Incidental Mutation 'R5355:Zfp747'
ID 424042
Institutional Source Beutler Lab
Gene Symbol Zfp747
Ensembl Gene ENSMUSG00000054381
Gene Name zinc finger protein 747
Synonyms 6430604K15Rik
MMRRC Submission 042934-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R5355 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 126971709-126975222 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 126973769 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 134 (F134L)
Ref Sequence ENSEMBL: ENSMUSP00000070685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067425] [ENSMUST00000205832]
AlphaFold Q8BHM7
Predicted Effect possibly damaging
Transcript: ENSMUST00000067425
AA Change: F134L

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000070685
Gene: ENSMUSG00000054381
AA Change: F134L

DomainStartEndE-ValueType
KRAB 22 82 3.64e-26 SMART
low complexity region 102 115 N/A INTRINSIC
ZnF_C2H2 152 174 3.63e-3 SMART
ZnF_C2H2 180 202 1.47e-3 SMART
ZnF_C2H2 208 230 6.42e-4 SMART
ZnF_C2H2 236 258 3.63e-3 SMART
ZnF_C2H2 264 286 1.13e-4 SMART
ZnF_C2H2 292 314 1.45e-2 SMART
ZnF_C2H2 320 342 1.5e-4 SMART
ZnF_C2H2 348 371 2.49e-1 SMART
ZnF_C2H2 377 399 3.69e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205832
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206942
Meta Mutation Damage Score 0.0934 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency 94% (50/53)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a T C 5: 8,776,873 (GRCm39) L857P probably damaging Het
Adam12 T C 7: 133,489,671 (GRCm39) *582W probably null Het
Adra1d A G 2: 131,403,007 (GRCm39) V361A probably damaging Het
Ank2 A G 3: 126,737,698 (GRCm39) probably benign Het
Atxn10 T A 15: 85,346,515 (GRCm39) N424K probably damaging Het
C8b A G 4: 104,637,860 (GRCm39) T111A probably benign Het
Ccdc168 A C 1: 44,097,139 (GRCm39) C1320G possibly damaging Het
Cdc45 C T 16: 18,614,647 (GRCm39) R205H probably damaging Het
Cdr2l T C 11: 115,284,396 (GRCm39) V244A possibly damaging Het
Col11a2 A G 17: 34,270,775 (GRCm39) M468V probably benign Het
Col4a2 G A 8: 11,495,984 (GRCm39) R1535H probably damaging Het
Cryab A T 9: 50,664,751 (GRCm39) S59C probably damaging Het
Cuzd1 G A 7: 130,917,853 (GRCm39) T249I probably damaging Het
Disp2 G A 2: 118,617,392 (GRCm39) V129M probably benign Het
Dlg2 G T 7: 91,099,011 (GRCm39) R31L probably benign Het
Dthd1 A C 5: 62,996,730 (GRCm39) L488F probably damaging Het
Dusp29 G A 14: 21,727,091 (GRCm39) R186W probably benign Het
Fat2 T G 11: 55,172,992 (GRCm39) I2574L probably damaging Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Fryl T C 5: 73,231,247 (GRCm39) D1610G probably damaging Het
Gm10330 T A 12: 23,830,131 (GRCm39) N17Y probably damaging Het
Gm4787 T A 12: 81,424,239 (GRCm39) R640* probably null Het
H2bc13 A T 13: 21,900,030 (GRCm39) I95N probably damaging Het
Ift88 T A 14: 57,675,699 (GRCm39) S71T probably benign Het
Isoc2b A G 7: 4,852,357 (GRCm39) probably benign Het
Itgb2 G T 10: 77,393,886 (GRCm39) R442L probably benign Het
Lama5 A T 2: 179,823,444 (GRCm39) N2658K possibly damaging Het
Lemd3 A T 10: 120,769,538 (GRCm39) I598K probably damaging Het
Lrp2 A T 2: 69,285,182 (GRCm39) C3825* probably null Het
Mep1a T C 17: 43,788,037 (GRCm39) D673G probably damaging Het
Met A G 6: 17,491,361 (GRCm39) Y41C probably damaging Het
Mfn2 A G 4: 147,979,035 (GRCm39) V99A probably damaging Het
Mmadhc A G 2: 50,181,436 (GRCm39) I78T probably benign Het
Mmp9 C A 2: 164,792,912 (GRCm39) P389T possibly damaging Het
Mvk T G 5: 114,590,499 (GRCm39) S7A probably damaging Het
Nlrp1a T A 11: 71,015,077 (GRCm39) T58S probably benign Het
Nlrp1c-ps C A 11: 71,148,839 (GRCm39) noncoding transcript Het
Nr1h3 A G 2: 91,022,253 (GRCm39) I125T possibly damaging Het
Or2a55-ps1 C T 6: 43,071,598 (GRCm39) noncoding transcript Het
Or8k39 A T 2: 86,563,680 (GRCm39) I92K probably damaging Het
Parn A G 16: 13,485,886 (GRCm39) I3T possibly damaging Het
Parp8 A G 13: 116,998,740 (GRCm39) probably null Het
Parva T C 7: 112,143,475 (GRCm39) probably null Het
Pwp2 A C 10: 78,011,378 (GRCm39) I672M possibly damaging Het
Sfswap C T 5: 129,616,810 (GRCm39) T418I probably benign Het
Slc6a3 A G 13: 73,709,078 (GRCm39) Y334C probably damaging Het
Slc7a13 C A 4: 19,839,267 (GRCm39) T290K probably benign Het
Spry2 A G 14: 106,130,712 (GRCm39) L158P probably damaging Het
Usp25 A G 16: 76,847,342 (GRCm39) E150G probably damaging Het
Zp3r A G 1: 130,524,518 (GRCm39) F175S probably benign Het
Zscan22 C A 7: 12,640,435 (GRCm39) N67K probably benign Het
Other mutations in Zfp747
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02964:Zfp747 APN 7 126,973,666 (GRCm39) missense probably benign 0.21
IGL03201:Zfp747 APN 7 126,973,180 (GRCm39) missense probably damaging 0.99
R0066:Zfp747 UTSW 7 126,973,772 (GRCm39) missense probably benign 0.00
R1056:Zfp747 UTSW 7 126,973,760 (GRCm39) missense probably benign
R1190:Zfp747 UTSW 7 126,973,726 (GRCm39) missense probably damaging 0.99
R1457:Zfp747 UTSW 7 126,973,676 (GRCm39) missense probably benign 0.37
R1727:Zfp747 UTSW 7 126,973,249 (GRCm39) missense probably damaging 0.99
R2072:Zfp747 UTSW 7 126,973,142 (GRCm39) missense possibly damaging 0.48
R2157:Zfp747 UTSW 7 126,974,929 (GRCm39) missense possibly damaging 0.92
R3724:Zfp747 UTSW 7 126,973,762 (GRCm39) missense probably benign 0.06
R4762:Zfp747 UTSW 7 126,973,498 (GRCm39) missense possibly damaging 0.92
R4770:Zfp747 UTSW 7 126,974,971 (GRCm39) missense probably damaging 0.99
R5135:Zfp747 UTSW 7 126,973,566 (GRCm39) missense probably damaging 0.98
R6232:Zfp747 UTSW 7 126,973,306 (GRCm39) missense probably damaging 1.00
R6263:Zfp747 UTSW 7 126,975,138 (GRCm39) start gained probably benign
R6835:Zfp747 UTSW 7 126,973,219 (GRCm39) missense possibly damaging 0.56
R7638:Zfp747 UTSW 7 126,973,819 (GRCm39) missense probably benign 0.09
R7735:Zfp747 UTSW 7 126,973,672 (GRCm39) missense probably damaging 0.99
R8043:Zfp747 UTSW 7 126,973,225 (GRCm39) missense probably benign 0.00
R8543:Zfp747 UTSW 7 126,973,655 (GRCm39) missense probably damaging 0.99
R9132:Zfp747 UTSW 7 126,974,922 (GRCm39) missense probably damaging 0.99
R9329:Zfp747 UTSW 7 126,973,655 (GRCm39) missense probably damaging 0.99
R9415:Zfp747 UTSW 7 126,973,198 (GRCm39) missense possibly damaging 0.71
Z1176:Zfp747 UTSW 7 126,974,631 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCGGCCAAATCGTTTGTTGC -3'
(R):5'- ACACTGCACATGCTCAGATGC -3'

Sequencing Primer
(F):5'- TTGCAGTCTGGGCACTGAAAC -3'
(R):5'- ACATGCTCAGATGCTGTGAC -3'
Posted On 2016-08-04