Incidental Mutation 'R5286:Or9s13'
ID 424334
Institutional Source Beutler Lab
Gene Symbol Or9s13
Ensembl Gene ENSMUSG00000061616
Gene Name olfactory receptor family 9 subfamily S member 13
Synonyms GA_x6K02T2R7CC-81134096-81133095, Olfr12, MOR208-5
MMRRC Submission 042870-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R5286 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 92547603-92548723 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92548084 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 152 (V152A)
Ref Sequence ENSEMBL: ENSMUSP00000150858 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081274] [ENSMUST00000213247]
AlphaFold Q60894
Predicted Effect probably benign
Transcript: ENSMUST00000081274
AA Change: V152A

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000080027
Gene: ENSMUSG00000061616
AA Change: V152A

DomainStartEndE-ValueType
transmembrane domain 13 30 N/A INTRINSIC
Pfam:7tm_4 38 314 8e-53 PFAM
Pfam:7tm_1 48 297 1.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213247
AA Change: V152A

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 T C 5: 121,742,358 (GRCm39) I417V probably benign Het
Adad1 T C 3: 37,119,399 (GRCm39) V160A possibly damaging Het
Adcy7 A G 8: 89,051,487 (GRCm39) E869G probably damaging Het
Birc6 G A 17: 74,977,242 (GRCm39) A4352T probably damaging Het
Brd2 T A 17: 34,334,205 (GRCm39) T286S probably damaging Het
Bsn G T 9: 107,988,123 (GRCm39) probably benign Het
Cables1 A G 18: 12,057,884 (GRCm39) T335A probably benign Het
Cacna1d A T 14: 30,072,682 (GRCm39) S98T possibly damaging Het
Ccdc181 A G 1: 164,105,810 (GRCm39) Y15C probably damaging Het
Dlgap4 T G 2: 156,587,839 (GRCm39) V39G probably damaging Het
Epb41l3 G A 17: 69,569,268 (GRCm39) R504H probably benign Het
Fbxo7 T C 10: 85,857,954 (GRCm39) L23P probably damaging Het
Gm42791 A C 5: 148,887,178 (GRCm39) probably benign Het
Gprc5b A T 7: 118,582,910 (GRCm39) F320I possibly damaging Het
Gtf3c1 G A 7: 125,262,580 (GRCm39) T1093M possibly damaging Het
Hddc3 G T 7: 79,993,543 (GRCm39) R83L probably damaging Het
Iars2 T C 1: 185,055,318 (GRCm39) probably benign Het
Ift25 T A 4: 107,136,998 (GRCm39) I132N probably damaging Het
Igfn1 T C 1: 135,895,599 (GRCm39) K1656E probably benign Het
Itk A C 11: 46,228,926 (GRCm39) probably null Het
Klra6 G A 6: 129,995,932 (GRCm39) T142I probably benign Het
Knop1 C T 7: 118,454,993 (GRCm39) A3T probably damaging Het
Lamc3 A G 2: 31,808,608 (GRCm39) H788R probably damaging Het
Lrif1 A G 3: 106,639,859 (GRCm39) R315G probably damaging Het
Mfap3l A G 8: 61,109,903 (GRCm39) D93G probably benign Het
Ngef T C 1: 87,473,552 (GRCm39) S77G probably benign Het
Nt5dc3 T C 10: 86,640,656 (GRCm39) S13P probably benign Het
Pclo T C 5: 14,729,761 (GRCm39) probably benign Het
Pkhd1l1 C T 15: 44,378,368 (GRCm39) Q1041* probably null Het
Ppl G A 16: 4,906,987 (GRCm39) R1103* probably null Het
Ppp4r3b T A 11: 29,161,667 (GRCm39) D680E probably benign Het
Rasgrf2 T G 13: 92,267,941 (GRCm39) K21T possibly damaging Het
Rev1 T A 1: 38,094,407 (GRCm39) K1004* probably null Het
Rgs9 T G 11: 109,130,277 (GRCm39) probably null Het
Rnf31 T C 14: 55,829,693 (GRCm39) L86P probably damaging Het
Rps13 A G 7: 115,933,155 (GRCm39) Y18H probably damaging Het
Rxfp2 T C 5: 149,958,909 (GRCm39) F33S probably damaging Het
Sfmbt1 G A 14: 30,538,777 (GRCm39) V799M probably damaging Het
Stard9 T A 2: 120,532,428 (GRCm39) V2895D probably benign Het
Syn3 T C 10: 86,187,428 (GRCm39) N232S possibly damaging Het
Taok3 T A 5: 117,404,140 (GRCm39) Y772N probably damaging Het
Tspan4 A G 7: 141,062,483 (GRCm39) probably null Het
Ttn C A 2: 76,684,530 (GRCm39) probably benign Het
Vwa3b T A 1: 37,084,120 (GRCm39) W98R probably damaging Het
Vwa5b2 A T 16: 20,415,058 (GRCm39) D360V probably damaging Het
Wdr73 A T 7: 80,541,557 (GRCm39) D328E probably benign Het
Xpo5 A G 17: 46,545,406 (GRCm39) N824S probably benign Het
Zbtb2 C T 10: 4,318,566 (GRCm39) G487S possibly damaging Het
Other mutations in Or9s13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Or9s13 APN 1 92,547,921 (GRCm39) missense possibly damaging 0.88
IGL01309:Or9s13 APN 1 92,548,057 (GRCm39) missense probably damaging 1.00
IGL02025:Or9s13 APN 1 92,548,269 (GRCm39) missense probably benign 0.00
IGL02517:Or9s13 APN 1 92,548,183 (GRCm39) missense probably benign
IGL02837:Or9s13 UTSW 1 92,548,404 (GRCm39) missense possibly damaging 0.73
R1394:Or9s13 UTSW 1 92,548,267 (GRCm39) missense probably benign 0.02
R1395:Or9s13 UTSW 1 92,548,267 (GRCm39) missense probably benign 0.02
R1590:Or9s13 UTSW 1 92,548,467 (GRCm39) missense possibly damaging 0.64
R1778:Or9s13 UTSW 1 92,548,342 (GRCm39) missense possibly damaging 0.94
R1924:Or9s13 UTSW 1 92,548,525 (GRCm39) missense probably damaging 1.00
R2011:Or9s13 UTSW 1 92,548,471 (GRCm39) missense probably benign 0.01
R3877:Or9s13 UTSW 1 92,547,805 (GRCm39) missense probably damaging 1.00
R5513:Or9s13 UTSW 1 92,548,102 (GRCm39) missense probably benign
R5727:Or9s13 UTSW 1 92,547,900 (GRCm39) missense probably benign 0.00
R5905:Or9s13 UTSW 1 92,547,864 (GRCm39) missense possibly damaging 0.49
R5921:Or9s13 UTSW 1 92,548,344 (GRCm39) missense probably benign 0.01
R7614:Or9s13 UTSW 1 92,548,183 (GRCm39) missense probably damaging 0.99
R7959:Or9s13 UTSW 1 92,548,029 (GRCm39) missense probably damaging 0.96
R8073:Or9s13 UTSW 1 92,547,806 (GRCm39) missense probably damaging 1.00
R8161:Or9s13 UTSW 1 92,548,078 (GRCm39) missense probably benign 0.00
R8680:Or9s13 UTSW 1 92,547,643 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- CCAAAGTCATCAGCTTTGAGGC -3'
(R):5'- CACGGTGATGTAGCCATAGG -3'

Sequencing Primer
(F):5'- AAAGTCATCAGCTTTGAGGCTTGTG -3'
(R):5'- GTGGTGCTCACAATGATGAACCC -3'
Posted On 2016-08-04