Incidental Mutation 'R5334:Apol11a'
ID423439
Institutional Source Beutler Lab
Gene Symbol Apol11a
Ensembl Gene ENSMUSG00000091650
Gene Nameapolipoprotein L 11a
SynonymsEG626615
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #R5334 (G1)
Quality Score225
Status Not validated
Chromosome15
Chromosomal Location77508271-77518051 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 77516753 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 147 (T147A)
Ref Sequence ENSEMBL: ENSMUSP00000132565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172191]
Predicted Effect probably benign
Transcript: ENSMUST00000172191
AA Change: T147A

PolyPhen 2 Score 0.139 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000132565
Gene: ENSMUSG00000091650
AA Change: T147A

DomainStartEndE-ValueType
Pfam:ApoL 28 328 1e-90 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc15 C T 7: 101,898,603 P68L probably damaging Het
Ap4s1 C T 12: 51,738,671 S142L probably benign Het
Aqp9 T C 9: 71,123,010 probably null Het
Arhgap25 T A 6: 87,463,261 N468I possibly damaging Het
Arhgef2 T A 3: 88,646,329 S924R probably damaging Het
Atad3a A T 4: 155,755,689 L144Q probably damaging Het
Ccbe1 T C 18: 66,083,245 I136V probably damaging Het
Col24a1 C A 3: 145,461,525 P1119Q possibly damaging Het
Dgkd T C 1: 87,938,267 probably null Het
Dnah7a A G 1: 53,503,646 I2455T probably benign Het
Dock2 T C 11: 34,228,643 T1795A probably benign Het
Dpp6 A T 5: 27,709,540 E541V probably benign Het
Edem1 T C 6: 108,848,832 probably null Het
Fbxo41 A G 6: 85,478,483 V573A probably damaging Het
Fech A C 18: 64,464,120 V256G probably damaging Het
Gad1-ps G A 10: 99,445,147 noncoding transcript Het
Gal3st4 T G 5: 138,265,721 K339Q probably benign Het
Gm11487 T A 4: 73,403,517 M94L probably benign Het
Gm884 T C 11: 103,613,873 Q2423R probably benign Het
Gpr158 T A 2: 21,827,505 S1139T probably benign Het
Gpr180 A T 14: 118,160,056 S321C probably damaging Het
Grik1 CGG CGGG 16: 87,923,194 probably null Het
Grin2c T G 11: 115,256,055 N438T possibly damaging Het
Hcn2 T C 10: 79,726,291 S374P probably damaging Het
Hmcn1 T A 1: 150,755,372 I892F probably damaging Het
Ifi207 C T 1: 173,727,531 V869I probably benign Het
Itgad T C 7: 128,189,286 Y390H probably damaging Het
Itgb4 C T 11: 115,984,157 R447W probably benign Het
Kcnj15 A G 16: 95,296,649 K377E probably damaging Het
Kcnq3 A G 15: 66,025,224 S276P probably damaging Het
Klhl26 T C 8: 70,452,318 D280G probably damaging Het
Lmnb2 C T 10: 80,903,957 V376I probably benign Het
Mepce T A 5: 137,786,627 R29S probably benign Het
Mlh3 A G 12: 85,245,761 probably null Het
Mlip T A 9: 77,243,676 T33S probably damaging Het
Mtpn C T 6: 35,512,290 D100N probably benign Het
Ncapg2 T C 12: 116,426,637 I402T probably damaging Het
Olfr1026 T C 2: 85,923,714 Y149H probably damaging Het
Olfr171 C G 16: 19,624,491 G203A probably benign Het
Pcsk5 T C 19: 17,461,851 D1301G probably benign Het
Pilrb1 T C 5: 137,854,903 M213V probably benign Het
Plxdc1 T C 11: 97,956,105 T163A possibly damaging Het
Pnpla2 T C 7: 141,459,493 L373P probably damaging Het
Prickle2 A G 6: 92,425,684 Y52H probably damaging Het
Rnf220 A G 4: 117,272,351 C294R probably damaging Het
Slc12a1 A G 2: 125,217,889 D903G probably damaging Het
Slc17a2 T C 13: 23,819,051 F228S probably damaging Het
Sptbn1 T C 11: 30,137,364 E1025G possibly damaging Het
Sult1c1 T G 17: 53,964,730 D143A probably damaging Het
Taar1 T G 10: 23,920,545 I47R probably damaging Het
Tctn3 G T 19: 40,602,822 Q514K probably benign Het
Tg T C 15: 66,678,055 F222S probably damaging Het
Tmem236 C A 2: 14,219,060 T220K possibly damaging Het
Trim50 C T 5: 135,367,476 T426M probably damaging Het
Vmn1r237 T C 17: 21,314,680 F222L probably benign Het
Wrap73 G A 4: 154,145,274 R34Q probably damaging Het
Zfp85 T C 13: 67,751,684 Y52C probably damaging Het
Other mutations in Apol11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Apol11a APN 15 77517107 missense probably benign 0.03
IGL03112:Apol11a APN 15 77517309 missense probably damaging 0.99
R1296:Apol11a UTSW 15 77511019 splice site probably benign
R1576:Apol11a UTSW 15 77516931 missense probably damaging 1.00
R1875:Apol11a UTSW 15 77513566 missense possibly damaging 0.81
R2517:Apol11a UTSW 15 77517195 missense probably benign 0.00
R4614:Apol11a UTSW 15 77516572 missense probably benign 0.08
R4892:Apol11a UTSW 15 77516990 nonsense probably null
R5027:Apol11a UTSW 15 77516953 missense probably damaging 1.00
R6208:Apol11a UTSW 15 77517041 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTGCGAGAGTTTCCTCAGTTG -3'
(R):5'- CGGCTAAATCTGCAACTGTAC -3'

Sequencing Primer
(F):5'- CGAGAGTTTCCTCAGTTGAAGAAG -3'
(R):5'- AAAACTTGTATGTGATCTTGGGC -3'
Posted On2016-08-04