Mutagenetix > Incidental Mutation

Incidental Mutation 'R5338:Or2r11'

423622

Institutional Source

Beutler Lab

Gene Symbol

Or2r11

Ensembl Gene

ENSMUSG00000068574

Gene Name

olfactory receptor family 2 subfamily R member 11

Synonyms

Olfr458, GA_x6K02T2P3E9-5100053-5100994, MOR257-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

R5338 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

42437010-42437951 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42437908 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 15 (M15T)

Ref Sequence

ENSEMBL: ENSMUSP00000149459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090156] [ENSMUST00000216650]

AlphaFold

Q8VF80

Predicted Effect

probably benign
Transcript: ENSMUST00000090156
AA Change: M15T

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000087617
Gene: ENSMUSG00000068574
AA Change: M15T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8.6e-52	PFAM
Pfam:7tm_1	41	310	3.7e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216650
AA Change: M15T

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4gnt	T	A	9: 99,502,597 (GRCm39)	N252K	probably damaging	Het
Abhd16a	A	G	17: 35,313,278 (GRCm39)	E132G	probably damaging	Het
Adgrv1	G	A	13: 81,677,165 (GRCm39)	R1889W	possibly damaging	Het
Aftph	A	T	11: 20,677,203 (GRCm39)	D135E	probably benign	Het
Arf1	A	C	11: 59,104,041 (GRCm39)	F63V	probably damaging	Het
Atg14	G	A	14: 47,805,656 (GRCm39)	R70C	probably damaging	Het
B3gnt7	T	A	1: 86,233,366 (GRCm39)	F87Y	probably damaging	Het
Bcat1	A	G	6: 144,953,353 (GRCm39)	Y345H	possibly damaging	Het
Birc2	G	T	9: 7,857,360 (GRCm39)	T371K	probably benign	Het
Ccdc175	A	T	12: 72,231,745 (GRCm39)	S5T	probably damaging	Het
Ccdc186	A	T	19: 56,801,689 (GRCm39)	S143T	possibly damaging	Het
Cct6b	A	T	11: 82,653,015 (GRCm39)	M28K	possibly damaging	Het
Cers4	C	A	8: 4,565,680 (GRCm39)	A42D	probably damaging	Het
Crmp1	G	T	5: 37,437,018 (GRCm39)	V236L	probably benign	Het
Ctdspl2	T	A	2: 121,811,793 (GRCm39)	N212K	probably benign	Het
Dclk3	T	C	9: 111,298,127 (GRCm39)	V557A	possibly damaging	Het
Dnmt1	A	T	9: 20,864,015 (GRCm39)	H23Q	probably benign	Het
Dpp8	G	T	9: 64,971,206 (GRCm39)	E609*	probably null	Het
Dtx3	C	A	10: 127,028,919 (GRCm39)	M106I	probably benign	Het
Ero1b	A	C	13: 12,589,732 (GRCm39)	D45A	probably damaging	Het
Fcho2	T	A	13: 98,867,399 (GRCm39)	D688V	probably damaging	Het
Fhod3	A	T	18: 25,161,138 (GRCm39)	S557C	probably damaging	Het
Flnc	T	C	6: 29,444,063 (GRCm39)	S626P	possibly damaging	Het
Foxi3	G	T	6: 70,937,602 (GRCm39)	G278V	probably damaging	Het
Gbp10	A	G	5: 105,372,166 (GRCm39)	L198P	probably damaging	Het
Gcn1	A	G	5: 115,721,462 (GRCm39)	T458A	probably benign	Het
Gigyf1	C	T	5: 137,521,422 (GRCm39)		probably benign	Het
Gtpbp2	A	C	17: 46,478,760 (GRCm39)	T526P	probably damaging	Het
Gys2	A	G	6: 142,400,239 (GRCm39)	L324S	probably damaging	Het
Hpn	C	A	7: 30,802,781 (GRCm39)	V119L	probably benign	Het
Ino80d	C	A	1: 63,098,098 (GRCm39)	V599L	probably benign	Het
Kcnh3	G	T	15: 99,140,275 (GRCm39)	G1054*	probably null	Het
Maml1	A	T	11: 50,157,778 (GRCm39)	D132E	probably benign	Het
Mastl	A	T	2: 23,023,503 (GRCm39)	S407T	probably benign	Het
Mettl1	T	C	10: 126,878,954 (GRCm39)	W3R	probably damaging	Het
Mprip	A	G	11: 59,651,399 (GRCm39)	Y1701C	probably damaging	Het
Mylk3	T	C	8: 86,069,350 (GRCm39)	N484D	probably damaging	Het
Nod2	G	A	8: 89,399,413 (GRCm39)		probably null	Het
Nrde2	A	T	12: 100,097,037 (GRCm39)	F921Y	probably damaging	Het
Nup88	G	T	11: 70,835,734 (GRCm39)	T575N	probably damaging	Het
Nxpe3	T	C	16: 55,686,706 (GRCm39)	T101A	possibly damaging	Het
Or1o3	T	A	17: 37,574,532 (GRCm39)	T8S	probably benign	Het
Or4c109	C	T	2: 88,817,809 (GRCm39)	V246I	possibly damaging	Het
Or52e15	A	G	7: 104,645,514 (GRCm39)	L199S	possibly damaging	Het
Or8g32	A	T	9: 39,305,371 (GRCm39)	I92F	probably damaging	Het
Pcnx3	A	T	19: 5,722,624 (GRCm39)	L1356Q	probably damaging	Het
Pkd1	A	T	17: 24,813,510 (GRCm39)	M4017L	probably benign	Het
Polg2	A	G	11: 106,670,064 (GRCm39)	C69R	possibly damaging	Het
Prr5l	T	G	2: 101,547,452 (GRCm39)	S358R	probably benign	Het
Ptprg	A	G	14: 12,154,111 (GRCm38)	T611A	probably benign	Het
Ryk	G	T	9: 102,774,516 (GRCm39)	E417*	probably null	Het
Sbp	T	C	17: 24,161,396 (GRCm39)		probably benign	Het
Sema4a	T	C	3: 88,358,804 (GRCm39)	T155A	probably benign	Het
Shank3	A	G	15: 89,415,914 (GRCm39)		probably null	Het
Slc35d2	A	T	13: 64,245,496 (GRCm39)	M294K	possibly damaging	Het
Slc41a3	A	T	6: 90,589,153 (GRCm39)	N88I	possibly damaging	Het
Slit3	A	G	11: 35,512,975 (GRCm39)	T534A	probably benign	Het
Ssx2ip	A	G	3: 146,142,296 (GRCm39)		probably null	Het
Stard13	T	C	5: 150,983,063 (GRCm39)	K648R	probably damaging	Het
Tanc1	A	T	2: 59,626,178 (GRCm39)	T512S	probably damaging	Het
Tbcc	T	C	17: 47,202,082 (GRCm39)	V156A	probably benign	Het
Terf1	T	G	1: 15,901,787 (GRCm39)	I273R	possibly damaging	Het
Tesc	A	G	5: 118,197,523 (GRCm39)	Y179C	probably damaging	Het
Ttc3	T	G	16: 94,184,900 (GRCm39)	V40G	probably damaging	Het
Tysnd1	T	A	10: 61,532,028 (GRCm39)	F227I	probably damaging	Het
Vps53	T	C	11: 75,972,034 (GRCm39)	E271G	probably damaging	Het
Wdfy4	C	T	14: 32,812,823 (GRCm39)	R1650H	probably damaging	Het

Other mutations in Or2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Or2r11	APN	6	42,437,884 (GRCm39)	missense	probably benign
IGL00983:Or2r11	APN	6	42,437,029 (GRCm39)	missense	probably benign
IGL01655:Or2r11	APN	6	42,437,474 (GRCm39)	missense	probably benign	0.41
IGL02017:Or2r11	APN	6	42,437,758 (GRCm39)	missense	probably benign	0.40
IGL02420:Or2r11	APN	6	42,437,110 (GRCm39)	missense	probably benign	0.03
IGL03145:Or2r11	APN	6	42,437,434 (GRCm39)	missense	probably benign	0.05
IGL03171:Or2r11	APN	6	42,437,464 (GRCm39)	missense	possibly damaging	0.89
IGL03333:Or2r11	APN	6	42,437,773 (GRCm39)	missense	probably damaging	1.00
R1768:Or2r11	UTSW	6	42,437,611 (GRCm39)	missense	probably damaging	1.00
R1908:Or2r11	UTSW	6	42,437,360 (GRCm39)	missense	probably benign	0.15
R2198:Or2r11	UTSW	6	42,437,950 (GRCm39)	start codon destroyed	probably null	1.00
R2336:Or2r11	UTSW	6	42,437,663 (GRCm39)	missense	probably damaging	1.00
R2512:Or2r11	UTSW	6	42,437,207 (GRCm39)	missense	probably damaging	0.99
R3433:Or2r11	UTSW	6	42,437,888 (GRCm39)	missense	probably benign
R5341:Or2r11	UTSW	6	42,437,098 (GRCm39)	missense	probably damaging	1.00
R5498:Or2r11	UTSW	6	42,437,228 (GRCm39)	missense	probably benign	0.11
R6558:Or2r11	UTSW	6	42,437,711 (GRCm39)	missense	probably benign	0.02
R6594:Or2r11	UTSW	6	42,437,309 (GRCm39)	missense	probably benign	0.01
R7107:Or2r11	UTSW	6	42,437,488 (GRCm39)	missense	possibly damaging	0.78
R7853:Or2r11	UTSW	6	42,437,573 (GRCm39)	missense	probably damaging	0.99
R8050:Or2r11	UTSW	6	42,437,764 (GRCm39)	missense	probably damaging	1.00
R8684:Or2r11	UTSW	6	42,437,827 (GRCm39)	missense	probably damaging	1.00
R9777:Or2r11	UTSW	6	42,437,029 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TCTCCATGAGGAAGTGTGCC -3'
(R):5'- GGTTAAAGTACCAGGCAGTGTGC -3'

Sequencing Primer
(F):5'- CTGGAGGTGTAGCAGATGTCCAC -3'
(R):5'- GTGCCAGGTCCAACTGCAATC -3'

Posted On

2016-08-04