Incidental Mutation 'R5330:Sult2a8'
ID 423140
Institutional Source Beutler Lab
Gene Symbol Sult2a8
Ensembl Gene ENSMUSG00000030378
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms 2810007J24Rik, mL-STL
MMRRC Submission 042912-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5330 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 14144611-14180694 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 14147679 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 204 (E204G)
Ref Sequence ENSEMBL: ENSMUSP00000128428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063509] [ENSMUST00000125941] [ENSMUST00000168252] [ENSMUST00000209425]
AlphaFold Q8BGL3
Predicted Effect possibly damaging
Transcript: ENSMUST00000063509
AA Change: E204G

PolyPhen 2 Score 0.534 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000066897
Gene: ENSMUSG00000030378
AA Change: E204G

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 275 1.6e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125941
SMART Domains Protein: ENSMUSP00000116469
Gene: ENSMUSG00000030378

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 189 4e-47 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000168252
AA Change: E204G

PolyPhen 2 Score 0.534 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000128428
Gene: ENSMUSG00000030378
AA Change: E204G

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 275 1.6e-73 PFAM
Pfam:Sulfotransfer_3 36 205 6.3e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209425
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 99% (95/96)
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
A2m A G 6: 121,615,375 (GRCm39) D83G probably benign Het
Abca16 T A 7: 120,102,600 (GRCm39) I833N probably benign Het
Adam6b C A 12: 113,454,200 (GRCm39) P339H possibly damaging Het
Adgrb2 A T 4: 129,915,995 (GRCm39) H1505L possibly damaging Het
Aktip A T 8: 91,853,352 (GRCm39) F122I probably damaging Het
Ankrd27 T A 7: 35,315,351 (GRCm39) L500* probably null Het
Blm T C 7: 80,108,684 (GRCm39) E55G possibly damaging Het
Carmil1 A T 13: 24,209,929 (GRCm39) probably null Het
Cdca7 T C 2: 72,315,042 (GRCm39) C311R probably damaging Het
Cds1 T C 5: 101,946,361 (GRCm39) S187P probably damaging Het
Chuk A T 19: 44,067,394 (GRCm39) V587E probably damaging Het
Commd10 T C 18: 47,093,497 (GRCm39) V19A probably damaging Het
Ctnnd2 C T 15: 30,332,261 (GRCm39) T48I probably damaging Het
Cyp2b10 T A 7: 25,613,414 (GRCm39) Y203* probably null Het
Dchs1 A T 7: 105,403,809 (GRCm39) V2911E probably damaging Het
Dnah12 G A 14: 26,495,787 (GRCm39) E1472K probably damaging Het
Dnah3 T C 7: 119,542,871 (GRCm39) T3514A probably benign Het
Dnah6 T A 6: 73,051,573 (GRCm39) I3074F probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Elp1 T C 4: 56,800,001 (GRCm39) T42A probably benign Het
Fam131c A T 4: 141,110,141 (GRCm39) T180S probably benign Het
Fbxo41 T C 6: 85,456,888 (GRCm39) E427G probably benign Het
Gabrr2 A G 4: 33,082,583 (GRCm39) K236E possibly damaging Het
Gm10152 A T 7: 144,317,283 (GRCm39) noncoding transcript Het
Gm10313 T A 8: 46,708,490 (GRCm39) noncoding transcript Het
Gm5414 C A 15: 101,533,099 (GRCm39) V443F probably damaging Het
Gm7334 T C 17: 51,006,160 (GRCm39) S149P possibly damaging Het
Grik2 G A 10: 49,008,867 (GRCm39) T740M probably damaging Het
Hdac5 T C 11: 102,088,180 (GRCm39) Y930C probably damaging Het
Hepacam2 T C 6: 3,483,377 (GRCm39) T211A probably benign Het
Herc4 G T 10: 63,143,578 (GRCm39) E703* probably null Het
Hivep2 A G 10: 14,007,164 (GRCm39) K1254R probably damaging Het
Hras T C 7: 140,772,853 (GRCm39) M1V probably null Het
Il23r T G 6: 67,400,479 (GRCm39) Q617P probably damaging Het
Kank1 A G 19: 25,388,693 (GRCm39) T789A probably damaging Het
Kcnj12 A G 11: 60,961,012 (GRCm39) K437E probably benign Het
Lct A T 1: 128,226,266 (GRCm39) D1374E probably benign Het
Luc7l C A 17: 26,494,707 (GRCm39) C104* probably null Het
Lurap1 G A 4: 116,001,601 (GRCm39) L31F probably damaging Het
Mark4 G A 7: 19,170,908 (GRCm39) P321S probably damaging Het
Med18 A G 4: 132,190,377 (GRCm39) probably benign Het
Mia2 A G 12: 59,142,598 (GRCm39) S5G probably benign Het
Mrgprb3 T C 7: 48,292,682 (GRCm39) T290A possibly damaging Het
Ms4a20 A G 19: 11,069,222 (GRCm39) probably benign Het
Negr1 A T 3: 156,774,913 (GRCm39) K210* probably null Het
Nktr T C 9: 121,581,834 (GRCm39) probably benign Het
Nob1 T G 8: 108,142,881 (GRCm39) T267P probably damaging Het
Nos3 A G 5: 24,574,902 (GRCm39) E307G probably damaging Het
Nrxn2 A G 19: 6,540,111 (GRCm39) T796A probably damaging Het
Nwd2 C A 5: 63,963,859 (GRCm39) L1148I probably benign Het
Pcdh17 T A 14: 84,770,486 (GRCm39) V988E probably damaging Het
Pcdha4 G A 18: 37,087,755 (GRCm39) R646H probably benign Het
Per3 G T 4: 151,125,759 (GRCm39) L187I probably damaging Het
Phlpp2 A G 8: 110,660,667 (GRCm39) D774G probably damaging Het
Pibf1 T C 14: 99,378,082 (GRCm39) Y403H probably damaging Het
Plcl2 G A 17: 50,816,876 (GRCm39) A81T probably benign Het
Polr2a T C 11: 69,638,101 (GRCm39) N123D probably benign Het
Psma5 T G 3: 108,175,386 (GRCm39) V146G possibly damaging Het
Ptprk A T 10: 28,463,076 (GRCm39) D189V probably damaging Het
Relb C T 7: 19,340,630 (GRCm39) G509S possibly damaging Het
Rgs11 A T 17: 26,421,947 (GRCm39) M1L probably benign Het
Rhbg T A 3: 88,152,775 (GRCm39) T313S probably benign Het
Ripply2 T A 9: 86,897,691 (GRCm39) probably benign Het
Scap T C 9: 110,210,701 (GRCm39) V1011A probably benign Het
Scarf1 G A 11: 75,406,406 (GRCm39) G230D probably damaging Het
Sel1l3 A T 5: 53,343,351 (GRCm39) Y314N possibly damaging Het
Slc17a8 A G 10: 89,425,356 (GRCm39) probably null Het
Slc22a14 A T 9: 119,059,662 (GRCm39) L153Q probably damaging Het
Slc22a27 A G 19: 7,856,820 (GRCm39) I406T probably benign Het
Slc30a6 A G 17: 74,730,190 (GRCm39) D355G probably benign Het
Snta1 C A 2: 154,219,940 (GRCm39) E403* probably null Het
Socs7 A G 11: 97,268,852 (GRCm39) D382G possibly damaging Het
Spata31d1a A T 13: 59,848,217 (GRCm39) C1304S possibly damaging Het
Srebf2 T A 15: 82,080,409 (GRCm39) I834N possibly damaging Het
Steap1 G T 5: 5,790,422 (GRCm39) H175Q probably damaging Het
Tacc2 T C 7: 130,335,258 (GRCm39) S524P probably damaging Het
Tbc1d9b C T 11: 50,037,140 (GRCm39) A263V probably benign Het
Tecta A C 9: 42,249,152 (GRCm39) D1903E probably damaging Het
Tmem222 A C 4: 133,004,935 (GRCm39) M34R possibly damaging Het
Tnik A G 3: 28,596,167 (GRCm39) T187A probably damaging Het
Trpv4 A G 5: 114,773,604 (GRCm39) Y253H probably damaging Het
Trpv5 G A 6: 41,637,266 (GRCm39) R358C probably benign Het
Ttll13 T C 7: 79,910,257 (GRCm39) V800A probably benign Het
Ush2a G A 1: 188,460,578 (GRCm39) G2613E probably benign Het
Vmn2r58 G A 7: 41,513,384 (GRCm39) Q420* probably null Het
Zranb3 G A 1: 127,887,457 (GRCm39) P990L probably damaging Het
Zswim9 T A 7: 12,993,912 (GRCm39) D748V probably damaging Het
Other mutations in Sult2a8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01558:Sult2a8 APN 7 14,159,377 (GRCm39) nonsense probably null
IGL01904:Sult2a8 APN 7 14,159,382 (GRCm39) missense probably damaging 1.00
IGL02060:Sult2a8 APN 7 14,159,326 (GRCm39) missense probably damaging 1.00
IGL02532:Sult2a8 APN 7 14,150,183 (GRCm39) missense probably benign 0.01
IGL02663:Sult2a8 APN 7 14,159,368 (GRCm39) missense possibly damaging 0.52
IGL02803:Sult2a8 APN 7 14,145,630 (GRCm39) utr 3 prime probably benign
R1070:Sult2a8 UTSW 7 14,147,698 (GRCm39) missense probably damaging 0.99
R1251:Sult2a8 UTSW 7 14,159,350 (GRCm39) nonsense probably null
R1465:Sult2a8 UTSW 7 14,150,208 (GRCm39) missense probably benign 0.00
R1465:Sult2a8 UTSW 7 14,150,208 (GRCm39) missense probably benign 0.00
R1799:Sult2a8 UTSW 7 14,157,451 (GRCm39) missense probably damaging 1.00
R2196:Sult2a8 UTSW 7 14,161,778 (GRCm39) missense probably benign 0.00
R4233:Sult2a8 UTSW 7 14,147,608 (GRCm39) missense probably benign 0.01
R4713:Sult2a8 UTSW 7 14,159,402 (GRCm39) missense probably benign 0.02
R4964:Sult2a8 UTSW 7 14,159,457 (GRCm39) missense probably damaging 0.98
R5114:Sult2a8 UTSW 7 14,147,584 (GRCm39) missense probably benign 0.01
R5439:Sult2a8 UTSW 7 14,159,439 (GRCm39) missense probably damaging 1.00
R5662:Sult2a8 UTSW 7 14,161,765 (GRCm39) missense probably benign 0.13
R7353:Sult2a8 UTSW 7 14,147,640 (GRCm39) missense possibly damaging 0.95
R7366:Sult2a8 UTSW 7 14,150,254 (GRCm39) splice site probably null
R7832:Sult2a8 UTSW 7 14,147,596 (GRCm39) missense probably benign 0.02
R9499:Sult2a8 UTSW 7 14,157,487 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACTTGTGATCATGTATGCCCAC -3'
(R):5'- AGCCTTTTCAGCATTCCCAAAC -3'

Sequencing Primer
(F):5'- CTTTCCCAATCACATGAAATTCCATG -3'
(R):5'- TCAGCATTCCCAAACCTCATTC -3'
Posted On 2016-08-04