Mutagenetix > Incidental Mutation

Incidental Mutation 'R5288:Dmxl2'

424498

Institutional Source

Beutler Lab

Gene Symbol

Dmxl2

Ensembl Gene

ENSMUSG00000041268

Gene Name

Dmx-like 2

Synonyms

E130119P06Rik, 6430411K14Rik

MMRRC Submission

042842-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5288 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

54272442-54408910 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 54286041 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 2715 (S2715P)

Ref Sequence

ENSEMBL: ENSMUSP00000113705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000118163] [ENSMUST00000118600]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000118163
AA Change: S2715P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113705
Gene: ENSMUSG00000041268
AA Change: S2715P

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
Pfam:Rav1p_C	1430	1903	1.5e-71	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2472	2490	N/A	INTRINSIC
low complexity region	2635	2649	N/A	INTRINSIC
low complexity region	2744	2766	N/A	INTRINSIC
WD40	2774	2809	5.73e0	SMART
WD40	2813	2852	8.88e0	SMART
WD40	2859	2901	2.67e-1	SMART
WD40	2907	2946	2.57e-2	SMART
WD40	2949	2988	3.61e-6	SMART
WD40	3001	3039	8.25e0	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000118600
AA Change: S2693P

SMART Domains

Protein: ENSMUSP00000113693
Gene: ENSMUSG00000041268
AA Change: S2693P

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
low complexity region	1426	1436	N/A	INTRINSIC
Pfam:Rav1p_C	1447	1903	4.2e-68	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2471	2489	N/A	INTRINSIC
low complexity region	2722	2744	N/A	INTRINSIC
WD40	2752	2787	5.73e0	SMART
WD40	2791	2830	8.88e0	SMART
WD40	2837	2879	2.67e-1	SMART
WD40	2885	2924	2.57e-2	SMART
WD40	2927	2966	3.61e-6	SMART
WD40	2979	3017	8.25e0	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000123709
AA Change: S1895P

SMART Domains

Protein: ENSMUSP00000119959
Gene: ENSMUSG00000041268
AA Change: S1895P

Domain	Start	End	E-Value	Type
low complexity region	63	77	N/A	INTRINSIC
low complexity region	147	163	N/A	INTRINSIC
WD40	187	231	1.15e1	SMART
WD40	438	475	2.84e2	SMART
Pfam:Rav1p_C	632	1105	9.1e-72	PFAM
low complexity region	1180	1195	N/A	INTRINSIC
coiled coil region	1319	1347	N/A	INTRINSIC
low complexity region	1391	1406	N/A	INTRINSIC
low complexity region	1453	1468	N/A	INTRINSIC
low complexity region	1674	1692	N/A	INTRINSIC
low complexity region	1925	1947	N/A	INTRINSIC
WD40	1955	1990	5.73e0	SMART
WD40	1994	2033	8.88e0	SMART
WD40	2040	2082	2.67e-1	SMART
WD40	2088	2127	2.57e-2	SMART
WD40	2130	2169	3.61e-6	SMART
WD40	2182	2220	8.25e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154092

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete prenatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(2) Gene trapped(2)

Other mutations in this stock

Total: 113 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc12	A	T	8: 87,293,168 (GRCm39)	Y7N	probably damaging	Het
Adcy1	A	C	11: 7,111,351 (GRCm39)	I881L	probably benign	Het
Aftph	T	C	11: 20,676,994 (GRCm39)	D205G	probably damaging	Het
Aldh7a1	T	A	18: 56,667,325 (GRCm39)	N316Y	possibly damaging	Het
Ankrd36	A	G	11: 5,639,340 (GRCm39)		probably benign	Het
Ccdc88a	T	G	11: 29,448,416 (GRCm39)	N1465K	possibly damaging	Het
Ccpg1	G	A	9: 72,920,326 (GRCm39)	S647N	probably benign	Het
Cep70	T	A	9: 99,163,128 (GRCm39)	L325Q	probably damaging	Het
Cfap46	A	G	7: 139,193,423 (GRCm39)		probably null	Het
Cftr	C	T	6: 18,226,128 (GRCm39)	Q359*	probably null	Het
Chrne	A	T	11: 70,505,913 (GRCm39)	N457K	possibly damaging	Het
Cntn2	A	G	1: 132,451,415 (GRCm39)	I438T	probably benign	Het
Cntn4	T	C	6: 106,158,765 (GRCm39)	L10P	possibly damaging	Het
Copg1	G	T	6: 87,867,189 (GRCm39)	M87I	possibly damaging	Het
Cyfip1	A	T	7: 55,574,883 (GRCm39)	M1045L	possibly damaging	Het
Cyp2c29	C	T	19: 39,318,816 (GRCm39)	P432L	probably damaging	Het
Dcaf11	T	A	14: 55,800,833 (GRCm39)	D96E	probably damaging	Het
Dnhd1	G	A	7: 105,363,644 (GRCm39)	E4069K	possibly damaging	Het
Dpy19l4	T	A	4: 11,289,721 (GRCm39)	N330I	probably damaging	Het
Dpy19l4	G	T	4: 11,304,014 (GRCm39)	A132D	probably damaging	Het
Duox2	A	G	2: 122,125,617 (GRCm39)	V330A	probably benign	Het
Dusp11	T	C	6: 85,924,587 (GRCm39)	*322W	probably null	Het
Dusp8	T	A	7: 141,643,730 (GRCm39)	Q61L	possibly damaging	Het
Eml3	G	A	19: 8,916,638 (GRCm39)	G720S	probably damaging	Het
F11	A	G	8: 45,699,833 (GRCm39)	S418P	probably damaging	Het
Fam91a1	G	A	15: 58,320,243 (GRCm39)	S645N	probably benign	Het
Fat2	G	A	11: 55,158,482 (GRCm39)	T3412I	probably benign	Het
Fbxo38	A	G	18: 62,674,042 (GRCm39)	M13T	probably benign	Het
Fbxo48	G	T	11: 16,904,329 (GRCm39)	L160F	possibly damaging	Het
Gm10134	T	A	2: 28,396,372 (GRCm39)		probably benign	Het
Gm11787	T	C	4: 3,511,795 (GRCm39)		noncoding transcript	Het
Gpatch8	A	T	11: 102,399,053 (GRCm39)		probably null	Het
Gucy2g	G	A	19: 55,203,548 (GRCm39)	A750V	probably damaging	Het
Hephl1	T	C	9: 14,988,150 (GRCm39)	T653A	possibly damaging	Het
Herc3	T	A	6: 58,851,263 (GRCm39)	M504K	probably damaging	Het
Hmcn2	A	G	2: 31,350,333 (GRCm39)	T5077A	probably benign	Het
Ifitm3	T	C	7: 140,590,554 (GRCm39)	N2S	probably benign	Het
Ighe	T	C	12: 113,235,092 (GRCm39)	H356R	probably benign	Het
Ighv10-3	T	A	12: 114,487,125 (GRCm39)	M99L	probably benign	Het
Izumo4	C	A	10: 80,538,639 (GRCm39)	C30*	probably null	Het
Jag1	A	T	2: 136,937,464 (GRCm39)	H303Q	possibly damaging	Het
Kif24	T	C	4: 41,395,373 (GRCm39)	E500G	probably benign	Het
Kng1	A	T	16: 22,897,842 (GRCm39)	D414V	probably damaging	Het
Loxhd1	A	C	18: 77,451,308 (GRCm39)	D410A	probably damaging	Het
Ltn1	T	C	16: 87,212,899 (GRCm39)	K554R	possibly damaging	Het
Ly75	A	G	2: 60,133,985 (GRCm39)	C1547R	probably damaging	Het
Ms4a6d	A	T	19: 11,564,500 (GRCm39)	S124T	possibly damaging	Het
Mtcl3	A	G	10: 29,072,766 (GRCm39)	D686G	probably benign	Het
Mtfr2	A	G	10: 20,233,448 (GRCm39)	D339G	probably damaging	Het
Myh10	T	A	11: 68,692,434 (GRCm39)	L1369Q	probably damaging	Het
Myh11	A	T	16: 14,025,872 (GRCm39)	V1366D	possibly damaging	Het
Nadsyn1	A	G	7: 143,357,023 (GRCm39)	V491A	possibly damaging	Het
Nav3	T	C	10: 109,688,966 (GRCm39)	N437S	probably benign	Het
Ncf1	A	G	5: 134,250,659 (GRCm39)	L373P	probably damaging	Het
Neb	A	T	2: 52,079,873 (GRCm39)	I85N	probably damaging	Het
Nktr	A	G	9: 121,577,659 (GRCm39)	K576E	probably benign	Het
Nmur2	T	A	11: 55,931,040 (GRCm39)	I224F	probably damaging	Het
Oas3	A	G	5: 120,895,055 (GRCm39)	F978S	probably damaging	Het
Or10ag53	C	T	2: 87,082,827 (GRCm39)	P182L	probably benign	Het
Or10ak9	T	C	4: 118,726,772 (GRCm39)	S264P	probably damaging	Het
Or2r3	T	A	6: 42,448,186 (GRCm39)	I309F	probably benign	Het
Or2t48	A	T	11: 58,420,308 (GRCm39)	M168K	probably damaging	Het
Or5p60	T	C	7: 107,724,375 (GRCm39)	T32A	probably benign	Het
Pcyox1	A	T	6: 86,369,336 (GRCm39)		probably null	Het
Pdcd7	G	A	9: 65,265,974 (GRCm39)	W477*	probably null	Het
Pitpnm1	T	C	19: 4,153,435 (GRCm39)	F197S	probably damaging	Het
Plce1	C	A	19: 38,748,535 (GRCm39)	N1755K	probably damaging	Het
Pnpla7	C	A	2: 24,931,031 (GRCm39)	P882Q	probably damaging	Het
Pold2	A	G	11: 5,826,760 (GRCm39)	L58P	probably damaging	Het
Pomt1	C	G	2: 32,134,311 (GRCm39)	Y277*	probably null	Het
Pou4f2	A	G	8: 79,162,958 (GRCm39)	Y26H	unknown	Het
Pphln1-ps1	T	G	16: 13,495,622 (GRCm39)	N240K	probably benign	Het
Ppm1e	A	T	11: 87,249,377 (GRCm39)	L118Q	possibly damaging	Het
Pramel34	C	T	5: 93,785,607 (GRCm39)	M224I	possibly damaging	Het
Prdx2	T	A	8: 85,698,302 (GRCm39)	Y164*	probably null	Het
Prkra	T	G	2: 76,469,622 (GRCm39)	T146P	probably damaging	Het
Prpf8	A	G	11: 75,386,625 (GRCm39)	D1038G	probably damaging	Het
Rab4a	A	T	8: 124,554,113 (GRCm39)	I16L	probably benign	Het
Rai2	A	G	X: 160,561,636 (GRCm39)	N363S	probably benign	Het
Ranbp17	A	T	11: 33,169,241 (GRCm39)	V991D	possibly damaging	Het
Rimbp2	G	A	5: 128,865,656 (GRCm39)	T557M	probably benign	Het
Rmi1	G	A	13: 58,557,280 (GRCm39)	G510R	probably damaging	Het
Sdad1	A	G	5: 92,434,684 (GRCm39)	*687Q	probably null	Het
Sema6d	T	C	2: 124,506,166 (GRCm39)	L720P	probably damaging	Het
Setx	T	G	2: 29,024,045 (GRCm39)		probably null	Het
Sgsm3	T	C	15: 80,892,200 (GRCm39)	V256A	probably benign	Het
Slc28a2b	C	A	2: 122,353,259 (GRCm39)	L480I	probably benign	Het
Sppl2c	T	A	11: 104,078,127 (GRCm39)	I309K	possibly damaging	Het
Stard9	A	G	2: 120,531,111 (GRCm39)	E2456G	probably damaging	Het
Strn3	C	G	12: 51,694,803 (GRCm39)	R320P	probably damaging	Het
Supv3l1	A	T	10: 62,266,375 (GRCm39)	N600K	possibly damaging	Het
Syne2	T	A	12: 76,146,112 (GRCm39)	S6377T	possibly damaging	Het
Tas2r123	A	T	6: 132,824,190 (GRCm39)	H29L	probably benign	Het
Tbl3	C	T	17: 24,924,944 (GRCm39)	V52M	possibly damaging	Het
Tbp	A	G	17: 15,727,609 (GRCm39)	I145V	probably benign	Het
Tcf20	A	T	15: 82,739,910 (GRCm39)	S514T	possibly damaging	Het
Tgm4	A	G	9: 122,885,559 (GRCm39)	Y367C	probably damaging	Het
Tle1	C	T	4: 72,060,081 (GRCm39)	V258M	probably damaging	Het
Tln1	C	T	4: 43,540,661 (GRCm39)	V1447I	probably benign	Het
Tnfrsf11b	C	T	15: 54,141,622 (GRCm39)	A8T	probably benign	Het
Trim80	A	T	11: 115,338,843 (GRCm39)	T558S	probably benign	Het
Trmt6	C	A	2: 132,650,703 (GRCm39)	A302S	probably benign	Het
Tsen15	C	T	1: 152,259,131 (GRCm39)	V76I	probably damaging	Het
Ttc17	A	T	2: 94,133,985 (GRCm39)	W1067R	probably damaging	Het
Ucn3	A	T	13: 3,991,474 (GRCm39)	F59L	probably benign	Het
Ulk3	T	A	9: 57,498,023 (GRCm39)	I108N	possibly damaging	Het
Vmn2r94	A	C	17: 18,464,728 (GRCm39)	Y521D	probably damaging	Het
Vps45	T	C	3: 95,965,086 (GRCm39)	M1V	probably null	Het
Vta1	C	A	10: 14,581,143 (GRCm39)	L21F	probably damaging	Het
Zdhhc21	C	T	4: 82,765,929 (GRCm39)	G2D	probably damaging	Het
Zfp169	A	T	13: 48,643,751 (GRCm39)	C459S	possibly damaging	Het
Zfp90	C	T	8: 107,152,000 (GRCm39)	T571M	probably damaging	Het
Zswim8	A	T	14: 20,768,939 (GRCm39)	N1119I	possibly damaging	Het

Other mutations in Dmxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Dmxl2	APN	9	54,308,988 (GRCm39)	missense	probably benign
IGL00226:Dmxl2	APN	9	54,323,277 (GRCm39)	missense	probably damaging	1.00
IGL00419:Dmxl2	APN	9	54,313,951 (GRCm39)	missense	probably damaging	0.96
IGL00551:Dmxl2	APN	9	54,358,122 (GRCm39)	missense	probably damaging	1.00
IGL00765:Dmxl2	APN	9	54,322,706 (GRCm39)	unclassified	probably benign
IGL00852:Dmxl2	APN	9	54,330,597 (GRCm39)	nonsense	probably null
IGL00857:Dmxl2	APN	9	54,283,604 (GRCm39)	missense	probably benign	0.32
IGL00952:Dmxl2	APN	9	54,324,166 (GRCm39)	missense	probably damaging	0.99
IGL01139:Dmxl2	APN	9	54,366,248 (GRCm39)	missense	probably damaging	1.00
IGL01346:Dmxl2	APN	9	54,322,759 (GRCm39)	missense	probably damaging	1.00
IGL01538:Dmxl2	APN	9	54,352,660 (GRCm39)	splice site	probably benign
IGL01645:Dmxl2	APN	9	54,286,017 (GRCm39)	missense	possibly damaging	0.93
IGL02096:Dmxl2	APN	9	54,308,349 (GRCm39)	missense	possibly damaging	0.89
IGL02104:Dmxl2	APN	9	54,311,299 (GRCm39)	nonsense	probably null
IGL02145:Dmxl2	APN	9	54,281,981 (GRCm39)	missense	probably benign	0.29
IGL02210:Dmxl2	APN	9	54,311,333 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dmxl2	APN	9	54,352,717 (GRCm39)	missense	probably damaging	1.00
IGL02255:Dmxl2	APN	9	54,301,052 (GRCm39)	missense	probably benign	0.06
IGL02364:Dmxl2	APN	9	54,301,127 (GRCm39)	missense	probably benign	0.02
IGL02423:Dmxl2	APN	9	54,301,032 (GRCm39)	missense	possibly damaging	0.89
IGL02440:Dmxl2	APN	9	54,313,899 (GRCm39)	missense	probably damaging	0.98
IGL02546:Dmxl2	APN	9	54,273,698 (GRCm39)	utr 3 prime	probably benign
IGL02668:Dmxl2	APN	9	54,324,229 (GRCm39)	missense	probably damaging	1.00
IGL03229:Dmxl2	APN	9	54,311,456 (GRCm39)	missense	probably damaging	1.00
IGL03244:Dmxl2	APN	9	54,323,655 (GRCm39)	missense	probably damaging	1.00
IGL03277:Dmxl2	APN	9	54,311,504 (GRCm39)	missense	probably damaging	1.00
IGL03399:Dmxl2	APN	9	54,353,956 (GRCm39)	missense	probably damaging	1.00
BB003:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
BB013:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
I2288:Dmxl2	UTSW	9	54,309,077 (GRCm39)	missense	probably damaging	1.00
P0014:Dmxl2	UTSW	9	54,309,048 (GRCm39)	missense	probably damaging	1.00
R0411:Dmxl2	UTSW	9	54,286,223 (GRCm39)	missense	probably damaging	1.00
R0422:Dmxl2	UTSW	9	54,307,224 (GRCm39)	critical splice donor site	probably null
R0432:Dmxl2	UTSW	9	54,324,235 (GRCm39)	missense	probably benign	0.01
R0436:Dmxl2	UTSW	9	54,291,034 (GRCm39)	missense	probably damaging	1.00
R0538:Dmxl2	UTSW	9	54,301,120 (GRCm39)	missense	probably benign	0.06
R0603:Dmxl2	UTSW	9	54,313,190 (GRCm39)	missense	possibly damaging	0.95
R0605:Dmxl2	UTSW	9	54,327,229 (GRCm39)	missense	probably benign	0.01
R0625:Dmxl2	UTSW	9	54,289,986 (GRCm39)	missense	probably benign
R0626:Dmxl2	UTSW	9	54,323,838 (GRCm39)	missense	probably damaging	1.00
R0736:Dmxl2	UTSW	9	54,286,101 (GRCm39)	missense	probably damaging	0.99
R0847:Dmxl2	UTSW	9	54,313,112 (GRCm39)	missense	probably damaging	1.00
R0855:Dmxl2	UTSW	9	54,273,724 (GRCm39)	missense	probably benign	0.03
R0962:Dmxl2	UTSW	9	54,353,696 (GRCm39)	missense	probably damaging	0.99
R1015:Dmxl2	UTSW	9	54,275,049 (GRCm39)	missense	probably benign	0.32
R1084:Dmxl2	UTSW	9	54,323,717 (GRCm39)	missense	probably damaging	1.00
R1328:Dmxl2	UTSW	9	54,303,533 (GRCm39)	missense	probably benign	0.12
R1401:Dmxl2	UTSW	9	54,322,712 (GRCm39)	critical splice donor site	probably null
R1503:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R1609:Dmxl2	UTSW	9	54,316,547 (GRCm39)	missense	possibly damaging	0.90
R1613:Dmxl2	UTSW	9	54,289,311 (GRCm39)	missense	probably benign
R1660:Dmxl2	UTSW	9	54,358,314 (GRCm39)	missense	possibly damaging	0.68
R1712:Dmxl2	UTSW	9	54,308,769 (GRCm39)	missense	probably benign	0.00
R1772:Dmxl2	UTSW	9	54,330,508 (GRCm39)	splice site	probably benign
R1832:Dmxl2	UTSW	9	54,368,233 (GRCm39)	missense	probably damaging	0.97
R1922:Dmxl2	UTSW	9	54,308,807 (GRCm39)	missense	probably benign
R2104:Dmxl2	UTSW	9	54,322,848 (GRCm39)	missense	probably damaging	1.00
R2109:Dmxl2	UTSW	9	54,301,097 (GRCm39)	missense	probably benign	0.06
R2145:Dmxl2	UTSW	9	54,323,194 (GRCm39)	missense	probably damaging	1.00
R2199:Dmxl2	UTSW	9	54,283,527 (GRCm39)	missense	probably benign	0.35
R2352:Dmxl2	UTSW	9	54,301,146 (GRCm39)	missense	probably damaging	1.00
R2516:Dmxl2	UTSW	9	54,307,378 (GRCm39)	missense	probably damaging	1.00
R2981:Dmxl2	UTSW	9	54,300,986 (GRCm39)	missense	probably damaging	1.00
R3430:Dmxl2	UTSW	9	54,384,745 (GRCm39)	missense	possibly damaging	0.94
R3625:Dmxl2	UTSW	9	54,300,927 (GRCm39)	missense	probably benign	0.23
R3725:Dmxl2	UTSW	9	54,301,053 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl2	UTSW	9	54,277,162 (GRCm39)	missense	probably damaging	1.00
R4002:Dmxl2	UTSW	9	54,381,116 (GRCm39)	splice site	probably benign
R4004:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4005:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4012:Dmxl2	UTSW	9	54,286,297 (GRCm39)	splice site	probably null
R4014:Dmxl2	UTSW	9	54,285,993 (GRCm39)	splice site	probably null
R4115:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R4232:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R4388:Dmxl2	UTSW	9	54,303,551 (GRCm39)	missense	probably damaging	1.00
R4513:Dmxl2	UTSW	9	54,327,168 (GRCm39)	missense	probably null	0.17
R4552:Dmxl2	UTSW	9	54,359,047 (GRCm39)	missense	probably damaging	1.00
R4609:Dmxl2	UTSW	9	54,353,796 (GRCm39)	missense	probably damaging	1.00
R4625:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R4694:Dmxl2	UTSW	9	54,354,189 (GRCm39)	missense	probably benign	0.04
R4711:Dmxl2	UTSW	9	54,358,208 (GRCm39)	missense	probably benign	0.37
R4715:Dmxl2	UTSW	9	54,353,689 (GRCm39)	splice site	probably null
R4746:Dmxl2	UTSW	9	54,359,080 (GRCm39)	missense	probably benign	0.04
R4789:Dmxl2	UTSW	9	54,287,099 (GRCm39)	missense	probably benign	0.30
R4825:Dmxl2	UTSW	9	54,311,325 (GRCm39)	missense	probably benign	0.01
R4911:Dmxl2	UTSW	9	54,318,937 (GRCm39)	missense	probably damaging	1.00
R4995:Dmxl2	UTSW	9	54,408,725 (GRCm39)	utr 5 prime	probably benign
R5026:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R5118:Dmxl2	UTSW	9	54,368,271 (GRCm39)	missense	probably damaging	1.00
R5174:Dmxl2	UTSW	9	54,352,768 (GRCm39)	splice site	probably null
R5373:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5374:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5385:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5386:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5418:Dmxl2	UTSW	9	54,281,935 (GRCm39)	critical splice donor site	probably null
R5540:Dmxl2	UTSW	9	54,301,141 (GRCm39)	missense	probably benign	0.21
R5568:Dmxl2	UTSW	9	54,330,643 (GRCm39)	splice site	probably null
R5733:Dmxl2	UTSW	9	54,283,550 (GRCm39)	missense	possibly damaging	0.64
R5758:Dmxl2	UTSW	9	54,380,248 (GRCm39)	missense	probably benign	0.28
R5759:Dmxl2	UTSW	9	54,282,792 (GRCm39)	missense	probably damaging	1.00
R5893:Dmxl2	UTSW	9	54,294,704 (GRCm39)	missense	possibly damaging	0.64
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6041:Dmxl2	UTSW	9	54,324,037 (GRCm39)	missense	probably damaging	1.00
R6174:Dmxl2	UTSW	9	54,301,011 (GRCm39)	missense	probably damaging	1.00
R6278:Dmxl2	UTSW	9	54,323,046 (GRCm39)	missense	probably damaging	1.00
R6307:Dmxl2	UTSW	9	54,289,990 (GRCm39)	missense	possibly damaging	0.68
R6349:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R6404:Dmxl2	UTSW	9	54,282,820 (GRCm39)	missense	probably damaging	1.00
R6516:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R6712:Dmxl2	UTSW	9	54,318,908 (GRCm39)	missense	probably damaging	1.00
R6747:Dmxl2	UTSW	9	54,323,372 (GRCm39)	missense	probably damaging	1.00
R6769:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6771:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6800:Dmxl2	UTSW	9	54,316,467 (GRCm39)	missense	probably damaging	1.00
R6891:Dmxl2	UTSW	9	54,387,664 (GRCm39)	missense	probably damaging	0.99
R6920:Dmxl2	UTSW	9	54,379,496 (GRCm39)	missense	probably damaging	1.00
R6979:Dmxl2	UTSW	9	54,358,163 (GRCm39)	missense	possibly damaging	0.49
R7147:Dmxl2	UTSW	9	54,324,013 (GRCm39)	missense	probably benign	0.06
R7327:Dmxl2	UTSW	9	54,308,869 (GRCm39)	missense	probably damaging	1.00
R7462:Dmxl2	UTSW	9	54,273,916 (GRCm39)	splice site	probably null
R7526:Dmxl2	UTSW	9	54,308,241 (GRCm39)	missense	possibly damaging	0.47
R7569:Dmxl2	UTSW	9	54,323,271 (GRCm39)	missense	possibly damaging	0.51
R7622:Dmxl2	UTSW	9	54,379,502 (GRCm39)	missense	probably damaging	0.99
R7638:Dmxl2	UTSW	9	54,365,078 (GRCm39)	missense	unknown
R7703:Dmxl2	UTSW	9	54,368,370 (GRCm39)	missense	probably benign	0.01
R7768:Dmxl2	UTSW	9	54,288,223 (GRCm39)	missense	probably damaging	1.00
R7926:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
R7969:Dmxl2	UTSW	9	54,354,165 (GRCm39)	missense	possibly damaging	0.85
R8007:Dmxl2	UTSW	9	54,290,975 (GRCm39)	nonsense	probably null
R8200:Dmxl2	UTSW	9	54,387,630 (GRCm39)	missense	probably benign
R8311:Dmxl2	UTSW	9	54,354,217 (GRCm39)	missense	probably benign	0.00
R8320:Dmxl2	UTSW	9	54,291,043 (GRCm39)	missense	probably benign
R8377:Dmxl2	UTSW	9	54,286,032 (GRCm39)	missense	probably damaging	1.00
R8400:Dmxl2	UTSW	9	54,291,037 (GRCm39)	missense	probably benign	0.03
R8509:Dmxl2	UTSW	9	54,335,341 (GRCm39)	nonsense	probably null
R8698:Dmxl2	UTSW	9	54,281,953 (GRCm39)	missense	probably benign	0.10
R8768:Dmxl2	UTSW	9	54,301,105 (GRCm39)	missense	possibly damaging	0.83
R8770:Dmxl2	UTSW	9	54,311,298 (GRCm39)	missense	probably benign	0.01
R8799:Dmxl2	UTSW	9	54,327,027 (GRCm39)	critical splice donor site	probably null
R8840:Dmxl2	UTSW	9	54,309,139 (GRCm39)	missense	possibly damaging	0.58
R8898:Dmxl2	UTSW	9	54,308,941 (GRCm39)	missense	probably benign	0.01
R8954:Dmxl2	UTSW	9	54,381,156 (GRCm39)	missense	probably benign	0.04
R9083:Dmxl2	UTSW	9	54,316,548 (GRCm39)	missense	probably benign	0.29
R9114:Dmxl2	UTSW	9	54,307,321 (GRCm39)	missense
R9115:Dmxl2	UTSW	9	54,309,011 (GRCm39)	missense	probably benign
R9263:Dmxl2	UTSW	9	54,358,945 (GRCm39)	missense	probably benign	0.01
R9272:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R9577:Dmxl2	UTSW	9	54,323,664 (GRCm39)	missense	unknown
R9673:Dmxl2	UTSW	9	54,294,840 (GRCm39)	missense	probably damaging	1.00
R9722:Dmxl2	UTSW	9	54,323,892 (GRCm39)	missense	probably benign	0.00
R9726:Dmxl2	UTSW	9	54,322,996 (GRCm39)	missense	probably benign	0.09
R9797:Dmxl2	UTSW	9	54,358,187 (GRCm39)	missense	probably benign	0.00
X0064:Dmxl2	UTSW	9	54,308,997 (GRCm39)	missense	probably benign
Z1177:Dmxl2	UTSW	9	54,289,318 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- AGCAGGTGTTTACTAAAGACAACAG -3'
(R):5'- AGGAATCTGACATGATCATGGC -3'

Sequencing Primer
(F):5'- GTCCTGAACTAGCTCTGCAGACTAG -3'
(R):5'- TGCCTTTGCTTCATAGGC -3'

Posted On

2016-08-04