Incidental Mutation 'R5364:Abcc10'
| ID |
423057 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcc10
|
| Ensembl Gene |
ENSMUSG00000032842 |
| Gene Name |
ATP-binding cassette, sub-family C member 10 |
| Synonyms |
Mrp7 |
| MMRRC Submission |
042942-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.105)
|
| Stock # |
R5364 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
46614146-46638954 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 46616577 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 1205
(R1205C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092895
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047970]
[ENSMUST00000061722]
[ENSMUST00000095261]
[ENSMUST00000166280]
[ENSMUST00000166617]
[ENSMUST00000167360]
[ENSMUST00000170271]
[ENSMUST00000188223]
[ENSMUST00000171584]
|
| AlphaFold |
Q8R4P9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047970
AA Change: R1246C
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000038041
Gene: ENSMUSG00000032842
AA Change: R1246C
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
28 |
50 |
N/A |
INTRINSIC |
|
transmembrane domain
|
70 |
89 |
N/A |
INTRINSIC |
|
transmembrane domain
|
99 |
121 |
N/A |
INTRINSIC |
|
transmembrane domain
|
134 |
153 |
N/A |
INTRINSIC |
|
transmembrane domain
|
168 |
190 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
286 |
552 |
5.4e-24 |
PFAM |
|
AAA
|
626 |
809 |
5.76e-8 |
SMART |
|
low complexity region
|
841 |
852 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
889 |
1203 |
1.7e-33 |
PFAM |
|
low complexity region
|
1231 |
1245 |
N/A |
INTRINSIC |
|
AAA
|
1281 |
1490 |
3.57e-13 |
SMART |
|
low complexity region
|
1506 |
1517 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061722
|
| SMART Domains |
Protein: ENSMUSP00000058470
Gene: ENSMUSG00000047428
| Domain | Start | End | E-Value | Type |
|---|
|
EGF_like
|
71 |
101 |
3.16e1 |
SMART |
|
EGF
|
102 |
132 |
7.76e-3 |
SMART |
|
EGF
|
137 |
172 |
2.14e-5 |
SMART |
|
EGF
|
177 |
215 |
3.79e-6 |
SMART |
|
EGF_CA
|
217 |
253 |
3.1e-11 |
SMART |
|
EGF_CA
|
255 |
291 |
9.47e-7 |
SMART |
|
transmembrane domain
|
349 |
371 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
394 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095261
AA Change: R1205C
PolyPhen 2
Score 0.251 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000092895
Gene: ENSMUSG00000032842
AA Change: R1205C
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
29 |
48 |
N/A |
INTRINSIC |
|
transmembrane domain
|
58 |
80 |
N/A |
INTRINSIC |
|
transmembrane domain
|
93 |
112 |
N/A |
INTRINSIC |
|
transmembrane domain
|
127 |
149 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
245 |
511 |
2.1e-30 |
PFAM |
|
AAA
|
585 |
768 |
5.76e-8 |
SMART |
|
low complexity region
|
800 |
811 |
N/A |
INTRINSIC |
|
transmembrane domain
|
836 |
858 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
896 |
1162 |
6.9e-26 |
PFAM |
|
low complexity region
|
1190 |
1204 |
N/A |
INTRINSIC |
|
AAA
|
1240 |
1424 |
1.67e-13 |
SMART |
|
low complexity region
|
1440 |
1451 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166280
|
| SMART Domains |
Protein: ENSMUSP00000126993
Gene: ENSMUSG00000047428
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
EGF_like
|
28 |
58 |
3.16e1 |
SMART |
|
EGF
|
59 |
89 |
7.76e-3 |
SMART |
|
EGF
|
94 |
129 |
2.14e-5 |
SMART |
|
EGF
|
134 |
172 |
3.79e-6 |
SMART |
|
EGF_CA
|
174 |
210 |
3.1e-11 |
SMART |
|
EGF_CA
|
212 |
248 |
9.47e-7 |
SMART |
|
transmembrane domain
|
306 |
328 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166617
|
| SMART Domains |
Protein: ENSMUSP00000128897
Gene: ENSMUSG00000047428
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
EGF_like
|
28 |
58 |
3.16e1 |
SMART |
|
EGF
|
59 |
89 |
7.76e-3 |
SMART |
|
EGF
|
94 |
129 |
2.14e-5 |
SMART |
|
EGF
|
134 |
172 |
3.79e-6 |
SMART |
|
EGF_CA
|
174 |
210 |
3.1e-11 |
SMART |
|
EGF_CA
|
212 |
248 |
9.47e-7 |
SMART |
|
transmembrane domain
|
306 |
328 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167360
AA Change: R1246C
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000131843
Gene: ENSMUSG00000032842
AA Change: R1246C
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
28 |
50 |
N/A |
INTRINSIC |
|
transmembrane domain
|
70 |
89 |
N/A |
INTRINSIC |
|
transmembrane domain
|
99 |
121 |
N/A |
INTRINSIC |
|
transmembrane domain
|
134 |
153 |
N/A |
INTRINSIC |
|
transmembrane domain
|
168 |
190 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
286 |
552 |
2.2e-30 |
PFAM |
|
AAA
|
626 |
809 |
5.76e-8 |
SMART |
|
low complexity region
|
841 |
852 |
N/A |
INTRINSIC |
|
transmembrane domain
|
877 |
899 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
937 |
1203 |
7.2e-26 |
PFAM |
|
low complexity region
|
1231 |
1245 |
N/A |
INTRINSIC |
|
AAA
|
1281 |
1465 |
1.67e-13 |
SMART |
|
low complexity region
|
1481 |
1492 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170271
|
| SMART Domains |
Protein: ENSMUSP00000132349
Gene: ENSMUSG00000047428
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
EGF_like
|
28 |
58 |
3.16e1 |
SMART |
|
EGF
|
59 |
89 |
7.76e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188223
|
| SMART Domains |
Protein: ENSMUSP00000141164
Gene: ENSMUSG00000047428
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:hEGF
|
88 |
100 |
7.9e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171584
|
| SMART Domains |
Protein: ENSMUSP00000132561
Gene: ENSMUSG00000032842
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
28 |
50 |
N/A |
INTRINSIC |
|
transmembrane domain
|
70 |
89 |
N/A |
INTRINSIC |
|
transmembrane domain
|
99 |
121 |
N/A |
INTRINSIC |
|
transmembrane domain
|
134 |
153 |
N/A |
INTRINSIC |
|
transmembrane domain
|
168 |
190 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
286 |
462 |
8.3e-18 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.3%
|
| Validation Efficiency |
100% (102/102) |
| MGI Phenotype |
FUNCTION: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homzozygous for a knock-out allele exhibit increased sensitivity to paclitaxel-induced mortality associated with weight loss, decreased white blood cell, and small spleen and thymus cortex due to apoptosis and/or depopulation of lymphoid cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
C |
G |
7: 27,278,192 (GRCm39) |
T242R |
probably damaging |
Het |
| Acer1 |
A |
G |
17: 57,289,000 (GRCm39) |
F37L |
probably damaging |
Het |
| Acp7 |
C |
A |
7: 28,310,448 (GRCm39) |
G463V |
probably benign |
Het |
| Actr2 |
A |
T |
11: 20,050,797 (GRCm39) |
|
probably benign |
Het |
| Adam15 |
A |
T |
3: 89,252,902 (GRCm39) |
I272K |
probably damaging |
Het |
| Adam1b |
T |
A |
5: 121,638,946 (GRCm39) |
I700F |
possibly damaging |
Het |
| Adam33 |
A |
G |
2: 130,896,392 (GRCm39) |
|
probably null |
Het |
| Ano1 |
T |
C |
7: 144,190,941 (GRCm39) |
Y380C |
probably damaging |
Het |
| Arfgap3 |
A |
C |
15: 83,198,562 (GRCm39) |
M307R |
probably damaging |
Het |
| Arhgap21 |
T |
A |
2: 20,854,533 (GRCm39) |
R1610W |
probably damaging |
Het |
| Bbs2 |
A |
G |
8: 94,801,023 (GRCm39) |
Y603H |
probably benign |
Het |
| Bbs9 |
G |
T |
9: 22,486,492 (GRCm39) |
|
probably null |
Het |
| Bcar3 |
A |
C |
3: 122,323,281 (GRCm39) |
M779L |
probably benign |
Het |
| Bub3 |
A |
T |
7: 131,162,467 (GRCm39) |
N10I |
possibly damaging |
Het |
| Cacna1c |
T |
G |
6: 118,633,504 (GRCm39) |
E1098D |
probably benign |
Het |
| Cacna1g |
T |
A |
11: 94,307,684 (GRCm39) |
M1738L |
probably benign |
Het |
| Camk2d |
G |
T |
3: 126,574,069 (GRCm39) |
G159C |
probably damaging |
Het |
| Ccdc51 |
A |
T |
9: 108,921,188 (GRCm39) |
E358D |
possibly damaging |
Het |
| Cdc42bpa |
A |
G |
1: 179,894,747 (GRCm39) |
D309G |
probably benign |
Het |
| Cdhr3 |
A |
T |
12: 33,101,007 (GRCm39) |
F468I |
possibly damaging |
Het |
| Chrd |
A |
G |
16: 20,551,898 (GRCm39) |
M1V |
probably null |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Dcdc2b |
T |
C |
4: 129,502,963 (GRCm39) |
Y253C |
probably damaging |
Het |
| Dclk1 |
A |
C |
3: 55,163,366 (GRCm39) |
N153H |
possibly damaging |
Het |
| Dgkg |
G |
T |
16: 22,419,211 (GRCm39) |
S96R |
probably benign |
Het |
| Dnah9 |
A |
G |
11: 65,772,522 (GRCm39) |
Y3737H |
possibly damaging |
Het |
| Elovl4 |
A |
T |
9: 83,672,076 (GRCm39) |
I81N |
probably benign |
Het |
| Epha7 |
T |
A |
4: 28,950,557 (GRCm39) |
Y791N |
probably damaging |
Het |
| Fam193a |
C |
A |
5: 34,623,597 (GRCm39) |
T1395N |
probably benign |
Het |
| Fbln5 |
A |
T |
12: 101,737,623 (GRCm39) |
V141E |
probably damaging |
Het |
| Flii |
T |
C |
11: 60,610,954 (GRCm39) |
T492A |
probably benign |
Het |
| Fnip2 |
A |
G |
3: 79,388,475 (GRCm39) |
I752T |
probably benign |
Het |
| Fpr3 |
T |
C |
17: 18,190,806 (GRCm39) |
W26R |
probably benign |
Het |
| Gabrb1 |
A |
T |
5: 72,294,105 (GRCm39) |
T460S |
probably benign |
Het |
| Gde1 |
T |
C |
7: 118,297,874 (GRCm39) |
N4S |
probably benign |
Het |
| Ghitm |
G |
T |
14: 36,847,156 (GRCm39) |
T306K |
probably benign |
Het |
| Ghitm |
A |
T |
14: 36,847,174 (GRCm39) |
I300N |
probably damaging |
Het |
| Gm4787 |
G |
C |
12: 81,424,604 (GRCm39) |
T518S |
probably benign |
Het |
| Iqcd |
T |
C |
5: 120,738,332 (GRCm39) |
I50T |
probably damaging |
Het |
| Itpripl1 |
G |
A |
2: 126,983,739 (GRCm39) |
P128S |
possibly damaging |
Het |
| Jag2 |
C |
A |
12: 112,874,154 (GRCm39) |
L1000F |
probably damaging |
Het |
| Klhdc4 |
A |
T |
8: 122,533,375 (GRCm39) |
|
probably benign |
Het |
| Klra5 |
A |
G |
6: 129,876,316 (GRCm39) |
F164L |
probably benign |
Het |
| Larp1b |
A |
G |
3: 40,931,658 (GRCm39) |
Y288C |
probably damaging |
Het |
| Lrfn3 |
T |
A |
7: 30,055,078 (GRCm39) |
E622D |
possibly damaging |
Het |
| Lyst |
A |
G |
13: 13,831,439 (GRCm39) |
D1621G |
probably benign |
Het |
| Mastl |
T |
C |
2: 23,023,665 (GRCm39) |
T353A |
probably benign |
Het |
| Mkln1 |
T |
C |
6: 31,473,647 (GRCm39) |
Y130H |
probably damaging |
Het |
| Mms22l |
T |
A |
4: 24,496,882 (GRCm39) |
|
probably benign |
Het |
| Mroh7 |
T |
A |
4: 106,548,840 (GRCm39) |
M1008L |
probably benign |
Het |
| Nipal1 |
T |
C |
5: 72,825,243 (GRCm39) |
V312A |
probably damaging |
Het |
| Nlrp5 |
T |
A |
7: 23,117,753 (GRCm39) |
Y492* |
probably null |
Het |
| Odad1 |
T |
A |
7: 45,585,756 (GRCm39) |
I105N |
probably damaging |
Het |
| Or1n1 |
T |
C |
2: 36,750,006 (GRCm39) |
Y118C |
probably damaging |
Het |
| Otulinl |
G |
A |
15: 27,660,031 (GRCm39) |
Q24* |
probably null |
Het |
| Pcdhb11 |
T |
A |
18: 37,555,232 (GRCm39) |
D187E |
probably benign |
Het |
| Pcdhb13 |
A |
G |
18: 37,576,561 (GRCm39) |
Y313C |
probably damaging |
Het |
| Pdpn |
G |
A |
4: 143,000,526 (GRCm39) |
T102I |
possibly damaging |
Het |
| Pear1 |
A |
T |
3: 87,665,668 (GRCm39) |
C120S |
probably damaging |
Het |
| Peg10 |
T |
C |
6: 4,756,128 (GRCm39) |
|
probably benign |
Het |
| Ppm1e |
A |
G |
11: 87,128,007 (GRCm39) |
W384R |
probably benign |
Het |
| Ppp1r10 |
C |
T |
17: 36,241,324 (GRCm39) |
P700S |
unknown |
Het |
| Prl2c5 |
G |
A |
13: 13,357,627 (GRCm39) |
R13K |
probably benign |
Het |
| Prmt3 |
C |
A |
7: 49,498,554 (GRCm39) |
P487T |
probably damaging |
Het |
| Proser3 |
C |
A |
7: 30,245,573 (GRCm39) |
A144S |
possibly damaging |
Het |
| Ptcd1 |
G |
A |
5: 145,088,241 (GRCm39) |
T590I |
probably damaging |
Het |
| Rbsn |
A |
G |
6: 92,170,958 (GRCm39) |
V321A |
probably damaging |
Het |
| Slc40a1 |
C |
A |
1: 45,964,383 (GRCm39) |
C14F |
probably damaging |
Het |
| Slc6a15 |
T |
C |
10: 103,229,369 (GRCm39) |
I136T |
probably damaging |
Het |
| Slc7a4 |
A |
G |
16: 17,391,227 (GRCm39) |
I449T |
probably benign |
Het |
| Snrnp48 |
T |
A |
13: 38,394,165 (GRCm39) |
|
probably null |
Het |
| Tada2a |
A |
G |
11: 84,011,973 (GRCm39) |
Y23H |
probably benign |
Het |
| Tbx15 |
A |
T |
3: 99,259,508 (GRCm39) |
S460C |
possibly damaging |
Het |
| Tbx21 |
C |
T |
11: 96,992,304 (GRCm39) |
|
probably null |
Het |
| Tmcc2 |
T |
G |
1: 132,285,534 (GRCm39) |
T376P |
probably damaging |
Het |
| Tmco4 |
G |
A |
4: 138,779,815 (GRCm39) |
C420Y |
probably damaging |
Het |
| Tmem235 |
C |
A |
11: 117,755,020 (GRCm39) |
Y157* |
probably null |
Het |
| Tmem63b |
T |
C |
17: 45,975,653 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf1a |
T |
C |
6: 125,334,356 (GRCm39) |
S92P |
possibly damaging |
Het |
| Top3b |
A |
T |
16: 16,704,834 (GRCm39) |
T397S |
probably benign |
Het |
| Trabd |
C |
A |
15: 88,967,007 (GRCm39) |
|
probably benign |
Het |
| Trbv21 |
A |
T |
6: 41,179,764 (GRCm39) |
I27L |
possibly damaging |
Het |
| Trim3 |
C |
T |
7: 105,268,276 (GRCm39) |
V169M |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,807,458 (GRCm39) |
T92A |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,738,860 (GRCm39) |
S3893N |
probably benign |
Het |
| Uchl4 |
A |
T |
9: 64,142,821 (GRCm39) |
I101F |
possibly damaging |
Het |
| Vmn1r5 |
T |
A |
6: 56,962,583 (GRCm39) |
M86K |
probably damaging |
Het |
| Vmn2r55 |
T |
A |
7: 12,404,830 (GRCm39) |
Q191L |
possibly damaging |
Het |
| Zfp458 |
A |
T |
13: 67,406,012 (GRCm39) |
C139* |
probably null |
Het |
| Zfp788 |
T |
C |
7: 41,299,551 (GRCm39) |
L729P |
probably damaging |
Het |
| Zmym2 |
T |
A |
14: 57,158,102 (GRCm39) |
M547K |
possibly damaging |
Het |
|
| Other mutations in Abcc10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00960:Abcc10
|
APN |
17 |
46,634,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Abcc10
|
APN |
17 |
46,621,352 (GRCm39) |
missense |
probably benign |
|
|
IGL01380:Abcc10
|
APN |
17 |
46,634,948 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01476:Abcc10
|
APN |
17 |
46,638,863 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL01723:Abcc10
|
APN |
17 |
46,624,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01867:Abcc10
|
APN |
17 |
46,635,364 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02065:Abcc10
|
APN |
17 |
46,623,827 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL02233:Abcc10
|
APN |
17 |
46,635,085 (GRCm39) |
splice site |
probably null |
|
|
IGL03394:Abcc10
|
APN |
17 |
46,635,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Decrepit
|
UTSW |
17 |
46,635,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Shrivelled
|
UTSW |
17 |
46,623,345 (GRCm39) |
missense |
probably benign |
|
|
PIT4514001:Abcc10
|
UTSW |
17 |
46,616,574 (GRCm39) |
missense |
probably benign |
|
|
R0366:Abcc10
|
UTSW |
17 |
46,635,724 (GRCm39) |
nonsense |
probably null |
|
|
R0437:Abcc10
|
UTSW |
17 |
46,623,846 (GRCm39) |
splice site |
probably benign |
|
|
R0437:Abcc10
|
UTSW |
17 |
46,623,845 (GRCm39) |
splice site |
probably null |
|
|
R0549:Abcc10
|
UTSW |
17 |
46,633,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0580:Abcc10
|
UTSW |
17 |
46,616,882 (GRCm39) |
splice site |
probably null |
|
|
R1056:Abcc10
|
UTSW |
17 |
46,614,880 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1426:Abcc10
|
UTSW |
17 |
46,635,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1595:Abcc10
|
UTSW |
17 |
46,633,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1745:Abcc10
|
UTSW |
17 |
46,623,359 (GRCm39) |
missense |
probably benign |
|
|
R1856:Abcc10
|
UTSW |
17 |
46,617,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1968:Abcc10
|
UTSW |
17 |
46,633,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2070:Abcc10
|
UTSW |
17 |
46,614,491 (GRCm39) |
missense |
probably benign |
|
|
R2071:Abcc10
|
UTSW |
17 |
46,614,491 (GRCm39) |
missense |
probably benign |
|
|
R2255:Abcc10
|
UTSW |
17 |
46,616,561 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2425:Abcc10
|
UTSW |
17 |
46,621,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Abcc10
|
UTSW |
17 |
46,634,817 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4510:Abcc10
|
UTSW |
17 |
46,618,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4511:Abcc10
|
UTSW |
17 |
46,618,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4645:Abcc10
|
UTSW |
17 |
46,635,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4689:Abcc10
|
UTSW |
17 |
46,634,996 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4778:Abcc10
|
UTSW |
17 |
46,615,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5384:Abcc10
|
UTSW |
17 |
46,615,361 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5509:Abcc10
|
UTSW |
17 |
46,635,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5568:Abcc10
|
UTSW |
17 |
46,614,834 (GRCm39) |
splice site |
probably null |
|
|
R5798:Abcc10
|
UTSW |
17 |
46,616,929 (GRCm39) |
nonsense |
probably null |
|
|
R5906:Abcc10
|
UTSW |
17 |
46,627,485 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5908:Abcc10
|
UTSW |
17 |
46,624,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5942:Abcc10
|
UTSW |
17 |
46,623,333 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5968:Abcc10
|
UTSW |
17 |
46,621,077 (GRCm39) |
missense |
probably benign |
|
|
R6038:Abcc10
|
UTSW |
17 |
46,615,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Abcc10
|
UTSW |
17 |
46,615,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6109:Abcc10
|
UTSW |
17 |
46,621,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6623:Abcc10
|
UTSW |
17 |
46,634,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6851:Abcc10
|
UTSW |
17 |
46,623,345 (GRCm39) |
missense |
probably benign |
|
|
R6927:Abcc10
|
UTSW |
17 |
46,635,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7176:Abcc10
|
UTSW |
17 |
46,635,203 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7314:Abcc10
|
UTSW |
17 |
46,626,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7463:Abcc10
|
UTSW |
17 |
46,634,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7527:Abcc10
|
UTSW |
17 |
46,623,830 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7584:Abcc10
|
UTSW |
17 |
46,626,304 (GRCm39) |
splice site |
probably null |
|
|
R7862:Abcc10
|
UTSW |
17 |
46,626,458 (GRCm39) |
nonsense |
probably null |
|
|
R7883:Abcc10
|
UTSW |
17 |
46,618,027 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7896:Abcc10
|
UTSW |
17 |
46,635,235 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7897:Abcc10
|
UTSW |
17 |
46,634,999 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8316:Abcc10
|
UTSW |
17 |
46,638,735 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8354:Abcc10
|
UTSW |
17 |
46,635,103 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8414:Abcc10
|
UTSW |
17 |
46,623,273 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8454:Abcc10
|
UTSW |
17 |
46,635,103 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8977:Abcc10
|
UTSW |
17 |
46,624,593 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9432:Abcc10
|
UTSW |
17 |
46,634,710 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9473:Abcc10
|
UTSW |
17 |
46,617,609 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9790:Abcc10
|
UTSW |
17 |
46,633,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9791:Abcc10
|
UTSW |
17 |
46,633,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Abcc10
|
UTSW |
17 |
46,635,046 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Abcc10
|
UTSW |
17 |
46,635,188 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Abcc10
|
UTSW |
17 |
46,624,626 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Abcc10
|
UTSW |
17 |
46,617,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATTGTCCAGGAGCACTCG -3'
(R):5'- TGACTGCTGCTATTCTTAACTGTG -3'
Sequencing Primer
(F):5'- TCCAGCAGCCGGAAGAG -3'
(R):5'- AACTGTGCCTCTCGCCAC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation