106746
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076687]
[ENSMUST00000097450]
[ENSMUST00000097453]
[ENSMUST00000111117]
[ENSMUST00000134959]
[ENSMUST00000212756]
|
| AlphaFold |
Q3UU96 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076687
AA Change: D309G
PolyPhen 2
Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000075980
Gene: ENSMUSG00000026490
AA Change: D309G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
588 |
N/A |
INTRINSIC |
|
coiled coil region
|
632 |
735 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
800 |
860 |
2.7e-29 |
PFAM |
|
C1
|
919 |
968 |
4.09e-7 |
SMART |
|
PH
|
989 |
1109 |
6.02e-8 |
SMART |
|
CNH
|
1134 |
1411 |
3.37e-17 |
SMART |
|
low complexity region
|
1456 |
1468 |
N/A |
INTRINSIC |
|
PBD
|
1477 |
1512 |
2.05e-10 |
SMART |
|
low complexity region
|
1531 |
1546 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1580 |
N/A |
INTRINSIC |
|
low complexity region
|
1606 |
1620 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097450
AA Change: D309G
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000095059
Gene: ENSMUSG00000026490
AA Change: D309G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.2e-29 |
PFAM |
|
C1
|
1000 |
1049 |
4.09e-7 |
SMART |
|
PH
|
1070 |
1190 |
6.02e-8 |
SMART |
|
CNH
|
1215 |
1492 |
3.37e-17 |
SMART |
|
low complexity region
|
1537 |
1549 |
N/A |
INTRINSIC |
|
PBD
|
1558 |
1593 |
2.05e-10 |
SMART |
|
low complexity region
|
1612 |
1627 |
N/A |
INTRINSIC |
|
low complexity region
|
1648 |
1661 |
N/A |
INTRINSIC |
|
low complexity region
|
1687 |
1701 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097453
AA Change: D309G
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000095062
Gene: ENSMUSG00000026490
AA Change: D309G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.5e-29 |
PFAM |
|
C1
|
972 |
1021 |
4.09e-7 |
SMART |
|
PH
|
1042 |
1162 |
6.02e-8 |
SMART |
|
CNH
|
1187 |
1464 |
3.37e-17 |
SMART |
|
low complexity region
|
1509 |
1521 |
N/A |
INTRINSIC |
|
PBD
|
1530 |
1565 |
2.05e-10 |
SMART |
|
low complexity region
|
1584 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1620 |
1633 |
N/A |
INTRINSIC |
|
low complexity region
|
1659 |
1673 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111117
AA Change: D309G
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000106746
Gene: ENSMUSG00000026490
AA Change: D309G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
low complexity region
|
484 |
499 |
N/A |
INTRINSIC |
|
Pfam:KELK
|
529 |
608 |
1.1e-32 |
PFAM |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.6e-29 |
PFAM |
|
C1
|
1013 |
1062 |
4.09e-7 |
SMART |
|
PH
|
1083 |
1203 |
6.02e-8 |
SMART |
|
CNH
|
1228 |
1505 |
3.37e-17 |
SMART |
|
low complexity region
|
1550 |
1562 |
N/A |
INTRINSIC |
|
PBD
|
1571 |
1606 |
2.05e-10 |
SMART |
|
low complexity region
|
1625 |
1640 |
N/A |
INTRINSIC |
|
low complexity region
|
1661 |
1674 |
N/A |
INTRINSIC |
|
low complexity region
|
1700 |
1714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134959
|
| SMART Domains |
Protein: ENSMUSP00000142018
Gene: ENSMUSG00000026490
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4AW2|A
|
2 |
90 |
1e-58 |
PDB |
|
SCOP:d1koba_
|
50 |
90 |
7e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212756
AA Change: D309G
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| Meta Mutation Damage Score |
0.2396 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.3%
|
| Validation Efficiency |
100% (102/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
C |
G |
7: 27,278,192 (GRCm39) |
T242R |
probably damaging |
Het |
| Abcc10 |
G |
A |
17: 46,616,577 (GRCm39) |
R1205C |
probably benign |
Het |
| Acer1 |
A |
G |
17: 57,289,000 (GRCm39) |
F37L |
probably damaging |
Het |
| Acp7 |
C |
A |
7: 28,310,448 (GRCm39) |
G463V |
probably benign |
Het |
| Actr2 |
A |
T |
11: 20,050,797 (GRCm39) |
|
probably benign |
Het |
| Adam15 |
A |
T |
3: 89,252,902 (GRCm39) |
I272K |
probably damaging |
Het |
| Adam1b |
T |
A |
5: 121,638,946 (GRCm39) |
I700F |
possibly damaging |
Het |
| Adam33 |
A |
G |
2: 130,896,392 (GRCm39) |
|
probably null |
Het |
| Ano1 |
T |
C |
7: 144,190,941 (GRCm39) |
Y380C |
probably damaging |
Het |
| Arfgap3 |
A |
C |
15: 83,198,562 (GRCm39) |
M307R |
probably damaging |
Het |
| Arhgap21 |
T |
A |
2: 20,854,533 (GRCm39) |
R1610W |
probably damaging |
Het |
| Bbs2 |
A |
G |
8: 94,801,023 (GRCm39) |
Y603H |
probably benign |
Het |
| Bbs9 |
G |
T |
9: 22,486,492 (GRCm39) |
|
probably null |
Het |
| Bcar3 |
A |
C |
3: 122,323,281 (GRCm39) |
M779L |
probably benign |
Het |
| Bub3 |
A |
T |
7: 131,162,467 (GRCm39) |
N10I |
possibly damaging |
Het |
| Cacna1c |
T |
G |
6: 118,633,504 (GRCm39) |
E1098D |
probably benign |
Het |
| Cacna1g |
T |
A |
11: 94,307,684 (GRCm39) |
M1738L |
probably benign |
Het |
| Camk2d |
G |
T |
3: 126,574,069 (GRCm39) |
G159C |
probably damaging |
Het |
| Ccdc51 |
A |
T |
9: 108,921,188 (GRCm39) |
E358D |
possibly damaging |
Het |
| Cdhr3 |
A |
T |
12: 33,101,007 (GRCm39) |
F468I |
possibly damaging |
Het |
| Chrd |
A |
G |
16: 20,551,898 (GRCm39) |
M1V |
probably null |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Dcdc2b |
T |
C |
4: 129,502,963 (GRCm39) |
Y253C |
probably damaging |
Het |
| Dclk1 |
A |
C |
3: 55,163,366 (GRCm39) |
N153H |
possibly damaging |
Het |
| Dgkg |
G |
T |
16: 22,419,211 (GRCm39) |
S96R |
probably benign |
Het |
| Dnah9 |
A |
G |
11: 65,772,522 (GRCm39) |
Y3737H |
possibly damaging |
Het |
| Elovl4 |
A |
T |
9: 83,672,076 (GRCm39) |
I81N |
probably benign |
Het |
| Epha7 |
T |
A |
4: 28,950,557 (GRCm39) |
Y791N |
probably damaging |
Het |
| Fam193a |
C |
A |
5: 34,623,597 (GRCm39) |
T1395N |
probably benign |
Het |
| Fbln5 |
A |
T |
12: 101,737,623 (GRCm39) |
V141E |
probably damaging |
Het |
| Flii |
T |
C |
11: 60,610,954 (GRCm39) |
T492A |
probably benign |
Het |
| Fnip2 |
A |
G |
3: 79,388,475 (GRCm39) |
I752T |
probably benign |
Het |
| Fpr3 |
T |
C |
17: 18,190,806 (GRCm39) |
W26R |
probably benign |
Het |
| Gabrb1 |
A |
T |
5: 72,294,105 (GRCm39) |
T460S |
probably benign |
Het |
| Gde1 |
T |
C |
7: 118,297,874 (GRCm39) |
N4S |
probably benign |
Het |
| Ghitm |
G |
T |
14: 36,847,156 (GRCm39) |
T306K |
probably benign |
Het |
| Ghitm |
A |
T |
14: 36,847,174 (GRCm39) |
I300N |
probably damaging |
Het |
| Gm4787 |
G |
C |
12: 81,424,604 (GRCm39) |
T518S |
probably benign |
Het |
| Iqcd |
T |
C |
5: 120,738,332 (GRCm39) |
I50T |
probably damaging |
Het |
| Itpripl1 |
G |
A |
2: 126,983,739 (GRCm39) |
P128S |
possibly damaging |
Het |
| Jag2 |
C |
A |
12: 112,874,154 (GRCm39) |
L1000F |
probably damaging |
Het |
| Klhdc4 |
A |
T |
8: 122,533,375 (GRCm39) |
|
probably benign |
Het |
| Klra5 |
A |
G |
6: 129,876,316 (GRCm39) |
F164L |
probably benign |
Het |
| Larp1b |
A |
G |
3: 40,931,658 (GRCm39) |
Y288C |
probably damaging |
Het |
| Lrfn3 |
T |
A |
7: 30,055,078 (GRCm39) |
E622D |
possibly damaging |
Het |
| Lyst |
A |
G |
13: 13,831,439 (GRCm39) |
D1621G |
probably benign |
Het |
| Mastl |
T |
C |
2: 23,023,665 (GRCm39) |
T353A |
probably benign |
Het |
| Mkln1 |
T |
C |
6: 31,473,647 (GRCm39) |
Y130H |
probably damaging |
Het |
| Mms22l |
T |
A |
4: 24,496,882 (GRCm39) |
|
probably benign |
Het |
| Mroh7 |
T |
A |
4: 106,548,840 (GRCm39) |
M1008L |
probably benign |
Het |
| Nipal1 |
T |
C |
5: 72,825,243 (GRCm39) |
V312A |
probably damaging |
Het |
| Nlrp5 |
T |
A |
7: 23,117,753 (GRCm39) |
Y492* |
probably null |
Het |
| Odad1 |
T |
A |
7: 45,585,756 (GRCm39) |
I105N |
probably damaging |
Het |
| Or1n1 |
T |
C |
2: 36,750,006 (GRCm39) |
Y118C |
probably damaging |
Het |
| Otulinl |
G |
A |
15: 27,660,031 (GRCm39) |
Q24* |
probably null |
Het |
| Pcdhb11 |
T |
A |
18: 37,555,232 (GRCm39) |
D187E |
probably benign |
Het |
| Pcdhb13 |
A |
G |
18: 37,576,561 (GRCm39) |
Y313C |
probably damaging |
Het |
| Pdpn |
G |
A |
4: 143,000,526 (GRCm39) |
T102I |
possibly damaging |
Het |
| Pear1 |
A |
T |
3: 87,665,668 (GRCm39) |
C120S |
probably damaging |
Het |
| Peg10 |
T |
C |
6: 4,756,128 (GRCm39) |
|
probably benign |
Het |
| Ppm1e |
A |
G |
11: 87,128,007 (GRCm39) |
W384R |
probably benign |
Het |
| Ppp1r10 |
C |
T |
17: 36,241,324 (GRCm39) |
P700S |
unknown |
Het |
| Prl2c5 |
G |
A |
13: 13,357,627 (GRCm39) |
R13K |
probably benign |
Het |
| Prmt3 |
C |
A |
7: 49,498,554 (GRCm39) |
P487T |
probably damaging |
Het |
| Proser3 |
C |
A |
7: 30,245,573 (GRCm39) |
A144S |
possibly damaging |
Het |
| Ptcd1 |
G |
A |
5: 145,088,241 (GRCm39) |
T590I |
probably damaging |
Het |
| Rbsn |
A |
G |
6: 92,170,958 (GRCm39) |
V321A |
probably damaging |
Het |
| Slc40a1 |
C |
A |
1: 45,964,383 (GRCm39) |
C14F |
probably damaging |
Het |
| Slc6a15 |
T |
C |
10: 103,229,369 (GRCm39) |
I136T |
probably damaging |
Het |
| Slc7a4 |
A |
G |
16: 17,391,227 (GRCm39) |
I449T |
probably benign |
Het |
| Snrnp48 |
T |
A |
13: 38,394,165 (GRCm39) |
|
probably null |
Het |
| Tada2a |
A |
G |
11: 84,011,973 (GRCm39) |
Y23H |
probably benign |
Het |
| Tbx15 |
A |
T |
3: 99,259,508 (GRCm39) |
S460C |
possibly damaging |
Het |
| Tbx21 |
C |
T |
11: 96,992,304 (GRCm39) |
|
probably null |
Het |
| Tmcc2 |
T |
G |
1: 132,285,534 (GRCm39) |
T376P |
probably damaging |
Het |
| Tmco4 |
G |
A |
4: 138,779,815 (GRCm39) |
C420Y |
probably damaging |
Het |
| Tmem235 |
C |
A |
11: 117,755,020 (GRCm39) |
Y157* |
probably null |
Het |
| Tmem63b |
T |
C |
17: 45,975,653 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf1a |
T |
C |
6: 125,334,356 (GRCm39) |
S92P |
possibly damaging |
Het |
| Top3b |
A |
T |
16: 16,704,834 (GRCm39) |
T397S |
probably benign |
Het |
| Trabd |
C |
A |
15: 88,967,007 (GRCm39) |
|
probably benign |
Het |
| Trbv21 |
A |
T |
6: 41,179,764 (GRCm39) |
I27L |
possibly damaging |
Het |
| Trim3 |
C |
T |
7: 105,268,276 (GRCm39) |
V169M |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,807,458 (GRCm39) |
T92A |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,738,860 (GRCm39) |
S3893N |
probably benign |
Het |
| Uchl4 |
A |
T |
9: 64,142,821 (GRCm39) |
I101F |
possibly damaging |
Het |
| Vmn1r5 |
T |
A |
6: 56,962,583 (GRCm39) |
M86K |
probably damaging |
Het |
| Vmn2r55 |
T |
A |
7: 12,404,830 (GRCm39) |
Q191L |
possibly damaging |
Het |
| Zfp458 |
A |
T |
13: 67,406,012 (GRCm39) |
C139* |
probably null |
Het |
| Zfp788 |
T |
C |
7: 41,299,551 (GRCm39) |
L729P |
probably damaging |
Het |
| Zmym2 |
T |
A |
14: 57,158,102 (GRCm39) |
M547K |
possibly damaging |
Het |
|
| Other mutations in Cdc42bpa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00498:Cdc42bpa
|
APN |
1 |
179,933,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Cdc42bpa
|
APN |
1 |
179,969,018 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL00972:Cdc42bpa
|
APN |
1 |
179,902,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01084:Cdc42bpa
|
APN |
1 |
179,969,839 (GRCm39) |
splice site |
probably benign |
|
|
IGL01149:Cdc42bpa
|
APN |
1 |
179,902,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01377:Cdc42bpa
|
APN |
1 |
179,892,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01541:Cdc42bpa
|
APN |
1 |
179,978,723 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01657:Cdc42bpa
|
APN |
1 |
179,939,431 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01720:Cdc42bpa
|
APN |
1 |
179,938,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02227:Cdc42bpa
|
APN |
1 |
179,921,989 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02234:Cdc42bpa
|
APN |
1 |
179,978,756 (GRCm39) |
nonsense |
probably null |
|
|
IGL02253:Cdc42bpa
|
APN |
1 |
179,859,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL02587:Cdc42bpa
|
APN |
1 |
179,921,510 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02671:Cdc42bpa
|
APN |
1 |
179,889,387 (GRCm39) |
missense |
probably benign |
|
|
IGL02746:Cdc42bpa
|
APN |
1 |
179,939,312 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02756:Cdc42bpa
|
APN |
1 |
179,936,824 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02994:Cdc42bpa
|
APN |
1 |
179,827,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03073:Cdc42bpa
|
APN |
1 |
179,921,941 (GRCm39) |
splice site |
probably benign |
|
|
IGL03295:Cdc42bpa
|
APN |
1 |
179,977,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0022:Cdc42bpa
|
UTSW |
1 |
179,788,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Cdc42bpa
|
UTSW |
1 |
179,859,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0268:Cdc42bpa
|
UTSW |
1 |
179,983,347 (GRCm39) |
intron |
probably benign |
|
|
R0472:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0492:Cdc42bpa
|
UTSW |
1 |
179,928,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0609:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Cdc42bpa
|
UTSW |
1 |
179,972,400 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0738:Cdc42bpa
|
UTSW |
1 |
179,827,027 (GRCm39) |
splice site |
probably benign |
|
|
R1547:Cdc42bpa
|
UTSW |
1 |
179,902,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1553:Cdc42bpa
|
UTSW |
1 |
179,921,540 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1601:Cdc42bpa
|
UTSW |
1 |
179,892,566 (GRCm39) |
nonsense |
probably null |
|
|
R1709:Cdc42bpa
|
UTSW |
1 |
179,894,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Cdc42bpa
|
UTSW |
1 |
179,974,533 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2279:Cdc42bpa
|
UTSW |
1 |
179,864,484 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2357:Cdc42bpa
|
UTSW |
1 |
179,894,792 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2373:Cdc42bpa
|
UTSW |
1 |
179,939,349 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2570:Cdc42bpa
|
UTSW |
1 |
179,977,742 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3709:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3816:Cdc42bpa
|
UTSW |
1 |
179,972,451 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3854:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3855:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3917:Cdc42bpa
|
UTSW |
1 |
179,933,719 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4604:Cdc42bpa
|
UTSW |
1 |
179,936,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4622:Cdc42bpa
|
UTSW |
1 |
179,902,223 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4664:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4665:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4887:Cdc42bpa
|
UTSW |
1 |
179,972,200 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4989:Cdc42bpa
|
UTSW |
1 |
179,965,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Cdc42bpa
|
UTSW |
1 |
179,892,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5050:Cdc42bpa
|
UTSW |
1 |
179,900,018 (GRCm39) |
nonsense |
probably null |
|
|
R5077:Cdc42bpa
|
UTSW |
1 |
179,922,098 (GRCm39) |
intron |
probably benign |
|
|
R5196:Cdc42bpa
|
UTSW |
1 |
179,899,978 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5276:Cdc42bpa
|
UTSW |
1 |
179,965,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5313:Cdc42bpa
|
UTSW |
1 |
179,911,998 (GRCm39) |
missense |
probably benign |
|
|
R5372:Cdc42bpa
|
UTSW |
1 |
179,892,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,966,085 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,894,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Cdc42bpa
|
UTSW |
1 |
179,933,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5713:Cdc42bpa
|
UTSW |
1 |
179,911,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6012:Cdc42bpa
|
UTSW |
1 |
179,892,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Cdc42bpa
|
UTSW |
1 |
179,939,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Cdc42bpa
|
UTSW |
1 |
179,921,561 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6609:Cdc42bpa
|
UTSW |
1 |
179,928,839 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7122:Cdc42bpa
|
UTSW |
1 |
179,892,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7289:Cdc42bpa
|
UTSW |
1 |
179,889,362 (GRCm39) |
nonsense |
probably null |
|
|
R7670:Cdc42bpa
|
UTSW |
1 |
179,892,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7912:Cdc42bpa
|
UTSW |
1 |
179,921,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8139:Cdc42bpa
|
UTSW |
1 |
179,896,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Cdc42bpa
|
UTSW |
1 |
179,989,690 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8378:Cdc42bpa
|
UTSW |
1 |
179,989,709 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8794:Cdc42bpa
|
UTSW |
1 |
179,894,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8835:Cdc42bpa
|
UTSW |
1 |
179,896,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cdc42bpa
|
UTSW |
1 |
179,958,373 (GRCm39) |
intron |
probably benign |
|
|
R9012:Cdc42bpa
|
UTSW |
1 |
179,859,077 (GRCm39) |
missense |
|
|
|
R9110:Cdc42bpa
|
UTSW |
1 |
179,945,258 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9178:Cdc42bpa
|
UTSW |
1 |
179,958,401 (GRCm39) |
missense |
|
|
|
R9184:Cdc42bpa
|
UTSW |
1 |
179,972,301 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9204:Cdc42bpa
|
UTSW |
1 |
179,939,460 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9227:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9230:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9299:Cdc42bpa
|
UTSW |
1 |
179,972,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9366:Cdc42bpa
|
UTSW |
1 |
179,921,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9381:Cdc42bpa
|
UTSW |
1 |
179,969,048 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9461:Cdc42bpa
|
UTSW |
1 |
179,969,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9559:Cdc42bpa
|
UTSW |
1 |
179,939,459 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cdc42bpa
|
UTSW |
1 |
179,892,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAAAGGATTTACGTCCATCATCCC -3'
(R):5'- CGTCATCCACATCAAAATTTGACG -3'
Sequencing Primer
(F):5'- GATTTACGTCCATCATCCCTGTGTC -3'
(R):5'- GACGTATCTGTCGGGCTACTAAC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation