Incidental Mutation 'R5364:Camk2d'
| ID |
422982 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Camk2d
|
| Ensembl Gene |
ENSMUSG00000053819 |
| Gene Name |
calcium/calmodulin-dependent protein kinase II, delta |
| Synonyms |
CaMK II, 8030469K03Rik, 2810011D23Rik |
| MMRRC Submission |
042942-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.204)
|
| Stock # |
R5364 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
126389951-126639975 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 126574069 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Cysteine
at position 159
(G159C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143677
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066466]
[ENSMUST00000106399]
[ENSMUST00000106400]
[ENSMUST00000106401]
[ENSMUST00000106402]
[ENSMUST00000163226]
[ENSMUST00000171289]
[ENSMUST00000199300]
[ENSMUST00000200171]
[ENSMUST00000134466]
[ENSMUST00000145454]
|
| AlphaFold |
Q6PHZ2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000066466
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000063359
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
7.4e-67 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
4.7e-13 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
476 |
3e-12 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106399
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000102007
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
357 |
484 |
3.5e-67 |
PFAM |
|
Pfam:DUF4440
|
361 |
475 |
5.4e-13 |
PFAM |
|
Pfam:SnoaL_3
|
361 |
487 |
3e-12 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106400
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000102008
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
4.7e-67 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
3.2e-13 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
476 |
2.1e-12 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106401
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000102009
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
1.33e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
3.8e-67 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
5.8e-13 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
510 |
3.2e-12 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106402
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000102010
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
1.1e-66 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
8.1e-13 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
510 |
5.3e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129293
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131869
|
| SMART Domains |
Protein: ENSMUSP00000126412
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
109 |
5.1e-26 |
PFAM |
|
Pfam:Pkinase_Tyr
|
3 |
111 |
4.5e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000171950
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163226
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133019
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171289
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129999
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
1.33e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
3.3e-63 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
3.2e-12 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
509 |
8.7e-12 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134987
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000169051
|
| SMART Domains |
Protein: ENSMUSP00000132554
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
6.9e-67 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
4.3e-13 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
476 |
2.8e-12 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000199300
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000143504
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
346 |
473 |
1.3e-62 |
PFAM |
|
Pfam:DUF4440
|
350 |
464 |
1.7e-11 |
PFAM |
|
Pfam:SnoaL_3
|
350 |
475 |
4.6e-11 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200171
AA Change: G159C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000143677
Gene: ENSMUSG00000053819
AA Change: G159C
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
14 |
272 |
9.91e-110 |
SMART |
|
Pfam:CaMKII_AD
|
380 |
507 |
9.8e-63 |
PFAM |
|
Pfam:DUF4440
|
384 |
498 |
2.5e-11 |
PFAM |
|
Pfam:SnoaL_3
|
384 |
509 |
5.7e-11 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147043
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134466
|
| SMART Domains |
Protein: ENSMUSP00000114801
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
14 |
140 |
1e-33 |
PFAM |
|
Pfam:Pkinase_Tyr
|
14 |
141 |
4.8e-16 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145454
|
| SMART Domains |
Protein: ENSMUSP00000130769
Gene: ENSMUSG00000053819
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
14 |
140 |
1.4e-33 |
PFAM |
|
Pfam:Pkinase_Tyr
|
14 |
142 |
4.7e-16 |
PFAM |
|
| Meta Mutation Damage Score |
0.9749 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.3%
|
| Validation Efficiency |
100% (102/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced response to heart induced stress. Mice homozygous for an allele that produces an oxidant-resistant product exhibit reduced response to myocardial infarction in a diabetic model. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
C |
G |
7: 27,278,192 (GRCm39) |
T242R |
probably damaging |
Het |
| Abcc10 |
G |
A |
17: 46,616,577 (GRCm39) |
R1205C |
probably benign |
Het |
| Acer1 |
A |
G |
17: 57,289,000 (GRCm39) |
F37L |
probably damaging |
Het |
| Acp7 |
C |
A |
7: 28,310,448 (GRCm39) |
G463V |
probably benign |
Het |
| Actr2 |
A |
T |
11: 20,050,797 (GRCm39) |
|
probably benign |
Het |
| Adam15 |
A |
T |
3: 89,252,902 (GRCm39) |
I272K |
probably damaging |
Het |
| Adam1b |
T |
A |
5: 121,638,946 (GRCm39) |
I700F |
possibly damaging |
Het |
| Adam33 |
A |
G |
2: 130,896,392 (GRCm39) |
|
probably null |
Het |
| Ano1 |
T |
C |
7: 144,190,941 (GRCm39) |
Y380C |
probably damaging |
Het |
| Arfgap3 |
A |
C |
15: 83,198,562 (GRCm39) |
M307R |
probably damaging |
Het |
| Arhgap21 |
T |
A |
2: 20,854,533 (GRCm39) |
R1610W |
probably damaging |
Het |
| Bbs2 |
A |
G |
8: 94,801,023 (GRCm39) |
Y603H |
probably benign |
Het |
| Bbs9 |
G |
T |
9: 22,486,492 (GRCm39) |
|
probably null |
Het |
| Bcar3 |
A |
C |
3: 122,323,281 (GRCm39) |
M779L |
probably benign |
Het |
| Bub3 |
A |
T |
7: 131,162,467 (GRCm39) |
N10I |
possibly damaging |
Het |
| Cacna1c |
T |
G |
6: 118,633,504 (GRCm39) |
E1098D |
probably benign |
Het |
| Cacna1g |
T |
A |
11: 94,307,684 (GRCm39) |
M1738L |
probably benign |
Het |
| Ccdc51 |
A |
T |
9: 108,921,188 (GRCm39) |
E358D |
possibly damaging |
Het |
| Cdc42bpa |
A |
G |
1: 179,894,747 (GRCm39) |
D309G |
probably benign |
Het |
| Cdhr3 |
A |
T |
12: 33,101,007 (GRCm39) |
F468I |
possibly damaging |
Het |
| Chrd |
A |
G |
16: 20,551,898 (GRCm39) |
M1V |
probably null |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Dcdc2b |
T |
C |
4: 129,502,963 (GRCm39) |
Y253C |
probably damaging |
Het |
| Dclk1 |
A |
C |
3: 55,163,366 (GRCm39) |
N153H |
possibly damaging |
Het |
| Dgkg |
G |
T |
16: 22,419,211 (GRCm39) |
S96R |
probably benign |
Het |
| Dnah9 |
A |
G |
11: 65,772,522 (GRCm39) |
Y3737H |
possibly damaging |
Het |
| Elovl4 |
A |
T |
9: 83,672,076 (GRCm39) |
I81N |
probably benign |
Het |
| Epha7 |
T |
A |
4: 28,950,557 (GRCm39) |
Y791N |
probably damaging |
Het |
| Fam193a |
C |
A |
5: 34,623,597 (GRCm39) |
T1395N |
probably benign |
Het |
| Fbln5 |
A |
T |
12: 101,737,623 (GRCm39) |
V141E |
probably damaging |
Het |
| Flii |
T |
C |
11: 60,610,954 (GRCm39) |
T492A |
probably benign |
Het |
| Fnip2 |
A |
G |
3: 79,388,475 (GRCm39) |
I752T |
probably benign |
Het |
| Fpr3 |
T |
C |
17: 18,190,806 (GRCm39) |
W26R |
probably benign |
Het |
| Gabrb1 |
A |
T |
5: 72,294,105 (GRCm39) |
T460S |
probably benign |
Het |
| Gde1 |
T |
C |
7: 118,297,874 (GRCm39) |
N4S |
probably benign |
Het |
| Ghitm |
G |
T |
14: 36,847,156 (GRCm39) |
T306K |
probably benign |
Het |
| Ghitm |
A |
T |
14: 36,847,174 (GRCm39) |
I300N |
probably damaging |
Het |
| Gm4787 |
G |
C |
12: 81,424,604 (GRCm39) |
T518S |
probably benign |
Het |
| Iqcd |
T |
C |
5: 120,738,332 (GRCm39) |
I50T |
probably damaging |
Het |
| Itpripl1 |
G |
A |
2: 126,983,739 (GRCm39) |
P128S |
possibly damaging |
Het |
| Jag2 |
C |
A |
12: 112,874,154 (GRCm39) |
L1000F |
probably damaging |
Het |
| Klhdc4 |
A |
T |
8: 122,533,375 (GRCm39) |
|
probably benign |
Het |
| Klra5 |
A |
G |
6: 129,876,316 (GRCm39) |
F164L |
probably benign |
Het |
| Larp1b |
A |
G |
3: 40,931,658 (GRCm39) |
Y288C |
probably damaging |
Het |
| Lrfn3 |
T |
A |
7: 30,055,078 (GRCm39) |
E622D |
possibly damaging |
Het |
| Lyst |
A |
G |
13: 13,831,439 (GRCm39) |
D1621G |
probably benign |
Het |
| Mastl |
T |
C |
2: 23,023,665 (GRCm39) |
T353A |
probably benign |
Het |
| Mkln1 |
T |
C |
6: 31,473,647 (GRCm39) |
Y130H |
probably damaging |
Het |
| Mms22l |
T |
A |
4: 24,496,882 (GRCm39) |
|
probably benign |
Het |
| Mroh7 |
T |
A |
4: 106,548,840 (GRCm39) |
M1008L |
probably benign |
Het |
| Nipal1 |
T |
C |
5: 72,825,243 (GRCm39) |
V312A |
probably damaging |
Het |
| Nlrp5 |
T |
A |
7: 23,117,753 (GRCm39) |
Y492* |
probably null |
Het |
| Odad1 |
T |
A |
7: 45,585,756 (GRCm39) |
I105N |
probably damaging |
Het |
| Or1n1 |
T |
C |
2: 36,750,006 (GRCm39) |
Y118C |
probably damaging |
Het |
| Otulinl |
G |
A |
15: 27,660,031 (GRCm39) |
Q24* |
probably null |
Het |
| Pcdhb11 |
T |
A |
18: 37,555,232 (GRCm39) |
D187E |
probably benign |
Het |
| Pcdhb13 |
A |
G |
18: 37,576,561 (GRCm39) |
Y313C |
probably damaging |
Het |
| Pdpn |
G |
A |
4: 143,000,526 (GRCm39) |
T102I |
possibly damaging |
Het |
| Pear1 |
A |
T |
3: 87,665,668 (GRCm39) |
C120S |
probably damaging |
Het |
| Peg10 |
T |
C |
6: 4,756,128 (GRCm39) |
|
probably benign |
Het |
| Ppm1e |
A |
G |
11: 87,128,007 (GRCm39) |
W384R |
probably benign |
Het |
| Ppp1r10 |
C |
T |
17: 36,241,324 (GRCm39) |
P700S |
unknown |
Het |
| Prl2c5 |
G |
A |
13: 13,357,627 (GRCm39) |
R13K |
probably benign |
Het |
| Prmt3 |
C |
A |
7: 49,498,554 (GRCm39) |
P487T |
probably damaging |
Het |
| Proser3 |
C |
A |
7: 30,245,573 (GRCm39) |
A144S |
possibly damaging |
Het |
| Ptcd1 |
G |
A |
5: 145,088,241 (GRCm39) |
T590I |
probably damaging |
Het |
| Rbsn |
A |
G |
6: 92,170,958 (GRCm39) |
V321A |
probably damaging |
Het |
| Slc40a1 |
C |
A |
1: 45,964,383 (GRCm39) |
C14F |
probably damaging |
Het |
| Slc6a15 |
T |
C |
10: 103,229,369 (GRCm39) |
I136T |
probably damaging |
Het |
| Slc7a4 |
A |
G |
16: 17,391,227 (GRCm39) |
I449T |
probably benign |
Het |
| Snrnp48 |
T |
A |
13: 38,394,165 (GRCm39) |
|
probably null |
Het |
| Tada2a |
A |
G |
11: 84,011,973 (GRCm39) |
Y23H |
probably benign |
Het |
| Tbx15 |
A |
T |
3: 99,259,508 (GRCm39) |
S460C |
possibly damaging |
Het |
| Tbx21 |
C |
T |
11: 96,992,304 (GRCm39) |
|
probably null |
Het |
| Tmcc2 |
T |
G |
1: 132,285,534 (GRCm39) |
T376P |
probably damaging |
Het |
| Tmco4 |
G |
A |
4: 138,779,815 (GRCm39) |
C420Y |
probably damaging |
Het |
| Tmem235 |
C |
A |
11: 117,755,020 (GRCm39) |
Y157* |
probably null |
Het |
| Tmem63b |
T |
C |
17: 45,975,653 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf1a |
T |
C |
6: 125,334,356 (GRCm39) |
S92P |
possibly damaging |
Het |
| Top3b |
A |
T |
16: 16,704,834 (GRCm39) |
T397S |
probably benign |
Het |
| Trabd |
C |
A |
15: 88,967,007 (GRCm39) |
|
probably benign |
Het |
| Trbv21 |
A |
T |
6: 41,179,764 (GRCm39) |
I27L |
possibly damaging |
Het |
| Trim3 |
C |
T |
7: 105,268,276 (GRCm39) |
V169M |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,807,458 (GRCm39) |
T92A |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,738,860 (GRCm39) |
S3893N |
probably benign |
Het |
| Uchl4 |
A |
T |
9: 64,142,821 (GRCm39) |
I101F |
possibly damaging |
Het |
| Vmn1r5 |
T |
A |
6: 56,962,583 (GRCm39) |
M86K |
probably damaging |
Het |
| Vmn2r55 |
T |
A |
7: 12,404,830 (GRCm39) |
Q191L |
possibly damaging |
Het |
| Zfp458 |
A |
T |
13: 67,406,012 (GRCm39) |
C139* |
probably null |
Het |
| Zfp788 |
T |
C |
7: 41,299,551 (GRCm39) |
L729P |
probably damaging |
Het |
| Zmym2 |
T |
A |
14: 57,158,102 (GRCm39) |
M547K |
possibly damaging |
Het |
|
| Other mutations in Camk2d |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Camk2d
|
APN |
3 |
126,631,921 (GRCm39) |
nonsense |
probably null |
|
|
IGL01113:Camk2d
|
APN |
3 |
126,574,061 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Camk2d
|
APN |
3 |
126,591,934 (GRCm39) |
splice site |
probably benign |
|
|
IGL01912:Camk2d
|
APN |
3 |
126,604,281 (GRCm39) |
splice site |
probably null |
|
|
IGL01934:Camk2d
|
APN |
3 |
126,628,304 (GRCm39) |
splice site |
probably null |
|
|
IGL02184:Camk2d
|
APN |
3 |
126,591,422 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02218:Camk2d
|
APN |
3 |
126,633,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02804:Camk2d
|
APN |
3 |
126,591,387 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL03347:Camk2d
|
APN |
3 |
126,590,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03354:Camk2d
|
APN |
3 |
126,590,615 (GRCm39) |
splice site |
probably null |
|
|
baryon
|
UTSW |
3 |
126,391,131 (GRCm39) |
nonsense |
probably null |
|
|
Neutron
|
UTSW |
3 |
126,574,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0024:Camk2d
|
UTSW |
3 |
126,591,372 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0024:Camk2d
|
UTSW |
3 |
126,591,372 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0628:Camk2d
|
UTSW |
3 |
126,604,273 (GRCm39) |
splice site |
probably benign |
|
|
R1114:Camk2d
|
UTSW |
3 |
126,633,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1433:Camk2d
|
UTSW |
3 |
126,601,873 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2021:Camk2d
|
UTSW |
3 |
126,574,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2096:Camk2d
|
UTSW |
3 |
126,574,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2098:Camk2d
|
UTSW |
3 |
126,574,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Camk2d
|
UTSW |
3 |
126,574,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2437:Camk2d
|
UTSW |
3 |
126,628,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Camk2d
|
UTSW |
3 |
126,601,880 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3738:Camk2d
|
UTSW |
3 |
126,565,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Camk2d
|
UTSW |
3 |
126,590,608 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4455:Camk2d
|
UTSW |
3 |
126,574,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Camk2d
|
UTSW |
3 |
126,573,646 (GRCm39) |
intron |
probably benign |
|
|
R4916:Camk2d
|
UTSW |
3 |
126,577,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Camk2d
|
UTSW |
3 |
126,478,390 (GRCm39) |
intron |
probably benign |
|
|
R5329:Camk2d
|
UTSW |
3 |
126,391,131 (GRCm39) |
nonsense |
probably null |
|
|
R5473:Camk2d
|
UTSW |
3 |
126,391,048 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R5509:Camk2d
|
UTSW |
3 |
126,633,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5958:Camk2d
|
UTSW |
3 |
126,573,514 (GRCm39) |
intron |
probably benign |
|
|
R6010:Camk2d
|
UTSW |
3 |
126,591,363 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6145:Camk2d
|
UTSW |
3 |
126,599,507 (GRCm39) |
missense |
probably benign |
|
|
R7267:Camk2d
|
UTSW |
3 |
126,591,379 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7708:Camk2d
|
UTSW |
3 |
126,391,089 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R8249:Camk2d
|
UTSW |
3 |
126,591,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8554:Camk2d
|
UTSW |
3 |
126,564,448 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9489:Camk2d
|
UTSW |
3 |
126,561,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9698:Camk2d
|
UTSW |
3 |
126,633,833 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGACAACAGTGCATGAGTTTG -3'
(R):5'- CCAATTTAAGATGGGATCCAGTG -3'
Sequencing Primer
(F):5'- ACAACAGTGCATGAGTTTGCTTCC -3'
(R):5'- GATGGGATCCAGTGTGTTAAAATTAG -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation