Incidental Mutation 'R5330:Tacc2'
| ID |
423153 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tacc2
|
| Ensembl Gene |
ENSMUSG00000030852 |
| Gene Name |
transforming, acidic coiled-coil containing protein 2 |
| Synonyms |
|
| MMRRC Submission |
042912-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5330 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
130179168-130366515 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 130335258 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 524
(S524P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147134
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033141]
[ENSMUST00000059145]
[ENSMUST00000084513]
[ENSMUST00000124096]
[ENSMUST00000207282]
[ENSMUST00000207376]
[ENSMUST00000207395]
[ENSMUST00000208722]
[ENSMUST00000208743]
[ENSMUST00000209108]
[ENSMUST00000207549]
[ENSMUST00000207789]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000033141
AA Change: S524P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000033141
Gene: ENSMUSG00000030852
AA Change: S524P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
63 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
71 |
181 |
1.04e-5 |
PROSPERO |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
258 |
345 |
6.53e-5 |
PROSPERO |
|
internal_repeat_1
|
373 |
456 |
1.04e-5 |
PROSPERO |
|
low complexity region
|
461 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
504 |
N/A |
INTRINSIC |
|
low complexity region
|
538 |
552 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
629 |
716 |
6.53e-5 |
PROSPERO |
|
coiled coil region
|
763 |
790 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
829 |
1035 |
3.4e-85 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000059145
AA Change: S634P
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000061242
Gene: ENSMUSG00000030852
AA Change: S634P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
173 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
291 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
345 |
356 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
483 |
566 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
571 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
603 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
662 |
N/A |
INTRINSIC |
|
coiled coil region
|
873 |
900 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
939 |
1145 |
4e-85 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000084513
AA Change: S2341P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000081561
Gene: ENSMUSG00000030852
AA Change: S2341P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
19 |
346 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
398 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
431 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
778 |
1068 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
1397 |
1415 |
N/A |
INTRINSIC |
|
low complexity region
|
1723 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1794 |
1809 |
N/A |
INTRINSIC |
|
low complexity region
|
1854 |
1880 |
N/A |
INTRINSIC |
|
low complexity region
|
2052 |
2063 |
N/A |
INTRINSIC |
|
low complexity region
|
2278 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2310 |
2321 |
N/A |
INTRINSIC |
|
low complexity region
|
2355 |
2369 |
N/A |
INTRINSIC |
|
coiled coil region
|
2606 |
2633 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
2673 |
2873 |
6.1e-87 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207282
AA Change: S512P
PolyPhen 2
Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207376
AA Change: S153P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207395
AA Change: S368P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000208722
AA Change: S634P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000208743
AA Change: S524P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000209108
AA Change: S137P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207549
AA Change: S133P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207789
|
| Meta Mutation Damage Score |
0.1570 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
99% (95/96) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930505A04Rik |
C |
T |
11: 30,376,349 (GRCm39) |
V173M |
probably damaging |
Het |
| A2m |
A |
G |
6: 121,615,375 (GRCm39) |
D83G |
probably benign |
Het |
| Abca16 |
T |
A |
7: 120,102,600 (GRCm39) |
I833N |
probably benign |
Het |
| Adam6b |
C |
A |
12: 113,454,200 (GRCm39) |
P339H |
possibly damaging |
Het |
| Adgrb2 |
A |
T |
4: 129,915,995 (GRCm39) |
H1505L |
possibly damaging |
Het |
| Aktip |
A |
T |
8: 91,853,352 (GRCm39) |
F122I |
probably damaging |
Het |
| Ankrd27 |
T |
A |
7: 35,315,351 (GRCm39) |
L500* |
probably null |
Het |
| Blm |
T |
C |
7: 80,108,684 (GRCm39) |
E55G |
possibly damaging |
Het |
| Carmil1 |
A |
T |
13: 24,209,929 (GRCm39) |
|
probably null |
Het |
| Cdca7 |
T |
C |
2: 72,315,042 (GRCm39) |
C311R |
probably damaging |
Het |
| Cds1 |
T |
C |
5: 101,946,361 (GRCm39) |
S187P |
probably damaging |
Het |
| Chuk |
A |
T |
19: 44,067,394 (GRCm39) |
V587E |
probably damaging |
Het |
| Commd10 |
T |
C |
18: 47,093,497 (GRCm39) |
V19A |
probably damaging |
Het |
| Ctnnd2 |
C |
T |
15: 30,332,261 (GRCm39) |
T48I |
probably damaging |
Het |
| Cyp2b10 |
T |
A |
7: 25,613,414 (GRCm39) |
Y203* |
probably null |
Het |
| Dchs1 |
A |
T |
7: 105,403,809 (GRCm39) |
V2911E |
probably damaging |
Het |
| Dnah12 |
G |
A |
14: 26,495,787 (GRCm39) |
E1472K |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,542,871 (GRCm39) |
T3514A |
probably benign |
Het |
| Dnah6 |
T |
A |
6: 73,051,573 (GRCm39) |
I3074F |
probably damaging |
Het |
| Dnase1l1 |
C |
T |
X: 73,320,644 (GRCm39) |
|
probably null |
Het |
| Elp1 |
T |
C |
4: 56,800,001 (GRCm39) |
T42A |
probably benign |
Het |
| Fam131c |
A |
T |
4: 141,110,141 (GRCm39) |
T180S |
probably benign |
Het |
| Fbxo41 |
T |
C |
6: 85,456,888 (GRCm39) |
E427G |
probably benign |
Het |
| Gabrr2 |
A |
G |
4: 33,082,583 (GRCm39) |
K236E |
possibly damaging |
Het |
| Gm10152 |
A |
T |
7: 144,317,283 (GRCm39) |
|
noncoding transcript |
Het |
| Gm10313 |
T |
A |
8: 46,708,490 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5414 |
C |
A |
15: 101,533,099 (GRCm39) |
V443F |
probably damaging |
Het |
| Gm7334 |
T |
C |
17: 51,006,160 (GRCm39) |
S149P |
possibly damaging |
Het |
| Grik2 |
G |
A |
10: 49,008,867 (GRCm39) |
T740M |
probably damaging |
Het |
| Hdac5 |
T |
C |
11: 102,088,180 (GRCm39) |
Y930C |
probably damaging |
Het |
| Hepacam2 |
T |
C |
6: 3,483,377 (GRCm39) |
T211A |
probably benign |
Het |
| Herc4 |
G |
T |
10: 63,143,578 (GRCm39) |
E703* |
probably null |
Het |
| Hivep2 |
A |
G |
10: 14,007,164 (GRCm39) |
K1254R |
probably damaging |
Het |
| Hras |
T |
C |
7: 140,772,853 (GRCm39) |
M1V |
probably null |
Het |
| Il23r |
T |
G |
6: 67,400,479 (GRCm39) |
Q617P |
probably damaging |
Het |
| Kank1 |
A |
G |
19: 25,388,693 (GRCm39) |
T789A |
probably damaging |
Het |
| Kcnj12 |
A |
G |
11: 60,961,012 (GRCm39) |
K437E |
probably benign |
Het |
| Lct |
A |
T |
1: 128,226,266 (GRCm39) |
D1374E |
probably benign |
Het |
| Luc7l |
C |
A |
17: 26,494,707 (GRCm39) |
C104* |
probably null |
Het |
| Lurap1 |
G |
A |
4: 116,001,601 (GRCm39) |
L31F |
probably damaging |
Het |
| Mark4 |
G |
A |
7: 19,170,908 (GRCm39) |
P321S |
probably damaging |
Het |
| Med18 |
A |
G |
4: 132,190,377 (GRCm39) |
|
probably benign |
Het |
| Mia2 |
A |
G |
12: 59,142,598 (GRCm39) |
S5G |
probably benign |
Het |
| Mrgprb3 |
T |
C |
7: 48,292,682 (GRCm39) |
T290A |
possibly damaging |
Het |
| Ms4a20 |
A |
G |
19: 11,069,222 (GRCm39) |
|
probably benign |
Het |
| Negr1 |
A |
T |
3: 156,774,913 (GRCm39) |
K210* |
probably null |
Het |
| Nktr |
T |
C |
9: 121,581,834 (GRCm39) |
|
probably benign |
Het |
| Nob1 |
T |
G |
8: 108,142,881 (GRCm39) |
T267P |
probably damaging |
Het |
| Nos3 |
A |
G |
5: 24,574,902 (GRCm39) |
E307G |
probably damaging |
Het |
| Nrxn2 |
A |
G |
19: 6,540,111 (GRCm39) |
T796A |
probably damaging |
Het |
| Nwd2 |
C |
A |
5: 63,963,859 (GRCm39) |
L1148I |
probably benign |
Het |
| Pcdh17 |
T |
A |
14: 84,770,486 (GRCm39) |
V988E |
probably damaging |
Het |
| Pcdha4 |
G |
A |
18: 37,087,755 (GRCm39) |
R646H |
probably benign |
Het |
| Per3 |
G |
T |
4: 151,125,759 (GRCm39) |
L187I |
probably damaging |
Het |
| Phlpp2 |
A |
G |
8: 110,660,667 (GRCm39) |
D774G |
probably damaging |
Het |
| Pibf1 |
T |
C |
14: 99,378,082 (GRCm39) |
Y403H |
probably damaging |
Het |
| Plcl2 |
G |
A |
17: 50,816,876 (GRCm39) |
A81T |
probably benign |
Het |
| Polr2a |
T |
C |
11: 69,638,101 (GRCm39) |
N123D |
probably benign |
Het |
| Psma5 |
T |
G |
3: 108,175,386 (GRCm39) |
V146G |
possibly damaging |
Het |
| Ptprk |
A |
T |
10: 28,463,076 (GRCm39) |
D189V |
probably damaging |
Het |
| Relb |
C |
T |
7: 19,340,630 (GRCm39) |
G509S |
possibly damaging |
Het |
| Rgs11 |
A |
T |
17: 26,421,947 (GRCm39) |
M1L |
probably benign |
Het |
| Rhbg |
T |
A |
3: 88,152,775 (GRCm39) |
T313S |
probably benign |
Het |
| Ripply2 |
T |
A |
9: 86,897,691 (GRCm39) |
|
probably benign |
Het |
| Scap |
T |
C |
9: 110,210,701 (GRCm39) |
V1011A |
probably benign |
Het |
| Scarf1 |
G |
A |
11: 75,406,406 (GRCm39) |
G230D |
probably damaging |
Het |
| Sel1l3 |
A |
T |
5: 53,343,351 (GRCm39) |
Y314N |
possibly damaging |
Het |
| Slc17a8 |
A |
G |
10: 89,425,356 (GRCm39) |
|
probably null |
Het |
| Slc22a14 |
A |
T |
9: 119,059,662 (GRCm39) |
L153Q |
probably damaging |
Het |
| Slc22a27 |
A |
G |
19: 7,856,820 (GRCm39) |
I406T |
probably benign |
Het |
| Slc30a6 |
A |
G |
17: 74,730,190 (GRCm39) |
D355G |
probably benign |
Het |
| Snta1 |
C |
A |
2: 154,219,940 (GRCm39) |
E403* |
probably null |
Het |
| Socs7 |
A |
G |
11: 97,268,852 (GRCm39) |
D382G |
possibly damaging |
Het |
| Spata31d1a |
A |
T |
13: 59,848,217 (GRCm39) |
C1304S |
possibly damaging |
Het |
| Srebf2 |
T |
A |
15: 82,080,409 (GRCm39) |
I834N |
possibly damaging |
Het |
| Steap1 |
G |
T |
5: 5,790,422 (GRCm39) |
H175Q |
probably damaging |
Het |
| Sult2a8 |
T |
C |
7: 14,147,679 (GRCm39) |
E204G |
possibly damaging |
Het |
| Tbc1d9b |
C |
T |
11: 50,037,140 (GRCm39) |
A263V |
probably benign |
Het |
| Tecta |
A |
C |
9: 42,249,152 (GRCm39) |
D1903E |
probably damaging |
Het |
| Tmem222 |
A |
C |
4: 133,004,935 (GRCm39) |
M34R |
possibly damaging |
Het |
| Tnik |
A |
G |
3: 28,596,167 (GRCm39) |
T187A |
probably damaging |
Het |
| Trpv4 |
A |
G |
5: 114,773,604 (GRCm39) |
Y253H |
probably damaging |
Het |
| Trpv5 |
G |
A |
6: 41,637,266 (GRCm39) |
R358C |
probably benign |
Het |
| Ttll13 |
T |
C |
7: 79,910,257 (GRCm39) |
V800A |
probably benign |
Het |
| Ush2a |
G |
A |
1: 188,460,578 (GRCm39) |
G2613E |
probably benign |
Het |
| Vmn2r58 |
G |
A |
7: 41,513,384 (GRCm39) |
Q420* |
probably null |
Het |
| Zranb3 |
G |
A |
1: 127,887,457 (GRCm39) |
P990L |
probably damaging |
Het |
| Zswim9 |
T |
A |
7: 12,993,912 (GRCm39) |
D748V |
probably damaging |
Het |
|
| Other mutations in Tacc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00836:Tacc2
|
APN |
7 |
130,360,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Tacc2
|
APN |
7 |
130,360,919 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01621:Tacc2
|
APN |
7 |
130,331,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02000:Tacc2
|
APN |
7 |
130,330,898 (GRCm39) |
splice site |
probably null |
|
|
IGL02075:Tacc2
|
APN |
7 |
130,330,582 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02201:Tacc2
|
APN |
7 |
130,227,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02205:Tacc2
|
APN |
7 |
130,228,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Tacc2
|
APN |
7 |
130,225,129 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02456:Tacc2
|
APN |
7 |
130,227,991 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02559:Tacc2
|
APN |
7 |
130,360,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02734:Tacc2
|
APN |
7 |
130,227,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02800:Tacc2
|
APN |
7 |
130,225,809 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02938:Tacc2
|
APN |
7 |
130,330,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tacc2
|
APN |
7 |
130,225,585 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03278:Tacc2
|
APN |
7 |
130,335,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03283:Tacc2
|
APN |
7 |
130,343,996 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL03371:Tacc2
|
APN |
7 |
130,227,791 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
aces
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Jacks
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
kings
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0002:Tacc2
|
UTSW |
7 |
130,223,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0119:Tacc2
|
UTSW |
7 |
130,223,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0244:Tacc2
|
UTSW |
7 |
130,353,555 (GRCm39) |
splice site |
probably benign |
|
|
R0619:Tacc2
|
UTSW |
7 |
130,318,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Tacc2
|
UTSW |
7 |
130,179,239 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0632:Tacc2
|
UTSW |
7 |
130,227,325 (GRCm39) |
nonsense |
probably null |
|
|
R1015:Tacc2
|
UTSW |
7 |
130,225,795 (GRCm39) |
missense |
probably benign |
|
|
R1081:Tacc2
|
UTSW |
7 |
130,330,304 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1086:Tacc2
|
UTSW |
7 |
130,228,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1351:Tacc2
|
UTSW |
7 |
130,264,733 (GRCm39) |
intron |
probably benign |
|
|
R1538:Tacc2
|
UTSW |
7 |
130,227,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1743:Tacc2
|
UTSW |
7 |
130,228,328 (GRCm39) |
nonsense |
probably null |
|
|
R1771:Tacc2
|
UTSW |
7 |
130,343,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1876:Tacc2
|
UTSW |
7 |
130,225,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1893:Tacc2
|
UTSW |
7 |
130,227,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Tacc2
|
UTSW |
7 |
130,225,932 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2005:Tacc2
|
UTSW |
7 |
130,333,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Tacc2
|
UTSW |
7 |
130,223,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2338:Tacc2
|
UTSW |
7 |
130,335,299 (GRCm39) |
splice site |
probably null |
|
|
R2407:Tacc2
|
UTSW |
7 |
130,223,770 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3051:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3052:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3053:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3116:Tacc2
|
UTSW |
7 |
130,360,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Tacc2
|
UTSW |
7 |
130,336,724 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3683:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3685:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3872:Tacc2
|
UTSW |
7 |
130,224,152 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4063:Tacc2
|
UTSW |
7 |
130,330,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4410:Tacc2
|
UTSW |
7 |
130,343,941 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4434:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4438:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4618:Tacc2
|
UTSW |
7 |
130,227,946 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4674:Tacc2
|
UTSW |
7 |
130,226,591 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4742:Tacc2
|
UTSW |
7 |
130,227,697 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4934:Tacc2
|
UTSW |
7 |
130,330,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4947:Tacc2
|
UTSW |
7 |
130,227,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4964:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Tacc2
|
UTSW |
7 |
130,225,678 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5052:Tacc2
|
UTSW |
7 |
130,336,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Tacc2
|
UTSW |
7 |
130,331,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Tacc2
|
UTSW |
7 |
130,224,990 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5556:Tacc2
|
UTSW |
7 |
130,276,336 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5645:Tacc2
|
UTSW |
7 |
130,225,781 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5886:Tacc2
|
UTSW |
7 |
130,330,850 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5996:Tacc2
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6074:Tacc2
|
UTSW |
7 |
130,227,165 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6127:Tacc2
|
UTSW |
7 |
130,227,845 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6156:Tacc2
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6298:Tacc2
|
UTSW |
7 |
130,228,255 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6444:Tacc2
|
UTSW |
7 |
130,225,142 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6533:Tacc2
|
UTSW |
7 |
130,224,567 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6724:Tacc2
|
UTSW |
7 |
130,330,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Tacc2
|
UTSW |
7 |
130,330,618 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7150:Tacc2
|
UTSW |
7 |
130,330,807 (GRCm39) |
missense |
probably benign |
|
|
R7290:Tacc2
|
UTSW |
7 |
130,331,103 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7404:Tacc2
|
UTSW |
7 |
130,225,066 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7460:Tacc2
|
UTSW |
7 |
130,226,363 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7651:Tacc2
|
UTSW |
7 |
130,224,884 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7666:Tacc2
|
UTSW |
7 |
130,318,544 (GRCm39) |
start gained |
probably benign |
|
|
R7695:Tacc2
|
UTSW |
7 |
130,330,633 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7766:Tacc2
|
UTSW |
7 |
130,345,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7793:Tacc2
|
UTSW |
7 |
130,224,843 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7861:Tacc2
|
UTSW |
7 |
130,227,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8204:Tacc2
|
UTSW |
7 |
130,226,159 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8244:Tacc2
|
UTSW |
7 |
130,330,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tacc2
|
UTSW |
7 |
130,331,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Tacc2
|
UTSW |
7 |
130,227,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8348:Tacc2
|
UTSW |
7 |
130,225,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8369:Tacc2
|
UTSW |
7 |
130,223,888 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8381:Tacc2
|
UTSW |
7 |
130,225,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8804:Tacc2
|
UTSW |
7 |
130,294,693 (GRCm39) |
missense |
probably benign |
|
|
R8809:Tacc2
|
UTSW |
7 |
130,276,421 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8835:Tacc2
|
UTSW |
7 |
130,228,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8880:Tacc2
|
UTSW |
7 |
130,318,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8918:Tacc2
|
UTSW |
7 |
130,227,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8936:Tacc2
|
UTSW |
7 |
130,228,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8953:Tacc2
|
UTSW |
7 |
130,227,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9026:Tacc2
|
UTSW |
7 |
130,225,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Tacc2
|
UTSW |
7 |
130,228,304 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,058 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9222:Tacc2
|
UTSW |
7 |
130,227,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9264:Tacc2
|
UTSW |
7 |
130,228,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Tacc2
|
UTSW |
7 |
130,223,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Tacc2
|
UTSW |
7 |
130,226,771 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9515:Tacc2
|
UTSW |
7 |
130,366,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:Tacc2
|
UTSW |
7 |
130,361,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tacc2
|
UTSW |
7 |
130,336,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,346,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,226,000 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,225,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,336,679 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,227,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,226,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAAAGGTCTCCAGCTTGGTGG -3'
(R):5'- CTTGTTAGAAACACAGCTAAGAGGG -3'
Sequencing Primer
(F):5'- CCAGCTTGGTGGGTCTTCC -3'
(R):5'- CAGTTGTGAACCACCATGTG -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation