Incidental Mutation 'R5335:Opcml'
ID 423479
Institutional Source Beutler Lab
Gene Symbol Opcml
Ensembl Gene ENSMUSG00000062257
Gene Name opioid binding protein/cell adhesion molecule-like
Synonyms 2900075O15Rik, B930023M13Rik, Obcam, LOC235104
MMRRC Submission 042916-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5335 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 27702071-28836706 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 28586621 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 113 (D113G)
Ref Sequence ENSEMBL: ENSMUSP00000110898 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073822] [ENSMUST00000115243]
AlphaFold G5E8G3
Predicted Effect possibly damaging
Transcript: ENSMUST00000073822
AA Change: D120G

PolyPhen 2 Score 0.714 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000073493
Gene: ENSMUSG00000062257
AA Change: D120G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IG 42 133 2.94e-10 SMART
IGc2 148 209 2.91e-14 SMART
IGc2 235 303 2e-12 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000115243
AA Change: D113G

PolyPhen 2 Score 0.877 (Sensitivity: 0.83; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000110898
Gene: ENSMUSG00000062257
AA Change: D113G

DomainStartEndE-ValueType
IG 35 126 2.94e-10 SMART
IGc2 141 201 1.36e-14 SMART
IGc2 227 295 2e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126673
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126845
Meta Mutation Damage Score 0.0822 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010003K11Rik A G 19: 4,548,292 (GRCm39) W86R probably damaging Het
Ankrd6 T C 4: 32,818,651 (GRCm39) E225G probably damaging Het
Atxn10 A G 15: 85,220,785 (GRCm39) probably null Het
Bcas2 A G 3: 103,082,951 (GRCm39) I146V probably damaging Het
C2cd6 T A 1: 59,043,393 (GRCm39) noncoding transcript Het
Cachd1 G A 4: 100,825,282 (GRCm39) V579I possibly damaging Het
Col11a1 A G 3: 113,888,889 (GRCm39) T311A unknown Het
Cyp2c50 A T 19: 40,079,060 (GRCm39) L134F probably benign Het
Cyp2j11 T C 4: 96,195,589 (GRCm39) H369R probably damaging Het
Dis3 A G 14: 99,335,089 (GRCm39) V171A possibly damaging Het
Dnah12 A G 14: 26,601,695 (GRCm39) N3718D probably damaging Het
Dnah17 T C 11: 118,003,340 (GRCm39) I541V probably damaging Het
Eif3i T C 4: 129,488,979 (GRCm39) D86G probably benign Het
Epc1 C T 18: 6,490,689 (GRCm39) probably benign Het
Epc2 A G 2: 49,403,242 (GRCm39) N110S probably benign Het
Epha8 A T 4: 136,659,246 (GRCm39) L831Q probably damaging Het
Esd G T 14: 74,979,553 (GRCm39) R119I probably damaging Het
F2 T C 2: 91,465,277 (GRCm39) K96E possibly damaging Het
Fcgbp T C 7: 27,789,159 (GRCm39) V575A probably damaging Het
Gad1-ps G A 10: 99,281,009 (GRCm39) noncoding transcript Het
Gemin6 T C 17: 80,533,184 (GRCm39) V39A probably damaging Het
Glmp G T 3: 88,233,962 (GRCm39) probably benign Het
Gm10306 C A 4: 94,445,044 (GRCm39) probably benign Het
Gm4846 A T 1: 166,325,022 (GRCm39) L23* probably null Het
Grik1 CGG CGGG 16: 87,720,082 (GRCm39) probably null Het
Ifi203 T C 1: 173,754,485 (GRCm39) T749A possibly damaging Het
Kcnip2 C A 19: 45,782,685 (GRCm39) A133S probably benign Het
Limch1 A T 5: 67,039,300 (GRCm39) I76F probably damaging Het
Mcph1 T A 8: 18,739,077 (GRCm39) probably null Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Mtcl3 A T 10: 29,023,102 (GRCm39) I150L probably benign Het
Myh7 A G 14: 55,224,020 (GRCm39) probably benign Het
Odad2 A T 18: 7,294,566 (GRCm39) Y16N probably benign Het
Or1j17 A T 2: 36,578,106 (GRCm39) I31F probably benign Het
Or1x2 A C 11: 50,918,161 (GRCm39) N111H probably benign Het
Or2ag18 A C 7: 106,404,941 (GRCm39) S243A probably damaging Het
Or2b6 A C 13: 21,822,949 (GRCm39) V248G probably damaging Het
Or51f1d A C 7: 102,700,742 (GRCm39) D79A probably damaging Het
Or52s19 A C 7: 103,007,729 (GRCm39) L224R probably damaging Het
Or5j1 T G 2: 86,879,509 (GRCm39) K24Q probably damaging Het
Pcdhb1 G T 18: 37,400,308 (GRCm39) C753F probably benign Het
Phip T C 9: 82,782,809 (GRCm39) S879G possibly damaging Het
Pi4k2b A G 5: 52,899,098 (GRCm39) D13G possibly damaging Het
Ptpn18 A T 1: 34,502,259 (GRCm39) I68F probably damaging Het
Rnf168 C T 16: 32,117,402 (GRCm39) T321I possibly damaging Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Srgap1 C T 10: 121,621,282 (GRCm39) probably benign Het
Sry A T Y: 2,663,647 (GRCm39) H4Q probably benign Het
Taf2 G A 15: 54,909,136 (GRCm39) A703V probably benign Het
Taf5l A G 8: 124,730,390 (GRCm39) F65L probably damaging Het
Tcp10b T C 17: 13,281,954 (GRCm39) probably null Het
Timm44 A T 8: 4,316,814 (GRCm39) I273N probably damaging Het
Tspan4 A G 7: 141,069,528 (GRCm39) T43A probably damaging Het
Ube2r2 T C 4: 41,190,846 (GRCm39) probably benign Het
Urgcp T C 11: 5,667,754 (GRCm39) T195A possibly damaging Het
Vmn1r197 T C 13: 22,512,361 (GRCm39) I94T probably damaging Het
Vmn2r15 A T 5: 109,434,673 (GRCm39) I677K probably damaging Het
Zfp853 T A 5: 143,274,318 (GRCm39) H434L unknown Het
Other mutations in Opcml
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00864:Opcml APN 9 28,812,887 (GRCm39) missense probably damaging 1.00
IGL00864:Opcml APN 9 28,812,886 (GRCm39) missense probably damaging 1.00
IGL00956:Opcml APN 9 28,586,624 (GRCm39) missense possibly damaging 0.86
IGL02391:Opcml APN 9 28,586,560 (GRCm39) missense probably damaging 0.96
IGL03210:Opcml APN 9 28,812,833 (GRCm39) missense probably damaging 0.99
R0373:Opcml UTSW 9 28,724,694 (GRCm39) missense possibly damaging 0.48
R1037:Opcml UTSW 9 28,814,595 (GRCm39) missense probably damaging 1.00
R1564:Opcml UTSW 9 28,814,612 (GRCm39) missense probably damaging 1.00
R2094:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R2268:Opcml UTSW 9 28,814,651 (GRCm39) missense possibly damaging 0.91
R2426:Opcml UTSW 9 28,814,663 (GRCm39) critical splice donor site probably null
R2938:Opcml UTSW 9 27,702,682 (GRCm39) start codon destroyed probably null 0.00
R3746:Opcml UTSW 9 28,812,826 (GRCm39) missense possibly damaging 0.54
R4058:Opcml UTSW 9 28,812,884 (GRCm39) missense probably damaging 1.00
R4173:Opcml UTSW 9 28,814,654 (GRCm39) missense probably benign
R4882:Opcml UTSW 9 28,812,886 (GRCm39) missense probably damaging 1.00
R7058:Opcml UTSW 9 28,586,507 (GRCm39) nonsense probably null
R7559:Opcml UTSW 9 28,814,620 (GRCm39) missense probably benign
R8050:Opcml UTSW 9 28,724,640 (GRCm39) missense probably damaging 0.97
R8250:Opcml UTSW 9 28,586,566 (GRCm39) missense probably damaging 1.00
R8350:Opcml UTSW 9 28,813,463 (GRCm39) missense probably benign 0.00
R8772:Opcml UTSW 9 27,702,707 (GRCm39) missense probably benign 0.04
R8879:Opcml UTSW 9 28,813,447 (GRCm39) missense probably damaging 1.00
R9355:Opcml UTSW 9 28,814,650 (GRCm39) missense probably benign 0.00
R9364:Opcml UTSW 9 28,814,624 (GRCm39) missense probably damaging 1.00
R9385:Opcml UTSW 9 28,586,459 (GRCm39) missense possibly damaging 0.62
Z1177:Opcml UTSW 9 28,315,673 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTACCATAGATGATCGGGTCAC -3'
(R):5'- CCTGGTGAGAACAAAGTGCTAG -3'

Sequencing Primer
(F):5'- GTCACCCGGGTAGCCTG -3'
(R):5'- GAAGCTTTGAAATGCTCAACCTGTG -3'
Posted On 2016-08-04