Incidental Mutation 'R5289:Atrnl1'
ID 424624
Institutional Source Beutler Lab
Gene Symbol Atrnl1
Ensembl Gene ENSMUSG00000054843
Gene Name attractin like 1
Synonyms Alp
MMRRC Submission 042872-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.182) question?
Stock # R5289 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 57599466-58121775 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 57645514 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 458 (T458M)
Ref Sequence ENSEMBL: ENSMUSP00000076514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077282]
AlphaFold Q6A051
Predicted Effect probably damaging
Transcript: ENSMUST00000077282
AA Change: T458M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: T458M

DomainStartEndE-ValueType
low complexity region 25 32 N/A INTRINSIC
EGF 61 90 5.71e-1 SMART
CUB 92 208 1.43e-11 SMART
EGF 209 244 1.95e1 SMART
Pfam:EGF_2 248 279 5.8e-7 PFAM
Pfam:Kelch_5 350 391 2.1e-9 PFAM
Pfam:Kelch_6 354 401 5.8e-8 PFAM
Pfam:Kelch_4 465 517 4.3e-7 PFAM
Pfam:Kelch_1 519 573 2.7e-6 PFAM
PSI 613 656 3.38e-1 SMART
PSI 665 708 2e-3 SMART
PSI 714 759 1.72e-2 SMART
CLECT 747 872 2.86e-20 SMART
PSI 888 938 6.26e-5 SMART
PSI 941 1011 1.73e-7 SMART
EGF_Lam 1013 1056 1.07e-5 SMART
low complexity region 1157 1173 N/A INTRINSIC
transmembrane domain 1229 1251 N/A INTRINSIC
low complexity region 1261 1272 N/A INTRINSIC
low complexity region 1326 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,669,203 (GRCm39) V1731A probably benign Het
Ahcyl1 A G 3: 107,577,206 (GRCm39) probably null Het
Aox1 T A 1: 58,131,717 (GRCm39) M1042K probably damaging Het
Atp10d C A 5: 72,412,466 (GRCm39) Q590K probably benign Het
Atp8b1 G T 18: 64,679,158 (GRCm39) N774K possibly damaging Het
Bltp1 C A 3: 37,054,258 (GRCm39) Q3126K probably damaging Het
Cnr1 T A 4: 33,943,910 (GRCm39) C99* probably null Het
Cnr2 A G 4: 135,644,318 (GRCm39) Y132C probably damaging Het
Commd9 C T 2: 101,729,239 (GRCm39) A115V probably benign Het
Diaph3 A G 14: 87,219,114 (GRCm39) F426S probably damaging Het
Diras1 G A 10: 80,858,078 (GRCm39) Q58* probably null Het
Dnaaf6rt A T 1: 31,262,608 (GRCm39) I197F probably benign Het
Dpy19l2 A G 9: 24,607,293 (GRCm39) L56P probably benign Het
Dsc1 A T 18: 20,234,910 (GRCm39) V248D possibly damaging Het
Frem3 A G 8: 81,338,948 (GRCm39) M414V probably benign Het
Frmd4b G T 6: 97,279,309 (GRCm39) probably null Het
Gabarapl2 T C 8: 112,669,227 (GRCm39) W62R probably damaging Het
Glt1d1 A G 5: 127,721,420 (GRCm39) R36G probably benign Het
Grb10 T C 11: 11,894,924 (GRCm39) silent Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Hc A G 2: 34,886,026 (GRCm39) probably null Het
Hgd A G 16: 37,448,913 (GRCm39) E379G possibly damaging Het
Ifi30 A T 8: 71,219,245 (GRCm39) probably benign Het
Iqgap1 T C 7: 80,388,472 (GRCm39) I842V possibly damaging Het
Iqsec3 T A 6: 121,363,659 (GRCm39) probably null Het
Kalrn A G 16: 34,072,711 (GRCm39) S724P possibly damaging Het
Lama2 C A 10: 27,088,069 (GRCm39) G903* probably null Het
Lrrc10 T C 10: 116,881,392 (GRCm39) V22A probably benign Het
Lzts3 T C 2: 130,478,021 (GRCm39) E245G probably benign Het
Man2a1 A G 17: 64,958,222 (GRCm39) T246A probably damaging Het
Mfsd13a A G 19: 46,356,719 (GRCm39) E240G probably benign Het
Mtor T C 4: 148,550,549 (GRCm39) I735T possibly damaging Het
Naa15 A T 3: 51,363,315 (GRCm39) H333L probably damaging Het
Nes C A 3: 87,885,725 (GRCm39) T1284K probably damaging Het
Nexn T G 3: 151,953,709 (GRCm39) H173P probably benign Het
Nid2 T C 14: 19,855,379 (GRCm39) V1173A possibly damaging Het
Npepps A G 11: 97,131,753 (GRCm39) probably null Het
Pgm1 T A 4: 99,824,266 (GRCm39) M313K probably damaging Het
Plag1 T A 4: 3,905,545 (GRCm39) K48N probably damaging Het
Prok1 G C 3: 107,146,935 (GRCm39) L11V probably benign Het
Ptpn9 T C 9: 56,967,347 (GRCm39) probably null Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Slc38a4 A T 15: 96,908,229 (GRCm39) F171I possibly damaging Het
Sycp1 A T 3: 102,841,569 (GRCm39) N78K possibly damaging Het
Tas2r110 T C 6: 132,844,972 (GRCm39) M1T probably null Het
Thoc2l G A 5: 104,667,523 (GRCm39) V682I probably benign Het
Tmem260 G A 14: 48,724,267 (GRCm39) V182M possibly damaging Het
Tmem30a A T 9: 79,683,436 (GRCm39) N144K probably damaging Het
Vmn2r108 A G 17: 20,691,866 (GRCm39) L219P probably damaging Het
Vmn2r57 A G 7: 41,049,398 (GRCm39) S784P probably damaging Het
Vwf T C 6: 125,644,473 (GRCm39) probably benign Het
Wdr62 A C 7: 29,967,300 (GRCm39) V318G probably damaging Het
Zfp398 T A 6: 47,840,115 (GRCm39) S115T probably benign Het
Zfp62 T A 11: 49,107,975 (GRCm39) C689S probably damaging Het
Zmynd15 C G 11: 70,356,830 (GRCm39) P580R unknown Het
Other mutations in Atrnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Atrnl1 APN 19 57,680,249 (GRCm39) missense probably benign 0.02
IGL00707:Atrnl1 APN 19 57,661,697 (GRCm39) missense probably damaging 0.96
IGL00921:Atrnl1 APN 19 57,690,585 (GRCm39) missense probably damaging 1.00
IGL01410:Atrnl1 APN 19 58,119,536 (GRCm39) missense probably damaging 1.00
IGL01468:Atrnl1 APN 19 57,688,144 (GRCm39) missense probably benign 0.02
IGL01756:Atrnl1 APN 19 57,641,380 (GRCm39) missense probably benign
IGL01971:Atrnl1 APN 19 57,741,715 (GRCm39) missense probably damaging 1.00
IGL02019:Atrnl1 APN 19 57,680,195 (GRCm39) splice site probably benign
IGL02580:Atrnl1 APN 19 57,703,008 (GRCm39) splice site probably benign
IGL02649:Atrnl1 APN 19 57,638,873 (GRCm39) splice site probably benign
IGL02676:Atrnl1 APN 19 57,680,316 (GRCm39) missense probably damaging 1.00
IGL03276:Atrnl1 APN 19 57,641,359 (GRCm39) missense probably damaging 0.99
IGL03379:Atrnl1 APN 19 57,630,973 (GRCm39) missense probably benign 0.02
Magnetogorsk UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
polar UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
PIT4812001:Atrnl1 UTSW 19 57,720,055 (GRCm39) missense probably benign 0.08
R0109:Atrnl1 UTSW 19 57,743,949 (GRCm39) missense possibly damaging 0.78
R0308:Atrnl1 UTSW 19 57,741,720 (GRCm39) missense probably benign 0.04
R0394:Atrnl1 UTSW 19 57,661,608 (GRCm39) missense probably benign 0.10
R0734:Atrnl1 UTSW 19 57,643,293 (GRCm39) missense probably damaging 1.00
R0811:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R0812:Atrnl1 UTSW 19 57,661,573 (GRCm39) missense probably benign 0.07
R1183:Atrnl1 UTSW 19 57,638,725 (GRCm39) missense probably damaging 0.97
R1213:Atrnl1 UTSW 19 57,626,894 (GRCm39) missense probably benign 0.25
R1344:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1418:Atrnl1 UTSW 19 57,924,137 (GRCm39) critical splice donor site probably null
R1707:Atrnl1 UTSW 19 57,675,169 (GRCm39) missense probably benign 0.00
R1748:Atrnl1 UTSW 19 57,703,134 (GRCm39) missense probably damaging 0.99
R2051:Atrnl1 UTSW 19 57,680,281 (GRCm39) missense probably benign 0.01
R2113:Atrnl1 UTSW 19 57,744,048 (GRCm39) nonsense probably null
R2130:Atrnl1 UTSW 19 57,643,426 (GRCm39) missense probably damaging 1.00
R3710:Atrnl1 UTSW 19 57,645,546 (GRCm39) missense probably damaging 1.00
R3916:Atrnl1 UTSW 19 57,924,084 (GRCm39) missense possibly damaging 0.82
R4524:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R4707:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4712:Atrnl1 UTSW 19 57,641,382 (GRCm39) missense probably benign 0.00
R4784:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4785:Atrnl1 UTSW 19 57,617,590 (GRCm39) missense probably damaging 0.97
R4798:Atrnl1 UTSW 19 58,030,793 (GRCm39) missense probably benign
R5172:Atrnl1 UTSW 19 57,673,945 (GRCm39) nonsense probably null
R5226:Atrnl1 UTSW 19 57,638,767 (GRCm39) missense probably benign
R5372:Atrnl1 UTSW 19 57,743,968 (GRCm39) missense probably benign
R5737:Atrnl1 UTSW 19 57,766,320 (GRCm39) missense possibly damaging 0.84
R5782:Atrnl1 UTSW 19 57,741,718 (GRCm39) missense possibly damaging 0.95
R5826:Atrnl1 UTSW 19 57,618,724 (GRCm39) nonsense probably null
R6169:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R6242:Atrnl1 UTSW 19 57,630,910 (GRCm39) missense probably benign 0.02
R6342:Atrnl1 UTSW 19 57,626,942 (GRCm39) missense probably damaging 1.00
R6372:Atrnl1 UTSW 19 57,638,764 (GRCm39) missense probably benign 0.01
R6811:Atrnl1 UTSW 19 57,643,393 (GRCm39) missense probably damaging 0.98
R6897:Atrnl1 UTSW 19 58,030,800 (GRCm39) missense probably benign 0.01
R7024:Atrnl1 UTSW 19 57,626,882 (GRCm39) critical splice acceptor site probably null
R7085:Atrnl1 UTSW 19 57,680,289 (GRCm39) missense probably damaging 1.00
R7144:Atrnl1 UTSW 19 58,030,784 (GRCm39) missense probably damaging 1.00
R7259:Atrnl1 UTSW 19 57,924,038 (GRCm39) nonsense probably null
R7289:Atrnl1 UTSW 19 57,638,846 (GRCm39) missense probably benign 0.13
R7310:Atrnl1 UTSW 19 57,630,856 (GRCm39) missense possibly damaging 0.69
R7372:Atrnl1 UTSW 19 57,924,078 (GRCm39) missense possibly damaging 0.47
R7432:Atrnl1 UTSW 19 57,743,956 (GRCm39) missense probably damaging 1.00
R7478:Atrnl1 UTSW 19 57,684,744 (GRCm39) missense possibly damaging 0.89
R7556:Atrnl1 UTSW 19 57,643,278 (GRCm39) missense probably benign
R7567:Atrnl1 UTSW 19 57,687,955 (GRCm39) missense probably damaging 0.98
R7608:Atrnl1 UTSW 19 57,703,119 (GRCm39) missense probably damaging 1.00
R7632:Atrnl1 UTSW 19 57,618,738 (GRCm39) missense probably damaging 1.00
R7655:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7656:Atrnl1 UTSW 19 57,599,811 (GRCm39) nonsense probably null
R7718:Atrnl1 UTSW 19 57,728,615 (GRCm39) nonsense probably null
R7721:Atrnl1 UTSW 19 57,684,763 (GRCm39) missense probably benign 0.00
R7726:Atrnl1 UTSW 19 57,690,504 (GRCm39) missense probably damaging 1.00
R7733:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense probably benign 0.00
R7774:Atrnl1 UTSW 19 57,688,103 (GRCm39) missense probably damaging 1.00
R8010:Atrnl1 UTSW 19 57,670,878 (GRCm39) missense probably benign 0.14
R8119:Atrnl1 UTSW 19 57,630,895 (GRCm39) missense probably benign 0.00
R9242:Atrnl1 UTSW 19 57,645,660 (GRCm39) missense probably benign 0.07
R9265:Atrnl1 UTSW 19 57,766,359 (GRCm39) missense probably benign 0.11
R9272:Atrnl1 UTSW 19 57,643,420 (GRCm39) missense probably benign 0.00
R9480:Atrnl1 UTSW 19 57,690,420 (GRCm39) missense possibly damaging 0.61
R9526:Atrnl1 UTSW 19 57,617,551 (GRCm39) missense probably damaging 0.99
R9672:Atrnl1 UTSW 19 57,618,695 (GRCm39) missense possibly damaging 0.87
R9673:Atrnl1 UTSW 19 57,599,786 (GRCm39) start codon destroyed probably null 0.04
RF021:Atrnl1 UTSW 19 57,630,905 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCATTTTGGGACATGCAGGATG -3'
(R):5'- GATAAAGATACTGTTGCCCAGCC -3'

Sequencing Primer
(F):5'- ACATGCAGGATGGTTAGGTTGC -3'
(R):5'- ATACTGTTGCCCAGCCCTTCC -3'
Posted On 2016-08-04